Clinical trials: Hypertrophic Scarring
Burn Scar
Microneedling for Burn Hypertrophic Scars
Approximately 33 to 91% of severe burn victims will develop hypertrophic scars. Hypertrophic scars are defined as erythematous (red), raised and rigid scars that can cause pain and itching, among other things.
- Trial name
- NCT05423613
- Testing
- Microneedling
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Ultra Tension-Reducing Suture Technique
A Self-Controlled Clinical Study of Fast-Absorbable Versus Slow-Absorbable Sutures Applied in Ultra Tension-Reducing Suture Technique
Hypertrophic scar formation after wound healing remains a clinical challenge in plastic surgery. Ultra Tension-Reducing Suture Technique is currently the primary surgical option for preventing and reducing hypertrophic…
- Trial name
- NCT07639372
- Testing
- Intervention 1: 5-0 Slow-absorbable PDS suture, Intervention 2: 5-0 Fast-absorbable Vicryl suture
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Zhenzhen Zhang
Cicatrix, Hypertrophic, Burns
Laser Therapy for Pediatric Burn Scars
A new era of outcomes for pediatric burn patients has begun as burn care continues to improve. Unfortunately, complete restoration of burn-injured skin may be limited by the development of hypertrophic scarring.
- Trial name
- NCT02707627
- Testing
- Laser Therapy
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Hypertrophic Scarring
A Randomized Control Trial for Preventative Scar Management
The study's objective is to compare the global scar outcomes in those treated with silicone only therapy (SOT) versus silicone pressure garment therapy (SPGT) for the prevention of hypertrophic scarring in children with skin…
- Trial name
- NCT01602458
- Testing
- Silicone Only Therapy (SOT), Silicone Pressure Garment Therapy (SPGT)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Seton Healthcare Family
Wound Healing
Plasma Therapy for Scar Management
This study is a prospective, multicenter, real-world observational study. It aims to evaluate whether adding plasma device therapy to standard scar care is effective and safe for treating various types of scars, including…
- Trial name
- NCT07548593
- Testing
- Plasma Device
- Volunteers
- 800 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Keloid, Alopecia Areata
Pain Outcomes Following Intralesional Corticosteroid Injections
Corticosteroid therapy, including intralesional and topical applications, has many indications within the fields of Dermatology, Plastic Surgery, and Orthopedics.
- Conditions
- Keloid, Alopecia Areata, Acne, Hypertrophic Scar
- Trial name
- NCT03630198
- Testing
- Corticosteroid with lidocaine, Corticosteroid with normal saline
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Burns
Use of Pressure Garments for Burn Scars
1. Will Pressure Garment Therapy better control hypertrophic scarring than no Pressure Garment Therapy. 2. How will Pressure Garment Therapy affect functional capacity or scar contracture development across joints either in…
- Trial name
- Jobst (NCT00675974)
- Testing
- Jobst Pressure Garment, Medical Z pressure garment
- Sponsor
- The University of Texas Medical Branch, Galveston
Cicatrix
Fractional Microplasma Radiofrequency Technology for Non-hypertrophic Post-burn Scars in Asians: A Prospective Study of 95 Patients
A prospective study to evaluate the efficacy and safety of FMRT for treating non-hypertrophic post-burn scars in an Asian population.
- Trial name
- NCT02861248
- Testing
- Fractional micro-plasma radiofrequency treatment
- Where
- China
- Volunteers
- 95 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Keloid
Keloid Radiation Registry
Radiation therapy has been, and is being used in treatment of patients with keloid. Radiation is typically used as an adjunct to surgery in order to reduce the recurrence rate of keloid.
- Trial name
- NCT01457079
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Tirgan, Michael H., M.D.
Hypertrophic Scar
Comparison of Cosmetic and Functional Outcome of Silicone Sheeting and Micro-needling on Hypertrophic Scars
Hypertrophic scars and keloids are frequently encountered in plastic surgery OPD. due to any reason, the normal wound healing is impaired, hypertrophic scars or keloids occur. These are thickened, wide and raised scars.
- Trial name
- NCT05108272
- Testing
- Microneedling, Percutaneous Collagen Induction
- Where
- 2 sites in Pakistan
- Volunteers
- 80 people
- Sponsor
- Foundation University Islamabad
Burn Scar
Nonsilicone Gel Sheet for Burn Hypertrophic Scars
Overview: The application of gel sheets holds promise for both the prevention and treatment of hypertrophic scar after deep dermal injuries.
- Trial name
- NCT05429411
- Testing
- Silicone gel
- Where
- Canada
- Volunteers
- 49 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Fibrosis, Scarring
High Fluence Light Emitting Diode-Red Light (LED-RL) in Human Skin
The goal of this study is to establish the safety of high fluence LED-RL from 160 J/cm2 up to 640 J/cm2 in healthy subjects. The hypothesis is that high fluence LED-RL phototherapy is safe in human skin.
- Conditions
- Fibrosis, Scarring, Scar, Wounds
- Trial name
- NCT02630303
- Testing
- LED-RL Phototherapy, Mock Therapy
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Jared Jagdeo, MD, MS
Burn Scar
Endermotherapy With Burn Hypertrophic Scars
Mechanical massage or endermotherapyTM is applied to scar tissue with the intended therapeutic value being the promotion of structural or physiological changes.
- Trial name
- NCT03697447
- Testing
- Endermotherapy
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Scar
Tissue-engineered Skin Graft Repair of Autologous Scar Dermal Scaffolds
Hypertrophic scar is an inevitable outcome of wound repair. It affects the appearance and some scar contracture often leads to joint dysfunction.Patients have low quality of life, long treatment cycle, heavy social burden and…
- Trial name
- NCT04389164
- Testing
- Tissue-engineered skin grafts of autologous scar dermal scaffolds
- Where
- China
- Volunteers
- 226 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Burn Scar, Scar
Mechanistic Basis of Ablative Carbon Dioxide Laser in Treating Hypertrophic Scars
This is an observational cohort study which will look at the biomarkers from blood and tissue sample for adult patients with hypertrophic scarring due to burns/trauma incident over 12 months from date of recruitment.
- Trial name
- SMOOTH (NCT04736251)
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Naiem Moiemen
Hypertrophic Scarring After Burn Injury
Effectiveness of Pressure Garment Therapy After Burns
Purpose - To determine the effectiveness of custom-fit pressure garment therapy in the prevention of hypertrophic scarring in healed burns. Background - Approximately one million people are burned each year in the United States.
- Trial name
- NCT01005732
- Testing
- Custom fabricated pressure garments
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- University of Washington
Keloid, Cicatrix, Hypertrophic
Prospective Evaluation of the Use of Intralesional Cryotherapy for Treatment of Keloid and Hypertrophic Scars
This prospective evaluation studies the effectiveness of IL cryotherapy in treating keloids and hypertrophic scars in a large population of mixed Fitzpatrick skin types.
- Trial name
- NCT01994616
- Testing
- Intralesional cryotherapy
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Amsterdam UMC, location VUmc
Scar Keloid
Intralesional Triamcinolone Acetonide and Its Combination With 5-fluorouracil in Keloids and Hypertrophic Scars
Summary: Keloids and hypertrophic scars are benign fibrous growth, differing mainly by overgrowth beyond the initial defect in keloid whereas hypertrophic scar is confined to initial lesion and tends to regress over the years.
- Trial name
- NCT04812626
- Testing
- 5-Fluorouracil
- Where
- Nepal
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- B.P. Koirala Institute of Health Sciences
Burn
Hypertrophic Scarring After Facial Burn
Subjects with a burn to the face and/or neck will be enrolled into the study and a Three-Dimensional scanner used to see if it can objectively measure scar color and volume and measure the effect of scar on motion of the face and…
- Trial name
- NCT00242970
- Testing
- 3-Dimensional Color Scanning
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Legacy Health System
Burns
Study of Silicone Material Inserts To Treat Burn Scars
The purpose of this study is to determine if the use of silicone material inserts within pressure garments is effective in decreasing hypertrophic burn scar formation as compared to standard pressure garment therapy.
- Trial name
- NCT03159182
- Testing
- Pressure garment and silicone insert, Pressure garment
- Sponsor
- University of Manitoba