Clinical trials: Hypertensive
Hypercholesterolemia, Hypertension
Effects of Rosiglitazone on Blood Vessels in Patients With High Blood Pressure and High Cholesterol
Cells in the lining of blood vessels produce various substances that cause the vessels to dilate (relax) and constrict (tighten), thereby regulating blood flow.
- Trial name
- NCT00006071
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Hypertension, Pregnancy
Effects of Dietary Nitrate in Hypertensive Pregnant Women
High blood pressure in pregnancy affects around 10% of pregnancies, and is associated with serious adverse outcomes for both mother and baby.
- Trial name
- NCT02520687
- Testing
- Beetroot juice, Nitrate-depleted beetroot juice
- Where
- United Kingdom
- Volunteers
- 44 people
- Sponsor
- University of Manchester
Cardiovascular Diseases, Hypertension
Blood Pressure Control in African Americans
The purpose of this study is to test the effectiveness of a multi-component evidence-based intervention that targets both patients and physicians, in improving BP control rates in patients followed in 30 Community/Migrant Health…
- Trial name
- NCT00233220
- Testing
- Multicomponent, multi-level intervention targeted at physicians and patients, Usual Care
- Where
- United States
- Volunteers
- 1,039 people
- Sponsor
- NYU Langone Health
Cardiovascular Diseases, Heart Diseases
Lipoprotein Metabolism in Hypertensive African-Americans
To study relationships among lipoprotein metabolism, hypertension, and hyperinsulinemia-insulin resistance in African American males and females.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hyperinsulinism, Hypertension
- Trial name
- NCT00005709
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Neuroimaging, Cognitive Dysfunction
Long-term Consequences of Neuroimaging and Perceived Cognitive Dysfunction in oPRES
The purpose of this study is to explore the long-term consequences of neuroimaging and perceived cognitive dysfunction in obstetrics posterior reversible encephalopathy syndrome.
- Conditions
- Neuroimaging, Cognitive Dysfunction, Posterior Reversible Encephalopathy Syndrome
- Trial name
- NCT05140850
- Testing
- neuroimaging examination,neuro-cognitive test,blood pressure,blood sample
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Dunjin Chen
Hypertension
307B - Safety, Tolerability and Pharmacokinetics Study of TOPROL-XL® in Hypertensive Pediatric Subjects
This was a 52-week, multicenter, open-label study to determine the safety, tolerability and pharmacokinetics of TOPROL-XL (metoprolol succinate) extended-release tablets (metoprolol CR/XL) in hypertensive pediatric subjects.
- Trial name
- NCT00255502
- Testing
- metoprolol succinate
- Where
- 31 sites in United States, Dominican Republic
- Volunteers
- 100 people
- Sponsor
- AstraZeneca
Pulmonary Hypertension
Study of Inhaled Iloprost in Pediatric Pulmonary Hypertension (PH) After Surgery
The aim of this study is to determine whether inhaled iloprost can be used to prevent and treat PH and PHC while in children after operation of CHD
- Trial name
- NCT01310751
- Testing
- iloprost nebuliser solusion, distilled water
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Pulmonary Hypertension
Multicenter Study of Iloprost Inhaled in Pulmonary Hypertension After Repair of Congenital Heart Diseases (CHD)
This study was designed to investigate treatment of postoperative pulmonary hypertension by iloprost inhalation in children with congenital heart defects.
- Trial name
- NCT01598441
- Testing
- iloprost nebuliser solution, distilled water
- Where
- 3 sites in China
- Volunteers
- 8 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Posterior Reversible Encephalopathy Syndrome, Pregnancy Outcomes
The Clinical and Prognostic Features of PRES
The purpose of this study is to determine the features of clinical imaging, disease severity and pregnancy outcomes in posterior reversible encephalopathy syndrome with preeclampsia or eclampsia.
- Conditions
- Posterior Reversible Encephalopathy Syndrome, Pregnancy Outcomes, Preeclampsia, Eclampsia
- Trial name
- NCT05143710
- Testing
- PRES in PE or E
- Where
- China
- Volunteers
- 354 people
- Sponsor
- Dunjin Chen
Pre-Eclampsia, Intrauterine Growth Restriction
PEPPI Study: Identification of Women at Risk for Placental Dysfunction
The main purpose of this study is to evaluate Fetal Medicine Foundation's pre-eclampsia risk calculator using maternal characteristics, first trimester serum placental growth factor (PlGF) and mean arterial pressure (MAP) in a…
- Conditions
- Pre-Eclampsia, Intrauterine Growth Restriction, Polycystic Ovary Syndrome, Iron-deficiency
- Trial name
- NCT06115122
- Testing
- Pre-eclampsia screening program
- Where
- Finland
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Oulu University Hospital
Hypertension
Dose Response of Valsartan on Sitting Systolic Blood Pressure in Children 6 Months - 5 Years of Age With High Blood Pressure
The purpose of this study is to evaluate the safety and efficacy of three doses of valsartan (0.25, 1.0, and 4.0 mg/kg) on mean sitting systolic blood pressure (MSSBP) and mean sitting diastolic blood pressure (MSDBP) in 6 months…
- Trial name
- NCT00435162
- Testing
- Valsartan 0.25 mg/kg, Valsartan 1.0 mg/kg, Valsartan 4.0 mg/kg
- Where
- 11 sites in United States, Belgium and 9 more
- Volunteers
- 74 people
- Sponsor
- Novartis Pharmaceuticals
Hypertension
The Relation Between Serum Level of Amioterminal Propeptide of Type I Procollagen and Diastolic Dysfunction in Hypertensive Patients Without Diabetes Mellitus
In the present study, we assessed the relation between diastolic dysfunction and myocardial fibrosis in hypertensive patients without diabetes mellitus.
- Trial name
- NCT00172406
- Sponsor
- National Taiwan University Hospital
Hypertension
A Study to Evaluate the Safety/Tolerability and Pharmacokinetics of Aliskiren in Hypertensive Pediatric and Adolescent Patients 6-17 Years of Age
This first open-label study in a pediatric population was designed to evaluate aliskiren safety and pharmacokinetics after single and multiple dosing in 6-17 year old children with hypertension.
- Trial name
- NCT00834041
- Testing
- Aliskiren 3.125 mini-tablets
- Where
- 5 sites in United States, Belgium and 3 more
- Volunteers
- 39 people
- Sponsor
- Novartis
Chronic Kidney Disease
Effect of Valsartan vs Perindopril on HOMA-IR Index in Patients With Chronic Kidney Disease
The purpose of this study is to compare the effect of valsartan and perindopril on HOMA-IR Index in patients with chronic kidney disease.
- Trial name
- NCT02299310
- Testing
- Valsartan, Perindopril
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Chinese PLA General Hospital
Preeclampsia
Hypertensive Disorders of Pregnancy in Adolescence and Primipaternity
Hypertensive disorders of pregnancy are one of the most frequent complications of pregnancy, being a serious health problem around the world.
- Trial name
- NCT01374477
- Where
- Panama
- Volunteers
- 110 people
- Sponsor
- Saint Thomas Hospital, Panama
Kidney Diseases
China Kidney Patient Trials Network
This is a prospective multi-centre, observational cohort study of incident and prevalent patients diagnosed with a kidney disease in China.
- Trial name
- CKPTN (NCT05036850)
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- George (Beijing) Clinical Research Co. Ltd.
Essential Hypertension
A Phase III Clinical Study of Valsartan Oral Solution for the Treatment of Hypertension in Children and Adolescents
This study was an randomized, double-Blind, placebo-controlled, multicenter Phase II/III study.
- Trial name
- NCT06863987
- Testing
- Valsartan Oral Solution
- Where
- China
- Volunteers
- 342 people
- Sponsor
- Shandong New Time Pharmaceutical Co., LTD
Cerebral Amyloid Angiopathy, Small Vessel Cerebrovascular Disease
Prognosis of Cerebral Small Vessel Disease
Prognosis of small vessel disease (SVD) depends on the underlying type of SVD and index manifestation. The aim of this prospective, observational cohort study is to determine the risk of different outcome events among patients…
- Conditions
- Cerebral Amyloid Angiopathy, Small Vessel Cerebrovascular Disease, Cadasil, CAA - Cerebral Amyloid Angiopathy
- Trial name
- PRO-SVD (NCT05734378)
- Where
- Switzerland
- Volunteers
- 900 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Intraocular Pressure
Ocular-hypertensive Response to Topical Steroids in Children After Bilateral Strabismus Surgery
This study aims to compare the effects of topical (Rimexolone versus Dexamethasone) on the IOP in children under 13 years of age who underwent bilateral strabismus surgery, and to compare the effects of topical (Rimexolone versus…
- Trial name
- NCT02816905
- Testing
- 0.1 % Dexamethasone, 0.1% Fluorometholone, 1% Rimexolone
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Heart Failure
Anti-Hypertensive Agent (ACEi) and Heart Function Improvement in Association With Rho Kinase Activity Changes in Human
Hypothesis: Rho, one of the small GTPase proteins, and its downstream target molecule, Rho-kinase (ROCK), play important roles in mediating various cellular functions, including contractility, actin cytoskeleton organization…
- Trial name
- NCT01069042
- Testing
- Enalapril
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Cheng-Kung University Hospital