Clinical trials: Hypertension Disorders in Pregnancy
Hypertension, Hypertension, Pregnancy-Induced
The Relaxation and Blood Pressure in Pregnancy (REBIP) Study
Over 10% of women have high blood pressure during their pregnancy which may affect their health or that of their baby. There are currently no methods to prevent most high blood pressure in pregnancy and some treatments are not…
- Conditions
- Hypertension, Hypertension, Pregnancy-Induced, Pre-Eclampsia
- Trial name
- NCT00303173
- Testing
- Guided Imagery
- Where
- 2 sites in Canada
- Volunteers
- 69 people
- Sponsor
- University of Toronto
Pre-Eclampsia
Indonesia Pravastatin to Prevent Preeclampsia Study
BACKGROUND Preeclampsia is a major cause of maternal and neonatal morbidity worldwide. There is currently no cure for preeclampsia, the only definitive treatment is termination of pregnancy by induction of labour or caesarean…
- Trial name
- INOVASIA (NCT03648970)
- Testing
- Pravastatin
- Where
- 7 sites in Indonesia
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Universitas Airlangga
Pre-Eclampsia; Complicating Pregnancy, Pre-eclampsia Aggravated
Comparison Between the Use of Phentolamine Versus Glyceryl Trinitrate for Their Effect on Renal Function in Pre-eclampsia Patients in ICU
Severe pre-eclamptic toxemia has a high incidence of renal complications. Rapid diagnosis and termination of pregnancy are still the gold standard main treatment for pre-eclampsia.
- Trial name
- NCT05687669
- Testing
- Glyceryl trinitrate vs phentolamine for prophylaxis against renal impairment
- Where
- Egypt
- Volunteers
- 170 people
- Sponsor
- Assiut University
Preeclampsia and Eclampsia
Springfusor for Administration of Magnesium Sulphate in Preeclampsia and Eclampsia
Magnesium Sulphate is the drug of choice for prevention and treatment of seizures in preeclampsia and eclampsia. It is administered parenterally by intravenous (IV) and or intramuscular (IM) routes.
- Trial name
- NCT03549767
- Testing
- Springfusor, Standard of care
- Where
- Uganda
- Volunteers
- 241 people
- Sponsor
- Makerere University
Postpartum CVD Risk in Women With Previous Preeclampsia.
Preeclampsia and Circulating Biomarkers
In order to assess circulating biomarkers of cardiovascular risk, we will conduct a 10-year follow-up study comparing 32 exposed (women with a history of pregnancy complicated by preeclampsia) and 32 unexposed (women with a…
- Trial name
- NCT02136667
- Where
- Denmark
- Volunteers
- 64 people
- Sponsor
- University of Aarhus
Pre-Eclampsia
Neurobehavioural Outcomes in Late Preterm Neonates
Hypertensive disorders are the most common medical complications in pregnancy and major causes of maternal, fetal, and neonatal morbidity and mortality.
- Trial name
- PRENB (NCT02443259)
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Lady Hardinge Medical College
Renal Artery Obstruction, Hypertension, Renovascular
A Prospective Danish National Registry of PTRA in Patients With Renovascular Hypertension
A prospective Danish national registry of percutaneous transluminal renal angioplasty (PTRA) in high-risk patients with renal artery stenosis selected on the basis of common national criteria, and with a common follow-up protocol…
- Conditions
- Renal Artery Obstruction, Hypertension, Renovascular, Cardiovascular Diseases, Kidney Diseases
- Trial name
- DAN-PTRA (NCT02770066)
- Testing
- Percutaneous transluminal renal angioplasty
- Where
- 5 sites in Denmark
- Volunteers
- 160 people
- Sponsor
- University of Aarhus
Preeclampsia
Hypertensive Disorders of Pregnancy in Adolescence and Primipaternity
Hypertensive disorders of pregnancy are one of the most frequent complications of pregnancy, being a serious health problem around the world.
- Trial name
- NCT01374477
- Where
- Panama
- Volunteers
- 110 people
- Sponsor
- Saint Thomas Hospital, Panama
Cardiovascular Diseases, Heart Diseases
Regulation of Placental Vascular Reactivity in Pregnancy-induced Hypertension
To elucidate the role of an imbalance in vasodilator prostacyclin (PGI2) and vasoconstrictor thromboxane (TxA2) in pregnancy-induced hypertension
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension, Pregnancy Toxemias
- Trial name
- NCT00005208
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Preeclampsia
Physical Therapy in Pregnant Women With Preeclampsia
The aim of this study is to evaluate the influence that has a physical therapy protocol in maternal and fetal hemodynamics in relation to blood pressure, maternal and fetal responses and perinatal outcomes.
- Trial name
- FPE (NCT01630772)
- Testing
- Physical therapy, No physical therapy
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo
Premature Birth, Pre-Eclampsia
Select Nutrient and Gene Variant Analysis in a Targeted Diet and Lifestyle Intervention Reduces Preterm Birth
Preterm birth (PTB) rates in the US are among the highest in wealthy nations across the globe, and they are particularly high in our most socio-economically disadvantaged populations.
- Conditions
- Premature Birth, Pre-Eclampsia, Small for Gestational Age Infant
- Trial name
- SNGLI-PTB (NCT05436119)
- Testing
- GrowBaby
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- GrowBaby Life Project
Hypertensive Disorder of Pregnancy
Improving Maternal Cardiovascular Outcomes Through the Implementation of a Hypertensive Disorders of Pregnancy Bundle in Nigeria
The goal of this interventional study is to learn from patients and healthcare providers at 4 health institutions (study sites) in Abuja and Kano in Nigeria what ways to best develop the content of a Hypertensive Disorders of…
- Trial name
- IMPACT-HDP (NCT06859359)
- Testing
- Hypertension Disorders of Pregnancy (HDP) Implementation Bundle
- Where
- 4 sites in Nigeria
- Volunteers
- 1,200 people
- Sponsor
- Washington University School of Medicine
Acute Kidney Injury, Chronic Kidney Disease
Long Term Impact of Pediatric Acute Renal Injury in Severe Sepsis
Sepsis is the most common cause of childhood death worldwide. Millions of children survive, but are left with impaired health. Sepsis-related Acute Kidney Injury (sAKI) is increasingly recognized as a significant factor…
- Conditions
- Acute Kidney Injury, Chronic Kidney Disease, Hypertension
- Trial name
- IMPRESS (NCT02372721)
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Preterm Birth, Intrauterine Growth Retardation
Fish Oil Trials in Pregnancy for the Prevention of Pregnancy Complications ('FOTIP')
The initial trial examined if fish oil supplementation during pregnancy could reduce the risk of pregnancy induced hypertension, intrauterine growth retardation, and preterm birth in pregnancies that were at increased risk of…
- Conditions
- Preterm Birth, Intrauterine Growth Retardation, Pregnancy Induced Hypertension
- Trial name
- FOTIP (NCT02229526)
- Testing
- Low dose fish oil, Low dose olive oil, High dose fish oil
- Volunteers
- 1,619 people
- Sponsor
- Sjurdur Frodi Olsen
Preeclampsia, Aspirin
Low Dose Aspirin Alerts in High-Risk Pregnancies
The goal of this study is to assess the effect of an electronic health record (EHR) clinical decision support tool, also known as a best practice alert (BPA), on healthcare provider recommendations for low dose aspirin use in a…
- Conditions
- Preeclampsia, Aspirin, Clinical Decision Support Systems, Economics, Behavioral
- Trial name
- NCT05802940
- Testing
- Electronic health record best practice alert
- Where
- United States
- Volunteers
- 830 people
- Sponsor
- Geisinger Clinic
Vitamin D Deficiency, Pre Eclampsia
Evaluation of the Effectiveness of Vitamin D Supplementation to Pregnant Women and Their Infants in Pakistan.
Vitamin D deficiency is wide spread in South Asian population and is contributing to burden of disease in this region including Pakistan.
- Conditions
- Vitamin D Deficiency, Pre Eclampsia, Stillbirths, Low Birth Weight
- Trial name
- NCT01229189
- Testing
- Vitamin D
- Where
- Pakistan
- Volunteers
- 460 people
- Sponsor
- Aga Khan University
Renal Pelvis Cancer, Restless Legs Syndrome
Gabapentin and Risk of Pancreatic Cancer and Renal Cancer (GPRD)
High doses of gabapentin are associated with pancreatic acinar cell tumors in rats, but there has been no post marketing pancreatic carcinogenicity signal with gabapentin as reported by spontaneous reports in the Adverse Events…
- Conditions
- Renal Pelvis Cancer, Restless Legs Syndrome, Epilepsy, Neuropathic Pain
- Trial name
- NCT01138124
- Testing
- Gabapentin prescriptions
- Volunteers
- 54,202 people
- Sponsor
- GlaxoSmithKline
Preeclampsia (PE)
Prevention of Preeclampsia in Denmark: A National Implementation Study
The goal of this clinical study is to learn if a new first-trimester screening program can better find pregnant women who are at high risk of developing preeclampsia and help prevent the condition with early treatment.
- Trial name
- PREPRED (NCT07485140)
- Testing
- First trimester screening for preeclampsia
- Where
- 3 sites in Denmark
- Volunteers
- 80,000 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital at Herlev
Hypertension, Pregnancy-Induced
Comparison of Urine Protein/Creatinine Ratio With 24-hour Urine Protein Excretion in Woman With Hypertensive Disorders
The presence of proteinuria (>300 mg/d) represents an important factor in the diagnosis and evaluation of the pregnant patient with an hypertensive disorder.
- Trial name
- NCT01508208
- Testing
- Hypertensive disorder of pregnancy
- Where
- Panama
- Volunteers
- 420 people
- Sponsor
- Saint Thomas Hospital, Panama
Preeclampsia
A Study to Evaluate the Use of Placenta Protein 13 (PP13) in the First Trimester of Pregnancy as a Diagnostic Aiding Tool in the Assessment of the Risk for Developing Preeclampsia in Women With Low and Unknown Risk
The purpose of this study is to evaluate whether it is possible to detect changes in the concentration of PP13 in the blood of pregnant women who may go on to develop the complication of preeclampsia later on in the pregnancy…
- Trial name
- NCT00572793
- Where
- United States
- Volunteers
- 431 people, healthy volunteers welcome
- Sponsor
- Carl Weiner, MD