Clinical trials: Hypertension, Renal
Anemia, Sickle Cell, Sickle Cell Disease
Preventing Sickle Cell Kidney Disease
Untreated hypertension and renal injury are risk factors for increased morbidity and mortality in sickle cell disease, yet early markers of progressive disease have not been identified and therapies to prevent the development of…
- Conditions
- Anemia, Sickle Cell, Sickle Cell Disease, Kidney Disease, Hypertension
- Trial name
- NCT02373241
- Testing
- Losartan
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Pediatric Hypertension With or Without CKD
Efficacy, Safety and Tolerability of Multiple Doses of Valsartan in Children With Hypertension With or Without CKD
To assess efficacy, safety and tolerability of valsartan when comparing two doses of valsartan in reducing and controlling blood pressure in children with hypertension with or without CKD.
- Trial name
- NCT01617681
- Testing
- VAL489
- Where
- 27 sites in Belgium, Brazil and 7 more
- Volunteers
- 127 people
- Sponsor
- Novartis Pharmaceuticals
Pre-Eclampsia; Complicating Pregnancy, Pre-eclampsia Aggravated
Comparison Between the Use of Phentolamine Versus Glyceryl Trinitrate for Their Effect on Renal Function in Pre-eclampsia Patients in ICU
Severe pre-eclamptic toxemia has a high incidence of renal complications. Rapid diagnosis and termination of pregnancy are still the gold standard main treatment for pre-eclampsia.
- Trial name
- NCT05687669
- Testing
- Glyceryl trinitrate vs phentolamine for prophylaxis against renal impairment
- Where
- Egypt
- Volunteers
- 170 people
- Sponsor
- Assiut University
Renal Artery Obstruction, Hypertension, Renovascular
A Prospective Danish National Registry of PTRA in Patients With Renovascular Hypertension
A prospective Danish national registry of percutaneous transluminal renal angioplasty (PTRA) in high-risk patients with renal artery stenosis selected on the basis of common national criteria, and with a common follow-up protocol…
- Conditions
- Renal Artery Obstruction, Hypertension, Renovascular, Cardiovascular Diseases, Kidney Diseases
- Trial name
- DAN-PTRA (NCT02770066)
- Testing
- Percutaneous transluminal renal angioplasty
- Where
- 5 sites in Denmark
- Volunteers
- 160 people
- Sponsor
- University of Aarhus
Kidney, Polycystic
HALT Progression of Polycystic Kidney Disease Study A
The efficacy of interruption of the renin-angiotensin-aldosterone system (RAAS) on the progression of cystic disease and on the decline in renal function in autosomal dominant kidney disease (ADPKD) will be assessed in two…
- Trial name
- HALT PKD A (NCT00283686)
- Testing
- Lisinopril, Telmisartan, Standard Blood Pressure Control
- Where
- 7 sites in United States
- Volunteers
- 558 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Acute Kidney Injury, Chronic Kidney Disease
Long Term Impact of Pediatric Acute Renal Injury in Severe Sepsis
Sepsis is the most common cause of childhood death worldwide. Millions of children survive, but are left with impaired health. Sepsis-related Acute Kidney Injury (sAKI) is increasingly recognized as a significant factor…
- Conditions
- Acute Kidney Injury, Chronic Kidney Disease, Hypertension
- Trial name
- IMPRESS (NCT02372721)
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Renal Pelvis Cancer, Restless Legs Syndrome
Gabapentin and Risk of Pancreatic Cancer and Renal Cancer (GPRD)
High doses of gabapentin are associated with pancreatic acinar cell tumors in rats, but there has been no post marketing pancreatic carcinogenicity signal with gabapentin as reported by spontaneous reports in the Adverse Events…
- Conditions
- Renal Pelvis Cancer, Restless Legs Syndrome, Epilepsy, Neuropathic Pain
- Trial name
- NCT01138124
- Testing
- Gabapentin prescriptions
- Volunteers
- 54,202 people
- Sponsor
- GlaxoSmithKline
Hypertension, Diabetes
Renin and Aldosterone Levels in the Preterm Neonate At Risk for Hypertension
The purpose of this study is to find out if mothers with high blood pressure (Hypertension) and/or diabetes have babies with high levels of different substances (that help to regulate blood pressure, called Renin and Aldosterone)…
- Conditions
- Hypertension, Diabetes, Infants Small for Gestational Age
- Trial name
- NCT01549444
- Testing
- presence of maternal risk factor for hypertension
- Where
- 2 sites in Canada
- Volunteers
- 76 people
- Sponsor
- Ottawa Hospital Research Institute
Hypertension
Post-marketing Surveillance for Hypertensive Patients With Diabetes and/or Chronic Kidney Disease
This study is a post-marketing surveillance in Japan, and it is a local prospective, company sponsored and observational study of patient who have been treated by Adalat CR for hypertension with diabetes and/or chronic kidney…
- Trial name
- NCT01363336
- Testing
- Nifedipine (Adalat CR, BAYA1040)
- Where
- Japan
- Volunteers
- 1,882 people
- Sponsor
- Bayer
Renal Artery Obstruction, Hypertension, Renovascular
Endovascular Therapy for Renal Artery Stenosis in China
A multicenter prospective registry planned to recruit more than 5 000 patients with renal artery stenosis was carried out in China.
- Trial name
- ETRAS-China (NCT03080519)
- Testing
- Endovascular Therapy
- Where
- 16 sites in China
- Volunteers
- 5,000 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Sickle Cell Anemia, Sickle Cell Disease
Heart Arteries and Sickle Cell Disease / Coeur Artères DREpanocytose
The CADRE study is a multinational observational cohort of patients with sickle-cell disease (SCD) in five west and central sub-Saharan African countries.
- Trial name
- CADRE (NCT03114137)
- Where
- 13 sites in Cameroon, Côte d’Ivoire and 4 more
- Volunteers
- 4,500 people, healthy volunteers welcome
- Sponsor
- Cardiologie et Développement
Acute Kidney Injury, Chronic Kidney Disease
Severe Sepsis in Children - IMPRESS-C
Sepsis is the most common cause of childhood death worldwide. Millions of children survive, but are left with impaired health. Sepsis-related Acute Kidney Injury (sAKI) is increasingly recognized as a significant factor…
- Conditions
- Acute Kidney Injury, Chronic Kidney Disease, Hypertension
- Trial name
- IMPRESS-C (NCT02598674)
- Testing
- Iodohippurate, 24 hour ambulatory Blood Pressure, Peripheral Arterial Tonometry
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Peripheral Artery Disease
Genetics of Peripheral Artery Genomics
Peripheral artery disease is a disease that contributes to significant morbidity and mortality of millions of Americans yearly. Very little is known about the pathophysiology of atherosclerosis in peripheral artery disease.
- Trial name
- NCT00615121
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Duke University
Atrial Fibrillation, Coronary Heart Disease
EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality
Health inequality and genetic disparity are a significant issue in the United Kingdom (UK). This study focuses on diseases that are associated with significant morbidity and mortality in the UK, and specifically examines the…
- Conditions
- Atrial Fibrillation, Coronary Heart Disease, Cardiovascular Diseases, Heart Failure
- Trial name
- EMPOWER (NCT03987633)
- Where
- United Kingdom
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- Future Genetics Limited
Chronic Kidney Diseases, Hypertension
Pilot to Examine Risk and Feasibility of Remote Management of BP From Childhood Into Early Adulthood
Hypertension is an increasingly common problem in children, especially among those who are obese or with diabetes and chronic kidney disease.
- Conditions
- Chronic Kidney Diseases, Hypertension, Blood Pressure
- Trial name
- PERFORMANCE2 (NCT03691701)
- Testing
- strict blood pressure control
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
HYPERTENSION RENAL
Electroacupuncture for Hypertension Patients With Chronic Kidney Disease
1. To observe the Efficiency of Electroacupuncture for Hypertension Patients With Chronic Kidney Disease. 2. To observe if different-time treatment having an impact on Hypertension Patients With Chronic Kidney Disease.
- Trial name
- NCT01766427
- Where
- China
- Volunteers
- 90 people
- Sponsor
- YueYiDeng
Renal Artery Obstruction, Kidney Disease
MRI to Detect Embolism Following Angiography and Angioplasty-Stenting of the Renal Artery
This study will use magnetic resonance imaging (MRI) to picture the kidney and renal arteries (arteries that supply blood to the kidney) in patients scheduled for kidney artery angiogram and angioplasty/stenting procedures.
- Trial name
- NCT00027469
- Testing
- MRI
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Posttransplant Diabetes Mellitus, Acute Graft Rejection
Silymarin's Advantage on Graft Effectiveness
The study examines the impact of silymarin supplementation during the early post-transplant period, administering 900 g daily for 30 days under standard treatment.
- Conditions
- Posttransplant Diabetes Mellitus, Acute Graft Rejection, Biopsy Proven Acute Rejection, Antibody Mediated Rejection of Kidney Transplant
- Trial name
- SAGE (NCT06801886)
- Testing
- Silymarine supplementation
- Where
- Slovakia
- Volunteers
- 130 people
- Sponsor
- University Hospital, Martin
Hypertension, Left Ventricular Hypertrophy
Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE)
Studying the causal roles of components of the renin-angiotensin-aldosterone system (including angiotensin-(1-7) (Ang-(1-7)), angiotensin-converting enzyme 2 (ACE2), Ang II, and ACE), uric acid, and klotho in pediatric…
- Conditions
- Hypertension, Left Ventricular Hypertrophy, Left Ventricular Dysfunction, Left Atrial Dilatation
- Trial name
- PHRASE (NCT04752293)
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Diabetes, Prediabetes
Meta-Analyses of the Effect of Plant Protein Versus Animal Protein on Cardiometabolic Risk
Vegetarian diets have been associated with a reduced risk of preventable diseases such as type 2 diabetes and cardiovascular disease. These effects may be mediated through direct or indirect pathways.
- Conditions
- Diabetes, Prediabetes, Metabolic Syndrome, Dysglycemia
- Trial name
- NCT02037321
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- John Sievenpiper