Clinical trials: Functional Seizures
Epileptic Seizure
A Clinical Study of Epilepsy Localization and Prognosis Based on PET and Resting-state fMRI
1. By following up the prognosis of surgical patients, the application value of Cortex ID quantitative analysis in the localization of epilepsy foci was studied. 2.
- Trial name
- NCT05567042
- Testing
- No intervention
- Volunteers
- 50 people
- Sponsor
- Li Shuangshuang
Lafora Disease
Natural History and Functional Status Study of Patients With Lafora Disease
A natural history and functional status study to characterize the clinical disease course in Lafora disease patients using standardized, quantitative evaluations and to identify useful biomarkers and clinical outcome measures for…
- Trial name
- NCT03876522
- Where
- 4 sites in United States, Italy and 1 more
- Volunteers
- 33 people
- Sponsor
- Ionis Pharmaceuticals, Inc.
Traumatic Brain Injury, Subarachnoid Hemorrhage
Comparison of Narcotrend and Cerebral Function Analysing Monitor in Intensive Care to Monitor Seizures and Deep Sedation
A study in the use of the Narcotrend depth of anaesthesia monitor to record a) seizures, and b) monitor a level of sedation referred to as 'burst suppression', in sedated patients in the adult and paediatric intensive care.
- Conditions
- Traumatic Brain Injury, Subarachnoid Hemorrhage, Intracerebral Haemorrhage, Encephalitis
- Trial name
- NCT06067750
- Testing
- Narcotrend compared to Cerebral Function Analysing Monitor (CFAM)
- Where
- United Kingdom
- Volunteers
- 44 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Functional Seizures, Convulsion, Non-Epileptic
A Multi-site Feasibility Clinical Trial of Retraining and Control Therapy (ReACT), a Mind and Body Treatment for Pediatric Functional Seizures
The purpose of this study is to assess the feasibility of conducting a future fully powered multi-site efficacy Randomized Controlled Trial (RCT) comparing two treatments for pediatric functional seizures (FS).
- Trial name
- NCT05819268
- Testing
- ReACT, CATCH-IT
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- University of Alabama at Birmingham
Focal Epilepsy
The Effects on Cognitive Function of Levetiracetam (Keppra®) Compared to Carbamazepine (Tegretol®, Carmazepine®) as Monotherapy for Children With Partial Seizure; A Multicentric Randomized Controlled Study
Unlike the first generation antiepileptic medications, newer drugs for epilepsy such as levetiracetam are reported to have less adverse effect in children but not many studies have systematically reviewed the subject.
- Trial name
- NCT02208492
- Testing
- Levetiracetam, Carabamazepine
- Where
- South Korea
- Volunteers
- 75 people
- Sponsor
- Yonsei University
Status Epilepticus, Ictal-interictal Continuum
The Role of Imaging in the Diagnosis, Management and Prognosis of Possible Non-convulsive Status Epilepticus
The investigators propose a prospective study of 20 control subjects and 180 consecutive patients with possible non-convulsive status epilepticus (NCSE). The investigators will obtain three functional images of the brain: 1.
- Conditions
- Status Epilepticus, Ictal-interictal Continuum, Positron-emission Tomography, Perfusion Weighted MRI
- Trial name
- NCT06017973
- Testing
- MRI scan including arterial spin labelling of the brain, CT perfusion scan of the brain, FDG-PET scan of the brain
- Where
- Belgium
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Epilepsy, Seizures
Mapping the Areas of the Brain Associated With Language in Children With Epilepsy
Researchers are interested in studying if magnetic resonance imaging (MRI) is practical for locating the areas of the brain associated with language in children with epilepsy.
- Trial name
- NCT00001366
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Bilateral Upper Limb Amputation, Transverse Short Amputation of the Hand
Bilateral Upper Limb Amputation Observatory
In France, there is currently no data to directly estimate the number of bilateral upper limb amputations, their characteristics and therapeutic care.
- Conditions
- Bilateral Upper Limb Amputation, Transverse Short Amputation of the Hand, Arm Amputation
- Trial name
- ARMOBS (NCT02835378)
- Testing
- No intervention
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Hospices Civils de Lyon
Anxiety Disorder, Head Injury
Neuropsychological Evaluation of Psychiatric and Neurological Patients
This study will allow researchers to use various types of tests to evaluate cognitive and sensory functions. These tests, referred to as "batteries" will evaluate attention, executive functions, general intellectual functioning…
- Conditions
- Anxiety Disorder, Head Injury, Mood Disorder, Schizophrenia
- Trial name
- NCT00001192
- Where
- 7 sites in United States, France and 1 more
- Volunteers
- 4,300 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Hypoxic Brain Damage, Hypoxic Ischaemic Encephalopathy (HIE)
Intranasal AAV9-PHP.eB Gene Therapy in Cerebral Palsy (CP) & Hypoxic Ischemic Encephalopathy (HIE)
This international study, organized by Healing Hope International, is an observational registry designed to collect real-world data on participants living with chronic hypoxic ischemic encephalopathy (HIE) who receive an emerging…
- Conditions
- Hypoxic Brain Damage, Hypoxic Ischaemic Encephalopathy (HIE), Hypoxic Ischaemic Encephalopathy Due to Cardiac Arrest, Hypoxic Ischemic Encephalopathy of Newborn
- Trial name
- GEN-HOPE (NCT07264166)
- Where
- Mexico
- Volunteers
- 25 people
- Sponsor
- Healing Hope International
Epilepsy
Intrinsic Optical Imaging Study to Map Neocortical Seizure in Human Epilepsy Patients
The purpose of this study is to develop a technique for the intraoperative identification of human functional and epileptiform cortex using intrinsic signal imaging.
- Trial name
- NCT00195052
- Testing
- Intrinsic signal imaging of human cortex
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Weill Medical College of Cornell University
Psychogenic Nonepileptic Seizures (PNESs)
Quality of Life and Psychogenic Nonepileptic Seizures.
The goal of this study is to identify the prognostic factors of quality of life in patients with psychogenic non-epileptic seizures
- Trial name
- PronoCNEP (NCT02821208)
- Where
- France
- Volunteers
- 72 people
- Sponsor
- University Hospital, Bordeaux
Neonatal Seizure, Hypoxic-Ischemic Encephalopathy
Neonatal Seizure Registry - Developmental Functional EValuation
The NSR-DEV study is a longitudinal cohort study of around 280 Neonatal Seizure Registry participants that aims to evaluate childhood outcomes after acute symptomatic neonatal seizures, as well as examine risk factors for…
- Conditions
- Neonatal Seizure, Hypoxic-Ischemic Encephalopathy, Stroke, Intracranial Hemorrhages
- Trial name
- NSR-DEV (NCT04337697)
- Where
- 9 sites in United States
- Volunteers
- 188 people
- Sponsor
- University of California, San Francisco
Epilepsy, Autism Spectrum Disorder
Biomarkers for Epilepsy Development and the Effect of Physical Exercise in Children With Autism
This study aims to identify novel biomarkers for epilepsy development in children with autism and to evaluate the effects of physical exercise on these biomarkers and clinical outcomes.
- Trial name
- ASD/EP (NCT07373431)
- Testing
- Physical activity program
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Region Skane
Epilepsy, Cognitive Dysfunction
Cognitive Function and Glymphatic System in Children with Epilepsy
Epilepsy, one of the most common neurological disorders in childhood, is a chronic brain disease characterized by neurobiological, psychological and cognitive effects.
- Conditions
- Epilepsy, Cognitive Dysfunction, Seizure, Epileptic
- Trial name
- NCT06143241
- Testing
- Threshold IMT, Antiepileptic medication
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Ege University
Epilepsy in Children, Coagulation and Hemorrhagic Disorders
The Prevalence and Risk Factors of Coagulopathy in Pediatric Epilepsy Surgery Patients
The hematologic consequences of novel Anti-seizure medications (ASMs) are rarely reported. Whether coagulation dysfunctions increase the risk of peri-operative bleeding remains controversial.
- Conditions
- Epilepsy in Children, Coagulation and Hemorrhagic Disorders, Epilepsy; Seizure, Antiepileptic Adverse Reaction
- Trial name
- NCT05675254
- Where
- China
- Volunteers
- 494 people
- Sponsor
- Children's Hospital of Fudan University
Seizures Newborn, Brain Injuries
Newborn Brain Test (NBT)
The aim of the overall project is to develop the Newborn Brain Test (NBT), a novel platform to detect abnormal brain activity in infants at birth through an automated AI assessment.
- Trial name
- NBT (NCT06580834)
- Testing
- Cergenx Wave
- Where
- Ireland
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Professor Geraldine Boylan
Dissociative Seizures
Cognitive Behavioural Therapy in Dissociative Seizures
The purpose of this study is to determine whether adults with disoociative (psychogenic non-epileptic) seizures receiving cognitive behavioural therapy (CBT) show a greater reduction in seizures and health service use and greater…
- Trial name
- NCT00688727
- Testing
- CBT, Standard Care
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- South London and Maudsley NHS Foundation Trust
Childhood Absence Epilepsy
Why Are Patients With Absence Seizures Absent? A Brain Imaging Study
Our study examines which different brain regions are involved in child absence seizures and how they are related to attention and cognition.
- Trial name
- NCT00393666
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Yale University
Epileptic Encephalopathy, SCN2A Encephalopathy
A Clinical Trial of Elsunersen in Pediatric SCN2A-DEE to Assess Efficacy and Safety
A Multi-Center, Single-Arm Clinical Trial to Investigate the Efficacy and Safety of Elsunersen in Pediatric Participants with Early Onset SCN2A Developmental and Epileptic Encephalopathy
- Trial name
- NCT07019922
- Testing
- 1mg elsunersen, 0.5mg elsunersen
- Where
- 10 sites in United States, Brazil and 2 more
- Volunteers
- 40 people
- Sponsor
- Praxis Precision Medicines