Clinical trials: Extubation
Extreme Prematurity
HFNC and NCPAP in Extremely Preterm Infants
To avoid or decrease the rate of complications in preterm infants after disconnection from a mechanical ventilation (extubation), non-invasive respiratory support is routinely used.
- Trial name
- NCT03649282
- Testing
- HFNC, NCPAP
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- Guilherme Sant'Anna, MD
Intubation
Oral Fluid Intake After Extubation
According to the current guidelines the patient is not allowed to drink any fluid at least 2 hours after extubation to prevent complications. However there is no evidence in the literature to support this approach.
- Trial name
- NCT05819645
- Testing
- Fluid intake not as per standard guidlines
- Where
- Czechia
- Volunteers
- 160 people
- Sponsor
- University Hospital, Motol
Post Extubation Stridor
Is High Resolution Endotracheal Tube Leak Data Indicative of the Development of Post-extubation Stridor in Children?
Post extubation stridor (PES) is a common and possibly serious complication of invasive ventilation via endotracheal tube (ETT) in pediatric intensive care (PICU) patients.
- Trial name
- PES (NCT07414472)
- Where
- Belgium
- Volunteers
- 400 people
- Sponsor
- University Hospital, Antwerp
Prematurity, Respiratory Failure
Non-invasive Neurally Adjusted Ventilatory Assist Versus Nasal Intermittent Positive Pressure Ventilation for Preterm Infants After Extubation
Non-invasive respiratory support has been emerging in the management of respiratory distress syndrome (RDS) in preterm infants to minimise the risk of lung injury.
- Conditions
- Prematurity, Respiratory Failure, Ventilator Lung; Newborn
- Trial name
- NCT03388437
- Testing
- NI-NAVA, NIPPV
- Where
- Saudi Arabia
- Volunteers
- 36 people
- Sponsor
- King Fahad Armed Forces Hospital
Myelomeningocele, Extubation Time
Operating Room Extubation and Postoperative Outcomes in Neonates With Meningomyelocele
Meningomyelocele is one of the most common neural tube defects requiring surgical repair in the neonatal period. Postoperative respiratory complications and the need for prolonged mechanical ventilation are important causes of…
- Conditions
- Myelomeningocele, Extubation Time, Neonatal
- Trial name
- MEROX (NCT07465055)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Gaziantep City Hospital
Neonates
Utility of Spontaneous Breathing Trial (SBT) Using ET-CPAP, in Predicting Extubation Failure in Neonates
Intubation and ventilation are lifesaving interventions in the neonatal intensive care unit (ICU), especially among preterm, low birth weight babies. However, timely extubation is also necessary.
- Trial name
- NCT03091387
- Testing
- Spontaneous Breathing Test
- Volunteers
- 110 people
- Sponsor
- Aga Khan University
Respiratory Distress Syndrome In Premature Infants
Successful Extubation and Noninvasive Ventilation in Preterm ≤ 1500g Terms
Noninvasive ventilation has been used in preterm newborn with respiratory distress syndrome in an attempt to assist failure extubation.
- Trial name
- NCT02396693
- Testing
- NIPPV, Bubble NCPAP, Ventilator NCPAP
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
Residual Neuromuscular Blockade
Residual Neuromuscular Blockade in Pediatric Anesthesia
Residual neuromuscular blockade (RNB) is frequent and it is associated with postoperative morbidity and mortality. The incidence of the RNB in pediatric anesthesia is currently not known.
- Trial name
- REPEB (NCT02939911)
- Testing
- Residual neuromuscular blockade measurement
- Where
- Czechia
- Volunteers
- 291 people
- Sponsor
- Brno University Hospital
High-Frequency Ventilation, Intermittent Positive-Pressure Ventilation
Nasal HFOV Versus Nasal SIPPV in Neonate Following Extubation: RCT Crossover Study
Mechanical ventilation was introduced to treat respiratory failure in preterm infants or sick neonates then improvements in survival (1,2).
- Conditions
- High-Frequency Ventilation, Intermittent Positive-Pressure Ventilation, Newborn Morbidity, Noninvasive Ventilation
- Trial name
- nHFOnSIPPV (NCT04323397)
- Testing
- Non-invasive ventilation
- Where
- Thailand
- Volunteers
- 133 people
- Sponsor
- Prince of Songkla University
Pulmonary Resection, Oxygen Therapy
Comparing The Outcome Of High Flow Oxygen Versus Conventional Oxygen In Extubated Patients After Lung Resection.
Conventional oxygen therapy (COT) is the main supportive treatment administered to patients postoperative after planned extubation and has conventionally been delivered using nasal prongs, cannula or masks.
- Trial name
- NCT05511636
- Testing
- Oxygen therapy
- Where
- Egypt
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Fasting, Pediatric ALL
Gastric Content Ultrasound Monitoring Prior to Extubation in Critically Ill Children
Nearly half of critically ill children are intubated and enterally fed according to recent guidelines. However, no evidence-based recommendation are available regarding fasting times prior to extubation.
- Conditions
- Fasting, Pediatric ALL, Aspiration
- Trial name
- GastrExtub (NCT05181904)
- Testing
- Gastric ultrasound
- Where
- France
- Volunteers
- 34 people
- Sponsor
- Hospices Civils de Lyon
Extubation Failure, Neonates
Predictors of Extubation Failure in Ventilated Neonates
This protocol proposes a prospective observational study to develop and validate such a model, directly addressing a critical evidence gap identified by recent systematic reviews.
- Conditions
- Extubation Failure, Neonates, NICU
- Trial name
- Neonates (NCT07764575)
- Volunteers
- 124 people
- Sponsor
- Assiut University
Respiratory Distress Syndrome
n-CPAP Versus n-BiPAP and NIPPV for Postextubation in RDS in Preterms
non-invasive ventilation in preterms complaining from RDS a randomized, controlled trial to compare between capap, n-bipap and NIPPV
- Trial name
- NCT01770925
- Testing
- N-CPAP, n-BiPAP, NIPPV
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Ain Shams University
Need for Tracheal Tube Exchange, Presence of Post-extubation Laryngeal Oedema
"Cuffed Versus Uncuffed Tracheal Tubes in Small Children"
This randomized controlled multi-centre trial in children from birth up to < 5 years of age aims to demonstrate equivalence as to the major outcome of post-extubation airway injury (stridor) comparing uncuffed tracheal tubes to…
- Trial name
- NCT00221377
- Testing
- Intubation using tracheal tubes with or without cuff
- Where
- 24 sites in Austria, Belgium and 6 more
- Volunteers
- 4,000 people
- Sponsor
- University Children's Hospital, Zurich
Respiratory Insufficiency
Monitoring Intercostal Muscles After Extubation
Mechanical ventilation is a life-saving treatment for critically ill patients who are unable to breathe on their own. At the time of recovery, separation from the ventilator is performed without difficulty for the majority of…
- Trial name
- MIME (NCT02853201)
- Where
- Canada
- Volunteers
- 124 people
- Sponsor
- Unity Health Toronto
Hypoxia
Effect of Different Positions During Extubation on Incidence of Hypoxemia in the Peri Extubation Period
Pediatric Obstructive Sleep Apnea Syndrome (OSAS) is common, often due to enlarged tonsils/adenoids. Tonsillectomy/adenoidectomy frequently performed under GA with tracheal intubation due to the age of children.
- Trial name
- NCT07231887
- Testing
- positioning during peri-extubation
- Volunteers
- 262 people
- Sponsor
- Assiut University
Mechanical Ventilation, Respiratory Failure
Prediction of Extubation Success by the Patient
The evidence-based approach to wean and consecutively extubate patients is based solely on objective criteria/tests. The introduction of subjective criteria could further improve the actual method.
- Conditions
- Mechanical Ventilation, Respiratory Failure, Extubation
- Trial name
- NCT00448565
- Where
- 2 sites in Switzerland
- Volunteers
- 200 people
- Sponsor
- Ospedale Regionale Bellinzona e Valli
Delirium on Emergence
Post Extubation Delirium and End-tidal Sevoflurane Concentration
The purpose of this study is to determine whether the incidence of emergence delirium will be reduced when end-tidal concentration of sevoflurane decreases.
- Trial name
- NCT02489734
- Testing
- sevoflurane
- Volunteers
- 109 people
- Sponsor
- Children's Hospital of Fudan University
Respiratory Distress Syndrome
Propofol Versus Midazolam as Premedication for Preterm Neonates With Respiratory Distress Syndrome (RDS)
The aim of the study is to compare the intubation conditions among propofol and remifentanil versus midazolam and remifentanil in premature neonates with respiratory distress syndrome.
- Trial name
- NCT00797160
- Testing
- propofol
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Federal University of Minas Gerais
Preterm Birth, Mechanical Ventilation Complication
Optimal High CPAP Pressures in Preterm Neonates Post-extubation
Use of continuous positive airway pressure (CPAP) in preterm neonates has traditionally been limited to between 5-8 cmH2O. In recent years, use of CPAP pressures ≥9 cmH2O is becoming more common in neonates with evolving chronic…
- Conditions
- Preterm Birth, Mechanical Ventilation Complication, Respiratory Distress Syndrome, Newborn
- Trial name
- NCT05230485
- Testing
- CPAP level
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- McMaster Children's Hospital