Clinical trials: Extracorporeal Membrane Oxygenation Complication
Extracorporeal Membrane Oxygenation Complication
Monitoring of Cerebral Autoregulation in Pediatric ECMO (ECMOX 1)
Children supported by Extra-Corporeal Membrane Oxygenation (ECMO) present a high risk of neurological complications and cerebral autoregulation (CA) impairment may be a risk factor.
- Trial name
- ECMOX1 (NCT04282525)
- Testing
- ECMO for hemodynamic or respiratory indication
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Nantes University Hospital
Septic Shock, Acute Respiratory Distress Syndrome
CytOSorb TreatMent Of Critically Ill PatientS Registry
Registry intended to provide a data repository and reporting infrastructure for the surveillance of CytoSorb device use in real-world critical care settings, and to serve as an objective, comprehensive, and scientifically-based…
- Conditions
- Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
- Trial name
- COSMOS (NCT05146336)
- Testing
- CytoSorb
- Where
- 28 sites in Austria, Germany and 4 more
- Volunteers
- 3,000 people
- Sponsor
- CytoSorbents, Inc
Extracorporeal Membrane Oxygenation Complication, Pediatric ALL
Study Comparing Bivalirudin Versus Heparin in Neonatal and Pediatric ECMO
The investigators will prospectively enroll 30 neonatal and pediatric ECMO patients at a single pediatric Level 1 trauma center.
- Conditions
- Extracorporeal Membrane Oxygenation Complication, Pediatric ALL, Anticoagulants
- Trial name
- NCT03318393
- Testing
- Bivalirudin, Unfractionated heparin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Texas Southwestern Medical Center
Septic Shock, Extracorporeal Membrane Oxygenation Complication
Study on the Efficacy and Timing of ECMO Therapy in Children With Refractory Septic Shock
Severe sepsis and septic shock remain the leading causes of child mortality worldwide. Sepsis is a complex process that ultimately leads to circulation disorders, organ perfusion abnormalities, capillary leakage, tissue hypoxia…
- Trial name
- NCT03948048
- Testing
- ECMO
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Children's Hospital of Fudan University
Extracorporeal Membrane Oxygenation Complication, Hemorrhage
ECMO Hemostatic Transfusions in Children
Critically ill children supported by extracorporeal membrane oxygenation (ECMO) receive large volumes of prophylactic platelet transfusions to prevent bleeding.
- Conditions
- Extracorporeal Membrane Oxygenation Complication, Hemorrhage, Thromboembolism, Transfusion Adverse Reaction
- Trial name
- ECSTATIC (NCT05796557)
- Testing
- Platelet Transfusion
- Where
- 10 sites in United States, Israel
- Volunteers
- 50 people
- Sponsor
- Yale University
Extracorporeal Membrane Oxygenation, Child, Only
ECMO Treatment of Children in China in the Past 10 Years
It is a cross-sectional study to summarize the extracorporeal membrane oxygenation （ECMO）treatment in children in China.
- Trial name
- NCT04709432
- Testing
- ECMO
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Children's Hospital of Fudan University
Kidney Diseases, Acute Injury of Kidney
Hemofilter Life Span, ECLS And/or CRRT
The goal of this project to better understand the immune-modulatory effects of continuous renal replacement therapy (CRRT) in neonatal and pediatric patients, particularly those receiving extracorporeal life support (ECLS).
- Conditions
- Kidney Diseases, Acute Injury of Kidney, Renal Failure, Renal Insufficiency
- Trial name
- NCT04193865
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Medical University of South Carolina
Persistent Fetal Circulation Syndrome, Diaphragmatic Hernia
Antibody Secreting Cell and Cyotokine Profiles in Neonates on ECMO
Infants are placed on ECMO for correction of reversible respiratory failure. Often, because a few of the reasons for respiratory failure show us similar things in the baby, it is difficult to determine exactly which is causing…
- Conditions
- Persistent Fetal Circulation Syndrome, Diaphragmatic Hernia, Meconium Aspiration, Sepsis
- Trial name
- NCT00371241
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- The University of Texas Health Science Center, Houston
Extracorporeal Circulation; Complications, Extracorporeal Membrane Oxygenation Complication
DIC Markers and Thrombin Generation Parameters in Patients on ECMO Support: a Pilot Study
To study the correlation between novel DIC markers and thrombin generation parameters with thrombotic and hemorrhagic complications of patients on ECMO support.
- Trial name
- DIC-ECMO (NCT06095518)
- Testing
- DIC markers and Thrombin Generation Parameters
- Where
- Hong Kong
- Volunteers
- 49 people
- Sponsor
- Queen Mary Hospital, Hong Kong
Extracorporeal Membrane Oxygenation Complication
Transplantation of Autologously Derived Mitochondria Following Ischemia
The investigators propose a robust therapeutic intervention to ameliorate myocardial ischemia/ reperfusion injury and significantly decrease morbidity and mortality in patients requiring extracorporeal membrane oxygenation…
- Trial name
- NCT02851758
- Testing
- autologous mitochondria transplantation
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Boston Children's Hospital
Extracorporeal Membrane Oxygenation Complication, ARDS (Acute Respiratory Distress Syndrome)
RECOMMEND Platform Trial
The goal of this platform trial is to determine the efficacy, safety and cost-effectiveness of various interventions in patients with acute cardiorespiratory failure requiring extracorporeal membrane oxygenation (ECMO) The main…
- Conditions
- Extracorporeal Membrane Oxygenation Complication, ARDS (Acute Respiratory Distress Syndrome), Intensive Care Medicine, Cardiac Arrest (CA)
- Trial name
- RECOMMEND (NCT06526533)
- Testing
- Liberal RBC Transfusion, Restrictive RBC Transfusion
- Where
- 3 sites in Australia
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Cardiac Failure, Extracorporeal Membrane Oxygenation Complication
Echocardiographic Assessment of Function During ECMO Support
The purpose of this study is to evaluate echocardiographic markers of cardiac function to assess the ability of patients to successfully end VA-ECMO support.
- Trial name
- NCT01551849
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Nationwide Children's Hospital
Extracorporeal Membrane Oxygenation Complication, Critical Care
Evaluation of Long-term Quality of Life in Children Supported with ExtraCorporeal Membrane Oxygenation (ECMO)
The main objective of this prospective transversal comparative study is to describe the quality of life of children supported by ECMO.
- Trial name
- ECMOQoL (NCT05721105)
- Testing
- Quality of life assessment using questionnaires
- Where
- France
- Volunteers
- 84 people
- Sponsor
- Nantes University Hospital
Brain Injuries, Congenital Heart Disease
Protecting Brains and Saving Futures - the PBSF Protocol
Background: Multiple neonatal disorders are associated with risks of neurological injury. Thus, management of these infants should involve a coordinated approach to permit early diagnosis with improved clinical care.
- Conditions
- Brain Injuries, Congenital Heart Disease, Newborn Morbidity, Intraventricular Hemorrhage
- Trial name
- PBSF (NCT03786497)
- Where
- 2 sites in Brazil
- Volunteers
- 2,268 people
- Sponsor
- Protecting Brains Saving Futures
Feasibility and Safety of a Low-field MRI, Acute Brain Injury
Low-Field Bedside Brain Magnetic Resonance Imaging in Pediatric Extracorporeal Membrane Oxygenation
The primary object of the study is to further characterize safety and feasibility of low-field bedside MRI in pediatric and neonatal ECMO patients.
- Conditions
- Feasibility and Safety of a Low-field MRI, Acute Brain Injury, Extracorporeal Membrane Oxygenation Complication
- Trial name
- NCT06074406
- Testing
- Hyperfine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's Mercy Hospital Kansas City
Extra Corporeal Membrane Oxygenation
Acute Neurological Complications and Neurodevelopmental Outcome in Children Undergoing Extracorporeal Membrane Oxygenation.
The purpose of this retrospective study is to describe the different types of acute neurologic complications in children who underwent extracorporeal membrane oxygenation (ECMO), and their risk factors.
- Trial name
- NeurECMO (NCT04519528)
- Testing
- DENVER scale (under 2 years old) or Pediatric Cerebral Performance Category (PCPC) score (over 2 years old), Pediatric Quality of Life Inventory™ (PedsQL)
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COVID-19, Extracorporeal Membrane Oxygenation Complication
Outcome of COVID-19 Patients After Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome
This study aims to investigate outcomes and predictors of outcome after extracorporeal membrane oxygenation (ECMO) therapy for severe acute respiratory syndrome (ARDS) in COVID-19 patients.
- Conditions
- COVID-19, Extracorporeal Membrane Oxygenation Complication, Acute Respiratory Distress Syndrome
- Trial name
- NCT04383678
- Testing
- Extracorporeal membrane oxygenation
- Where
- 11 sites in Finland, France and 4 more
- Volunteers
- 132 people
- Sponsor
- Helsinki University Central Hospital
Extracorporeal Membrane Oxygenation Complication, Cardiopulmonary Bypass
Evaluation Of The Pharmacokinetics Of Antithrombin III In Neonates And Infants Undergoing CPB And ECMO Support
The potential role of ATIII in achieving and maintaining adequate anticoagulation in pediatric patients on the heart-lung machine has recently taken on increased importance as caregivers strive to mitigate the risk for clinically…
- Trial name
- NCT02631174
- Testing
- Antithrombin III
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Cardiac Arrest, Extracorporeal Membrane Oxygenation
Hydrogen's Feasibility and Safety as a Therapy in ECPR
The purpose of this project is to test the feasibility and safety of inhaled hydrogen gas (H2) administration as a rescue therapy during cardiac arrest requiring extracorporeal cardiopulmonary resuscitation (ECPR, i.e.
- Conditions
- Cardiac Arrest, Extracorporeal Membrane Oxygenation, Reperfusion Injury
- Trial name
- HydrogenFAST (NCT05574296)
- Testing
- Hydrogen, Usual care
- Where
- 4 sites in United States
- Volunteers
- 53 people
- Sponsor
- Boston Children's Hospital
Extracorporeal Membrane Oxygenation Complication, Neonatal Aspiration Pneumonia
Evaluating the Safety and Performance of the MiniLung Petite Kit in Neonatal and Pediatric Patients With Acute Respiratory and Cardiac Failure
This prospective observational study will evaluate the safety and performance of the MiniLung petite kit in neonatal and pediatric patients with acute respiratory and cardiac failure.
- Conditions
- Extracorporeal Membrane Oxygenation Complication, Neonatal Aspiration Pneumonia, Acute Respiratory Failure, Acute Lung Injury
- Trial name
- PETIT (NCT06750536)
- Testing
- MiniLung petite kit combined with the Xenios console
- Where
- 2 sites in Germany
- Volunteers
- 20 people
- Sponsor
- Xenios AG