Clinical trials: Esophagectomy
Esophagectomy, No Signs of Cancer Recurrence
Pylorus Dysfunction After Esophagectomy and Gastric Tube Reconstruction. Effect of Pneumatic Pylorus Dilatation During Hospital Stay, Surgical Complications During in Hospital Stay
Delayed emptying of the gastric tube after esophagectomy is a frequent and durable problem. No treatment is currently available.
- Conditions
- Esophagectomy, No Signs of Cancer Recurrence, Delayed Gastric Emptying
- Trial name
- NCT02086461
- Testing
- Pneumatic pyloric dilatation, 15 mm pyloric balloon dilatation
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Karolinska University Hospital
Esophageal Cancer, Esophagectomy
Shanghai Clinical Cohort - Esophageal Cancer
A prospective cohort of patients who received esophagectomy for esophageal cancer in participating centers.
- Trial name
- NCT07312526
- Testing
- esophagectomy
- Where
- China
- Volunteers
- 2,116 people
- Sponsor
- Shanghai Chest Hospital
Oesophageal Cancer
The Association Between Preoperative CPEX and Postoperative Morbidity Following Oesophagectomy
A retrospective hospital-based cohort study of the association between preoperative cardiopulmonary exercise test (CPEX) variables and short-term postoperative morbidity following oesophagectomy.
- Trial name
- NCT03216694
- Testing
- Cardiopulmonary exercise testing
- Where
- United Kingdom
- Volunteers
- 254 people
- Sponsor
- University of East Anglia
Symptoms and Signs, Quality of Life
Quality of Life After Surgery for End-stage Achalasia
Therapy for end-stage achalasia is under debate: comparative data on the long-term functional results of myotomy and oesophagectomy are lacking.
- Trial name
- NCT04152902
- Testing
- Objective outcome, Quality of life
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Bologna
Oesophageal Cancer
Post Oesophagectomy Outcomes in a Single Regional Centre in Australia
Literature review/rationale for project Oesophageal cancer is associated with a grim prognosis despite many advances in treatment.
- Trial name
- NCT06662513
- Testing
- No Intervention: Observational Cohort
- Where
- Australia
- Volunteers
- 100 people
- Sponsor
- Launceston General Hospital
Esophageal Cancer
Value of Pleural Lavage Cytology in Resectable Esophageal Carcinoma Eastern Cooperative Thoracic Oncology Projects 2005, ECTOP-2005)
Disease recurrence and metastasis are common after curative treatment for patients with esophageal cancer. Thus, it is important to identify the risk factors to predict disease recurrence and metastasis.
- Trial name
- ECTOP-2005 (NCT05443841)
- Testing
- pleural lavage
- Where
- 11 sites in China
- Volunteers
- 385 people
- Sponsor
- Fudan University
Esophagectomy
Utility of the Evaluation of Blood Flow of the Remnant Esophagus in Esophagectomy With Pedicled Jejunum Reconstruction
Pedicled jejunal flap can be utilized with various tips for esophageal reconstruction in patients with a history of gastrectomy, or those who have undergone synchronous esophagogastrectomy, although the rate of anastomosis…
- Trial name
- NCT04597398
- Testing
- Evaluation of blood flow with indocyanine green
- Volunteers
- 50 people
- Sponsor
- Shizuoka Cancer Center
Esophageal Cancer
Effect of Cervical Paraesophageal Lymph Node Metastasis Versus Supraclavicular Lymph Node Metastasis on the Overall Survival of Patients With Thoracic Esophageal Squamous Cell Carcinoma: An Observational Study
The goal of this observational study is to learn about in health conditions of ESCC. The main question[s] it aims to answer are: •Lymph node metastasis(LNM) in cervical paraesophageal or supraclavicular which influence OS more.
- Trial name
- ECPLNMvsSLNM (NCT06165094)
- Where
- China
- Volunteers
- 122 people
- Sponsor
- Sichuan Cancer Hospital and Research Institute
Operable Esophageal Cancer, Embolization of the Left Gastric Artery Prior to Surgery
Gastric Ischemic Preconditioning Before Esophagectomy
The aim of the study is to investigate the impact of left gastric artery embolization before esophagectomy on postoperative complications, particularly anastomotic leaks and necrosis of the gastric conduit.
- Trial name
- NCT06453031
- Testing
- Gastric Ischemic Preconditioning Before Esophagectomy
- Where
- France
- Volunteers
- 20 people
- Sponsor
- CHU Rennes - Hopital Pontchaillou
Anastomotic Leakage
The Optimal Width of Gastric Conduit for Minimally Invasive Esophagectomy: Wide or Narrow?
The study hypothesized that a narrow gastric conduit(less than 3cm in width) would minimize anastomotic leakage following minimally invasive esophagectomy.
- Trial name
- NCT01696682
- Testing
- Narrowed Gastric Conduit, Widened Gastric Conduit
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Fudan University
Esophageal Cancer (EsC)
Non-intubated Versus Intubated Anesthesia in Thoracoscopic Esophagectomy for Esophageal Cancer
This is a prospective, single-center, non-inferiority randomized controlled trial designed to evaluate the perioperative safety and feasibility of non-intubated spontaneous ventilation anesthesia (NIV) compared to conventional…
- Trial name
- NCT07104838
- Testing
- Non-intubated spontaneous ventilation anesthesia
- Volunteers
- 500 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Esophageal Carcinoma (Squamous Cell Carcinoma - Adenocarcinoma)
Early Metabolic Response in Locally Advanced Esophageal Cancer Undergoing Induction Chemoradiotherapy
Early metabolic response evaluation may predict clinical and histopathological response after neoadjuvant chemotherapy. Its value in neoadjuvant chemoradiotherapy (CRT) is unknown.
- Trial name
- NCT01269970
- Testing
- 18-FDG-PET-CT
- Where
- Belgium
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Esophageal Cancer
PET/MRI in Predicting the Outcome of Neoadjuvant Chemoradiotherapy With Esophagectomy in Esophageal Cancer Patients
Integrated PET/MRI has the advantage to assess the metabolism, diffusion, and perfusion parameters of the tumor simultaneously. Recently, PET/MRI has been investigated in several cancers with promising results.
- Trial name
- NCT05855291
- Testing
- PET/MRI
- Where
- Taiwan
- Volunteers
- 43 people
- Sponsor
- Chang Gung Memorial Hospital
Esophageal Neoplasms, Esophagectomy
Metachronic Brain Metastases After Esophagectomy for Esophageal Cancer (METABREC)
Esophagectomy is the cornerstone of the curative treatment of esophageal carcinoma. Despite this treatment, patients can suffer from locoregional or distant metastatic disease and only a very selected group of patients can be…
- Conditions
- Esophageal Neoplasms, Esophagectomy, Brain Metastases
- Trial name
- METABREC (NCT04654975)
- Testing
- Esophagectomy for esophageal cancer
- Where
- 8 sites in United States, Belgium and 4 more
- Volunteers
- 10,000 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Esophageal Cancer
Endoscopic Submucosal Dissection Versus Esophagectomy for Early Esophageal Carcinoma
Endoscopic submucosal dissection (ESD) is a minimally invasive alternative to esophagectomy for early esophageal squamous cell carcinoma (EESCC), The data of EESCC patients who received ESD or esophagectomy were retrospectively…
- Trial name
- NCT06060106
- Testing
- Endoscopic submucosal dissection, Esophagectomy
- Where
- China
- Volunteers
- 191 people
- Sponsor
- Changhai Hospital
Esophagus Cancer, Esophagectomy
Comparison of Long-term Survival and Quality of Life After Minimally Invasive Esophagectomy Versus Open Esophagectomy
To analyze and compare the long-term recurrence-free survival rate, overall survival rate and quality of survival after minimally invasive esophagectomy and open esophagectomy, and to conduct subgroup analysis according to the…
- Conditions
- Esophagus Cancer, Esophagectomy, Quality of Life, Survival
- Trial name
- NCT06147180
- Where
- China
- Volunteers
- 1,474 people
- Sponsor
- Qilu Hospital of Shandong University
Pleura; Effusion, Esophageal Adenocarcinoma
Outcomes of a Single Chest Drain vs Two Drains
Esophagectomy is a major surgical procedure done for carcinoma of esophagus. Usually bilateral chest tubes are placed in surgery for prevention of fluid accumulation in chest.
- Conditions
- Pleura; Effusion, Esophageal Adenocarcinoma, Esophageal Anastomotic Leak
- Trial name
- NCT07125248
- Testing
- Bilateral chest tube placement, Single drain placement
- Where
- Pakistan
- Volunteers
- 68 people
- Sponsor
- Khyber Teaching Hospital
Esophageal Neoplasms, Esophagostomy Complication
Tissue Oxygen Saturation for Esophagectomy
Tissue oxygen saturation monitoring was a useful indicator of blood flow insufficiency in the gastric tube leading to anastomotic leakage during radical esophagectomy.
- Conditions
- Esophageal Neoplasms, Esophagostomy Complication, Anastomotic Leak, Oxygen Deficiency
- Trial name
- NCT04973046
- Where
- Japan
- Volunteers
- 18 people
- Sponsor
- Shizuoka Cancer Center
Esophageal Neoplasms, Carcinoma, Squamous Cell
A Trial of Chemotherapy Before and After Surgery for Stage II,III Esophageal Squamous Cell Carcinoma
To determine whether chemotherapy before surgery makes better outcome than chemotherapy after surgery in patients with esophageal squamous cell carcinoma
- Trial name
- NCT00190554
- Testing
- Surgery +(Cisplatin 80 mg/㎡+5FU 800mg/㎡×5days)×2, (Cisplatin 80 mg/㎡+5FU 800mg/㎡×5days)×2＋Surgery
- Where
- 24 sites in Japan
- Volunteers
- 330 people
- Sponsor
- Japan Clinical Oncology Group
Esophageal Cancer
Robotic Versus Thoracolaparoscopic Esophagectomy for Esophageal Cancer
Esophageal cancer is a debilitating condition. The treatment involved is complex requiring a combination of chemotherapy and surgery in most cases.
- Trial name
- NCT03727126
- Testing
- Robotic esophagectomy, Thoracolaparoscopic esophagectomy
- Where
- 2 sites in India
- Volunteers
- 40 people
- Sponsor
- GEM Hospital & Research Center