Clinical trials: Esketamine
Autism Spectrum Disorder
The Effects of Preoperative Intranasal Administration of Dexmedetomidine and Esketamine on Negative Postoperative Behavioral Changes in Children With Autism Spectrum Disorder
The goal of this clinical trial is to learn whether intranasal sedation given before anesthesia can lower negative postoperative behavioral changes in children with autism spectrum disorder who undergo elective surgery.
- Trial name
- NPOBCs (NCT07324057)
- Testing
- Intranasal dexmedetomidine, Intranasal Esketamine, saline control
- Where
- China
- Volunteers
- 234 people
- Sponsor
- Sun Fei
Autism Spectrum Disorder
Esketamine and Propofol for Children With Autism Spectrum Disorder Undergoing Colonoscopy
The purpose of this study is to examine the dose-response relationship of esketamine in combination with propofol for children with Autism Spectrum Disorder undering colonoscopy.
- Trial name
- NCT05951465
- Testing
- Esketamine, Propofol
- Where
- China
- Volunteers
- 46 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Suicide Prevention, Ketamine
Esketamine Versus Crisis Response Planning Versus Enhanced Treatment as Usual for Suicide Prevention: A Pragmatic Randomized Trial in a Brazilian Municipality (SAVE)
The SAVE study will test whether a single esketamine infusion or a single Crisis Response Planning session, each added to enhanced treatment as usual, reduces future suicide-related events compared with enhanced treatment as…
- Conditions
- Suicide Prevention, Ketamine, Crisis Response Plan
- Trial name
- SAVE (NCT07120477)
- Testing
- Intravenous Esketamine, Crisis Response Planning (CRP), Enhanced Treatment as Usual (eTAU)
- Where
- Brazil
- Volunteers
- 478 people
- Sponsor
- University of Sao Paulo
Breast Cancer Surgery
Effect of Intravenous S-ketamine on Opioid Consumption
Female patients with an American Society of Anesthesia (ASA) physical status I-II, scheduled for elective breast cancer surgery will be included in the study.
- Trial name
- NCT05060068
- Testing
- S-ketamine (low dose), S-ketamine (high dose)
- Where
- China
- Volunteers
- 345 people
- Sponsor
- The Second Hospital of Anhui Medical University
Autism Spectrum Disorder, Dexmedetomidine
Esketamine Combined With Dexmedetomidine Sedation in Head MRI Examination of Children With Autism Spectrum Disorder
Objective: To investigate the use of ketamine combined with dexmedetomidine for sedation in children with autism spectrum disorder, Methods:aged 2-6 years,, ASA grade I or II.
- Conditions
- Autism Spectrum Disorder, Dexmedetomidine, Esketamine, Sedation
- Trial name
- NCT06633315
- Testing
- low dos dexmedetomidine, high dos dexmedetomidine, dexmedetomidine and esketamine
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Maternal and Child Health Hospital of Hubei Province
Esketamine, Consciousness Disorders
Effect of Esketamine on Conscious State in Patients With pDoC
The goal of this clinical trial is to learn about the effect of intraoperative infusion of subanesthetic dose of esketamine on conscious status in patients with prolonged disorders of consciousness under sevoflurane anesthesia.
- Trial name
- NCT06389344
- Testing
- Esketamine, normal saline
- Where
- China
- Volunteers
- 116 people
- Sponsor
- Beijing Tiantan Hospital
Adverse Respiratory Events, Hypoxemia
Comparing Esketamine and Remazolam With Propofol for Breathing Safety in Pediatric Gastroscopy
Gastroscopy is important for diagnosing and treating upper gastrointestinal diseases in children. To ensure the procedure is safe and smooth, most children require sedation.
- Conditions
- Adverse Respiratory Events, Hypoxemia, Children, Gastroscopy
- Trial name
- NCT07748884
- Testing
- Fentanyl and Propofol, Esketamine and remimazolam
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Phimosis
The Best Dose of Esketamine for Day Surgery of Pediatric Circumcision Pediatric Circumcision
In recent years, daytime operation has been developed gradually in China. Circumcision in children is a common type of daytime operation.
- Trial name
- NCT04698434
- Testing
- Esketamine
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Yangzhou University
Inguinal Hernia
Effects of Esketamine at Subanesthetic Dose on Emergence Delirium in Preschool Children Undergoing Ambulatory Laparoscopic Surgery
Emergence delirium (ED) is a manifestation of acute postoperative brain dysfunction that occurs with a relatively high frequency after pediatric anesthesia.
- Trial name
- NCT06789185
- Testing
- 0.1mg/kg esketamine, 0.2mg/kg esketamine, 0.1ml/kg normal saline
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Qiu jinpeng
Autism Spectrum Disorder
Application of Esketamine in Anesthesia of Autism Children
Autism Spectrum Disorder (ASD) is a group of serious neurodevelopmental disorders. Autistic children appear with significant frequency for medical services, lots of which requiring procedural sedation or anaesthesia.
- Trial name
- NCT05960942
- Testing
- propofol combined with esketamine, propofol-sufentanil
- Where
- China
- Volunteers
- 120 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Adverse Event
Comparison of the Sedation Effect of Esketamine and Sevoflurane for Pediatric Ophthalmological Procedure
Emergence agitation is the most common reason for post-anesthesia care unit delay. Sevoflurane is used frequently inhalational anaesthetic agent to provide pediatric anaesthesia because of the nonirritant nature.
- Trial name
- NCT05321160
- Testing
- Esketamine, Sevoflurane
- Where
- China
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Eye & ENT Hospital of Fudan University
Ketamine, Fentanyl
Esketamine Sedation and Fentanyl Sedation in Pediatric Dental Patients
Since the 1970s, ketamine has been used in clinical anesthesia treatment. Compared with ketamine, esketamine has a higher clearance rate, so it has a shorter recovery time after anesthesia.
- Conditions
- Ketamine, Fentanyl, Sedation Complication
- Trial name
- NCT04597320
- Testing
- Fentanyl, Esketamine, Midazolam
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Peking University
S-ketamine, Esketamine
Safety and Efficacy Evaluation of S (+) - Ketamine in Children
A multicenter, randomized, open-label, active controlled pragmatic clinical trial that evaluates the safety and efficacy of S (+) -ketamine for postoperative acute pain in children in perioperative settings.
- Conditions
- S-ketamine, Esketamine, Acute Pain, Postoperative Pain
- Trial name
- NCT04834427
- Testing
- Conventional therapy + S (+)-Ketamine, Conventional therapy
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Chinese PLA General Hospital
Opioid Analgesic Adverse Reaction
Cardiovascular Protection Conservative Effects of Esketamine Versus µ-opioid Receptor Agonists in General Anesthesia
Pain is 'a double-edged sword', disturbing daily life of the sufferers and activating the intrinsic protective mechanisms. Transient receptor potential vanilloid 1 (TRPV1), play such role as 'a double agent', transmitting the…
- Trial name
- NCT04553536
- Testing
- Esketamine, Sulfentanil or/and Remifentanil
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Second Hospital of Shanxi Medical University
Preoperative Anxiety, Preoperative Sedation
Determination of ED50 and ED95 With Clinical Efficacy of Intranasal Dexmedetomidine Combined With Esketamine for Preoperative Sedation in Pediatric General Anesthesia
For pediatric patients undergoing general anesthesia, poor anesthesia induction compliance often has adverse effects on individual behavior in the early postoperative period.
- Conditions
- Preoperative Anxiety, Preoperative Sedation, Children, Dexmedetomidine
- Trial name
- NCT06853431
- Testing
- dexmedetomidine, Esketamine
- Where
- 2 sites in China
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Remimazolam, Dexmedetomidine
Application of Remimazolam, Dexmedetomidine, and Esketamine in Pediatric Preoperative Sedation
By comparing the application effects of three drugs in pediatric preoperative sedation, this study explores the optimal medication regimen, aiming to provide safer, more effective, and more personalized medication options for…
- Conditions
- Remimazolam, Dexmedetomidine, Esketamine
- Trial name
- NCT07050212
- Testing
- remimazolam group, dexmedetomidine group, esketamine group
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Maternal and Child Health Hospital of Hubei Province
Behavior Problem
Intranasal Dexmedetomidine or Esketamine for Negative Postoperative Behavioral Changes in Children
The goal of this clinical trial is to learn whether intranasal dexmedetomidine or esketamine given before anesthesia can reduce negative postoperative behavioral changes in children undergoing day surgery.
- Trial name
- PEDI-NPOBCs (NCT07570160)
- Testing
- Dexmedetomidine, Esketamine, Normal Saline
- Where
- China
- Volunteers
- 342 people
- Sponsor
- Nanjing Children's Hospital
Pain Management, Postoperative Pain
Effects of S-ketamine on Perioperative Opioid Consumption
This study is a triple-blind randomized controlled trial conducted at a tertiary care hospital in Brussels. It investigates whether a single dose of S-ketamine can reduce opioid (morphine) consumption in the first 24 hours after…
- Conditions
- Pain Management, Postoperative Pain, Opioid Consumption, Postoperative, Opioid Analgesia
- Trial name
- NCT07528651
- Testing
- Esketamine at low dose, Saline (0.9% NaCl)
- Where
- Belgium
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Erasme University Hospital
Anxiety-depression
Effect of Esketamine on Reducing Postoperative Anxiety and Depression in Adolescent Patients
This study intends to conduct a prospective, double-blind, randomized, controlled trial. Adolescents aged 8-17 years old are selected as subjects.
- Trial name
- NCT06073015
- Testing
- Esketamine
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Henan Provincial People's Hospital
Sevoflurane
Comparison of Sedation by Esketamine and Sevoflurane
Pediatric diseases，including congenital cataract,，corneal injury，corneal ulcer, usually need suture removal and ophthalmic examination after Surgery for several days.
- Trial name
- NCT05011214
- Testing
- Sevoflurane, Esketamine
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Eye & ENT Hospital of Fudan University