Clinical trials: Epilepsy Intractable
Infantile Spasms
Short-term Ketogenic Diet as Compared With Conventional Long-term Trial in Refractory Infantile Spasms: A Randomized, Controlled Study
This is a randomized, controlled study to compare Short-term ketogenic diet with conventional long-term trial in refractory infantile spasms.
- Trial name
- NCT00968136
- Sponsor
- Yonsei University
Epilepsy
Atkins Plus KetoCal for Childhood Epilepsy
The modified Atkins diet (MAD) is a relatively new, alternative dietary therapy for intractable childhood and adult epilepsy. Recent evidence suggests that a strict, highly ketotic, first month may be advantageous to both…
- Trial name
- NCT00681239
- Testing
- Modified Atkins diet and KetoCal
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Drug Resistant Epilepsy, Ketogenic Diet
Feasibility, Tolerability and Efficacy of the Ketogenic Diet in Children With Drug-resistant Epilepsy in South Vietnam
According to the World Health Organization, more than 50 million people have epilepsy. Among them, nearly 80% of epileptic patients live in developing countries and 75% of them do not have access to treatment.
- Conditions
- Drug Resistant Epilepsy, Ketogenic Diet, Feasibility, Tolerability
- Trial name
- NCT05697887
- Testing
- Ketogenic diet
- Where
- Vietnam
- Volunteers
- 45 people
- Sponsor
- Number 2 Children's Hospital, Ho Chi Minh City
Epilepsy
Treatment of Drug Resistant Epilepsy
The main goal of this study is to provide treatment with cannabidiol (CBD) to children with drug resistant epilepsy through a Physician Expanded Access Investigation New Drug protocol.
- Trial name
- Cannabidiol (NCT02461706)
- Testing
- cannabidiol, Blood Test
- Where
- 2 sites in United States
- Sponsor
- University of Florida
Epilepsy
P-glycoprotein Inhibition as Adjunct Treatment for Medically Refractory Epilepsy.
In up to 1 out of 3 patients with epilepsy, seizures continue to occur despite the use of one or more antiepileptic medications.
- Trial name
- NCT00524134
- Testing
- Carvedilol-CR
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Columbia University
CDKL5 Deficiency Disorder
Study of Adjunctive Ganaxolone Treatment in Children and Young Adults With CDKL5 Deficiency Disorder
A clinical study to evaluate the efficacy, safety, and tolerability of adjunctive ganaxolone therapy compared to placebo for the treatment of seizures in children and young adults with genetically confirmed CDKL5 gene mutation.
- Trial name
- Marigold (NCT03572933)
- Testing
- ganaxolone
- Where
- 36 sites in United States, Australia and 6 more
- Volunteers
- 101 people
- Sponsor
- Marinus Pharmaceuticals
Epilepsy, Lennox-Gastaut Syndrome, Intractable
Children's Adaptive Deep Brain Stimulation for Epilepsy Trial (CADET): Pilot
The CADET Pilot will investigate the safety and feasibility of deep brain stimulation (DBS) to treat children with Lennox-Gastaut syndrome using a novel DBS device (Picostim DyNeuMo-1).
- Trial name
- CADET Pilot (NCT05437393)
- Testing
- Deep brain stimulation
- Where
- 2 sites in United Kingdom
- Volunteers
- 4 people
- Sponsor
- University College, London
Refractory Epilepsy
Trial to Evaluate the Safety and Effectiveness of Vagus Nerve Stimulation for Children With Refractory Epilepsy
Children with refractory epilepsy who are candidates for a treatment with vagus nerve stimulation will be prospectively randomized into 2 arms.
- Trial name
- NCT03062514
- Testing
- PINS Vagus Nerve Stimualtor
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Beijing Pins Medical Co., Ltd
Epilepsy, Epileptic Encephalopathy
Tele-epic (Telemedicine for Epilepsy Care)
Epilepsy is a chronic condition that requires consistent follow-up aimed at seizure control, surveillance of comorbidities, monitoring of antiepileptic drugs (AED) levels and side effects.
- Conditions
- Epilepsy, Epileptic Encephalopathy, Refractory Epilepsy
- Trial name
- Tele-epic (NCT04496310)
- Testing
- Telemedicine
- Where
- 2 sites in Italy
- Volunteers
- 600 people
- Sponsor
- Azienda Usl di Bologna
Pediatric Epileptic Syndrome, Partial-onset Seizures
A Study to Evaluate Efficacy and Safety of Perampanel Administered as an Adjunctive Therapy in Pediatric Participants With Childhood Epilepsy
The purpose of the study is to evaluate the efficacy of perampanel as measured by the 50 percent (%) responder rate during the maintenance period of the core study for seizure frequency in participants with pediatric epileptic…
- Trial name
- NCT04015141
- Testing
- Perampanel Oral Suspension, Perampanel Tablet
- Where
- 35 sites in United States, Belgium and 4 more
- Volunteers
- 100 people
- Sponsor
- Eisai Inc.
Partial Drug-resistant Epilepsy
High Resolution Imaging of Cerebral Vasculature by Functional Micro-Doppler Sonography During Brain Surgery
High Resolution Imaging of Cerebral Vasculature by Functional Micro-Doppler Sonography During Brain Surgery (ULYS)
- Trial name
- ULYS (NCT02090569)
- Testing
- Functional micro-Doppler Sonography (fmDS)
- Where
- France
- Volunteers
- 3 people
- Sponsor
- Centre Hospitalier St Anne
Epilepsy
Possible Immuno-Modulatory Effect of Tocilizumab in Patients With Refractory Status Epilepticus.
Recently, the pathogenesis of epilepsy is immuno-modulatory and neuro-inflammatory which is commonly activated in epileptogenic brain regions in humans and is clearly involved in animal models of epilepsy.
- Trial name
- NCT05346666
- Testing
- Tocilizumab Prefilled Syringe [Actemra]. propofole, phenobarbital, midazolam
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Damanhour University
Developmental and Epileptic Encephalopathy, Epilepsy in Children
Developmental and Epileptic Encephalopathies Diagnosed Via Long-read Genome Sequencing
This study focuses on children with Developmental and Epileptic Encephalopathy (DEE), a severe form of epilepsy that often has a genetic origin.
- Trial name
- EEPILOG (NCT07396883)
- Testing
- Long-read Whole Genome Sequencing (lrWGS)
- Where
- 4 sites in France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Strasbourg, France
Epilepsy, Epilepsy Intractable
Effects of Green Light Exposure on Epileptic Spikes in Patients With Refractory Epilepsy
The purpose of this study is to obtain preliminary data in advance of a larger clinical trial aimed to test whether a single session of green light exposure can lead to a clinically significant reduction in epileptic spikes in…
- Trial name
- NCT03857074
- Testing
- Green Light Exposure
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Boston Children's Hospital
Refractory Focal Epilepsy
Slow Oscillatory Transcranial Direct Current Stimulation for Refractory Focal Epilepsy
This pilot study evaluated whether a type of non-invasive brain stimulation called slow-oscillatory transcranial direct current stimulation (so-tDCS) can reduce seizure frequency in patients with drug-resistant focal epilepsy.
- Trial name
- so-tDCS-RE (NCT07684352)
- Testing
- Slow-oscillatory transcranial direct current stimulation (so-tDCS)
- Where
- China
- Volunteers
- 10 people
- Sponsor
- The First Hospital of Hebei Medical University
Epilepsy
Modified Atkins Diet in Children and Adolescents With Drug-resistant Epilepsy
The purpose of the study is to evaluate the effect of the Modified Atkins Diet in children and adolescents with drug-resistant epilepsy regarding seizure control, and to create a protocol for the use of the Modified Atkins Diet…
- Trial name
- NCT01278966
- Testing
- The Modified Atkins Diet
- Where
- Norway
- Volunteers
- 21 people
- Sponsor
- Oslo University Hospital
Epilepsy, Focal
A Study of Brivaracetam in Subjects With Partial Onset Seizures
This trial will evaluate the efficacy and safety of brivaracetam (at doses of 50 and 150 mg/day in twice a day administration) as add on therapy in subjects with focal epilepsy
- Trial name
- NCT00175929
- Testing
- Brivaracetam
- Where
- 56 sites in Belgium, Czechia and 7 more
- Volunteers
- 157 people
- Sponsor
- UCB Pharma
Drug Resistant Epilepsy
MiRNA223 and HMGB1 as Apredictos for Drug Resistant Epilepsy
Evaluation of the role of estimation of serum level of miRNAs223 and HMGB1in detection of patient with drug resistant epilepsy. Early detection of the prognosis might help in guiding patients for proper management and treatment…
- Trial name
- NCT05555537
- Testing
- MiRNA223 and High mobility group box1(HMGB1)
- Volunteers
- 90 people
- Sponsor
- Assiut University
Epilepsy
A Study for Evaluating the Efficacy and Safety of Zonisamide and Lamotrigine (Lamictal) for Subjects With Refractory Simple Partial, Complex Partial or Partial With Secondary Generalized Seizures
The purpose of this study is to evaluate the efficacy and safety of zonisamide for anti-epilepsy drugs (AEDs) treated subjects with refractory simple partial, complex partial or partial with secondary generalized seizures.
- Trial name
- NCT00292461
- Testing
- Zonisamide, Lamotrigine
- Where
- 8 sites in China
- Volunteers
- 64 people
- Sponsor
- Eisai Inc.
Epilepsy and Focal Cortical Dysplasia II
A Study Investigating the Anti-epileptic Efficacy of Afinitor (Everolimus) in Patients With Refractory Seizures Who Have Focal Cortical Dysplasia Type II (FCD II)
This is a prospective, randomized, double-blind, placebo-controlled cross over study designed to evaluate the efficacy and safety of everolimus (trough 5-15 ng/mL) given as adjunctive therapy in patients with focal cortical…
- Trial name
- NCT03198949
- Testing
- Afinitor (everolimus)
- Where
- South Korea
- Volunteers
- 23 people
- Sponsor
- Yonsei University