Clinical trials: Dental Sedation
Preoperative Sedation
Intranasal Dexmedetomidine Premedication in Children
BACKGROUND INFORMATION AND RATIONALE Pediatric patients scheduled for dental procedures under general anesthesia can have significant anxiety before the procedure.
- Trial name
- NCT02250703
- Testing
- Midazolam, Dexmedetomidine
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Mississippi Medical Center
Conscious Sedation
Effects of Oral Midazolam in Comparison Promethazine With Nitrous Oxide for Uncooperative Children
The purpose of this study is to compare the safety and efficacy of sedation using orally administered midazolam and promethazine with nitrous oxide/oxygen in uncooperative children receiving dental treatments.
- Trial name
- NCT01118884
- Testing
- Promethazine
- Where
- Iran
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University
Surgery
Evaluation of the Use of RELAX Glasses on Anxiety of Patients Undergoing Dental Extraction > 2 Teeth, Under Local Anesthesia, Compared With Those Not Using Glasses
The vast majority of tooth extraction surgery is performed under local anaesthetic, and can be a source of anxiety. In their 2015 article, Appukuttan et al studied the anxiety felt by 1148 patients prior to tooth extraction, and…
- Trial name
- BRIGAND (NCT06589908)
- Testing
- RELAX glasses
- Where
- France
- Volunteers
- 106 people
- Sponsor
- Centre Hospitalier de Valenciennes
Anxiety
High-Concentration Nitrous Oxide for Dental Procedural Sedation in Children
The use of nitrous oxide as a sedative agent is very common in pediatric dentistry. In concentrations up to 50% it is considered as mild sedation and it is very safe.
- Trial name
- NCT02886351
- Testing
- Nitrous Oxide
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bnai Zion Medical Center
Anti-anxiety Agents, Moderate Sedation
Sublingual Versus Intranasal Administration of Dexmedetomidine for Sedation of Children Undergoing Dental Treatment
The aim of this study is to assess the efficacy of Dexmedetomidine drug either used sublingually or intranasally in managing healthy children during dental treatment
- Trial name
- NCT04237532
- Testing
- Intranasal Dexmedetomidine, Sublingual Dexmedetomidine
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Nourhan M.Aly
Dental Caries in Children, Pediatric Dental Sedation
Comparing Pediatric Dental Oral Sedation Outcomes With and Without Meperidine in Children Aged 3-7 Years
The primary objective of this randomized controlled trial is to assess the effects of oral sedation using midazolam and hydroxyzine with and without meperidine (a narcotic) on sedation outcomes in pediatric dental patients…
- Conditions
- Dental Caries in Children, Pediatric Dental Sedation, Meperidine, Hydroxyzine
- Trial name
- NCT04068948
- Testing
- Meperidine, Hydroxyzine, Midazolam
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Washington
Dental Caries, Child Behavior
Efficacy of Moderate Sedation for Dental Treatment of Young Children
There is lack of clinical trials on pediatric dental sedation. The purpose of this study is to test (using a randomized controlled trial design) the hypothesis that young children behavior during dental treatment improves with…
- Conditions
- Dental Caries, Child Behavior, Conscious Sedation Failure During Procedure
- Trial name
- NCT00902395
- Testing
- Midazolam, Protective stabilization, Midazolam, ketamine
- Where
- Brazil
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Goias
Dental Cares
Use of 50% Nitrous Oxide / 50% Oxygen Premix in Primary Care Dental Centers
A 50% nitrous oxide / 50% oxygen premix is administrated to the patient during the realization of dental cares. This openly clinical trial is done in 36 French primary care dental centers, especially on anxious and phobic…
- Trial name
- NCT00643838
- Testing
- Kalinox 170 bar
- Where
- France
- Volunteers
- 549 people
- Sponsor
- Air Liquide Santé International
Sedative Overdose
Local Anesthesia Impact on Dental Sedation
The goal of this observational study is to investigate the impact of local anesthesia in health children who were sedated for dental procedures.
- Trial name
- NCT06218173
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Ankara University
Conscious Sedation
Nasal Versus Oral Midazolam Sedation in Routine Pediatric Dental Care
The general objective of the study is to compare the efficacy of administering midazolam orally as syrup versus nasally with nasal atomizer.
- Trial name
- NCT02679781
- Testing
- oral midazolam, nasal midazolam
- Where
- Israel
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Early Childhood Caries
Midazolam Efficacy for Sedating Preschoolers Undergoing Dental Treatment
Evaluation of oral midazolam to improve children's behavior and reduces the stress and anxiety during dental treatment
- Trial name
- Pedsed-I (NCT01795222)
- Testing
- Midazolam
- Where
- Brazil
- Volunteers
- 18 people
- Sponsor
- Universidade Federal de Goias
Ketamine, Fentanyl
Esketamine Sedation and Fentanyl Sedation in Pediatric Dental Patients
Since the 1970s, ketamine has been used in clinical anesthesia treatment. Compared with ketamine, esketamine has a higher clearance rate, so it has a shorter recovery time after anesthesia.
- Conditions
- Ketamine, Fentanyl, Sedation Complication
- Trial name
- NCT04597320
- Testing
- Fentanyl, Esketamine, Midazolam
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Peking University
Dental Anxiety
Effectiveness of Children Experiencing Nitrous Oxide/Oxygen Inhalation Sedation at an Assessment Visit Before Having Treatment.
The purpose of this study is to find out the effect of experience of dental sedation at assessment on children's anxiety before the actual treatment session.
- Trial name
- NCT06056492
- Testing
- Experience of nitrous oxide sedation at assessment
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Dr Richard Balmer
Anxiety Postoperative
Evaluation of the Effects Using the Combination of Sedative Agents on Dental Anxiety in Pediatric Patients
The aims of this study were firstly, to evaluate the changes in the anxiety level after deep sedation with various intravenous sedative agents using salivary cortisol level in pediatric dental patients and secondly, to compare…
- Trial name
- NCT04623970
- Testing
- Dental Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Dental Sedation
Intranasal Versus Nebulized Midazolam in Behaviuor Modification of Preschool Children Undergoing Dental Treatment
The aim of the current study is to compare the effect of intranasal versus nebulized route of administration of midazolam as moderate sedative agents in preschoolers undergoing dental treatment.
- Trial name
- NCT05883150
- Testing
- Nebulized Midazolam, Intranasal Midazolam
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- Nourhan M.Aly
Dental Pain
Buffered Local Anesthetic
The purpose of this research study is to compare responses in children during dental injections of local anesthetic (used for numbing), while children are under deep sedation (breathing on their own, often with a loss of…
- Trial name
- NCT05757648
- Testing
- Non-buffered Anesthetic, Buffered Anesthetic, Onset
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Dental Anxiety
Sevoflurane Associated With Oral Midazolam and Ketamine for Dental Sedation
There is still extensive debate on the best method of controlling the behavior of preschool children during dental treatment. Protective stabilization, moderate sedation and general anesthesia are advanced behavior control…
- Trial name
- NCT02284204
- Testing
- Midazolam, Ketamine and Sevoflurane, Midazolam and Ketamine
- Where
- Brazil
- Volunteers
- 27 people
- Sponsor
- Universidade Federal de Goias
Vital Signs
Dexmedetomidine Compared to Ketofol for Sedation in Paediatrics
Dental fear and anxiety remain common problems that should be managed by both the dentist and the anesthetist. The currently available evidence for safe and effective sedative drugs for children undergoing the dental procedure is…
- Trial name
- NCT04678050
- Testing
- Ketamine/ propofol, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Dental Anxiety
Nebulized Midazolam, Dexmedetomidine, and Their Combination in Sedation of Preschoolers Undergoing Dental Treatment
The aim of the study is to evaluate the effect of nebulized Midazolam, Dexmedetomidine, and their combination as procedural, moderate sedative agents in preschoolers undergoing dental treatment.
- Trial name
- NCT03827408
- Testing
- Midazolam group (MDZ), Dexmedetomidine group (DEX), Combination of Midazolam and Dexmedetomidine (MDZ/DEX)
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Nourhan M.Aly
Dental Caries
Isolite and Dental Treatment Under Conscious Sedation
Hypothesis The use of Isolite® system does not produce upper airway obstruction in the pediatric population during dental treatment with conscious sedation.
- Trial name
- NCT01683851
- Testing
- Isolite System
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio