Clinical trials: Defiant Disorder, Oppositional
Irritability, Disruptive Mood Dysregulation Disorder
Psychotherapy for Irritability in Youth: Comparing Active Treatment to Nonactive Psychoeducation Supportive Psychotherapy
Background: Irritability is defined as proneness to anger that may impair a person's ability to function. It is a common reason for why some children need mental health care.
- Conditions
- Irritability, Disruptive Mood Dysregulation Disorder, Oppositional Defiant Disorder, Attention Deficit Hyperactivity Disorder
- Trial name
- NCT07640802
- Testing
- Psychotherapy
- Where
- United States
- Volunteers
- 410 people
- Sponsor
- National Institute of Mental Health (NIMH)
Disruptive Behavior Disorders, Conduct Disorder
Augmenting Parent Management Training for Child Temper Outbursts Using a Digital Tool
Background: Pediatric disruptive behavior disorders (DBDs) are characterized by severe irritability, anger, and temper outbursts. The primary way to treat children with DBDs is parent management training (PMT).
- Conditions
- Disruptive Behavior Disorders, Conduct Disorder, Oppositional Defiant Disorder, Attention-deficit/Hyperactivity Disorder
- Trial name
- NCT07764536
- Testing
- Psychotherapy
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- National Institute of Mental Health (NIMH)
Child Behavior Problem, Disruptive Behavior
Pilot Study of Cognitive Behavior Therapy With Role-plays in Virtual Reality for Children With Behavior Problems
The main aim of this small pilot trial is to evaluate preliminary effects and feasibility of the child intervention YourSkills for child disruptive behavior (e.g., enhanced anger or aggressive behavior) when evaluated in Sweden…
- Conditions
- Child Behavior Problem, Disruptive Behavior, Oppositional Defiant Disorder, Conduct Problems
- Trial name
- NCT06559800
- Testing
- YourSkills: Cognitive behavioral therapy for children/youth with role-plays in virtual reality
- Where
- Sweden
- Volunteers
- 10 people
- Sponsor
- Karolinska Institutet
Child Behavior Problem, Disruptive Behavior
Pilot Study of Parent Training With Role-plays in Virtual Reality for Parents of Children With Behavior Problems
The main aim of this pilot trial is to evaluate preliminary effects and feasibility of a new parent training program for parents of children aged 8-16 years with disruptive behavior (e.g., angry, aggressive or defiant behavior).
- Conditions
- Child Behavior Problem, Disruptive Behavior, Oppositional Defiant Disorder, Conduct Problems
- Trial name
- NCT06559813
- Testing
- Step-by-step: A cognitive behavioral parent program with role-plays in virtual reality
- Where
- Sweden
- Volunteers
- 8 people
- Sponsor
- Karolinska Institutet
Problem Behavior, Child Behavior
Digital Therapeutics for Behavior Problems
In this project, the investigators aim to test the effectiveness of a mobile health (mHealth) system as a standalone versus coach-assisted intervention with the goal of achieving reach and scalability.
- Trial name
- NCT05647772
- Testing
- UseIt! App, Coach, SmilingMind App
- Where
- United States
- Volunteers
- 324 people
- Sponsor
- University of Pittsburgh
Oppositional Defiant Disorder, Conduct Disorder
Integrated Smart Speaker Promoting Positive Parenting Among Caregivers of Youth With Challenging Behaviors
This project will develop and evaluate the feasibility of an integrated smart speaker and mobile/web-based application, "FamilyNet" (FN) to assist parents in implementing empirically supported behavioral parenting strategies to…
- Trial name
- FamilyNet (NCT05535387)
- Testing
- FamilyNet smart speaker/mobile application
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Oregon Research Behavioral Intervention Strategies, Inc.
Conduct Disorder, Oppositional Defiant Disorder
Pathways 2 Success
This study involves a 3-arm randomized controlled trial designed to investigate the feasibility and acceptability of three preventive interventions designed to reduce risk for escalations in adolescent conduct problems.
- Trial name
- NCT06831123
- Testing
- L2B, L2B + App, skills for success
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Minnesota
Behavioural Disorder, Disruptive Behavior Disorder
Personalizing Psychosocial Intervention for Children With Disruptive Behaviour
This study will develop and test whether personalized profiles of children with Disruptive Behaviour Disorder (DBD) and their parents based on important psychological, emotional, and neuropsychological indicators predict their…
- Conditions
- Behavioural Disorder, Disruptive Behavior Disorder, Attention Deficit Hyperactivity Disorder, Conduct Disorder
- Trial name
- MATCH-PIP (NCT07495683)
- Testing
- Behavioral Parent Training
- Volunteers
- 600 people
- Sponsor
- Centre for Addiction and Mental Health
Depression, Emotional Problem
Addressing Depression and Positive Parenting Techniques (ADAPT)
Children with emotional and behavioural difficulties (EBD) experience disproportionate social, family and academic impairment and have between two to five times increased likelihood of developing an anxiety disorder, mood…
- Conditions
- Depression, Emotional Problem, Disruptive Behavior Disorder, Attention Deficit Hyperactivity Disorder
- Trial name
- ADAPT (NCT04298437)
- Testing
- Addressing Depression and Positive Parenting Techniques (ADAPT) Program
- Where
- 2 sites in Canada
- Volunteers
- 80 people
- Sponsor
- Centre for Addiction and Mental Health
Disruptive Behavior Disorder, Emotional Disorder
Matching Assessment and Treatment for Children With Disruptive Behaviour and Their Parents
This study will develop and test whether personalized profiles of children with Disruptive Behaviour Disorder (DBD) and their parents based on important psychological, emotional, and neuropsychological indicators predict their…
- Conditions
- Disruptive Behavior Disorder, Emotional Disorder, Behavioural Disorder, Attention Deficit Hyperactivity Disorder
- Trial name
- MATCH-DB (NCT06373484)
- Testing
- Behavioral Parent Training
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Centre for Addiction and Mental Health
Social Anxiety Disorder (SAD), Oppositional Defiant Disorder
ACTsocially: The (Dis)Similarities of ACT for Changing Internalizing and Externalizing Symptomatology in Adolescence
Social functioning, fundamental to adolescent's development and mental health, may be impaired by polarizing problematic social functioning, namely externalizing symptoms manifested by Oppositional Defiant Disorder and…
- Trial name
- ACTsocially (NCT07456631)
- Testing
- ACTsocially
- Where
- Portugal
- Volunteers
- 54 people
- Sponsor
- University of Coimbra
Child Behavior Problem, Disruptive Behavior
Step-by-Step: Evaluation of a Stepped Care Model
The primary aim of this project is to examine the effectiveness of a stepped care model of interventions for children's defiant or aggressive behavior problems.
- Conditions
- Child Behavior Problem, Disruptive Behavior, Oppositional Defiant Disorder, Conduct Problems
- Trial name
- NCT06902649
- Testing
- Internet-based parenting support, "YourSkills" for children/youth, Step-by-step parent support
- Where
- Sweden
- Volunteers
- 210 people
- Sponsor
- Karolinska Institutet
Conduct Disorder, Oppositional Defiant Disorder
On-line Treatment for Conduct Problems
The research evaluates the use of online versions of delivering an effective psychological treatment for children clinically referred for serious oppositional, aggressive, and antisocial behavior.
- Trial name
- NCT01822392
- Testing
- Online Parent Management Training (Interactive), Online Parent Management Training (Recorded)
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Yale University
Conduct Disorder, Oppositional Defiant Disorder
Genetic and Clinical Correlates of Disruptive Behavior Disorder With and Without Callous-Unemotional Traits
Disruptive Behavior Disorders (DBD), such as Conduct Disorder (CD) and Oppositional Defiant Disorder (ODD), affect children and adolescents in different ways.
- Conditions
- Conduct Disorder, Oppositional Defiant Disorder, Callous Unemotional Traits
- Trial name
- GENCU 2025 (NCT07322055)
- Where
- 2 sites in Italy
- Volunteers
- 200 people
- Sponsor
- IRCCS Fondazione Stella Maris
Emotional Dysregulation, Externalizing Problems
Assessing Real Life Effectiveness of Treatment in Neurodevelopmental Disorders
The goal of this observational study is to learn if and how pharmacological and psychotherapeutic group treatments can treat clinical symptoms of children and adolescent patients with ADHD.
- Conditions
- Emotional Dysregulation, Externalizing Problems, Oppositional Defiant, Conduct Disorder
- Trial name
- ALERT (NCT07273695)
- Testing
- methyphenidate, Group psychological treatment
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- IRCCS Eugenio Medea
Conduct Disorders in Children, Disruptive Behavior
Effects and Implementation of a Brief Version of Parent-Child Interaction Therapy
The aim of this study is to evaluate the effects and feasibility of a shortened version of Parent-Child Interaction Therapy (PCIT), supplemented with video vignettes of parenting skills and 360-virtual reality (VR)-films for…
- Conditions
- Conduct Disorders in Children, Disruptive Behavior, Oppositional Defiant Disorder
- Trial name
- NCT07201090
- Testing
- Brief Parent-Child Interaction Therapy with videos and virtual reality (360-degree VR)-films
- Where
- 2 sites in Sweden
- Volunteers
- 15 people
- Sponsor
- Karolinska Institutet
Conduct Disorders in Adolescence, Oppositional Defiant Disorder
Is Mentalization-based Therapy More Effective Than Treatment-as-usual for Adolescents With Dissocial Disorders?
The goal of this clinical trial is to investigate if Mentalization-based therapy (MBT) is superior to enhanced usual care (treatment-as-usual-plus (TAU-plus)) for adolescents with disruptive behavior or dissocial disorders.
- Trial name
- MEDAL (NCT07181928)
- Testing
- Mentalization-Based Therapy (MBT), Treatment-as-usual-plus (TAU-plus)
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- University Hospital Heidelberg
Attention Deficit Hyperactivity Disorder (ADHD), Anxiety Disorders and Symptoms
Safety and Efficacy of Mexidol® for ADHD in Children Aged 6-12
The primary objective of this study was to evaluate the efficacy and safety of Mexidol® film-coated tablets (125 mg) compared to a placebo in children aged 6 to 12 years with Attention Deficit Hyperactivity Disorder (ADHD).
- Trial name
- MEGA (NCT06854601)
- Testing
- Mexidol
- Where
- 14 sites in Russia
- Volunteers
- 333 people
- Sponsor
- Pharmasoft
Attention-deficit/Hyperactivity Disorder, Oppositional Defiant Disorder in Children
A Study to Assess the Effectiveness and Safety of Clonidine Extended-Release OnydaTM XR in Children With ADHD and ODD
This is a study to see how safe and effective OnydaTM XR is to treat Attention-Deficit/Hyperactivity Disorder (ADHD) in children aged 6 to 12 years who also have Oppositional Defiant Disorder (ODD).
- Trial name
- NCT07044609
- Testing
- Clonidine extended release oral suspension
- Volunteers
- 162 people
- Sponsor
- Las Vegas Medical Research, LLC DBA Vector Clinical Trials
Childhood Externalizing Disorder, Childhood Oppositional Defiant Disorder
Randomized Controlled Trial of Regulation-Focused Psychotherapy (RFP-C)
Regulation Focused Psychotherapy for Children (RFP-C) is a manualized, time-limited psychodynamic treatment for children with externalizing symptoms.
- Conditions
- Childhood Externalizing Disorder, Childhood Oppositional Defiant Disorder, Childhood Conduct Disorder
- Trial name
- NCT06060353
- Testing
- Regulation Focused Psychotherapy (RFP-C), Parental Awareness and Child Social Skills Group
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Istanbul Bilgi University