Clinical trials: Comparative Effectiveness
Burns
Sodic Heparin Effectiveness of the Treatment of Burns
Burns are injuries caused by agents thermal, chemical, electrical or radioactive who act in the tissue lining of the human body and may partially or totally destroy the skin and its annexes, to the deeper layers, as subcutaneous…
- Trial name
- Heparin (NCT00701623)
- Testing
- heparin, folder water
- Where
- Brazil
- Volunteers
- healthy volunteers welcome
- Sponsor
- Azidus Brasil
Insomnia
Infant Behavioral Sleep Intervention: Comparative Efficacy
While frequent night awakenings in newborns are common and expected, an estimated 20-30% of older infants and toddlers have frequent problematic night wakings requiring parental intervention throughout the night.
- Trial name
- NCT03447665
- Testing
- Bedtime routine, Sleep schedule, Intervention (bedtime)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana University
Head Lice
Safety and Efficacy of a Head Lice Shampoo
This study is designed to compare the effectiveness and safety of test head lice shampoo (Test product) versus Goldgeist® Forte (reference product) following two applications.
- Trial name
- NCT06333054
- Testing
- Pyrethrum Extract
- Where
- Germany
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Oystershell NV
Femoral Shaft Fracture, Pediatric ALL
Femoral Pediatric Fractures. Walking Spica Cast vs Synthetic Pants
Femoral pediatric shaft fractures are a common orthopedic injury. Conservative treatment is still the preferred method by orthopedic surgeons.
- Trial name
- NCT04311866
- Testing
- Synthetic pants, Spica cast
- Where
- Mexico
- Volunteers
- healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Nuevo Leon
Intra-Bony Defects in Periodontitis Patients
The Efficacy of Exosomes Combined With Synthetic Bone Graft for the Treatment of Periodontal Intra-bony Defects
The aim of this study will be to evaluate clinically, radiographically and biochemically the efficacy of exosomes combined with synthetic bone graft for the treatment of periodontal intra-bony defects.
- Trial name
- NCT07897292
- Testing
- single flap approach, single flap approach combined with nanocrystalline hydroxyapatite bone substitute, Exosomes
- Where
- 2 sites in Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Khoshoe Al-mokhtar Mohammed
Child, Early Childhood Caries
Evaluation of Remineralizing Efficacy of Combination Varnishes on White Spot Lesions in ECC Children
The remineralizing efficacy of 3 fluoride varnishes were assessed in children with white spot lesion under 6 years of age ( children with early childhood caries)
- Trial name
- NCT03360266
- Testing
- Sodium Fluoride with CPP-ACP varnish, sodium fluoride with ACP varnish, 5% Sodium Fluoride Varnish
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Indira Gandhi Institute of Dental Science
Necrotic Pulp
Comparative Evaluation of the Regenerative Capacity of Two Platelet Concentrates
Injectable platelet-rich fibrin (I-PRF) is a flowable blood concentrate that is entirely natural and allows ease of access and flow within the root canal. It was first developed in 2014 by modifying the centrifugation parameters.
- Trial name
- NCT03698188
- Testing
- Injectable platelet-rich fibrin, Platelet-rich plasma
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Sedation for Children Undergoing MRI
A Comparison Between Oral Melatonin With Nasal Sevoflurane Versus Oral Chloral Hydrate With Nasal Sevoflurane in Sedation of Children Undergoing Brain MRI
The patients will be randomized into 2 equal groups by a computer-generated random numbers table, named group A, B. Group A: will receive oral Melatonin and nasal Sevoflurane.
- Trial name
- NCT06606899
- Testing
- Melatonin 3 MG, Chloral Hydrate, Sevoflurane
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Pain
Study of Pain Control With Hormonal IUS Insertion
This study aims to compare pain during insertion of the Skyla® IUS using a 100mm visual analog scale (VAS) among 92 young women aged 14 to 22 years randomized to receive a paracervical (n=46) block versus a sham paracervical…
- Trial name
- SOPHI (NCT02352714)
- Testing
- Paracervical Nerve Block
- Where
- 3 sites in United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Quality of Life, Body Mass Index
Study of Parental Ratings of Quality of Life and Body Composition in 5-19 Year Olds While Participating in the Good NEWS 4 Kids Program
This study will compare changes in body composition (lean mass, fat, and bone)and parent ratings of quality of life in 5-19 Year Olds as a function of participation in one of four versions of the Good NEWS 4 Kids Program (GN4K).
- Trial name
- NCT01855009
- Testing
- MannaBears, AlgaeCal Calcium, Calcium carbonate
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Integrative Health Technologies, Inc.
Contraception
Comparative Safety and Efficacy of Vaginal Dinoprostone Versus Lidocaine-prilocaine Cream in Copper IUD Insertion
the aim of the present study is to Compare Safety and Efficacy of Vaginal dinoprostone Versus Lidocaine-prilocaine Cream in copper IUD Insertion in nulliparous women: a randomized controlled trial
- Trial name
- NCT04340778
- Testing
- vaginal dinoprostone, Lidocaine-prilocaine Cream
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Cairo University
Acne Vulgaris
Efficacy and Tolerability Evaluation of a Novel Dermo-cosmetic Product for Mild-to-moderate Acne
The goal of this non-interventional, observational study is to evaluate the real-world efficacy and tolerance of a novel dermocosmetic cream containing 15% Azelaic acid and a complex of active ingredients (α-AZ cream) in patients…
- Trial name
- NCT07759505
- Where
- Romania
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- ISISPHARMA
Pediculus Capitis Infestation
Safety and Efficacy Study of NatrOVA Creme Rinse - 1% and NIX Creme Rinse in Subjects 6 Months or Older With Head Lice
A comparative safety and efficacy study of NatrOVA Creme Rinse - 1% versus NIX Creme Rinse, under actual use conditions in subjects 6 months of age or greater who are infested with Pediculosis capitis (Head lice).
- Trial name
- NCT00545168
- Testing
- Spinosad, Permethrin 1%
- Where
- 6 sites in United States
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- ParaPRO LLC
Pediculosis Capitis
Efficacy and Safety of Licefreee Spray Against Nix 1% Permethrin
The purpose of this study is to evaluate the safety and efficacy of Licefreee Spray in eradicating head lice as compared to Nix, both are available over-the-counter lice treatments.
- Trial name
- NCT01514513
- Testing
- Licefreee Spray, 1% permethrin creme rinse
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- South Florida Family Health and Research Centers
Sickle Cell Disease, Sickle Cell Anemia
Decision Aid for Therapeutic Options In Sickle Cell Disease
Sickle cell disease (SCD) is an inherited disorder with chronic multi-system manifestations affecting 100,000 individuals in the US, largely of minority origin and associated with substantial morbidity, premature mortality…
- Conditions
- Sickle Cell Disease, Sickle Cell Anemia, Hemoglobin SS, Hemoglobin SC
- Trial name
- NCT02326597
- Testing
- Decision Aid Tool, Standard Practice
- Where
- United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Emory University
Molar Incisor Hypomineralization, Hypersensitivity
Intraosseous vs Infiltration Anesthesia in Molar-Incisor Hypomineralization (MIH) Children
This study aims to compare the effectiveness of intraosseous and infiltration anesthesia techniques administered using a computer-assisted anesthesia device (SleeperOne® 5; Dental HiTec, France) during restorative treatments of…
- Trial name
- MIH (NCT07352813)
- Testing
- Intraosseous anaesthesia using a computerized system, Infiltration anaesthesia using a computerized system
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Urea Cycle Disorders
PCORI Urea Cycle Disorder Study
Urea cycle disorders (UCD) are genetic disorders caused by the liver's inability to break down ammonia from proteins; ammonia then accumulates and is toxic to the brain.
- Trial name
- NCT02740153
- Testing
- No Intervention Given
- Where
- United States
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
ADHD, ADHD - Attention Deficit Disorder With Hyperactivity
Comparative Efficacy of Organizational Skills Training (OST) and Mindfulness-Based Intervention (MBI)
This randomized control trial comparing Organizational Skills Training (OST) and Mindfulness-Based Intervention (MBI) among adolescents with a pre-existing ADHD diagnosis presenting to the Duke ADHD Program.
- Trial name
- NCT07089745
- Testing
- Mindfulness-Based Intervention, Organizational Skills Training
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Duke University
Contraception
Cervical Lidocaine-Prilocaine Cream vs Glyceryl Trinitrate Cream in Nulliparous Women With LNG-IUD Insertion
the aim of the present study is to compare safety and efficacy of cervical Lidocaine-Prilocaine cream versus glyceryl trinitrate cream on pain perception during levonorgestrel- intrauterine device insertion among nulliparous…
- Trial name
- NCT04355598
- Testing
- Lidocaine-Prilocaine cream, glyceryl trinitrate cream
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Cairo University
HIV Infections, Hepatitis
Comparative Effectiveness of Web-based Versus Traditional Adolescent HIV Prevention
This study will evaluate the comparative effectiveness and cost-effectiveness of a customized, interactive web-based HIV, sexually transmitted infections (STI) and hepatitis prevention intervention as compared to a traditional…
- Conditions
- HIV Infections, Hepatitis, Sexually Transmitted Infections
- Trial name
- NCT01142882
- Testing
- Traditional Prevention, Web-based Prevention
- Where
- 3 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Development and Research Institutes, Inc.