Clinical trials: Cognitive Deficits
Sickle Cell Disease, Executive Dysfunction
Methylphenidate to Address Attention and Executive Deficits Among Children With Sickle Cell Disease
The purpose of this study is to determine if patients with sickle cell disease (SCD) can consistently take a drug called Methylphenidate (MPH) daily, once a day for 4 weeks to help with any thinking, attention or schoolwork…
- Conditions
- Sickle Cell Disease, Executive Dysfunction, Cognitive Impairment, Attention Deficit/Hyperactivity Disorder (ADHD)
- Trial name
- NCT07226219
- Testing
- Extended-Release Methylphenidate
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- St. Jude Children's Research Hospital
Math Learning Disability, Child Development
Interventions in Mathematics and Cognitive Skills
The purpose of this study is to investigate neurocognitive mechanisms underlying response to intervention aimed at enhancing, and remediating weaknesses in, numerical skills in children, including those with mathematical learning…
- Conditions
- Math Learning Disability, Child Development, Developmental Disability, Learning Disabilities
- Trial name
- NCT05201534
- Testing
- Interventions in Mathematics and Cognitive Skills - Experimental, Interventions in Mathematics and Cognitive Skills - Active Comparator
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Stanford University
Cognitive Function, Mood Disorders
RCT on the Neurobehavioral Effects of Fruits and Vegetables in Shanghai Children
This project proposal outlines a randomized-controlled trial (RCT) aimed at evaluating the effects of increased fruit and vegetable (F\&V) intake on cognitive performance, attention, and mood in Chinese children aged 7-11…
- Conditions
- Cognitive Function, Mood Disorders, Attention-deficit
- Trial name
- NCT06560359
- Testing
- F&V, No F&V
- Where
- China
- Volunteers
- 251 people, healthy volunteers welcome
- Sponsor
- Fudan University
Cognitive Function, Quality of Life
EFFECT OF PERCEPTUAL-MOTOR TRAINING ON COGNITIVE FUNCTIONS, MOTOR ABILITIES AND QUALITY OF LIFE IN CHILDREN WITH ATTENTION DEFICIT HYPERACTIVE DISORDER
This study aims to Determine the effect of perceptual-motor training on: cognitive functions, motor abilities, and quality of life in ADHD children.
- Conditions
- Cognitive Function, Quality of Life, ADHD - Attention Deficit Disorder With Hyperactivity, Motor Abilities
- Trial name
- NCT07139210
- Testing
- perceptual motor training
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Traumatic Brain Injury, Traumatic Brain Injury (TBI) Patients
Safety and Outcomes of MUSE Stem Cell Therapy in Individuals With Traumatic Brain Injury
This prospective observational study evaluates the safety profile and patient-reported outcomes associated with MUSE (Multilineage-differentiating Stress-Enduring) stem cell therapy in individuals aged 6 to 75 with chronic…
- Conditions
- Traumatic Brain Injury, Traumatic Brain Injury (TBI) Patients, Traumatic Brain Injury (TBI); Concussion, Initial Encounter, Traumatic Brain Injury (TBI); Concussion, Subsequent Encounter
- Trial name
- MUSE-TBI-OBS (NCT07326059)
- Testing
- MUSE Stem Cell Therapy
- Where
- 2 sites in United States, Mexico
- Volunteers
- 10 people
- Sponsor
- Healing Hope International
Cognitive Change
Executive Function Training for Children and Adolescents
The goal of this clinical trial is to evaluate how different approaches to executive function (like adding game-like features, varying the number of tasks, and providing coaching) can enhance executive function outcomes in…
- Trial name
- NCT07147894
- Testing
- Nongamified N-back training, Gamified N-back training, Multiple Domain Training
- Where
- United States
- Volunteers
- 780 people, healthy volunteers welcome
- Sponsor
- Northeastern University
Sickle Cell Disease, Attention Deficit
Feasibility and Efficacy of Attentional-Control Training in Sickle Cell Disease
Children with sickle cell disease (SCD) exhibit significantly reduced cognitive functioning (often difficulties with attention) compared to peers and siblings without SCD.
- Conditions
- Sickle Cell Disease, Attention Deficit, Cognitive Deficit in Attention
- Trial name
- ACT (NCT05099874)
- Testing
- EndeavorRx
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's National Research Institute
Pediatric Cancer, Pediatric ALL
Feasibility/Acceptability of Attentional-Control Training in Survivors
This is a multicenter pilot randomized controlled trial, with an active control condition, of the feasibility, acceptability, and preliminary efficacy of EndeavorRx in a cohort of survivors of acute lymphoblastic leukemia or…
- Conditions
- Pediatric Cancer, Pediatric ALL, Pediatric Brain Tumor, Attention Difficulties
- Trial name
- FAACTS (NCT05528939)
- Testing
- EndeavorRx, Control video game
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Children's National Research Institute
Attention Deficit Disorder With Hyperactivity, Sensory Integration Disorder
Effect of ASI on Sensory, Motor, Cognitive, Behavioral Skills and Social Participation in Children With ADHD
Attention Deficit Hyperactivity Disorder (ADHD) is a very common neurodevelopmental disorder in childhood characterized by short attention span, impulsivity and hyperactivity.
- Conditions
- Attention Deficit Disorder With Hyperactivity, Sensory Integration Disorder, Motor Activity, Cognitive Deficit in Attention
- Trial name
- ASI-ADHD (NCT05718427)
- Testing
- Ayres Sensory Integration Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Cognitive Deficit in Attention, Executive Dysfunction
Maternal Choline Supplementation and Offspring Cognition in Adolescence
The goal of this 13-year follow up of a randomized control trial is to study the effect of maternal choline supplementation on offspring cognition in adolescence.
- Conditions
- Cognitive Deficit in Attention, Executive Dysfunction, Emotional Regulation
- Trial name
- CholTeens (NCT05859126)
- Testing
- Maternal Choline Supplementation 930 mg/d, Maternal Choline Supplementation 480 mg/d
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cornell University
ADHD, Cognitive Deficit
Cognitive Intervention in Attention Deficit and Hyperactivity Disorder
Attention Deficit Hyperactivity Disorder is a disorder in which children show insufficient attention span, hyperactivity and impulsivity according to their developmental level.
- Trial name
- NCT05063669
- Testing
- Cognitive Occupational Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 21 people
- Sponsor
- Biruni University
Sleep Disorder, ADHD
Sleep Patterns in Children and Adolescents With ADHD
This study is aimed to find out Sleep profile differences in children and adolescents with and without ADHD,Relationship between sleep profile disturbance and ADHD symptoms, Impact of sleep disturbance on cognition functions and…
- Conditions
- Sleep Disorder, ADHD, Cognitive Change
- Trial name
- NCT03737552
- Testing
- Polysomnography
- Where
- Egypt
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Assiut University
Cognitive Deficit
Deep Brain Stimulation (DBS) of the Nucleus Basalis of Meynert (NbM) in Patients With Parkinson's Disease
The existing DBS setting in patients with DBS of the globus pallidus interna (GPi), which aims to treat motor symptoms by a high-frequency stimulation, will be temporarily reprogramed to stimulate the NbM at a low frequency using…
- Trial name
- NCT02763397
- Testing
- NBM-DBS, DBS
- Volunteers
- 13 people
- Sponsor
- University Medical Center Groningen
Distorted; Balance, Motor Deficit
Virtual Reality Based Balance Training in People With Mild Cognitive Impairment
The aim of the present study is to evaluate an innovative virtual reality-based balance training intervention for improving clinically relevant motor performances (balance and gait) in people with mild cognitive impairment.
- Conditions
- Distorted; Balance, Motor Deficit, Cognitive Deficit
- Trial name
- NCT02214342
- Testing
- Balance Training
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Arizona
Visual Cognitive Deficits
Evaluation of the Efficacy of Optometric Rehabilitation on Visual Cognitive Deficits in Children
Visual cognitive deficits in children are frequent, with an impact on working and daily activities. Optometric therapy may improve those functions, however few studies have been performed.
- Trial name
- NCT02061501
- Testing
- Optometric therapy during 6 months, Optometric therapy during 12 months
- Where
- France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Strasbourg, France
Cognitive Deficits, Cognitive Ability, General
Childhood Anesthesia and Cognitive Function
The purpose of this study is to determine whether pediatric anesthesia is associated with long-term hippocampal dysfunction
- Trial name
- UCSF-Anes-01 (NCT01359215)
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco