Clinical trials: Chloroquine
Malaria, Vivax Malaria
Chlorproguanil/Dapsone Compared With Chloroquine and SP for Vivax Malaria
To determine whether two cheap antifolates (chlorproguanil-dapsone and sulfadoxine-pyrimethamine) which work against falciparum malaria in this region are sufficiently effective against vivax malaria to be deployed in areas where…
- Trial name
- NCT00158561
- Testing
- sulfadoxine-pyrimethamine and chlorproguanil-dapsone
- Where
- Pakistan
- Volunteers
- 750 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Proliferative Nephritis, Chloroquine Retinopathy
Proliferative Lupus Nephritis Treatment With Chloroquine and Hydroxychloroquine
Evaluation the efficacy of chloroquine and hydroxychloroquine in the treatment of proliferative lupus nephritis class III and IV in children and adolescents and evaluate the side effects of both drugs .
- Trial name
- NCT03687905
- Testing
- Chloroquine, Hydroxychloroquine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Malaria, Plasmodium Falciparum Malaria
CQSP in Malawi: Chloroquine and Sulfadoxine-pyrimethamine Efficacy for the Treatment of Malaria in Malawi
The purpose of this research study is to find out how well chloroquine works as a drug to treat malaria in children, compared to the standard malaria treatment in Malawi.
- Trial name
- NCT00125489
- Testing
- chloroquine sulfate, sulfadoxine/pyrimethamine
- Where
- Malawi
- Volunteers
- 210 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria
Prevention of P. Vivax Malaria During Pregnancy in Bolivia
The purpose of this study is to determine which, between weekly prophylaxis or malaria attack treatment, both by chloroquine, is the most appropriate way to protect women and foetus from P.
- Trial name
- NCT00290420
- Testing
- Chloroquine profilaxis
- Volunteers
- healthy volunteers welcome
- Sponsor
- Institut de Recherche pour le Developpement
Malaria, Vivax, Therapeutics
DHA-PQP vs Chloroquine and Primaquine for Radical Cure of Vivax Malaria in Brazil
Plasmodium vivax can be cause of severe malaria and mortality. There are serious public health implications associated with cases of P.
- Trial name
- CuraVivax (NCT03208907)
- Testing
- CQ coadministered with PQ, DHA-PQP coadministered with PQ, CQ and PQ starting on Day 42
- Where
- Brazil
- Volunteers
- 419 people
- Sponsor
- Fundação de Medicina Tropical Dr. Heitor Vieira Dourado
Plasmodium Vivax Malaria Without Complication, Plasmodium Falciparum Malaria (Uncomplicated)
Ethiopian Antimalarial Therapeutic Efficacy Study 2026
Background: The WHO recommends monitoring the efficacy of antimalarial drugs at least once every two years after implementation.
- Trial name
- TES2026 (NCT07840898)
- Testing
- Artemether-Lumefantrine + Primaquine and Chloroquine + Primaquine
- Where
- Ethiopia
- Volunteers
- 1,200 people
- Sponsor
- Ethiopian Public Health Institute
Malaria in Pregnancy, HIV Infections
Influence of Chloroquine on HIV Viral Load Among Pregnant Women in Uganda
There is conflicting evidence regarding the influence of HIV infection on the success of malaria prevention in pregnancy and effect on pregnancy outcome.
- Trial name
- NCT00132535
- Testing
- sulfadoxine-pyrimethamine intermittent preventive treatment, chloroquine
- Where
- Uganda
- Volunteers
- 2,548 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Uncomplicated Plasmodium Knowlesi Malaria
P. Knowlesi Trial of Artesunate-mefloquine Versus Chloroquine
Preliminary studies have supported the background efficacy of local standard anti-malarial medications in the treatment of uncomplicated knowlesi malaria, however this has not been tested systematically and there are no current…
- Trial name
- ACT KNOW (NCT01708876)
- Testing
- Artesunate-mefloquine, Chloroquine, Primaquine
- Where
- 3 sites in Malaysia
- Volunteers
- 250 people
- Sponsor
- Menzies School of Health Research
Vivax Malaria, G6PD Deficiency
Safety and Efficacy of Different Regimens of Primaquine on Vivax Malaria Treatment in G6PD Deficient Patients
A clinical study to assess the safety and efficacy of alternative regimens of primaquine for radical cure of vivax malaria in glucose 6-phosphate dehydrogenase (G6PD) deficient. G6PD deficient patients with P.
- Trial name
- NCT03529396
- Testing
- Chloroquine, Primaquine
- Where
- 2 sites in Brazil
- Volunteers
- 106 people
- Sponsor
- Fundação de Medicina Tropical Dr. Heitor Vieira Dourado
Sickle Cell Disease
Vascular Function Intervention Trial in Sickle Cell Disease
Sickle cell disease (SCD) is the most common inherited disorder worldwide affecting 300,000 births annually, most occuring in sub-Saharan Africa (SSA) where poor detection and care result in high childhood mortality…
- Trial name
- V-FIT (NCT01718054)
- Testing
- Vascular ready-to-use supplementary food, Regular Ready-to-use supplementary food, Chloroquine
- Where
- Tanzania
- Volunteers
- 120 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria, Vivax
An Interventional Study to Compare the Efficacy and Safety of Tafenoquine (TQ) and Primaquine (PQ) When Either Are Taken Together With Chloroquine (CQ) for the Treatment of P. Vivax Malaria in Indian Participants Aged 2 Years and Older
The aim of this study is to collect efficacy and safety data to support the registration of tafenoquine in India.
- Trial name
- NCT06666491
- Testing
- Tafenoquine, Primaquine, Chloroquine
- Where
- 5 sites in India
- Volunteers
- 324 people
- Sponsor
- GlaxoSmithKline
Malaria, Falciparum
Extended-dose Chloroquine (ECQ) for Resistant Falciparum Malaria Among Afghan Refugees in Pakistan
The purpose of this study was to provide stronger evidence for extended-dose chloroquine treatment of falciparum-positive Afghan refugees in Northwest Frontier Province (NWFP), Pakistan or justification for discontinuation of the…
- Trial name
- ECQNWFP (NCT01019408)
- Testing
- Chloroquine
- Where
- 3 sites in Pakistan
- Volunteers
- 163 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria, Vivax Malaria
TES of Chloroquine for Pv in the Philippines in 2016
Chloroquine (CQ) is officially used as a first-line drug of Plasmodium vivax malaria in the Philippines. In this study, the therapeutic efficacy of CQ for the treatment of uncomplicated P.
- Conditions
- Malaria, Vivax Malaria, Recrudescence
- Trial name
- TES (NCT05958797)
- Testing
- Chloroquine, Primaquine
- Volunteers
- 74 people
- Sponsor
- Research Institute for Tropical Medicine, Philippines
Malaria
Efficacy of Combination Therapy for Prevention of Effects of Malaria During Pregnancy
This study is an investigation to compare the efficacy of two different intermittent sulfadoxine/pyrimethamine (SP) treatment regimens and intermittent sulfadoxine/pyrimethamine (SP) + artesunate (SP/AS) treatment of HIV negative…
- Trial name
- NCT00164255
- Testing
- sulfadoxine/pyrimethamine, sulfadoxine/pyrimethamine plus artesunate
- Where
- 2 sites in Tanzania
- Volunteers
- 1,614 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Malaria, Falciparum Malaria
TES of Artemether-lumefantrine for Pf and Chloroquine for Pv in the Philippines From 2013-2014
An antimalarial drug efficacy trial was conducted for artemether-lumefantrine (AL) and chloroquine (CQ) in the three (3) municipalities (Bataraza, Brookes and Rizal) of Palawan.
- Conditions
- Malaria, Falciparum Malaria, Vivax Malaria, Malaria Recrudescence
- Trial name
- TES (NCT04222088)
- Testing
- Arthemeter-lumefantrine, Chloroquine, Primaquine
- Volunteers
- 159 people
- Sponsor
- Research Institute for Tropical Medicine, Philippines
Vivax Malaria
Safety and Efficacy of Chloroquine and Primaquine for Vivax Malaria in Bhutan
This research is intended to study the efficacy of chloroquine (CQ) and primaquine (PQ) for Plasmodium vivax (P.vivax) infection, and also to study the recurrence rate among patients with P.vivax malaria on standard doses of CQ…
- Trial name
- NCT01716260
- Testing
- Chloroquine, Primaquine
- Where
- Bhutan
- Volunteers
- 24 people
- Sponsor
- Menzies School of Health Research
Malaria, Vivax
Study to Assess the Incidence of Hemolysis, Safety, and Efficacy of Tafenoquine (SB-252263, WR238605) Versus Primaquine in Subjects With Plasmodium Vivax Malaria
This is a prospective, double-blind, double-dummy, multicenter, comparative study. A total of 300 subjects will be randomized to treatment on Day 1, of which a minimum of 50 female subjects must be enrolled that display moderate…
- Trial name
- NCT02216123
- Testing
- Tafenoquine, Chloroquine, Primaquine
- Where
- 10 sites in Brazil, Colombia and 4 more
- Volunteers
- 251 people
- Sponsor
- GlaxoSmithKline
Malaria
Safety and Efficacy of Pyronaridine Artesunate Vs Chloroquine in Children and Adult Patients With Acute Vivax Malaria
The primary objective of this clinical study is to compare the efficacy and safety of the fixed combination of pyronaridine artesunate (180:60 mg) with that of standard chloroquine therapy in children and adults with acute…
- Trial name
- NCT04368910
- Testing
- Pyronaridine - artesunate, Chloroquine
- Where
- 2 sites in South Korea
- Volunteers
- 30 people
- Sponsor
- Medicines for Malaria Venture
Vivax Malaria
Comparison Between 7 and 14 Day Primaquine Combined With Dihydroartemisinin-piperaquine or 3 Day Chloroquine Radical Cure of P. Vivax (BPD)
In Southeast Asia, Plasmodium vivax (Pv) infection reaches 50-80% and bears a greater burden of disease than Plasmodium falciparum (Pf).
- Trial name
- NCT01640574
- Testing
- Dihydroartemisinin-Piperaquine, Chloroquine
- Where
- Thailand
- Volunteers
- 680 people
- Sponsor
- University of Oxford
Malaria
Ethiopia Malaria Therapeutic Efficacy Study
In this stdy, patients aged above 6 months with symptomatic malaria presenting to health centers will be enrolled for treatment with artemether-lumefantrine for P.
- Trial name
- NCT01052584
- Testing
- Chloroquine- P. vivax, Artemether-Lumefantrine: P. vivax, Artemether-lumefantrine: P. falciparum
- Where
- 2 sites in Ethiopia
- Volunteers
- 354 people
- Sponsor
- Centers for Disease Control and Prevention