Clinical trials: Central Adiposity
Prader-Willi Syndrome
Study of Tesomet With Open-label Extension in Subjects With Prader-Willi Syndrome
This study will evaluate the safety and efficacy of Tesomet (tesofensine + metoprolol) in subjects with PWS.
- Trial name
- PWS (NCT05198362)
- Testing
- Tesomet
- Where
- United States
- Sponsor
- Saniona
Bardet-Biedl Syndrome, Visual Impairment
Treatment of Bardet-Biedl-Syndrome With Metformin for Evaluation of a Possible Visual Improvement
In this prospective pilot study without control group children and young adults (10-25 years old) diagnosed with Bardet-Biedl syndrome and treated with Metformin for their adipositas will be evaluated for a possible additional…
- Trial name
- BBS (NCT03490019)
- Testing
- Metformin
- Sponsor
- University Hospital Tuebingen
Rett Syndrome, Prader-Willi Syndrome
Sleep Abnormalities in Rare Genetic Disorders: AS, RTT, and PW
This study will investigate sleep behavior in subjects with Angelman Syndrome, Rett Syndrome or Prader-Willi Syndrome. The study will also investigate sleep behavior in healthy siblings of subjects with Angelman Syndrome, Rett…
- Conditions
- Rett Syndrome, Prader-Willi Syndrome, Angelman Syndrome, Sleep Problems
- Trial name
- RDCRN (NCT02670694)
- Where
- 9 sites in United States
- Volunteers
- 804 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Cardiovascular Diseases, Heart Diseases
Pawtucket Heart Health Program
To conduct a community-based research and demonstration project in cardiovascular disease prevention in the town of Pawtucket, Rhode Island.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypercholesterolemia, Hypertension
- Trial name
- NCT00005151
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Pediatric Obesity, Overweight and Obesity
Pediatric Obesity Treatment in a Safety Net Clinic: Piloting the Step by Step Program
Obesity treatment interventions have been studied in pediatric primary care offices and are often conducted in low-income and minority populations, and pediatric obesity clinics.
- Trial name
- NCT04297228
- Testing
- Step by Step: A Family-Centered Healthy Lifestyle Intervention
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Community Volunteers In Medicine
Bardet-Biedl Syndrome
Genetics and Clinical Characteristics of Bardet-Biedl Syndrome
This study will evaluate patients with a rare inherited condition called Bardet-Biedl syndrome . The purpose of the study is to learn more about the genetics and clinical characteristics of this disorder.
- Trial name
- NCT00078091
- Where
- United States
- Volunteers
- 194 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Childhood Obesity, Family
FamCe-HLP- Family-centered Obesity Management Program in Primary Care Settings
This clinical trial aims to compare the adiposity and weight status among mother-child dyads with overweight or obesity who receive the Fam-Ce-HLP intervention with the mother-child dyads with overweight or obesity who did not…
- Conditions
- Childhood Obesity, Family, Behavior, Health, Lifestyle, Healthy
- Trial name
- NCT06394882
- Testing
- Family-Centered Healthy Lifestyle Program (FamCe-HLP)
- Where
- 4 sites in Oman
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Oman Ministry of Health
Hypothalamic Obesity, Hypothalamic Tumor
Efficacy and Safety of Phentermine/Topiramate in Youth With Hypothalamic Obesity
Hypothalamic obesity (HO) refers to the substantial weight gain that often complicates hypothalamic brain tumors. Children with this treatment-recalcitrant form of obesity have excess rates of metabolic sequelae compared to…
- Conditions
- Hypothalamic Obesity, Hypothalamic Tumor, Craniopharyngioma
- Trial name
- NCT06299891
- Testing
- Phentermine / Topiramate Extended Release Oral Capsule [Qsymia]
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Seattle Children's Hospital
Obesity & Overweight
Efficacy of Center-based Childcare to Mitigate Unhealthy Weight Gain in Preschoolers From Low-income Households During the Summer
Studies show that preschool-age children are especially vulnerable to accelerated weight gain during the summer, with those from low-income households (≤185% poverty level or Medicaid eligible - the target population for this…
- Trial name
- NCT07583459
- Testing
- Childcare
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Crohn Disease, Ulcerative Colitis
Safety and Efficacy of Fecal Microbiota Transplantation
The gut microbiota is critical to health and functions with a level of complexity comparable to that of an organ system. Dysbiosis, or alterations of this gut microbiota ecology, have been implicated in a number of disease…
- Conditions
- Crohn Disease, Ulcerative Colitis, Celiac Disease, Irritable Bowel Syndrome
- Trial name
- NCT04014413
- Testing
- Fecal Microbiota Transplantation
- Where
- Hong Kong
- Volunteers
- 450 people
- Sponsor
- Chinese University of Hong Kong
Coronary Disease, Heart Diseases
VA HDL Intervention Trial (VA-HIT) Ancillary Study Data Analysis
To evaluate additional cardiovascular risk factors using data from the VA HDL Intervention Trial (VA-HIT).
- Conditions
- Coronary Disease, Heart Diseases, Cardiovascular Diseases, Carotid Artery Diseases
- Trial name
- NCT00035711
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Hypopituitarism, Hypogonadism
Detection and Treatment of Endocrine Abnormalities in Childhood Cancer Survivors and Hematopoietic Stem Cell Transplant Recipients
This study will determine the prevalence of endocrine-related side effects in children who have been treated for cancer and establish a database and registry organized according to cancer diagnosis, treatments and endocrine side…
- Conditions
- Hypopituitarism, Hypogonadism, Thyroid Dysfunction, Bone Diseases, Metabolic
- Trial name
- NCT00504218
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Pediatric Obesity
Healthy Start to Increase Physical Activity and Improve Healthy Eating in Early Childcare Centres
Childhood obesity is one of the greatest challenges facing public health and recent evidence shows it begins in preschool aged children.
- Trial name
- NCT02375490
- Testing
- Healthy Start
- Where
- 2 sites in Canada
- Volunteers
- 897 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Lead Poisoning, Obesity
QI Study of a Practice Facilitator's Impact in Working With Clinics on Improving Dental, Lead & Obesity Measures for Children
Funded by the Ohio Department of Job and Family Services - Medicaid Technical Assistance and Policy Program (MEDTAPP), the "Child Health Excellence Center - a University-Practice-Public Partnership" (CHEC-UPPP) focuses on…
- Conditions
- Lead Poisoning, Obesity, Dental Decay
- Trial name
- NCT01739166
- Testing
- Practice-tailored intervention to increase rates of targeted services
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Obesity
W8Loss2Go: mHealth Weight Management Strategy
The investigators will test a recent mobile technology based (mHealth) behavioral weight loss intervention (W8Loss2Go), which is designed for children and adolescents, and uses an addiction model to promote withdrawal from…
- Trial name
- NCT02689154
- Testing
- W8Loss2Go
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Children's Hospital Los Angeles
Dietary Behavior
Lunch is in the Bag: Helping Parents Increase Fruit, Vegetables, and Whole Grains in Preschool Sack Lunches
Lunch is in the Bag is an intervention designed to increase fruits, vegetables, and whole grains in sack lunches prepared for preschool children.
- Trial name
- LIITB (NCT01292434)
- Testing
- Lunch is in the Bag behavioral intervention
- Where
- 2 sites in United States
- Volunteers
- 1,266 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Obesity
B'More Healthy; Communities for Kids (BHCK)
The BHCK study will develop, implement, and evaluate a community-based obesity prevention program, which operates at multiple levels of an urban food system (policy, wholesaler, corner stores, carryout, household, individual; in…
- Trial name
- BHCK (NCT02181010)
- Testing
- Intervention
- Where
- United States
- Volunteers
- 890 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Overweight
Barriers to Effective Weight Loss in Overweight Adolescents
The current study aims to investigate the impact of a comprehensive, team-based, family-centered, lifestyle modification program on body weight, metabolic abnormalities, fitness measures, and self-esteem in overweight adolescents…
- Trial name
- TEENS (NCT00562263)
- Testing
- Lifestyle modification
- Where
- United States
- Volunteers
- 257 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Silver Russell Syndrome, Beckwith-Wiedemann Syndrome
IDMet (RaDiCo Cohort) (RaDiCo-IDMet)
The goal of this observational study is to describe the natural history of imprinting disorders (IDs) according to their metabolic profile in all patients (adults and children) affected with an ID regardless of the severity of…
- Conditions
- Silver Russell Syndrome, Beckwith-Wiedemann Syndrome, Transient Neonatal Diabetes Mellitus, Angelman Syndrome
- Trial name
- IDMet (NCT05945576)
- Where
- 20 sites in France
- Volunteers
- 2,000 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Obesity, Overweight
Pediatric Preventative Health Screenings - Obesity and Family-Centered Outcomes
In 2012, an Expert Panel of the National Heart Lung and Blood Institute published guidelines on cardiovascular health and risk reduction in children; among these guidelines were screening recommendations for obesity and…
- Conditions
- Obesity, Overweight, Blood Pressure, Hypercholesteremia
- Trial name
- NCT02850224
- Testing
- Motivational interviewing to elicit PCO in pediatrics
- Where
- United States
- Volunteers
- 703 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System