Clinical trials: Cardio-pulmonary Bypass
Cardiopulmonary Arrest
Measurement of Cerebral Flow Using Transfontanellar Doppler in Infants Under Cardiopulmonary Bypass
Transfontanellar Doppler can measure the velocity at both the carotid artery and the anterior cerebral artery during cardiopulmonary bypass in congenital heart disease patients.
- Trial name
- NCT01996020
- Where
- South Korea
- Volunteers
- 43 people
- Sponsor
- Seoul National University Hospital
Systemic Inflammatory Response Syndrome (SIRS), Sepsis
Genotypes and Phenotypes in Pediatric SIRS and Sepsis
The aim of this investigation is to longitudinally quantify host gene expression and serum proteins in children with infectious and non-infectious SIRS.
- Trial name
- GAPPSS (NCT02728401)
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Seattle Children's Hospital
Postoperative; Dysfunction Following Cardiac Surgery
Oral Triiodothyronine for Children Undergoing Cardiopulmonary Bypass in Indonesia
A condition of decreased serum T3 level in children after cardiac surgery using cardiopulmonary bypass has been commonly recognized as euthyroid sick syndrome (ESS).
- Trial name
- OTICC (NCT02521168)
- Testing
- Oral triiodothyronine
- Where
- Indonesia
- Volunteers
- 177 people
- Sponsor
- National Cardiovascular Center Harapan Kita Hospital Indonesia
Acute Kidney Injury
Peritoneal Dialysis vs Furosemide for Acute Kidney Injury After Cardiopulmonary Bypass
Acute kidney injury (AKI) after cardiopulmonary bypass (CPB) in infants is common and associated with poor outcomes. Peritoneal dialysis (PD) and furosemide have been used to attain negative fluid balance due to AKI induced…
- Trial name
- NCT01709227
- Testing
- Furosemide, Peritoneal Dialysis
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Congenital Cardiovascular Defects, Low Cardiac Output Syndrome
Levosimendan in Congenital Cardiac Surgery
Many pediatric patients undergoing cardiac surgery under cardiopulmonary bypass for repair of complex congenital malformations, require inotropic support for low cardiac output syndrome.
- Trial name
- NCT00695929
- Testing
- Levosimendan, Milrinone
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Ischemia/Reperfusion Injury After Neonatal Cardiac Surgery, Inflammatory Reaction After Neonatal Cardiac Surgery
Efficacy of Nitric Oxide Administration in Attenuating Ischemia/Reperfusion Injury During Neonatal Cardiopulmonary Bypass
Around 7500 neonates born yearly in the United States have complex congenital heart disease that require surgical repair in the first few days of life.
- Trial name
- NCT02151877
- Testing
- Inhaled Nitric Oxide
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Wake Forest University Health Sciences
Cardiopulmonary Bypass Surgery
Post-market Clinical Follow-up Study on the Performance and Safety of a Vent Catheter Used During Cardiopulmonary Bypass.
Prior to the implementation of the Medical Device Regulation (MDR), the clinical evaluation of existing devices was conducted by Notified Bodies (NBs) based on clinical data obtained from equivalent devices, and CE certificates…
- Trial name
- NCT07628920
- Testing
- Vent Catheter
- Volunteers
- 45 people
- Sponsor
- Bıçakcılar Tıbbi Cihazlar Sanayi ve Ticaret A.Ş.
Cardiovascular Disease, Renal Insufficiency, Acute
Acetylcysteine Against Acute Renal Insult During Cardiopulmonary Bypass.
The purpose of this study is to determine whether N-acetylcysteine is effective in the prophylaxis of post-cardiopulmonary bypass acute renal impairment.
- Conditions
- Cardiovascular Disease, Renal Insufficiency, Acute, Cardiopulmonary Bypass
- Trial name
- NCT00190034
- Testing
- N-Acetylcysteine 600mg/tab
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Far Eastern Memorial Hospital
Cardiac Surgery, Cardiopulmonary Bypass
Effect of Rewarming Rate During Cardiopulmonary Bypass on Clinical Prognosis of Infants Undergoing Cardiac Surgery
The purpose of this study is to investigate the relationship between rewarming rate during cardiopulmonary bypass and clinical prognosis in infants undergoing cardiac surgery.
- Conditions
- Cardiac Surgery, Cardiopulmonary Bypass, Rewarming Rate
- Trial name
- NCT01398709
- Testing
- Slow rewarming strategy, Fast rewarming strategy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xijing Hospital
Adrenal Cortex Diseases, Infant Morbidity
Adrenal Responsiveness During the Perioperative Period in Children Undergoing Congenital Cardiac Surgery
Our objective was to determine whether a standard 1mg/kg intraoperative dose of dexamethasone results in similar drug levels for all patients and to characterize the relationship between these drug levels and the innate stress…
- Trial name
- NCT01839812
- Testing
- Cosyntropin
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Mayo Clinic
Heart Defects, Congenital, Cardiopulmonary Bypass
Nesiritide Use Following Cardiac Surgery in Infants
The purpose of this study is to determine the effects of nesiritide on urine output and hemodynamics following cardiopulmonary bypass in infants. Safety and pharmacokinetic data will also be obtained.
- Trial name
- NCT00281671
- Testing
- nesiritide
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Boston Children's Hospital
Coronary Artery Disease, Heart Failure
Study to Determine if Using Ventilation During Open Heart Surgery Improves Lung Outcomes
To demonstrate that using continuous mechanical lung ventilatory support in combination with Positive End Expiratory Pressure (PEEP)during open heart surgery will improve lung function and decrease lung complications after…
- Trial name
- PEEP (NCT01522222)
- Testing
- continuous, mechanical ventilatory support
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Aurora BayCare Medical Center
Heart Defects, Congenital
Effects of Perioperative Nesiritide or Milrinone Infusion on Recovery From Fontan Surgery
The staged surgical pathway to treat children with single ventricle heart defects culminates with the Fontan operation. In this procedure, systemic venous return is rerouted directly to the pulmonary arteries, which serves to…
- Trial name
- NCT00543309
- Testing
- nesiritide, milrinone
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- John M Costello
Cardiac Surgery, Thoracic Surgery
Heart Lung Machine Registry
The HeaLMe post-market clinical follow-up registry is undertaken to evaluate the safety and performance of the index devices Heart Lung Machine HL 40 and Temperature Probes TPO-D-HLM L1.8 Adult / Pediatric in patients undergoing…
- Conditions
- Cardiac Surgery, Thoracic Surgery, Vascular Surgery, Cardiopulmonary Bypass
- Trial name
- HeaLMe (NCT06159517)
- Where
- 3 sites in Italy, Spain
- Volunteers
- 184 people
- Sponsor
- Maquet Cardiopulmonary GmbH
Heart Defects, Congenital, Transposition of Great Vessels
Hypertonic Saline Dextran in Pediatric Cardiac Surgery
The purpose of this study is to determine whether infusion of hypertonic saline dextran attenuates the inflammatory response and the water overload, during and after major cardiac surgery in small children.
- Conditions
- Heart Defects, Congenital, Transposition of Great Vessels, Heart Septal Defects, Ventricular, Endocardial Cushion Defects
- Trial name
- NCT00199771
- Testing
- 7.5% NaCl in 6% dextran 70 solution
- Volunteers
- 14 people
- Sponsor
- Oslo University Hospital
Atrial Fibrillation
Heart Rhythm Changes in Patients With Atrial Fibrillation After Cardiopulmonary Bypass: a Retrospective Analysis
The goal of this observational study is to learn about the lthe effect of the tetralogy of medication regimen on intraoperative cardioversion in patients with persistent AF.
- Trial name
- NCT06553391
- Testing
- The tetralogy of medication regimen
- Where
- China
- Volunteers
- 106 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Congenital Heart Defect, Blood Coagulation Disorder
Bedside Evaluation of Coagulation in Children With Congenital Heart Disease
The purpose of this study is to assess coagulation and platelet function in children with congenital heart disease, measured with a bedside device (thromboelastometry and impedance aggregometry).
- Trial name
- POCHEMO (NCT02387944)
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Acute Kidney Injury
Aminophylline to Prevent Acute Kidney Injury in Children After Cardiac Surgery
Children with congenital heart defects often need cardiac surgery with cardiopulmonary bypass (the "heart-lung machine"). Approximately 35 to 50% of these children will have "acute kidney injury," or damage to the kidneys, after…
- Trial name
- KIDPROAM (NCT01245595)
- Testing
- Aminophylline
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Stanford University
Cardiac Surgery, Cardiopulmonary Bypass
Pentastarch Use in Cardiac Surgery
Patients undergoing cardiac surgery with cardiopulmonary bypass require significant fluid administration. Fluids are used routinely to replace blood lost during and after surgery.
- Trial name
- NCT00182377
- Testing
- Pentastarch (displace either 500 ml or 1000 ml of pump prime with pentastarch)
- Where
- Canada
- Sponsor
- Hamilton Health Sciences Corporation
Heart Defects, Congenital
Lactate Levels During Cardiopulmonary Bypass in Pediatric Patients
Many variables measured in critically ill patients have been used to estimate severity of disease, prognosticate morbidity and mortality, evaluate costs of treatment, and finally indicate specific treatment and monitor the…
- Trial name
- NCT02618707
- Testing
- Lactate
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Assiut University