Clinical trials: Bladder Exstrophy
Urinary Incontinence
Transurethral Myoblast Injection for Urinary Incontinence in Children With Bladder Exstrophy
Muscle precursor cells constantly regenerate striated muscles, and include the quiescent satellite cells located beneath the basal lamina of skeletal myofibers, which are responsible for repair of the terminally differentiated…
- Trial name
- NCT02075216
- Testing
- Myoblast Transplantation, Neonatal Cystourethroscope Injection
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Al-Azhar University
Bladder Exstrophy
Outcome Of Classic Bladder Exstrophy Repair, Assiut University Experience
1. To review surgical and medical outcomes of the previous repaired bladder exstrophy cases. 2. To present recent developments in surgical techniques and care of these patients.
- Trial name
- NCT04580186
- Testing
- bladder exstrophy repair
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Assiut University
Chronic Kidney Diseases, Bladder Dysfunction
Concomitant Renal and Urinary Bladder Allograft Transplantation
The purpose of this study is to establish if concomitant renal and vascularized urinary bladder allograft transplantation is feasible.
- Conditions
- Chronic Kidney Diseases, Bladder Dysfunction, Bladder Absence, Posterior Urethral Valve
- Trial name
- NCT04626167
- Testing
- Concomitant Renal and Urinary Bladder Allograft Transplantation
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Classic Bladder Exstrophy, Renal Function
Kidney Function in Patients With Bladder Exstrophy
Patients with classical bladder exstrophy undergo many surgical interventions with secondary urinary tract infections complicating their course.
- Conditions
- Classic Bladder Exstrophy, Renal Function, GFR, Proteinuria
- Trial name
- NCT02192801
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Bladder Exstrophy-Epispadias Complex
Use of Platelet-Rich Fibrin in Bladder Exstrophy Repair
Bladder exstrophy-epispadias complex (BEEC) is a rare condition in which the bladder and surrounding structures do not form normally.
- Trial name
- PRF-BEEC (NCT07294612)
- Testing
- Autologous Platelet-Rich Fibrin, Standard Surgical Closure
- Where
- Uzbekistan
- Volunteers
- 20 people
- Sponsor
- National Children's Medical Center, Uzbekistan
Bladder Exstrophy
Navigation of the Pelvic Floor in Bladder Exstrophy Using Pre-operative MRI
The aim of this study is to investigate the use of intraoperative stereotactic imaging of the pelvic floor musculature during closure of bladder exstrophy.
- Trial name
- NCT01878500
- Testing
- Intraoperative stereotactic imaging with VectorVision
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Johns Hopkins University
Bladder Exstrophy
Long-term Outcomes of Patients Treated for Bladder Exstrophy by Questionnaires.
The bladder exstrophy epispadias complex (BEEC) is a rare spectrum of congenital conditions due to abnormal development of the cloacal membrane.
- Trial name
- QUALEXSTRO (NCT05690594)
- Testing
- Self or straight administered questionnaire
- Where
- 2 sites in France
- Volunteers
- 42 people
- Sponsor
- Hospices Civils de Lyon
Bladder Exstrophy
EVALUATION OF THE SAFETY AND EFFICACY OF ADJUSTABLE CONTINENCE THERAPY BALLOONS IN BLADDER EXSTROPHY AND INCONTINENT EPISPADIAS PATIENTS
The purpose of this study is to evaluate the effectiveness and safety of a minimally invasive surgical procedure with ACT (Adjustable Continence Therapy) balloons implantation for the treatment of urinary incontinence in children…
- Trial name
- ACT (NCT04935918)
- Testing
- ACT
- Where
- France
- Volunteers
- 7 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Bladder Exstrophy, Urinary Incontinence
Muscle Derived Cell Therapy for Bladder Exstrophy Epispadias Induced Incontinence
The aim of this study is to study safety, tolerability and efficacy of muscle derived cell (MDC) therapy in children with bladder exstrophy epispadias induced urinary incontinence.
- Trial name
- MDC (NCT01011777)
- Testing
- MDC
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Johns Hopkins University
Hypospadias, Hypospadias and Epispadias and Other Penile Anomalies
Efficacy of Amniotic Membranes in Complex Genitourinary Reconstruction
Urinary fistulas are unfortunately one of the most common post operative complications in hypospadias repairs and bladder neck transections on pediatric and adult populations, an estimated 20%, resulting in multiple repeat…
- Conditions
- Hypospadias, Hypospadias and Epispadias and Other Penile Anomalies, Fistula, Fistula, Urinary
- Trial name
- NCT03685955
- Testing
- Amniotic membranes
- Sponsor
- Johns Hopkins University
Endocrinology, Disorders of Sexual Development
Retrospective Analysis of the Neonatal Management of Patients with an Antenatal Diagnosis of Genital Development Variation At the Hospital of Lyon
Variations in genital development (VDG) account for 0.5% to 1% of births. Advances in ultrasound techniques, as well as in prenatal diagnosis techniques, particularly in genetics, have led to improvements in the prenatal…
- Conditions
- Endocrinology, Disorders of Sexual Development, Prenatal Diagnosis, Psychology
- Trial name
- PECAN-VDG (NCT06687252)
- Where
- France
- Volunteers
- 170 people
- Sponsor
- Hospices Civils de Lyon
Bladder Exstrophy
Early Versus Delayed Closure of Bladder Exstrophy in Female Patients
This study compared two timings for primary single-stage surgery in female newborns with classic bladder exstrophy. Participants were randomly assigned to surgery within 72 hours of birth or at 6 to 12 weeks of age.
- Trial name
- NCT07794540
- Testing
- Early Primary Single-Stage Closure, Delayed Primary Single-Stage Closure
- Where
- Pakistan
- Volunteers
- 124 people
- Sponsor
- Khyber Teaching Hospital
Bladder Extrophy, Surgery in Children
A Pilot Study Comparison of Programmed Intermittent Bolus Versus Continuous Infusion
The purpose of this study is to determine whether programmed intermittent epidural bolus (PIEB) offers advantages over continuous epidural infusion (CEI) in this pediatric post-surgical population by randomizing patients to…
- Trial name
- NCT07839039
- Testing
- Ropivacaine (Epidural analgesia) intermittent bolus, Ropivacaine (Epidural analgesia) continuous infusion, Chloroprocaine intermittent bolus
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Giorgio Veneziano
Bladder Exstrophy
Pelvic Osteotomy in Bladder Exstrophy
The study focuses on the surgical treatment of bladder exstrophy, a congenital condition where the bladder is located outside the body.
- Trial name
- NCT06717386
- Testing
- diagonal pelvic osteotomy
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Sohag University
Bladder Exstrophy
Biomechanical Assessment of Level Gait in Patient's Status Post Bladder Exstrophy
The purpose of this study is to determine whether patients who have undergone exstrophy closure may be at risk for long-term orthopedic issues manifest by gait abnormalities.
- Trial name
- Gait (NCT00863070)
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Connecticut Children's Medical Center