Clinical trials: Analgesia, open to volunteers
Placebo Analgesia, Pediatric Pain
Applying a Small Procedure Prior to Injection/Vaccination Reduces Pain in Children
In this proposed study, the investigators aim to apply a minor procedure prior to a treatment that induces pain (e.g., injection/vaccination) to help manage pediatric pain.
- Conditions
- Placebo Analgesia, Pediatric Pain, Vaccination
- Trial name
- NCT06313788
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Lingnan University
Scoliosis; Adolescence, Pain After Surgery
Tegileridine for Postoperative Pain After Adolescent Scoliosis Surgery
The goal of this clinical trial is to see if a new pain medicine called Tegileridine is at least as effective as morphine (the standard treatment) for pain relief after spinal surgery in teenagers with scoliosis.
- Conditions
- Scoliosis; Adolescence, Pain After Surgery, Analgesia, Patient-controlled
- Trial name
- NCT07229495
- Testing
- Tegileridine, morphine
- Where
- 6 sites in China
- Volunteers
- 171 people
- Sponsor
- Peking Union Medical College Hospital
Local Analgesia Via Infiltration
A Study of Bupivacaine Liposome Injection in Local Analgesia of Pediatric Patients
The study is being conducted to evaluate the safety and efficacy of bupivacaine liposome injection for local infiltration analgesia in pediatric orthopedic surgery in the real world.
- Trial name
- NCT06344091
- Testing
- Bupivacaine Liposome Injection
- Where
- China
- Volunteers
- 232 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Procedural Sedation and Analgesia
PRedictors Of Maladaptive Behaviors in Children Undergoing Procedural SEDation
Procedural sedation for children outside of the operating room is a common practice in emergency departments, outpatient clinics, radiology suites, and dental offices for painful and anxiety-provoking procedures.
- Trial name
- PRoSEED (NCT07495826)
- Where
- 2 sites in Canada
- Volunteers
- 2,145 people
- Sponsor
- London Health Sciences Centre Research Institute
Anesthesia, Analgesia
Conversion of Labor Analgesia for Intrapartum Cesarean Delivery: DPE v CSE v Epidural
As the dural puncture epidural (DPE) is increasing in popularity for labor analgesia, it is important to understand how it impacts outcomes in parturients.
- Trial name
- NCT05514431
- Testing
- Epidural, Dural Puncture Epidural (DPE) technique, Combined Spinal-Epidural (CSE) technique
- Where
- 2 sites in United States, Canada
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Analgesia
Analgesia for Perineal Surgeries in High-risk Pediatric Patients
Perioperative pain management in pediatric patients, especially for anorectal and penile surgeries, presents significant challenges for anesthetists.
- Trial name
- NCT07602894
- Testing
- Systemic analgesia, Sacral multifidus plane block
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Zagazig University
Sore Throat, Dexmedetomidine Analgesia
Effect of Preoprative Nebulized Dexmedetomidine Compared to Nebulized Lidocaine in Attenuating Sore Throat Following Tonsillectomy In Childern.
The aim of the study is to compare the effect of nebulized Dexmedetomidine compared to nebulized Lidocaine on postoperative sore throat in childern undergoing Tonsillectomy.
- Conditions
- Sore Throat, Dexmedetomidine Analgesia, Tonsillectomy
- Trial name
- NCT07780760
- Testing
- Group D (dexmedetomidine group), Group L (Lidocaine group)
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Fayoum University Hospital
Opioid Consumption, Multimodal Analgesia
Magnesium Sulfate in Children Undergoing Laparoscopic Appendectomy
Magnesium sulfate is one of the most commonly used co-analgetics. Its antinociceptive effect is related to antagonizing NMDA (N-methyl-D-aspartate) receptors of the nervous system, has an anti-inflammatory effect by reducing the…
- Conditions
- Opioid Consumption, Multimodal Analgesia, Acute Appendicitis, Complication of Treatment
- Trial name
- NCT06563349
- Testing
- Intravenous magnesium sulfate, Normal saline infusion
- Where
- Poland
- Volunteers
- 188 people
- Sponsor
- Medical University of Warsaw
Dental Anaesthesia, Dental Pain
Photobiomodulation and Tooth Analgesia
The purpose of this study is to test photobiomodulation (PBM) with a non-invasive light device for reducing discomfort during dental treatments in children.
- Conditions
- Dental Anaesthesia, Dental Pain, Dental Analgesia
- Trial name
- NCT06691269
- Testing
- Photobiomodulation, Topical Benzocaine, Local Anesthesia
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Mechanical Ventilation, Pediatric Acute Respiratory Failure
Optimizing Pain Treatment in Children On Mechanical Ventilation
In this clinical trial, investigators want to learn more about using non-opioid pain medications for children with acute respiratory failure.
- Conditions
- Mechanical Ventilation, Pediatric Acute Respiratory Failure, Analgesics, Opioid, Sedation and Analgesia
- Trial name
- OPTICOM (NCT06994442)
- Testing
- Acetaminophen, Ketorolac
- Where
- 16 sites in United States
- Volunteers
- 644 people
- Sponsor
- Weill Medical College of Cornell University
Patient-Controlled Analgesia
Nausea and Vomiting in Postoperative Paediatric Patients With Patient-Controlled Analgesia (PCA): Morphine vs Oxycodone
POPCORN trial will compare the side effects and effectiveness of Morphine versus Oxycodone medication when prescribed for use as patient controlled analgesia (PCA) for pain relief for paediatric patients after-surgery.
- Trial name
- POPCORN (NCT06186141)
- Testing
- Morphine, Oxycodone
- Where
- Australia
- Volunteers
- 690 people
- Sponsor
- Murdoch Childrens Research Institute
Postoperative Analgesia, Transversus Abdominis Plane (TAP) Block
Transversalis Fascia Plane Versus Transversus Abdominis Plane Block for Postoperative Analgesia in Children
This prospective clinical study aims to compare the postoperative analgesic efficacy of the ultrasound-guided transversalis fascia plane block (TFPB) and the transversus abdominis plane (TAP) block in pediatric patients…
- Conditions
- Postoperative Analgesia, Transversus Abdominis Plane (TAP) Block, Transversalis Fascia Plane Block, Pediatric Surgical Procedures
- Trial name
- NCT07242196
- Testing
- Postoperative analgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Sakarya University
Neonatal Pain, Retinopathy of Prematurity (ROP)
Fentanyl Intranasal for Retinopathy of Prematurity Screening in Preterm Infants
The goal of this clinical trial is to learn whether intranasal fentanyl (a pain medicine given as a nasal spray) can reduce pain and is safe to use during routine eye examinations for retinopathy of prematurity (ROP) in preterm…
- Conditions
- Neonatal Pain, Retinopathy of Prematurity (ROP), Pain Management, Infant, Premature
- Trial name
- FIREFLY (NCT07112430)
- Testing
- Fentanyl Citrate (Intranasal)
- Where
- Canada
- Volunteers
- 58 people
- Sponsor
- Marsha Campbell-Yeo
Sedation and Analgesia
a Comparive Study of Ketamine-Propofol Versus Dexmedetomidine-Propofol Sedation in Pediatric Patients Undergoing Cardiac Catheterization for Device Closure of Simple Left-to-right Shunts
This study aims To compare the safety and efficacy of ketamine-propofol versus dexmedetomidine-propofol sedation in pediatric patients undergoing cardiac catheterization for device closure of simple left-to-right shunts
- Trial name
- NCT07669012
- Testing
- Ketamine + propofol, Dexmedetomidine + propofol
- Where
- Egypt
- Volunteers
- 124 people
- Sponsor
- Ain Shams University
Subtransverse Process Interligamentary Plane Block, Rhomboid Intercostal Block
Subtransverse Process Interligamentary Plane Block Versus Rhomboid Intercostal Block Combined With Sub-Serratus Plane Block for Analgesia in Pediatric Thoracotomy
This study aims to compare ultrasound guided subtransverse process interligamentary plane block versus rhomboid intercostal block combined with sub-serratus plane block for postoperative analgesia in pediatric thoracotomy.
- Conditions
- Subtransverse Process Interligamentary Plane Block, Rhomboid Intercostal Block, Sub-Serratus Plane Block, Analgesia
- Trial name
- NCT07666334
- Testing
- Standard intravenous analgesia, Subtransverse process interligamentary plane block, Rhomboid intercostal block (RIB) combined with sub-serratus plan block group
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Tanta University
Cryo Analgesia, Pectus Surgery
Long Term Safety of Preoperative Percutaneous Intercostal Cryoneurolysis
Follow up of patients who underwent percutaneous cryoneurolysis for pectus excavatum repair (the Nuss procedure) pain management
- Trial name
- CRYOFUP (NCT07657845)
- Testing
- Self-report Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) Questionnaire - Pediatric Quality of Life Inventory (PedsQL™) Questionnaire - Patient Self-Assessment Sensory Scale
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Papa Giovanni XXIII Hospital
Cleft Lip Palate, Orofacial Cleft
Effect of Opioid-Free vs Opioid-Based Anesthesia on Postoperative Pain and Emergence Agitation in Children Undergoing Cleft Surgery
Orofacial clefts are among the most common congenital malformations, affecting approximately 1 in 700-1500 live births worldwide.
- Conditions
- Cleft Lip Palate, Orofacial Cleft, Agitation, Emergence, Analgesia Assessment
- Trial name
- NCT07557576
- Testing
- Ketamine (1 mg/kg), Dexmedetomidine (1-0,8-0,6-0,4 mcg/kg/h), Fentanyl 5 mcg/kg
- Where
- Croatia
- Volunteers
- 90 people
- Sponsor
- Iva Smiljanić
Postoperative Analgesia
Analgesic Techniques for Robotic Prostatectomy Procedures
Robot-assisted radical prostatectomy and robot-assisted simple prostatectomy are minimally invasive procedures associated with reduced postoperative pain compared to open surgery.
- Trial name
- PROPAIN (NCT07483840)
- Testing
- Thoracic Erector Spinae Plane Block (ESPB-T), Rectus Sheath Block (RSB), Low-dose Spinal Analgesia (SA)
- Where
- Italy
- Volunteers
- 147 people
- Sponsor
- Ente Ospedaliero Ospedali Galliera
Procedural Sedation and Analgesia, Pediatric ALL
Study of the Efficacy of Moderate Sedation With Intra-NAsal Dexmedetomidine Monitored by EEG MOnitoring
This is a prospective, monocentric diagnostic study aiming to evaluate whether a sedation score obtained by a per-procedural electroencephalogram (EEG), the PSI score, could identify patients for whom a 2 μg/kg dose of DEX would…
- Trial name
- DINAMO (NCT06867289)
- Testing
- EEG
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Post Operative Analgesia, Tonsillectomy With or Without Adenoidectomy
Preoperative High-Dose Oral Paracetamol for Postoperative Analgesia in Children Undergoing Tonsillectomy"
This randomized clinical trial compares two different preoperative doses of oral paracetamol (acetaminophen) in children undergoing elective tonsillectomy.
- Trial name
- NCT07463482
- Testing
- Paracetamol (acetaminophen)
- Where
- Thailand
- Volunteers
- 54 people
- Sponsor
- Thammasat University