Clinical trials: Amyotrophic Lateral Sclerosis, completed
Amyotrophic Lateral Sclerosis
Italian Validation of the Beaumont Behavioural Inventory (BBI)
Up to 50% of patients affected with amyotrophic lateral sclerosis (ALS) can show behavioral dysfunctions within the spectrum of frontotemporal degenerations (FTD) - namely, apathy, disinhibition, loss of sympathy/empathy…
- Trial name
- BBI (NCT04440644)
- Testing
- BBI
- Where
- Italy
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Motor Neuron Disease
EncoreAnywhere Use in Motor Neurone Disease
Motor neurone disease is a progressive incurable disease causing weakness and paralysis of muscles. Respiratory failure is the most common cause of death in motor neurone disease.
- Trial name
- NCT03154450
- Testing
- EncoreAnywhere with data available to review, EncoreAnywhere with no data available to review
- Where
- United Kingdom
- Volunteers
- 19 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
ALS
National Registry of Veterans With Amyotrophic Lateral Sclerosis and DNA Bank
This study will identify living veterans with amyotrophic lateral sclerosis (ALS) through a national registry that is being developed. Diagnosis of ALS will be verified by study neurologists via medical record review.
- Trial name
- ALS Registry (NCT00076154)
- Where
- United States
- Volunteers
- 2,121 people
- Sponsor
- US Department of Veterans Affairs
Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis Web Based Patient Care Database: ALSConnection.Org
The purpose is to collect data for ALS research. The data will be used to learn more about the origin of ALS and to improve quality of care for people with ALS.
- Trial name
- NCT00302198
- Testing
- ALS Registry
- Where
- United States
- Volunteers
- 15,000 people
- Sponsor
- Forbes Norris MDA/ALS Research Center
Amyotrophic Lateral Sclerosis
Study of Gene Polymorphisms Involved in the Metabolism and Action of Vitamin D in Amyotrophic Lateral Sclerosis
This is a case-control study performed on a biological collection. The polymorphisms present on a pre-defined list of genes will be studied for 400 Amyotrophic Lateral Sclerosis (sporadic type) DNA samples and 400 control DNA…
- Trial name
- SLA_Vit_D (NCT02893605)
- Where
- France
- Volunteers
- 800 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Amyotrophic Lateral Sclerosis
Geometrical Facial Deformation According to Posture in Amyotrophic Lateral Sclerosis
The measurement of the facial deformation according to the body posture will be conducted by 3D scanning for each posture after marking the landmarks on the face.
- Trial name
- NCT04798183
- Testing
- 3-dimensional scan
- Where
- South Korea
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Pusan National University Yangsan Hospital
Amyotrophic Lateral Sclerosis
Treatment of Intravenous Infusion Plasma in Amyotrophic Lateral Sclerosis
To evaluate the safety and effectiveness of intravenous infusion of plasma from healthy young people for the treatment of amyotrophic lateral sclerosis.
- Trial name
- NCT04454840
- Testing
- Plasma from healthy young people treatment + Riluzole, Riluzole
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Peking University Third Hospital
Amyotrophic Lateral Sclerosis, Cognitive Impairment
Edinburgh Cognitive and Behavioural Amyotrophic Lateral Sclerosis Screen in Norway: A Prospective Cohort Study
This study evaluate use of a translated Norwegian version of the Edinburgh cognitive and behavioral amyotrophic lateral sclerosis screen (ECAS-N) as an early predictor in car-driving, working and use of advanced life-prolonging…
- Trial name
- NCT03578796
- Testing
- ECAS-N, MoCA, CDR
- Where
- Norway
- Volunteers
- 31 people
- Sponsor
- Haukeland University Hospital
Spinal Cord Injuries, Amyotrophic Lateral Sclerosis
Diaphragmatic Pacer Placement: Anesthetic Management (DP)
The diaphragmatic pacemaker (DP) has proven its utility in replacing mechanical ventilation (MV) in patients with chronic spinal cord injury (SCI) and Amyotrophic Lateral Sclerosis (ALS), by improving the patients quality of life…
- Conditions
- Spinal Cord Injuries, Amyotrophic Lateral Sclerosis, Respiratory Paralysis
- Trial name
- DP (NCT02942953)
- Testing
- Diaphragmatic Pacer
- Volunteers
- 16 people
- Sponsor
- Institut Guttmann
Amyotrophic Lateral Sclerosis, Progressive Muscular Atrophy
Study of ALS Reversals 4: LifeTime Exposures
Hypothesis: There exists patients who have met ALS or PMA diagnostic criteria and subsequently experienced robust and sustained improvement, i.e.
- Conditions
- Amyotrophic Lateral Sclerosis, Progressive Muscular Atrophy, Motor Neuron Disease
- Trial name
- StARLiTE (NCT03706391)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Duke University
Amyotrophic Lateral Sclerosis
Open Label Study: Treatment of ALS Fatigue With PolyMVA
Amyotrophic lateral sclerosis (ALS) is a disease that causes the death of upper and lower motor neurons. ALS symptoms are characterized by stiffness, muscle twitching, and worsening weakness due to muscle breakdown.
- Trial name
- NCT04557410
- Testing
- PolyMVA
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Missouri-Columbia
Primary Lateral Sclerosis, Hereditary Spastic Paraplegia
Nuclear Magnetic Spectroscopy Imaging to Evaluate Primary Lateral Sclerosis, Hereditary Spastic Paraplegia and Amyotrophic Lateral Sclerosis
This study will use a magnetic resonance imaging technique called nuclear magnetic spectroscopy (H-MRS) to define the pathology and progression of primary lateral sclerosis, hereditary spastic paraplegia and amyotrophic lateral…
- Conditions
- Primary Lateral Sclerosis, Hereditary Spastic Paraplegia, Amyotrophic Lateral Sclerosis
- Trial name
- NCT00023075
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Amyotrophic Lateral Sclerosis
In-situ Cytokines Expression in the CNS in Amyotrophic Lateral Sclerosis (ALS)
The investigators aim at exploring the differential/topographical in-situ expression of cytokines in the central nervous system (CNS) of patients who died with amyotrophic lateral sclerosis (ALS), using archived histopathology…
- Trial name
- NCT02582385
- Testing
- in-situ cytokine expression
- Where
- Belgium
- Volunteers
- 5 people
- Sponsor
- Brugmann University Hospital
Amyotrophic Lateral Sclerosis
Evaluation of Palliative Care for Patients With ALS and Their Caregivers
Rationale: Amyotrophic lateral sclerosis (ALS) is a degenerative illness which currently has no medical cure. It is routinely accompanied by a significant symptom burden including high levels of distress in patients and their…
- Trial name
- NCT04257760
- Testing
- Palliative Care consultation outside standard of care
- Where
- Canada
- Volunteers
- 66 people
- Sponsor
- Ottawa Hospital Research Institute
Amyotrophic Lateral Sclerosis
Muscle Training of Patients With Amyotrophic Lateral Sclerosis (ALS)
Patients with neuropathic diseases are experiencing increasing muscle weakness, loss of muscle strength and functional abilities during their illness.
- Trial name
- ALS-project (NCT01504009)
- Testing
- Muscle training
- Where
- Denmark
- Volunteers
- 6 people
- Sponsor
- University of Southern Denmark
Amyotrophic Lateral Sclerosis
Investigation on Home Care Needs of ALS Patients and Their Caregivers
The research target 1. To investigate the home nursing knowledge needs of ALS patients; 2. Investigate the needs of ALS caregivers for home nursing knowledge; 3.
- Trial name
- NCT04950231
- Testing
- The questionnaire survey
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Peking University Third Hospital
Nutritional Deficiency, Neuro-Degenerative Disease
Nutritional Prognostic Factors in ALS
Background. Several nutritional factors have been evaluated as prognostic factors for survival in ALS patients at earlier stages of the disease [body mass index (BMI), body composition expressed as fat free mass (FFM), fat mass…
- Conditions
- Nutritional Deficiency, Neuro-Degenerative Disease, Gastrostomy
- Trial name
- PEG-ALS (NCT03487536)
- Testing
- Nutritional assessment
- Where
- Italy
- Volunteers
- 47 people
- Sponsor
- University of Bari
Amyotrophic Lateral Sclerosis, ALS
Open Label Extension Study of AMX0035 in Patients With ALS
This extension study, in which all participants received active treatment (AMX0035), was designed to assess the longer-term safety and therapeutic potential of AMX0035 for participants who have completed the Main Study (AMX3500…
- Trial name
- CENTAUR-OLE (NCT03488524)
- Testing
- AMX0035
- Where
- 24 sites in United States
- Volunteers
- 90 people
- Sponsor
- Amylyx Pharmaceuticals Inc.
ALS - Amyotrophic Lateral Sclerosis
Evaluation of a Structurally Suitable Neck Exoskeleton in Patients With Amyotrophic Lateral Sclerosis
The investigators will evaluate a new powered neck exoskeleton in patients with amyotrophic lateral sclerosis (ALS) to understand whether this device allows adequate head range of motion and achieves satisfaction from users.
- Trial name
- NCT07491562
- Testing
- powered neck exoskeleton
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Utah
Amyotrophic Lateral Sclerosis
Relationship Between Respiratory Functional Tests and Image Thoracic Techniques in Patients With Neuromuscular Diseases
It is very important monitoring respiratory muscle function in patients with amyotrophic lateral sclerosis (ALS). We have at our disposal Respiratory Functional Tests (forced vital capacity (FVC), maximal mouth-inspiratory force…
- Trial name
- NCT01090674
- Testing
- No intervention
- Where
- Spain
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau