Clinical trials: Acute Trauma Brain Injury
Alzheimer Disease, Late Onset, Stroke
Explore the Sharing Model Intervene to Improve the Knowledge, Attitudes, Service Intentions and Service Start-up Effects of the Eight Major Non-cancer Disease End-stage Caregivers on Well-being and Palliative Care
Since September 1st, 2009, Taiwan has begun to pay attention to the care of patients with organ failure, dementia and the elderly, and brought eight of non-cancer terminal patients into health insurance subsidies to implement the…
- Conditions
- Alzheimer Disease, Late Onset, Stroke, Heart Failure, Pulmonary Disease, Chronic Obstructive
- Trial name
- NCT05407272
- Testing
- Health Education Manual, manual
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wen-Shiou Pan
Traumatic Brain Injury
Effects of Hypothermia Upon Outcomes After Acute Traumatic Brain Injury
Induction of hypothermia to < 35˚C by < 2.5 hours after severe traumatic brain injury, reaching 33˚C by 4 hours after injury and maintained for 48 hours in patients aged 16-45 will result in an increased number of patients with…
- Trial name
- NABIS:HIIR (NCT00178711)
- Testing
- Hypothermia
- Where
- 5 sites in United States, Canada
- Volunteers
- 232 people
- Sponsor
- The University of Texas Health Science Center, Houston
Post-Concussion Syndrome, COVID Long-Haul
Percutaneous Electrical Nerve Field Stimulation (PENFS) in Patients With Post Concussion Syndrome (PCS)
The purpose of this study is to test the effect of Auricular Percutaneous Electrical Nerve Field Stimulation (a Neurostim device) on children with pain and Post Concussion symptoms.
- Conditions
- Post-Concussion Syndrome, COVID Long-Haul, COVID-19
- Trial name
- NCT04978571
- Testing
- percutaneous electrical nerve-field stimulation, PENFS, percutaneous electrical nerve-field stimulation, PENFS (COVID active device)
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Children's Hospital of Orange County
Acute Brain Injury, Hypoxia, Brain
Portable MRI for Pediatric Hypoxic Ischemic Brain Injury
This study will evaluate the sensitivity and specificity of low field portable MRI (pMRI) for detection of hypoxic ischemic brain injuries in pediatric patients compared to clinically obtained neuroimaging to define pediatric…
- Conditions
- Acute Brain Injury, Hypoxia, Brain, Ischemia, Brain, Brain Injuries
- Trial name
- pMRI for HIBI (NCT07577336)
- Testing
- Portable MRI, Scavenged Sample Collection
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Children's Mercy Hospital Kansas City
Moderate to Severe Traumatic Brain Injury
Ante-hypophyseal Dysfunctions in Children Following Moderate to Severe Traumatic Brain Injuries
Annual incidence of severe traumatic brain injuries (TBI) varies from 180 to 300 out of 100.000. Mortality or severe sequelae risk is increased 8 fold after a TBI.
- Trial name
- Endoc-TC (NCT01250132)
- Testing
- Biological and behavioral explorations
- Where
- 2 sites in France
- Volunteers
- 110 people
- Sponsor
- Hospices Civils de Lyon
Traumatic Brain Injury, Severe Traumatic Brain Injury
Aquatic Sequential Preparatory Approach and Severe Traumatic Brain Injury
Traumatic brain injury (TBI) is an acquired insult to the brain from an external mechanical force. It is considered a major cause of mortality and of long-term disabilities in young adults, especially considering high-income…
- Trial name
- NCT04383405
- Testing
- Aquatic Training, Conventional Training
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Traumatic Brain Injury
Long Pressure Autoregulation Index
The pressure reactivity index (PRx) has emerged as a surrogate method for the continuous bedside estimation of global cerebral autoregulation and a significant predictor of unfavorable outcomes.
- Trial name
- Long PAx (NCT05043545)
- Where
- Italy
- Volunteers
- 263 people
- Sponsor
- Papa Giovanni XXIII Hospital
Concussion, Mild Traumatic Brain Injury
Interhemispheric Anterior Delta Desynchronization in Children Who Present to the Emergency Department With Acute Concussion: A Proof of Concept Study
Approximately 150,000 children present each year to emergency departments (EDs) in the US with concussion and many more are treated by primary care physician, or outpatient specialists.
- Trial name
- NCT02916108
- Testing
- Reading EEG
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Acute Kidney Injury, Hypoxic-Ischemic Encephalopathy
PK and Safety of Caffeine in Neonates With Hypoxic Ischemic Encephalopathy Receiving Therapeutic Hypothermia
A phase 1 study investigating the tolerability and pharmacokinetics of caffeine citrate in neonates with hypoxic ischemic encephalopathy receiving therapeutic hypothermia.
- Conditions
- Acute Kidney Injury, Hypoxic-Ischemic Encephalopathy, Caffeine
- Trial name
- NCT05295784
- Testing
- Caffeine citrate
- Where
- 2 sites in United States
- Sponsor
- University of Arkansas
Cognitive Dysfunction, Acquired Brain Injury
Fareon Open Label Device Clinical Trial
The purpose of this study is to assess the safety and feasibility of an at-home MMT treatment in patients with cognitive dysfunction related to acquired brain injury, Long COVID, traumatic brain injury, myalgic encephalomyelitis…
- Conditions
- Cognitive Dysfunction, Acquired Brain Injury, Traumatic Brain Injury
- Trial name
- NCT07600320
- Testing
- Fareon device
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Brain Injuries, Traumatic
CREACTIVE - Collaborative REsearch on ACute Traumatic Brain Injury in intensiVe Care Medicine in Europe
CREACTIVE is a large-scale observational cohort study concerning Traumatic Brain Injury (TBI) care in the ICU setting
- Trial name
- CREACTIVE (NCT02004080)
- Testing
- Intensive Care treatment
- Where
- 20 sites in Italy
- Volunteers
- 8,000 people
- Sponsor
- Gruppo Italiano per la Valutazione degli Interventi in Terapia Intensiva
Neurologic Decompensation, Acute, Traumatic Brain Injury
Ventilatory Parameters in Acute Neurological Injury
The goal of this observational study is to test the association between baseline ventilatory parameters (in particular mechanical power (MP), mechanical power normalized to predicted body weight (MP/PBW) and driving pressure (DP)…
- Conditions
- Neurologic Decompensation, Acute, Traumatic Brain Injury, Stroke, Subarachnoid Hemorrhage
- Trial name
- NCT06192342
- Where
- Argentina
- Volunteers
- 19 people
- Sponsor
- Ramos Mejía Hospital
Acute Brain Injuries, Consciousness Disorders
CONNECT-ME: Consciousness in Neurocritical Care Cohort Study Using fMRI and EEG
Detecting preserved consciousness in brain-injured patients by traditional clinical means requires presence of motor function. Otherwise, patients may be erroneously classified as being in a vegetative state.
- Trial name
- CONNECT-ME (NCT02644265)
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Mild Traumatic Brain Injury, Concussion, Mild
Neural Injury in Adolescents With Concussion
This study utilizes multimodal brain imaging to obtain quantitative biomarkers of brain injury and to improve understanding of the biological basis of brain pathology in adolescents with concussion.
- Conditions
- Mild Traumatic Brain Injury, Concussion, Mild, Acute Brain Injury
- Trial name
- NCT03011983
- Testing
- MEG, MRI, Neuropsychology assessment
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Brain Injuries, Acute, Brain Injuries, Traumatic
Antiseizure Medication in Seizure Networks at Early Acute Brain Injury
The goal of this clinical trial is to explore the effect of FDA-approved antiseizure drugs in the brain connectivity patterns of severe and moderate acute brain injury patients with suppression of consciousness.
- Conditions
- Brain Injuries, Acute, Brain Injuries, Traumatic, Brain Ischemia, Brain Hypoxia
- Trial name
- NCT06081283
- Testing
- Phenobarbital Sodium Injection, Levetiracetam, Lacosamide Injectable Product
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of North Carolina, Chapel Hill
Dementia, Mild Cognitive Impairment
Video Games to Track Cognitive Health
The purpose of this study is to assess cognitive function using a rapid, portable, computerized neurocognitive testing device in a wide variety of clinical settings.
- Conditions
- Dementia, Mild Cognitive Impairment, Cognitive Impairment, Cognitive Decline
- Trial name
- NCT03608722
- Testing
- SLUMS, MMSE, MoCA
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- BrainCheck, Inc.
Acute Brain Injury
Outcome Predictors in Acute Brain Injury
This study will attempt to evaluate clinical, laboratory and radiographic parameters together to assess heir values in outcome prediction from brain injury.
- Trial name
- NCT00163800
- Volunteers
- 60 people
- Sponsor
- Bayside Health
Osteoarthritis, Osteosarcoma
Clinical Orthopaedic Data Bank (Acute and Chronic)
Data involving orthopaedic conditions and rehabilitation aspects of musculoskeletal and neuromuscular disorders will be collected and stored as part of the normal clinical care of patients seen in the University of Florida (UF)…
- Conditions
- Osteoarthritis, Osteosarcoma, Scoliosis, Cerebral Palsy
- Trial name
- NCT00411060
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- University of Florida
Brain Injuries, Acute, Brain Trauma
BRIDGE-US: Bridging Readiness in Deployed Neurotrauma Gaps for Excellence
The purpose of this research study is to prospectively collect biospecimens, imaging, and clinical data from patients with penetrating brain injuries across high-volume PBI sites in the US (including UChicago).
- Conditions
- Brain Injuries, Acute, Brain Trauma, Penetrating Head Injury, Traumatic Brain Injury
- Trial name
- BRIDGE-US (NCT07636213)
- Testing
- Blood Sample Collection
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- University of Chicago
Post-Acute COVID-19 Syndrome, ME/CFS
Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related…
- Conditions
- Post-Acute COVID-19 Syndrome, ME/CFS, Rheumatic Arthritis, Juvenile Rheumatoid Arthritis (JRA)
- Trial name
- NCT04806620
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Brain Inflammation Collaborative