Clinical trials: Accuracy of Tissue Diagnosis
Solitary Skin Lesions, Skin Neoplasms
CNN-Based AI Versus Physicians for Solitary Skin Lesion Diagnosis
The goal of this observational study is to evaluate the diagnostic accuracy of a CNN-based artificial intelligence model in patients with solitary skin lesions.
- Conditions
- Solitary Skin Lesions, Skin Neoplasms, Skin Neoplasm Malignant
- Trial name
- NCT07415291
- Where
- Turkey (Türkiye)
- Volunteers
- 17,625 people
- Sponsor
- Istanbul Training and Research Hospital
Skin and Connective Tissue Diseases, Neglected Tropical Diseases
Early Detection and AI-Based Management of Skin-Related Neglected Tropical Diseases in Sub-Saharan Africa by Frontline Health Workers
Skin-related Neglected Tropical Diseases (Skin NTDs) affect about 1.8 billion people worldwide, particularly in poor and rural communities where healthcare access is limited.
- Conditions
- Skin and Connective Tissue Diseases, Neglected Tropical Diseases, Leprosy, Buruli Ulcer
- Trial name
- SkincAIr (NCT07506967)
- Testing
- A mobile app with AI functionality for diagnosing skin-related NTDs
- Where
- 5 sites in Democratic Republic of the Congo, Ethiopia and 3 more
- Volunteers
- 2,420 people
- Sponsor
- Kenya Medical Research Institute
Breast Cancer
The Impact of Respiratory Training of DIBH Radiotherapy for Breast Cancer
Breast cancer DIBH (Deep Inspiration Breath Hold) radiotherapy represents a high-precision treatment approach that substantially minimizes radiation exposure to vital organs such as the heart, thus enhancing protection of the…
- Trial name
- NCT06488391
- Testing
- Using a Portable Visualized Device for Self-Directed Breathing Training
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Jianjun Lai
Chronic Hepatitis
Accuracy of RTE for Evaluating Hepatic Fibrosis in Chronic Hepatitis: a Prospective Multicenter Study
Our study is a prospective multicenter research and the aim is to explore a variety of suitable evaluation indicators and criteria for diagnosis of diffuse liver fibrosis, to get the corresponding diagnosis threshold, with the…
- Trial name
- NCT02143180
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Potentially Malignant Lesions, Oral Lichen Planus
Diagnostic Accuracy of lncRNA DQ786243 and miRNA146a in Saliva of Oral Potentially Malignant Lesions
The aim of this study is to evaluate salivary expression of lncRNA DQ786243 as a potential marker for diagnosis of oral potentially malignant lesions compared to normal controls and its effect on salivary expression of miRNA146a.
- Conditions
- Potentially Malignant Lesions, Oral Lichen Planus, Leukoplakia, Oral
- Trial name
- NCT05730855
- Testing
- Real-time Polymerase Chain Reaction technique
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Asthma (Diagnosis)
First-Line Diagnostic Investigations for Suspected Adult Asthma
Asthma is a common long-term condition that can be difficult to diagnose accurately. Symptoms such as breathlessness, wheeze and cough can vary over time and may be caused by other conditions.
- Trial name
- NCT07792213
- Testing
- Spirometry, Fractional Exhaled Nitric Oxide, bronchodilator response
- Where
- United Kingdom
- Volunteers
- 2,176 people, healthy volunteers welcome
- Sponsor
- George Eliot Hospital
Peutz-Jeghers Syndrome
Study of Accurate Diagnosis and Treatment of Peutz-Jeghers Syndrome
The mutation of STK11 has been regcognized to be the major cause of Peutz-Jeghers syndrome (PJS).The aim of this study was to confirm the mutation rate of gene associated with gastrointestinal malignancies,including STK11…
- Trial name
- NCT03806075
- Testing
- Second generation sequencing, 16s rRNA gene sequencing
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Yiqi Du
Neuroblastoma
Identification of New Gene Spliceosomes in Neuroblastoma
Neuroblastoma is an early childhood embryonic malignancy that originates from neural crest cells. Neuroblastoma shows high heterogeneity in biological, morphological, genetic, and clinical features.
- Trial name
- NCT06502210
- Testing
- Personalized surgical therapy of neuroblastoma
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Affiliated Hospital of Nantong University
Skin Diseases
Deep Neural Networks on the Accuracy of Skin Disease Diagnosis in Non-Dermatologists
Background: Deep neural networks (DNN) has been applied to many kinds of skin diseases in experimental settings. Objective: The objective of this study is to confirm the augmentation of deep neural networks for the diagnosis of…
- Trial name
- NCT04636164
- Testing
- Model Dermatology (deep neural networks; Build 2020)
- Where
- South Korea
- Volunteers
- 55 people
- Sponsor
- Pyoeng Gyun Choe
Breast Cancer
The Accuracy of Sentinel Node Biopsy of Breast Cancer With Sonographic Abnormal Axillary Lymph Nodes
This is a phase II, prospective, single-center, non-randomized, non-controlled study. Sentinel lymph node biopsy (SNB) is a standard staging procedure in early breast cancer.
- Trial name
- NCT02005926
- Testing
- Wire-localized abnormal node
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Tao OUYANG
Soft Tissue Sarcoma of the Limb
Biopsy Needle Size in Soft Tissue Sarcoma
Soft tissue sarcomas (STS) require accurate biopsy for diagnosis, grading, and management decisions. Although tru-cut biopsy is widely used, the optimal needle gauge remains uncertain.
- Trial name
- NCT07066774
- Testing
- Tru-cut Biopsy with 14 G Needle, Tru-cut Biopsy with 16G tru-cut needle, Tru-cut Biopsy with 18G tru-cut needle
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Ankara City Hospital Bilkent
Osteogenic Sarcoma
Accuracy of Deep-learning Algorithm for Detection and Risk Stratification of Lung Nodules
Osteosarcoma is regarded as most common malignant bone tumor in children and adolescents. Approximately 15% to 20% of patients with osteosarcoma present with detectable metastatic disease, and the majority of whom (85%) have…
- Trial name
- NCT04022512
- Testing
- computed tomography
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- Chinese University of Hong Kong
Hydrocephalus, Normal Pressure Hydrocephalus
A Precision and Accuracy Study of the Codman Valve Position Verification (VPV) System.
The purpose of this study is to determine the agreement rate between the CODMAN Valve Position Verification (VPV) adjustment outcome (reprogramming) and X-ray verification in order to support an alternative to X-ray confirmation…
- Trial name
- NCT00196196
- Testing
- Codman VPV System
- Where
- 8 sites in United States
- Volunteers
- 274 people
- Sponsor
- Codman & Shurtleff
Pulp and Periapical Tissue Disease
Comparative Analysis of Diagnostic Accuracy and Case Difficulty Assessment of Three Large Language Models
This prospective, blinded diagnostic accuracy study aims to compare the performance of three large language models-ChatGPT (GPT-5.5 Pro), Gemini 3.1 Pro, and Claude Opus 4.7-in endodontic diagnosis and case difficulty assessment.
- Trial name
- NCT07732985
- Testing
- ChatGPT (GPT-5.5 Pro), Gemini 3.1 Pro, Claude Opus 4.7
- Volunteers
- 342 people, healthy volunteers welcome
- Sponsor
- Cairo University
Lichen Sclerosus, Lichen Planus
Diagnostic Accuracy of "Three Rings Vulvoscopy" for Detection of Vulvar Dermatosis
The objective of the study was to determine sensitivity, specificity and diagnostic accuracy of "Three Rings Vulvoscopy" for detection of vulvar dermatosis using histopathology as the reference standard.
- Conditions
- Lichen Sclerosus, Lichen Planus, Lichen Simplex Chronicus, Vulvodynia
- Trial name
- DATRIV (NCT02732145)
- Testing
- "Three Rings Vulvoscopy" (TRIV), Histopathology
- Where
- Croatia
- Volunteers
- 328 people, healthy volunteers welcome
- Sponsor
- Ginekološka Poliklinika Dr. Vesna Harni
Phyllodes Breast Tumor, Artificial Intelligence
AI-Assisted System for Accurate Diagnosis and Prognosis of Breast Phyllodes Tumors
Breast phyllodes tumor (PT) is a rare fibroepithelial tumor, accounting for 1% to 3% of all breast tumors, categorized by the WHO into benign, borderline, and malignant, based on histopathology features such as tumor border…
- Conditions
- Phyllodes Breast Tumor, Artificial Intelligence, Multiomics, Prognostic Cancer Model
- Trial name
- NCT06286267
- Testing
- imaging
- Where
- 4 sites in China
- Volunteers
- 4,000 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Dental Malocclusion
The Accuracy of Computer Software Prediction of Soft Tissue Profile for Patients Undergoing Fixed Orthodontic Treatment
A clinical study to evaluate the accuracy of computer software in predicting soft tissue profile changes in patients undergoing fixed orthodontic treatment
- Trial name
- NCT05978856
- Testing
- Accuracy of computer software in predicting soft tissue profile changes
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Hemolytic-Uremic Syndrome, Membranoproliferative Glomerulonephritis
New Analytic Tools for aHUS and C3G Diagnosis
This protocol is part of a larger project, COMPRare (COMPlement-mediated Rare kidney diseases), which has been financed on behalf of the EJP RD (European Joint Programme on Rare Diseases) program of EU and is leaded by a…
- Conditions
- Hemolytic-Uremic Syndrome, Membranoproliferative Glomerulonephritis, Healthy
- Trial name
- COMPRare (NCT05985122)
- Testing
- C3NEF assay
- Where
- Italy
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Mario Negri Institute for Pharmacological Research
Cutaneous Leishmaniasis, Skin Diseases, Parasitic
Accuracy of a Rapid Diagnostic Test for Cutaneous Leishmaniasis in Morocco
The aim of this study is to estimate the accuracy of CL Detect Rapid Test™ compared to a composite reference standard test (Direct examination of skin smears + PCR test) in patients with clinically suspected Cutaneous…
- Conditions
- Cutaneous Leishmaniasis, Skin Diseases, Parasitic, Neglected Diseases
- Trial name
- NCT02979002
- Where
- 9 sites in Morocco
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- National School of Public Health, Morocco
Breast Cancer
Digital Breast Tomosynthesis in Younger Symptomatic Women
This study will examine a new imaging technique called digital breast tomosynthesis (DBT) compared to standard mammography in women under 60 presenting with signs of breast cancer.
- Trial name
- NCT01241981
- Where
- United Kingdom
- Volunteers
- 446 people
- Sponsor
- NHS Tayside