Clinical trials: AMR
Rotavirus Gastroenteritis, Rotavirus Vaccines
ROTA-biotic: Measuring the Impact of Rotavirus Vaccines on Paediatric Antibiotic Usage
Rotavirus is the most common aetiology of serious diarrhoea in young children. Despite antibiotics not being indicated in its treatment, diarrhoea remains a very common cause for antibiotic prescribing in low-income settings.
- Conditions
- Rotavirus Gastroenteritis, Rotavirus Vaccines, Antimicrobial Resistance (AMR), Antibiotic
- Trial name
- NCT06882070
- Testing
- Vaccine
- Where
- 2 sites in Ghana, Zambia
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Gram Negative Infection, Antimicrobial Resistance (AMR)
PK/PD Analysis of Ceftazidime/Avibactam or Cefiderocol With or Without Fosfomycin for the Treatment of Difficult To-treat Gram-negative Infections
A multicenter, national, prospective, observational pharmacological study of patients with difficult-to-treat Gram-negative infections treated with ceftazidime/avibactam (CAZ/AVI) or cefiderocol (CEF) monotherapy or combination…
- Trial name
- PACCOF (NCT06651047)
- Where
- 11 sites in Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Bologna
Antibiotic Resistant Strain, Transmission, Close-Contact
Dynamics of AMR Spread, Persistence and Evolution Between Humans, Animals and Their Environment
Humans in contact with animals such as dog owners, may be at risk of antimicrobial resistance (AMR) acquisition. This is the central issue to be investigated in DYASPEO
- Trial name
- Dyaspeo (NCT06262009)
- Testing
- human faecal collection, ancillary study
- Where
- France
- Volunteers
- 525 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Penicillin Allergy, Antimicrobial Drug Resistance
A Study of the Impact of Penicillin Allergy on Antimicrobial Resistance and ouTcomes
Penicillin allergy is one of the commonest reported allergies. The presence of a penicillin allergy record in a patients notes leads to the avoidance of recommended first-line penicillin antibiotics and the use of alternative…
- Conditions
- Penicillin Allergy, Antimicrobial Drug Resistance, AMR
- Trial name
- IMPAART (NCT07177690)
- Where
- United Kingdom
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Polio
Environmental Surveillance (ES) for Polio and AMR Using the TaqMan Array Card
This study will be used to develop a tool to streamline poliovirus environmental surveillance for the polio endgame and to provide a tool for detecting polio in places where there is no capacity to carry out the gold standard…
- Trial name
- NCT03818477
- Where
- Bangladesh
- Volunteers
- 8,500 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Antibiotic Use
Generating Collective Solutions to Reduce Unnecessary Antibiotic Use in Vietnam
The study aims to develop community-based interventions targetting inappropriate antibiotic dispensing and use behaviours in rural Vietnam and has 3 research components.
- Trial name
- NCT04358289
- Testing
- Basic antimicrobial stewardship education, Participatory action research group in commune health center and community, Antimicrobial stewardship program in hospitals
- Where
- Vietnam
- Volunteers
- 3,315 people, healthy volunteers welcome
- Sponsor
- Oxford University Clinical Research Unit, Vietnam