Local Epinephrine in MyomectomyNCT07918027
Reducing Blood Loss During Myomectomy by Comparing Local Epinephrine and Uterine Artery Tourniquet During Procedure
A study testing Temporary uterine artery occlusion using a Foley catheter tourniquet during myomectomy and Local infiltration of dilute epinephrine into the myoma bed and surrounding myometrium during myomectomy. in people with Local Epinephrine in Myomectomy, run by Pakistan Institute of Medical Sciences at 1 site in Pakistan.
Trial summary
To reduce blood loss during myomectomy We will make 2 groups and will compare the use of epinephrine and uterine artery tourniquet in each group Blood loss will be calculated and quantified then each group will be analyzed accordingly Read more about this study
- Who is it for?
- Ages 18 to 50 years, women only
- Conditions the study is for
- Local Epinephrine in Myomectomy
- What is being tested?
- Temporary uterine artery occlusion using a Foley catheter tourniquet during myomectomy and Local infiltration of dilute epinephrine into the myoma bed and surrounding myometrium during myomectomy.
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 80 participants
- Where
- 1 sitePakistan
- Study dates
- Feb 2027to Aug 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 50 years
- Women only
- No healthy volunteers
- Adult
Who may be able to join
- Hb > 10 Women 18 to 50 yrs
Who cannot join
- known bleeding disorder Pregnancy Hepatic or renal impairment Malignancy
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Local Epinephrine Versus Uterine Artery Tourniquet To Reduce Bleeding During Myomectomy
To reduce blood loss during myomectomy We will make 2 groups and will compare the use of epinephrine and uterine artery tourniquet in each group Blood loss will be calculated and quantified then each group will be analyzed accordingly
- Conditions
- Local Epinephrine in Myomectomy
- Being tested
- Temporary uterine artery occlusion using a Foley catheter tourniquet during myomectomy, Local infiltration of dilute epinephrine into the myoma bed and surrounding myometrium during myomectomy.
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Temporary uterine artery occlusion using a Foley catheter tourniquet during myomectomyOther
Blood loss comparison in myomectomy
Local infiltration of dilute epinephrine into the myoma bed and surrounding myometrium during myomectomy.Other
Blood loss comparison in myomectomy
| Study group | Role | What they receive |
|---|---|---|
| Arm A: Uterine Artery Tourniquet Group - | Active comparator | Myomectomy performed using temporary uterine artery occlusion with folley catheter Receives: Other: Temporary uterine artery occlusion using a Foley catheter tourniquet during myomectomy |
| Arm B: Epinephrine Infiltration Group | Active comparator | Myomectomy performed using local epinephrine infiltration (1:250,000) into the myoma bed to reduce blood loss. Receives: Other: Local infiltration of dilute epinephrine into the myoma bed and surrounding myometrium during myomectomy. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Blood Loss
Blood loss in term of millilitres By measuring suction and soaked gauzes will be calculated and added together
Measured: 6 months
Operative Time
Total surgery time in terms of hours and minutes will be calculated
Measured: Intraoperative
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Nov 2026
- Study startFeb 2027 (estimated)
- Primary completionJul 2027 (estimated)
- Study completionAug 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Local Epinephrine in MyomectomyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 80 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Pakistan Institute of Medical Sciences
- Sponsor type
- Other government
- Responsible party
- Principal investigator, Saira Tariq, Pakistan Institute of Medical Sciences
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07918027
- Sponsor's protocol ID
- F522024**123
- Status last verified
- Nov 2026
- First submitted
- 29 Oct 2026
- Last updated
- 5 Nov 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 5 Nov 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Local Epinephrine Versus Uterine Artery Tourniquet To Reduce Bleeding During Myomectomy
- ClinicalTrials.gov ID
- NCT07918027
- Acronym / sponsor ID
- F522024**123
- Conditions
- Local Epinephrine in Myomectomy
- Study type
- Interventional
- Recruitment status
- Enrolling by invitation
- Enrolment
- 80 participants (estimated)
- Lead sponsor
- Pakistan Institute of Medical SciencesOther government
- Study start
- Feb 2027 (estimated)
- Primary completion
- Jul 2027 (estimated)
- Study completion
- Aug 2027 (estimated)
- First posted
- 5 Nov 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
To reduce blood loss during myomectomy We will make 2 groups and will compare the use of epinephrine and uterine artery tourniquet in each group Blood loss will be calculated and quantified then each group will be analyzed accordingly
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Arm A: Uterine Artery Tourniquet Group - | Active comparator | Other: Temporary uterine artery occlusion using a Foley catheter tourniquet during myomectomyMyomectomy performed using temporary uterine artery occlusion with folley catheter |
| Arm B: Epinephrine Infiltration Group | Active comparator | Other: Local infiltration of dilute epinephrine into the myoma bed and surrounding myometrium during myomectomy.Myomectomy performed using local epinephrine infiltration (1:250,000) into the myoma bed to reduce blood loss. |
Who may qualify
- Ages
- 18 to 50 years
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (1 listed)
- Hb > 10 Women 18 to 50 yrs
Key exclusion criteria (1 listed)
- known bleeding disorder Pregnancy Hepatic or renal impairment Malignancy
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Temporary uterine artery occlusion using a Foley catheter tourniquet during myomectomyBlood loss comparison in myomectomy | Other | Arm A: Uterine Artery Tourniquet Group - |
| Local infiltration of dilute epinephrine into the myoma bed and surrounding myometrium during myomectomy.Blood loss comparison in myomectomy | Other | Arm B: Epinephrine Infiltration Group |
Primary outcome
Blood Loss
Time frame: 6 months
Blood loss in term of millilitres By measuring suction and soaked gauzes will be calculated and added together
Operative Time
Time frame: Intraoperative
Total surgery time in terms of hours and minutes will be calculated
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Nov 2026.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Temporary uterine artery occlusion using a Foley catheter tourniquet during myomectomy and Local infiltration of dilute epinephrine into the myoma bed and surrounding myometrium during myomectomy. in people with Local Epinephrine in Myomectomy, run by Pakistan Institute of Medical Sciences at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: enrolling by invitation, as of the sponsor's last update on 5 Nov 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Blood Loss (time frame: 6 months). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Nov 2026.