PTSD - Post Traumatic Stress DisorderNCT07914634
Virtual Reality Assisted Trauma Focused CBT
A study testing VR Photoscan and Trauma-Focused Cognitive Behavioural Therapy (TF-CBT) in people with PTSD - Post Traumatic Stress Disorder, run by Queen's University, Belfast at 1 site in United Kingdom.
Trial summary
Virtual Reality (VR) is becoming an increasingly important tool in mental healthcare, offering new ways to enhance patient treatment. Over the past decade, there's been growing interest in using VR therapies because they create immersive, controlled environments tailored to individual therapeutic needs. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- PTSD - Post Traumatic Stress Disorder
- What is being tested?
- VR Photoscan and Trauma-Focused Cognitive Behavioural Therapy (TF-CBT)
- Type of treatment
- Medical device, Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- 1 siteUnited Kingdom
- Study dates
- 5 Oct 2026to 31 Oct 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Adults who self-report the experience of type 1 trauma (NI related)
- PTSD symptoms as identified via PCL-5 > 31
- Ability to give informed consent -Suitable and willingness to engage in TF- CBT
Who cannot join
- History of seizures, seizure disorder, or epilepsy
- History of bipolar disorder, psychosis, or schizophrenia
- Younger than 18 years old
- Previously engaged in TF-CBT within the PTS in past 12 months
- Actively suicidal or undertaken suicidal action in past 3 months*
- Severe substance dependency *Participants who have been actively suicidal or have undertaken suicidal actions within the past three months will be excluded from the study. However, given the complexities of mental health and its treatment, the presence of passive suicidal ideation (e.g., thoughts of not wanting to live, without intent or plan) does not automatically lead to exclusion, provided that the participant is assessed as not being at immediate risk. Clinical judgement will be used during the screening process, and ongoing risk will be monitored throughout the study. A distress protocol is in place for the intervention
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United Kingdom1 site, 1 recruiting
- Recruiting
Whiteabbey Hospital - Psychological Therapies Service
Newtownabbey, County Antrim, BT379RH
Dave Rogers, CPsychol, 028 9055 2598, Dave.Rogers@northerntrust.hscni.net
About this study
Official title: Exploring the Feasibility of Virtual Reality-Assisted Trauma-Focused Cognitive Behavioural Therapy for PTSD: A Mixed Methods Study
Virtual Reality (VR) is becoming an increasingly important tool in mental healthcare, offering new ways to enhance patient treatment. Over the past decade, there's been growing interest in using VR therapies because they create immersive, controlled environments tailored to individual therapeutic needs. In a safe and controlled, therapeutic setting, these environments can help patients work through difficult emotions and experiences. However, despite its potential, the widespread adoption of VR in routine mental healthcare has been slow due to the high costs of the necessary technology, making it less accessible for many patients and therapists.
VR is particularly valuable in mental health therapy because it can evoke strong cognitive, emotional, and physical responses, much like traditional therapeutic techniques that use imagery or visualisation. Research has shown that VR can offer unique benefits, such as real-time monitoring of a patient's responses and creating customised exposure therapies that safely mimic real-world scenarios. These features can be incredibly effective in treating conditions like Post Traumatic Stress Disorder (PTSD), anxiety, and phobias.
This study aims to overcome the barriers to VR adoption by developing a more affordable approach to creating virtual environments that can be used in everyday mental healthcare. Collaborating with a software company called ProPeer Solutions, the project has created a process called "VR Photoscan." This method allows for the creation of virtual environments at a lower cost, making it more accessible to clinics and therapists. The ultimate goal is to integrate VR into standard mental health treatments, making this innovative technology available to more people who could benefit from it, specifically within routine psychological therapy services for adults with PTSD.
Read the detailed description
Background Northern Ireland is a country that has recently emerged from around 30 years of civil conflict that has resulted in the deaths of over 3500 people. This period known colloquially as 'The Troubles' has resulted in a legacy of trauma related mental health problems and has a higher estimated prevalence of Post-Traumatic Stress Disorder (PTSD) than any other comparable country that has experienced civil conflict. This has resulted in an estimated 39% of the population experiencing (directly or indirectly) a conflict related 'event'. PTSD has an estimated prevalence of 3.6% in the general world population, and a disproportionately high prevalence of 5.1% in among the Northern Ireland population.
Trauma-Focused Cognitive Behavioural Therapy (TF-CBT) has been demonstrated to be an effective treatment for PTSD evolved from the Ehlers and Clark (2000) Cognitive Model of persistent PTSD. The evidence-based treatment of non-conflict related trauma such as sexual assault, road traffic accidents have highlighted the effectiveness and common acceptance of TF-CBT and is currently recommended by the NICE. as the first line of clinical treatment for PTSD. TF-CBT for individuals in Northern Ireland suffering from PTSD which has arisen from acts of terrorism and civil conflict has added to the emergent evidence base as a successful therapeutic intervention.
The model suggests that PTSD can develop if the patient continues to feel a sense of current threat after the trauma has ended, which can lead to further dysfunctional behaviours and feelings, even after the event has taken place. During the course of therapy, clients with PTSD revisits the trauma memory in order to fully process what has occurred. This technique is known as Imaginal Exposure (IE) via Reliving and whilst shown to be effective, IE can be a difficult process for clients given the associated, somatic and cognitive symptoms that it incurs. People diagnosed with PTSD can be highly avoidant and emotionally distant from trauma memories, meaning they find it challenging to engage with the exposure process. In addition, when trauma has occurred several decades previously, the trauma memory may be difficult to access or may have lost detail resulting in poor treatment outcomes.
Given the role of imaginal techniques within PTSD treatment, a growing number of studies have explored the use of immersive technology such as Virtual Reality (VR) to support this process. VR is no longer a futuristic concept and headsets are readily accessible, being used in many households for entertainment purposes. Currently there are many ways to create a virtual world and if used correctly can be therapeutically helpful to patients and clinicians. VR can generate environments such as social settings or classrooms that essentially simulate real or imagined worlds to meet the specific clinical requirement of the patient in therapy. Through use of VR, patients can enter a world in which they exposed to a traumatic memory in a controlled therapeutic way, and, in result, has shown to be effective in the treatment for PTSD patients across a number of settings such as military combat, terrorist attacks and road traffic accidents. Specific to military, in 2003, due to the deployments to Afghanistan and Iraq there was an increase in combat related PTSD in which the United States recognised the need to advance in evidence-based treatments to address these complexities.
Despite these successes we are yet to see the widespread adoption of VR based interventions for PTSD in routine clinical settings. Potential barriers are hypothesised to occur due to the idiosyncratic nature of the trauma memory, which requires the recreation of a personalised environment and thus has significant cost implications. Another barrier may be due the acceptability or lack thereof of these new technologies among clinicians.
Theoretical Framework The clinical presentation of PTSD is idiosyncratic; with specific symptoms experienced differing from individual to individual. Unwanted, intrusive, and involuntary distressing memories of the traumatic event are a core symptom of PTSD. Most successful treatment protocols for PTSD focus on the patient's memory of the traumatic event and its meaning. Therefore, a range of interventions have been developed to reduce the stress associated with these memories. Such interventions include Prolonged Exposure (PE), imaginal reliving of the trauma, and cognitive interventions to support the elaboration of traumatic memory to link with autobiographical memories. For this study, Ehlers and Clark's Cognitive Model of Persistent PTSD was used as a framework to develop the current treatment protocol.
In their cognitive model, Ehlers and Clark posit that chronic PTSD developed because individuals engage in sensory processing of the event rather than processing the meaning and implications. This causes disturbance in autobiographical memory, i.e., episodic (personal memories including places, objects, events) and semantic memory (memories about general knowledge and facts). Subsequently, this prevents the processing of trauma memories. They also postulated that individuals who experience PTSD develop excessively negative appraisals in which the probability of risk of harm is overestimated, and the ability to cope with threat is underestimated. Such maladaptive cognitive errors/biases cause avoidance of threats and provide short-term relief. These include avoiding trauma-related stimuli, remembering or suppressing unwanted trauma-related thoughts. However, in the long term, these activities maintain the sense of persistent threat as the coping strategies prevent negative appraisals from being corrected. Thus, the authors proposed that recalling the traumatic memories and updating them is the core of the trauma treatment. Ehlers and Clark's model follows the general style of reliving suggested by Foa and Rothbaum with some fluidity and in vivo exposure (i.e., trauma site visit). During the treatment process of reliving, clients are asked to close their eyes and intentionally recall the traumatic memories, i.e., relive the trauma in their mind in detail and narrate their experience in present tense, including recalling images, sensory experiences, thoughts, and feelings. VR-based PTSD treatments can promote emotional engagement and the process of trauma via providing visual, auditory, and haptic sensory cues.
Project Aim and Objectives
The study aims to explore the feasibility of integrating low-cost Virtual Reality (VR) Photoscan technology into Trauma-Focused Cognitive Behavioural Therapy (TF-CBT) for individuals with Post-Traumatic Stress Disorder (PTSD). The goal is to assess whether this novel VR-assisted approach can enhance traditional therapy methods, making the intervention more accessible and practical within routine psychological services.
Objectives
- To evaluate the feasibility of using low-cost Virtual Reality (VR) Photoscan technology alongside TF-CBT for adults with PTSD. This will include assessing the practicality of the technology's integration into clinical workflows within the Northern Health and Social Care Trust (NHSCT).
- To gather data on participant recruitment, retention, and engagement throughout the study to understand the logistics of running the intervention in real-world clinical settings.
- To train mental health professionals in the use of VR Photoscan technology and evaluate their ability to competently deliver TF-CBT with the added VR component.
- To assess the acceptability, perceived benefits, and challenges of using VR Photoscan technology from the perspective of both clients and clinicians through qualitative interviews.
- To explore the potential of using VR to enhance the therapy process, specifically during trauma reliving phases of TF-CBT, by providing a more immersive and controlled environment for exposure.
- To conduct a preliminary power calculation based on the data gathered, to determine the appropriate sample size for a future, larger-scale randomized controlled trial (RCT) on the effectiveness of VR-assisted TF-CBT for PTSD.
- Conditions
- PTSD - Post Traumatic Stress Disorder
- Being tested
- VR Photoscan, Trauma-Focused Cognitive Behavioural Therapy (TF-CBT)
- Keywords
- Virtual reality, VR, VR Photoscan, PTSD, TF-CBT
- Medical subject headings
- Combat Disorders, Stress Disorders, Post-Traumatic
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
VR PhotoscanDevice
VR Photoscan is an immersive virtual reality intervention that uses digitally reconstructed three-dimensional environments representing trauma-related locations. The technology enables patients to revisit and engage with these environments within a controlled therapeutic setting, supporting trauma-focused exposure, memory processing and the reduction of avoidance behaviours. VR Photoscan is delivered as an adjunct to trauma-focused cognitive behavioural therapy (TF-CBT), under the guidance and supervision of a qualified clinician within a specialist psychological therapies service.
Trauma-Focused Cognitive Behavioural Therapy (TF-CBT)Behavioural
Also called TF-CBT
Trauma-focused cognitive behavioural therapy (TF-CBT) is an evidence-based psychological intervention for the treatment of post-traumatic stress disorder (PTSD). The therapy aims to reduce PTSD symptoms through the processing of traumatic memories, cognitive restructuring, and addressing trauma-related avoidance behaviours. Treatment is delivered by qualified clinicians within a specialist psychological therapies service in Northern Ireland, following established clinical protocols and individualised treatment plans. The frequency and duration of therapy are determined by individual clinical needs.
| Study group | Role | What they receive |
|---|---|---|
| Treatment As Usual | Active comparator | Participants allocated to the control arm (n=20) will receive Treatment as Usual (TAU), consisting of standard trauma-focused cognitive behavioural therapy (TF-CBT) for post-traumatic stress disorder (PTSD). Treatment will be delivered by qualified clinicians within a specialist psychological therapies service in Northern Ireland, following established clinical protocols and routine service delivery practices. The frequency and duration of sessions will be determined by individual clinical needs. Receives: Behavioral: Trauma-Focused Cognitive Behavioural Therapy (TF-CBT) |
| VR Photoscan | Experimental | Participants allocated to the experimental arm (n=20) will receive VR Photoscan as an adjunct to Treatment as Usual (TAU), consisting of trauma-focused cognitive behavioural therapy (TF-CBT) for post-traumatic stress disorder (PTSD). VR Photoscan uses immersive, digitally reconstructed environments representing trauma-related locations to support trauma processing and exposure-based therapeutic work. The intervention will be delivered under the supervision of qualified clinicians within a specialist psychological therapies service in Northern Ireland. Participants will continue to receive standard TF-CBT, with VR Photoscan integrated into their treatment according to individual clinical needs. Receives: Device: VR Photoscan; Behavioral: Trauma-Focused Cognitive Behavioural Therapy (TF-CBT) |
What is being measured
The primary outcome is the main question the study is designed to answer.
PCL-5
The Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5) is a 20-item self-report measure that assesses the severity of PTSD symptoms. The measure covers four symptom clusters: intrusion, avoidance, negative alterations in cognitions and mood, and alterations in arousal and reactivity. Each item is rated on a 5-point Likert scale ranging from 0 (not at all) to 4 (extremely). Total scores range from 0 to 80, with higher scores indicating greater PTSD symptom severity and therefore worse outcomes. The PCL-5 will be administered at baseline and weekly throughout treatment to monitor changes in PTSD symptoms.
Measured: Baseline (week 1) and weekly throughout treatment (up to 20 weeks max)
Secondary outcomes (5)
BDI-II
The Beck Depression Inventory-II (BDI-II) is a 21-item self-report measure used to assess the severity of depressive symptoms. Each item corresponds to a symptom of depression and is scored on a 4-point scale ranging from 0 to 3. Total scores range from 0 to 63, with higher scores indicating greater depressive symptom severity and therefore worse outcomes. The BDI-II will be administered at baseline and at the end of treatment to assess changes in depressive symptoms.
Measured: Baseline (week 1) and end of treatment (up to 20 weeks max)
ITQ
The International Trauma Questionnaire (ITQ) is an 18-item self-report measure designed to assess symptoms of PTSD and Complex PTSD in accordance with ICD-11 diagnostic criteria. The questionnaire assesses PTSD symptoms, disturbances in self-organisation (DSO), and associated functional impairment. Items are rated on a 5-point Likert scale ranging from 0 (not at all) to 4 (extremely). The six PTSD symptom items and six DSO symptom items each produce scores ranging from 0 to 24. The combined PTSD and DSO symptom score ranges from 0 to 48, with higher scores indicating greater trauma-related symptom severity and therefore worse outcomes. The ITQ will be administered at baseline and at the end of treatment to assess changes in trauma-related symptoms.
Measured: Baseline (week 1), then weekly up to week 20 (if therapy was not completed before)
CORE-OM
The Clinical Outcomes in Routine Evaluation - Outcome Measure (CORE-OM) is a 34-item self-report measure designed to assess psychological distress and changes associated with psychological therapy. The questionnaire covers four domains: subjective wellbeing, problems and symptoms, life functioning, and risk. Each item is rated on a 5-point scale ranging from 0 (not at all) to 4 (most or all of the time). The mean item score ranges from 0 to 4 and can be multiplied by 10 to produce a clinical score ranging from 0 to 40. Higher scores indicate greater psychological distress and therefore worse outcomes. The CORE-OM will be administered at baseline and at the end of treatment to assess changes in psychological wellbeing.
Measured: Baseline (week 1) and end of treatment (up to 20 weeks max)
CORE-10
The Clinical Outcomes in Routine Evaluation - 10 (CORE-10) is a 10-item self-report measure used to monitor psychological distress and changes in mental health during treatment. The questionnaire assesses symptoms, functioning and risk, and is designed for routine session-by-session monitoring. Each item is rated on a 5-point scale ranging from 0 (not at all) to 4 (most or all of the time). Total scores range from 0 to 40, with higher scores indicating greater psychological distress and therefore worse outcomes. The CORE-10 will be administered weekly throughout treatment to monitor changes in psychological wellbeing.
Measured: Weekly throughout treatment (up to 20 weeks max)
IPQ
The Igroup Presence Questionnaire (IPQ) is a 14-item self-report measure designed to assess the subjective experience of presence within a virtual environment. The questionnaire measures spatial presence, involvement and experienced realism, alongside a general presence item. Items are rated on a 7-point scale, which can be scored from -3 to +3. Mean scores for each domain range from -3 to +3, with higher scores indicating a stronger sense of presence, involvement or perceived realism within the virtual environment. The IPQ will be administered following the first session in which VR Photoscan technology is used to assess the participant's experience of the virtual environment.
Measured: Following the first use of VR Photoscan during treatment (approx week 5)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 Nov 2026
- Study start5 Oct 2026
- Primary completion31 Oct 2028 (estimated)
- Study completion31 Oct 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for PTSD - Post Traumatic Stress DisorderStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- This study uses a two-arm, parallel-group interventional design involving 40 adults receiving treatment for post-traumatic stress disorder (PTSD) within a specialist trauma service in Northern Ireland. Twenty participants will receive VR Photoscan as an adjunct to treatment as usual (TAU), while 20 participants will receive TAU alone. The study will examine the feasibility and acceptability of delivering VR-assisted therapy within routine clinical practice, alongside preliminary clinical outcomes. The parallel-group design enables comparison of intervention delivery and clinical outcomes between participants receiving VR-assisted treatment and those receiving TAU alone.
- Masking
- None (open label)
- Enrolment
- 40 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Queen's University, Belfast
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Dr Paul Best, Queen's University, Belfast
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07914634
- Sponsor's protocol ID
- 25/NI/0071
- Status last verified
- Oct 2026
- First submitted
- 22 Oct 2026
- Last updated
- 3 Nov 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be made publicly available or shared with external researchers due to the sensitive nature of the mental health information collected and the importance of protecting participant confidentiality. Study findings will be disseminated through publications and presentations using aggregated, non-identifiable data.
Study at a glance
From the registry record, last updated by the sponsor on 3 Nov 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Exploring the Feasibility of Virtual Reality-Assisted Trauma-Focused Cognitive Behavioural Therapy for PTSD: A Mixed Methods Study
- ClinicalTrials.gov ID
- NCT07914634
- Acronym / sponsor ID
- 25/NI/0071
- Conditions
- PTSD - Post Traumatic Stress Disorder
- Keywords
- Virtual reality, VR, VR Photoscan, PTSD, TF-CBT
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 40 participants (estimated)
- Lead sponsor
- Queen's University, BelfastUniversity, hospital or other
- Study start
- 5 Oct 2026 (actual)
- Primary completion
- 31 Oct 2028 (estimated)
- Study completion
- 31 Oct 2028 (estimated)
- First posted
- 3 Nov 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Virtual Reality (VR) is becoming an increasingly important tool in mental healthcare, offering new ways to enhance patient treatment. Over the past decade, there's been growing interest in using VR therapies because they create immersive, controlled environments tailored to individual therapeutic needs. In a safe and controlled, therapeutic setting, these environments can help patients work through difficult emotions and experiences. However, despite its potential, the widespread adoption of VR in routine mental healthcare has been slow due to the high costs of the necessary technology, making it less accessible for many patients and therapists.
VR is particularly valuable in mental health therapy because it can evoke strong cognitive, emotional, and physical responses, much like traditional therapeutic techniques that use imagery or visualisation. Research has shown that VR can offer unique benefits, such as real-time monitoring of a patient's responses and creating customised exposure therapies that safely mimic real-world scenarios. These features can be incredibly effective in treating conditions like Post Traumatic Stress Disorder (PTSD), anxiety, and phobias.
This study aims to overcome the barriers to VR adoption by developing a more affordable approach to creating virtual environments that can be used in everyday mental healthcare. Collaborating with a software company called ProPeer Solutions, the project has created a process called "VR Photoscan." This method allows for the creation of virtual environments at a lower cost, making it more accessible to clinics and therapists. The ultimate goal is to integrate VR into standard mental health treatments, making this innovative technology available to more people who could benefit from it, specifically within routine psychological therapy services for adults with PTSD.
Detailed description
Background Northern Ireland is a country that has recently emerged from around 30 years of civil conflict that has resulted in the deaths of over 3500 people. This period known colloquially as 'The Troubles' has resulted in a legacy of trauma related mental health problems and has a higher estimated prevalence of Post-Traumatic Stress Disorder (PTSD) than any other comparable country that has experienced civil conflict. This has resulted in an estimated 39% of the population experiencing (directly or indirectly) a conflict related 'event'. PTSD has an estimated prevalence of 3.6% in the general world population, and a disproportionately high prevalence of 5.1% in among the Northern Ireland population.
Trauma-Focused Cognitive Behavioural Therapy (TF-CBT) has been demonstrated to be an effective treatment for PTSD evolved from the Ehlers and Clark (2000) Cognitive Model of persistent PTSD. The evidence-based treatment of non-conflict related trauma such as sexual assault, road traffic accidents have highlighted the effectiveness and common acceptance of TF-CBT and is currently recommended by the NICE. as the first line of clinical treatment for PTSD. TF-CBT for individuals in Northern Ireland suffering from PTSD which has arisen from acts of terrorism and civil conflict has added to the emergent evidence base as a successful therapeutic intervention.
The model suggests that PTSD can develop if the patient continues to feel a sense of current threat after the trauma has ended, which can lead to further dysfunctional behaviours and feelings, even after the event has taken place. During the course of therapy, clients with PTSD revisits the trauma memory in order to fully process what has occurred. This technique is known as Imaginal Exposure (IE) via Reliving and whilst shown to be effective, IE can be a difficult process for clients given the associated, somatic and cognitive symptoms that it incurs. People diagnosed with PTSD can be highly avoidant and emotionally distant from trauma memories, meaning they find it challenging to engage with the exposure process. In addition, when trauma has occurred several decades previously, the trauma memory may be difficult to access or may have lost detail resulting in poor treatment outcomes.
Given the role of imaginal techniques within PTSD treatment, a growing number of studies have explored the use of immersive technology such as Virtual Reality (VR) to support this process. VR is no longer a futuristic concept and headsets are readily accessible, being used in many households for entertainment purposes. Currently there are many ways to create a virtual world and if used correctly can be therapeutically helpful to patients and clinicians. VR can generate environments such as social settings or classrooms that essentially simulate real or imagined worlds to meet the specific clinical requirement of the patient in therapy. Through use of VR, patients can enter a world in which they exposed to a traumatic memory in a controlled therapeutic way, and, in result, has shown to be effective in the treatment for PTSD patients across a number of settings such as military combat, terrorist attacks and road traffic accidents. Specific to military, in 2003, due to the deployments to Afghanistan and Iraq there was an increase in combat related PTSD in which the United States recognised the need to advance in evidence-based treatments to address these complexities.
Despite these successes we are yet to see the widespread adoption of VR based interventions for PTSD in routine clinical settings. Potential barriers are hypothesised to occur due to the idiosyncratic nature of the trauma memory, which requires the recreation of a personalised environment and thus has significant cost implications. Another barrier may be due the acceptability or lack thereof of these new technologies among clinicians.
Theoretical Framework The clinical presentation of PTSD is idiosyncratic; with specific symptoms experienced differing from individual to individual. Unwanted, intrusive, and involuntary distressing memories of the traumatic event are a core symptom of PTSD. Most successful treatment protocols for PTSD focus on the patient's memory of the traumatic event and its meaning. Therefore, a range of interventions have been developed to reduce the stress associated with these memories. Such interventions include Prolonged Exposure (PE), imaginal reliving of the trauma, and cognitive interventions to support the elaboration of traumatic memory to link with autobiographical memories. For this study, Ehlers and Clark's Cognitive Model of Persistent PTSD was used as a framework to develop the current treatment protocol.
In their cognitive model, Ehlers and Clark posit that chronic PTSD developed because individuals engage in sensory processing of the event rather than processing the meaning and implications. This causes disturbance in autobiographical memory, i.e., episodic (personal memories including places, objects, events) and semantic memory (memories about general knowledge and facts). Subsequently, this prevents the processing of trauma memories. They also postulated that individuals who experience PTSD develop excessively negative appraisals in which the probability of risk of harm is overestimated, and the ability to cope with threat is underestimated. Such maladaptive cognitive errors/biases cause avoidance of threats and provide short-term relief. These include avoiding trauma-related stimuli, remembering or suppressing unwanted trauma-related thoughts. However, in the long term, these activities maintain the sense of persistent threat as the coping strategies prevent negative appraisals from being corrected. Thus, the authors proposed that recalling the traumatic memories and updating them is the core of the trauma treatment. Ehlers and Clark's model follows the general style of reliving suggested by Foa and Rothbaum with some fluidity and in vivo exposure (i.e., trauma site visit). During the treatment process of reliving, clients are asked to close their eyes and intentionally recall the traumatic memories, i.e., relive the trauma in their mind in detail and narrate their experience in present tense, including recalling images, sensory experiences, thoughts, and feelings. VR-based PTSD treatments can promote emotional engagement and the process of trauma via providing visual, auditory, and haptic sensory cues.
Project Aim and Objectives
The study aims to explore the feasibility of integrating low-cost Virtual Reality (VR) Photoscan technology into Trauma-Focused Cognitive Behavioural Therapy (TF-CBT) for individuals with Post-Traumatic Stress Disorder (PTSD). The goal is to assess whether this novel VR-assisted approach can enhance traditional therapy methods, making the intervention more accessible and practical within routine psychological services.
Objectives
- To evaluate the feasibility of using low-cost Virtual Reality (VR) Photoscan technology alongside TF-CBT for adults with PTSD. This will include assessing the practicality of the technology's integration into clinical workflows within the Northern Health and Social Care Trust (NHSCT).
- To gather data on participant recruitment, retention, and engagement throughout the study to understand the logistics of running the intervention in real-world clinical settings.
- To train mental health professionals in the use of VR Photoscan technology and evaluate their ability to competently deliver TF-CBT with the added VR component.
- To assess the acceptability, perceived benefits, and challenges of using VR Photoscan technology from the perspective of both clients and clinicians through qualitative interviews.
- To explore the potential of using VR to enhance the therapy process, specifically during trauma reliving phases of TF-CBT, by providing a more immersive and controlled environment for exposure.
- To conduct a preliminary power calculation based on the data gathered, to determine the appropriate sample size for a future, larger-scale randomized controlled trial (RCT) on the effectiveness of VR-assisted TF-CBT for PTSD.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- This study uses a two-arm, parallel-group interventional design involving 40 adults receiving treatment for post-traumatic stress disorder (PTSD) within a specialist trauma service in Northern Ireland. Twenty participants will receive VR Photoscan as an adjunct to treatment as usual (TAU), while 20 participants will receive TAU alone. The study will examine the feasibility and acceptability of delivering VR-assisted therapy within routine clinical practice, alongside preliminary clinical outcomes. The parallel-group design enables comparison of intervention delivery and clinical outcomes between participants receiving VR-assisted treatment and those receiving TAU alone.
| Arm | Type | Receives |
|---|---|---|
| Treatment As Usual | Active comparator | Behavioral: Trauma-Focused Cognitive Behavioural Therapy (TF-CBT)Participants allocated to the control arm (n=20) will receive Treatment as Usual (TAU), consisting of standard trauma-focused cognitive behavioural therapy (TF-CBT) for post-traumatic stress disorder (PTSD). Treatment will be delivered by qualified clinicians within a specialist psychological therapies service in Northern Ireland, following established clinical protocols and routine service delivery practices. The frequency and duration of sessions will be determined by individual clinical needs. |
| VR Photoscan | Experimental | Device: VR Photoscan, Behavioral: Trauma-Focused Cognitive Behavioural Therapy (TF-CBT)Participants allocated to the experimental arm (n=20) will receive VR Photoscan as an adjunct to Treatment as Usual (TAU), consisting of trauma-focused cognitive behavioural therapy (TF-CBT) for post-traumatic stress disorder (PTSD). VR Photoscan uses immersive, digitally reconstructed environments representing trauma-related locations to support trauma processing and exposure-based therapeutic work. The intervention will be delivered under the supervision of qualified clinicians within a specialist psychological therapies service in Northern Ireland. Participants will continue to receive standard TF-CBT, with VR Photoscan integrated into their treatment according to individual clinical needs. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Adults who self-report the experience of type 1 trauma (NI related)
- PTSD symptoms as identified via PCL-5 > 31
- Ability to give informed consent -Suitable and willingness to engage in TF- CBT
Key exclusion criteria (6 listed)
- History of seizures, seizure disorder, or epilepsy
- History of bipolar disorder, psychosis, or schizophrenia
- Younger than 18 years old
- Previously engaged in TF-CBT within the PTS in past 12 months
- Actively suicidal or undertaken suicidal action in past 3 months*
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| VR PhotoscanVR Photoscan is an immersive virtual reality intervention that uses digitally reconstructed three-dimensional environments representing trauma-related locations. The technology enables patients to revisit and engage with these environments within a controlled therapeutic setting, supporting trauma-focused exposure, memory processing and the reduction of avoidance behaviours. VR Photoscan is delivered as an adjunct to trauma-focused cognitive behavioural therapy (TF-CBT), under the guidance and supervision of a qualified clinician within a specialist psychological therapies service. | Device | VR Photoscan |
| Trauma-Focused Cognitive Behavioural Therapy (TF-CBT)Also: TF-CBTTrauma-focused cognitive behavioural therapy (TF-CBT) is an evidence-based psychological intervention for the treatment of post-traumatic stress disorder (PTSD). The therapy aims to reduce PTSD symptoms through the processing of traumatic memories, cognitive restructuring, and addressing trauma-related avoidance behaviours. Treatment is delivered by qualified clinicians within a specialist psychological therapies service in Northern Ireland, following established clinical protocols and individualised treatment plans. The frequency and duration of therapy are determined by individual clinical needs. | Behavioural | Treatment As Usual, VR Photoscan |
Primary outcome
PCL-5
Time frame: Baseline (week 1) and weekly throughout treatment (up to 20 weeks max)
The Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5) is a 20-item self-report measure that assesses the severity of PTSD symptoms. The measure covers four symptom clusters: intrusion, avoidance, negative alterations in cognitions and mood, and alterations in arousal and reactivity. Each item is rated on a 5-point Likert scale ranging from 0 (not at all) to 4 (extremely). Total scores range from 0 to 80, with higher scores indicating greater PTSD symptom severity and therefore worse outcomes. The PCL-5 will be administered at baseline and weekly throughout treatment to monitor changes in PTSD symptoms.
5 secondary outcomes
BDI-II
Time frame: Baseline (week 1) and end of treatment (up to 20 weeks max)
ITQ
Time frame: Baseline (week 1), then weekly up to week 20 (if therapy was not completed before)
CORE-OM
Time frame: Baseline (week 1) and end of treatment (up to 20 weeks max)
CORE-10
Time frame: Weekly throughout treatment (up to 20 weeks max)
IPQ
Time frame: Following the first use of VR Photoscan during treatment (approx week 5)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Nov 2026.
- Individual participant dataSharing planned: No. Individual participant data will not be made publicly available or shared with external researchers due to the sensitive nature of the mental health information collected and the importance of protecting participant confidentiality. Study findings will be disseminated through publications and presentations using aggregated, non-identifiable data.
Related trials for PTSD - Post Traumatic Stress Disorder
Recruiting
Deep Brain Reorienting in Post-traumatic Stress Disorder
PTSD, Post-traumatic Stress Disorder
RecruitingPhase 3
An Evaluation of the Safety and Efficacy of TSND-201 for the Treatment of PTSD
Post Traumatic Stress Disorder
Recruiting
Restorative Early Sleep Treatment After the Emergency Department
Insomnia, Nightmares Associated With Trauma and Stress
RecruitingPhase 3
Examining 3,4-methylenedioxymethamphetamine (MDMA) Effects on Psychological, Relational and Hyperarousal-Related Neural Reactivity Mechanisms in Veterans With PTSD and Moral Injury
PTSD, Post Traumatic Stress Disorder, Moral Injury
Not yet recruiting
The Development of a Transdiagnostic Intervention to Improve Social Functioning and Intimate Relationships Among Veterans
Alcohol Problems, Post-Traumatic Stress Disorder
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing VR Photoscan and Trauma-Focused Cognitive Behavioural Therapy (TF-CBT) in people with PTSD - Post Traumatic Stress Disorder, run by Queen's University, Belfast at 1 site in United Kingdom.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 3 Nov 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United Kingdom. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Paul Best, PhD, MsC (02890973256, p.best@qub.ac.uk), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
PCL-5 (time frame: Baseline (week 1) and weekly throughout treatment (up to 20 weeks max)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Nov 2026.