Parkinson DiseaseNCT07907718
Cognitive-Motor Training for Gait Adaptability in Parkinson Disease
A study testing Cognitive-motor training and Conventional physiotherapy in people with Parkinson Disease, run by National Yang Ming Chiao Tung University at 1 site in Taiwan.
Trial summary
Cognitive-motor training combines thinking tasks with physical movements, encouraging participants to choose appropriate actions and adjust their movements according to different task demands. Read more about this study
- Who is it for?
- Ages 18 to 80 years
- Conditions the study is for
- Parkinson Disease
- What is being tested?
- Cognitive-motor training and Conventional physiotherapy
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 50 participants
- Where
- 1 siteTaiwan
- Study dates
- 1 Nov 2026to 31 Aug 2029
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 80 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- A clinical diagnosis of idiopathic Parkinson's disease
- Stable use of prescribed antiparkinsonian medication for at least two weeks
- Modified Hoehn and Yahr stage I to III
- Age between 18 and 80 years
- Ability to ambulate independently for at least 30 meters without assistive devices
- A Mini-Mental State Examination (MMSE) score of ≥ 24
- Corrected vision and hearing sufficient to effectively receive external stimuli
Who cannot join
- The presence of any neurological, musculoskeletal, or cardiovascular disorders that could affect participation in this study
- The presence of psychiatric disorders that could interfere with the ability to follow instructions or comply with study procedures
- A history of brain surgery, such as deep brain stimulation (DBS)
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Taiwan1 site
National Yang Ming Chiao Tung University
Taipei, 112
Yea-Ru Yang, PhD, yryang@nycu.edu.tw
About this study
Official title: Cognitive-Motor Training on Cognitive Function and Gait Adaptability in People With Parkinson's Disease
Cognitive-motor training combines thinking tasks with physical movements, encouraging participants to choose appropriate actions and adjust their movements according to different task demands. Training that involves stopping or changing a movement may help people with Parkinson's disease respond to changing situations. These abilities may also support walking in challenging environments, such as stepping over obstacles. However, the effects of this type of training on cognitive function, walking performance, and brain activity remain unclear. Therefore, this study aims to compare the effects of cognitive-motor co-dependent training with conventional exercise training on these outcomes in people with Parkinson's disease.
- Conditions
- Parkinson Disease
- Being tested
- Cognitive-motor training, Conventional physiotherapy
- Keywords
- Cognitive-motor training, Gait adaptability, Executive function, Electroencephalography
- Medical subject headings
- Parkinson Disease
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Cognitive-motor trainingOther
Cognitive-motor training is that cognitive tasks incorporated into motor tasks.
Conventional physiotherapyOther
Conventional physiotherapy includes ROM exercise, stretching, strengthening exercise, and eye-hand coordination.
| Study group | Role | What they receive |
|---|---|---|
| Cognitive-motor training group | Experimental | Participants receive 16 sessions of cognitive-motor training. Receives: Other: Cognitive-motor training |
| Conventional exercise training group | Active comparator | Participants receive 16 sessions of conventional physiotherapy. Receives: Other: Conventional physiotherapy |
What is being measured
The primary outcome is the main question the study is designed to answer.
Gait speed
Gait speed during obstacle crossing was measured using the GAITRite system. Continuous obstacle-crossing walking performance was assessed using the GaitUp system.
Measured: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Step length
Using GAITRite system to measure step length
Measured: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Step width
Using GAITRite system to measure step width
Measured: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Single support time
Using GAITRite system to measure single support time
Measured: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Gait Variability
Gait variability during continuous obstacle crossing will be assessed using the GaitUp system and expressed as the coefficient of variation (CV = standard deviation / mean × 100%) of step time and stride length.
Measured: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Stride length
Using the GaitUp system to measure stride length during continuous obstacle-crossing walking.
Measured: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Swing phase
Using the GaitUp system to measure swing phase during continuous obstacle-crossing walking.
Measured: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Four Square Step Test
The Four Square Step Test is a test used to assess the ability to step over objects and measures the time in seconds to navigate all four squares.
Measured: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Event-related potential - N2
Measure event-related potential through electroencephalography during the Go/No-go test
Measured: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Event-related potential - P300
Measure event-related potential through electroencephalography during the Go/No-go test
Measured: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Stroop color and word test
Record numbers of corrected color words which the subject responds within 45 sec.
Measured: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Trail making test
Trail making test contain part A and part B. Faster completing the test indicates better executive function.
Measured: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Secondary outcomes (3)
Part III of the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS)
Motor symptoms will be assessed using Part III of the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS). Scores range from 0 to 132, with higher scores indicating greater motor impairment.
Measured: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Single-Leg Standing Balance
Balance will be assessed by measuring the time, in seconds, that participants can stand on one leg. Longer standing times indicate better balance.
Measured: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Montreal Cognitive Assessment
Montreal Cognitive Assessment ranges from 0 to 30. Higher scores reflect better cognitive performances.
Measured: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted30 Oct 2026
- Study start1 Nov 2026 (estimated)
- Primary completion31 Aug 2029 (estimated)
- Study completion31 Aug 2029 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Parkinson DiseaseStudies of the same condition, open and under way.
- More trials run by National Yang Ming Chiao Tung UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 50 participants (estimated)
Sponsor and investigators
- Lead sponsor
- National Yang Ming Chiao Tung University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Yea-Ru Yang, National Yang Ming Chiao Tung University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07907718
- Sponsor's protocol ID
- NYCU114252AF2
- Status last verified
- Oct 2026
- First submitted
- 24 Oct 2026
- Last updated
- 30 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 30 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Cognitive-Motor Training on Cognitive Function and Gait Adaptability in People With Parkinson's Disease
- ClinicalTrials.gov ID
- NCT07907718
- Acronym / sponsor ID
- NYCU114252AF2
- Conditions
- Parkinson Disease
- Keywords
- Cognitive-motor training, Gait adaptability, Executive function, Electroencephalography
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 50 participants (estimated)
- Lead sponsor
- National Yang Ming Chiao Tung UniversityUniversity, hospital or other
- Study start
- 1 Nov 2026 (estimated)
- Primary completion
- 31 Aug 2029 (estimated)
- Study completion
- 31 Aug 2029 (estimated)
- First posted
- 30 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Cognitive-motor training combines thinking tasks with physical movements, encouraging participants to choose appropriate actions and adjust their movements according to different task demands. Training that involves stopping or changing a movement may help people with Parkinson's disease respond to changing situations. These abilities may also support walking in challenging environments, such as stepping over obstacles. However, the effects of this type of training on cognitive function, walking performance, and brain activity remain unclear. Therefore, this study aims to compare the effects of cognitive-motor co-dependent training with conventional exercise training on these outcomes in people with Parkinson's disease.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Cognitive-motor training group | Experimental | Other: Cognitive-motor trainingParticipants receive 16 sessions of cognitive-motor training. |
| Conventional exercise training group | Active comparator | Other: Conventional physiotherapyParticipants receive 16 sessions of conventional physiotherapy. |
Who may qualify
- Ages
- 18 to 80 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (7 listed)
- A clinical diagnosis of idiopathic Parkinson's disease
- Stable use of prescribed antiparkinsonian medication for at least two weeks
- Modified Hoehn and Yahr stage I to III
- Age between 18 and 80 years
- Ability to ambulate independently for at least 30 meters without assistive devices
Key exclusion criteria (3 listed)
- The presence of any neurological, musculoskeletal, or cardiovascular disorders that could affect participation in this study
- The presence of psychiatric disorders that could interfere with the ability to follow instructions or comply with study procedures
- A history of brain surgery, such as deep brain stimulation (DBS)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Cognitive-motor trainingCognitive-motor training is that cognitive tasks incorporated into motor tasks. | Other | Cognitive-motor training group |
| Conventional physiotherapyConventional physiotherapy includes ROM exercise, stretching, strengthening exercise, and eye-hand coordination. | Other | Conventional exercise training group |
Primary outcome
Gait speed
Time frame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Gait speed during obstacle crossing was measured using the GAITRite system. Continuous obstacle-crossing walking performance was assessed using the GaitUp system.
Step length
Time frame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Using GAITRite system to measure step length
Step width
Time frame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Using GAITRite system to measure step width
Single support time
Time frame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Using GAITRite system to measure single support time
Gait Variability
Time frame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Gait variability during continuous obstacle crossing will be assessed using the GaitUp system and expressed as the coefficient of variation (CV = standard deviation / mean × 100%) of step time and stride length.
Stride length
Time frame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Using the GaitUp system to measure stride length during continuous obstacle-crossing walking.
Swing phase
Time frame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Using the GaitUp system to measure swing phase during continuous obstacle-crossing walking.
Four Square Step Test
Time frame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
The Four Square Step Test is a test used to assess the ability to step over objects and measures the time in seconds to navigate all four squares.
Event-related potential - N2
Time frame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Measure event-related potential through electroencephalography during the Go/No-go test
Event-related potential - P300
Time frame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Measure event-related potential through electroencephalography during the Go/No-go test
Stroop color and word test
Time frame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Record numbers of corrected color words which the subject responds within 45 sec.
Trail making test
Time frame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Trail making test contain part A and part B. Faster completing the test indicates better executive function.
3 secondary outcomes
Part III of the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS)
Time frame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Single-Leg Standing Balance
Time frame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Montreal Cognitive Assessment
Time frame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Oct 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Cognitive-motor training and Conventional physiotherapy in people with Parkinson Disease, run by National Yang Ming Chiao Tung University at 1 site in Taiwan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 30 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Taiwan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Yea-Ru Yang, PhD (+886228267279, yryang@nycu.edu.tw), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Gait speed (time frame: Before and after 8 weeks of intervention, as well as 4 weeks after intervention). The study lists 12 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Oct 2026.