Menstrual CycleNCT07907471
Dynamic Knee Stability in Middle Aged Women Through Different Phases of Menstrual Cycle
An observational study of Menstrual Cycle, run by Cairo University at 1 site in Egypt.
Trial summary
The purpose of the study was to provide a data base about knee functional stability in normal adult female and to clarify the effect of monthly hormonal fluctuations during phases of normal female menstrual cycle on functional knee performance. Read more about this study
- Who is it for?
- Ages 18 to 30 years, women onlyHealthy volunteers can take part
- Conditions the study is for
- Menstrual Cycle
- How many people
- 30 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Jan 2026to 30 Jul 2026
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 30 years
- Women only
- Healthy volunteers accepted
- Adult
Study population: This study was conducted on thirty single adult female subjects within age between 18 and 30 years. Each individual was evaluated at three phases (phase I: follicular phase, phase II: ovulatory phase, and luteal phase) of normal female menstrual cycle and the parameters related to functional knee stability (Isokinetic hamstring quadriceps ratio (HQR) at angular velocity of 60°/sec , HQR at angular velocity of 180°/sec) of each phase was compared with the parameters of other two phases within the same subject.
Who may be able to join
- Adult females who met the following inclusion criteria were participated in the study:
- Normal (not suffering from any orthopedic, neurological, cardiopulmonary or gynecological disorders).
- Single.
- Aging between 18 and 30 years.
- 28-days menstrual cycle.
Who cannot join
- Subjects were excluded for any of the following reasons:
- Serious knee injury at the time of the testing.
- History of previous surgeries or traumas in lower limbs.
- Concurrent injuries in the lower limbs and trunk.
- Subjects with history of disturbed menstrual cycle or endocrinal deficits.
- Subjects taking drugs or medications that may affect normal female menstrual cycle or sex hormones.
Trial locations and contacts
1 site in 1 country.
About this study
The purpose of the study was to provide a data base about knee functional stability in normal adult female and to clarify the effect of monthly hormonal fluctuations during phases of normal female menstrual cycle on functional knee performance.
Read the detailed description
The significance of the study was based on the concept of "prevention is better than cure" especially in sports field. Trying to reduce the rate of ACL injuries in susceptible groups is surely one of the most worthwhile enterprises taken on by the health care community.
Because the menstrual cycle with its monthly hormonal fluctuations is one of the most basic differences between men and women, the association between the incidence of anterior cruciate ligament tears and menstrual cycle phases was investigated. Estrogen has been implicated as a potential risk factor for injury. The discovery of estrogen and progesterone receptors in the human ACL has further fueled interest in the role of hormonal risk factors.
- Conditions
- Menstrual Cycle
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Other
| Study group | Role | What they receive |
|---|---|---|
| Adult athletic female group | This study was conducted on thirty single adult female subjects within age between 18 and 30 years. Each individual was evaluated at three phases (phase I: follicular phase, phase II: ovulatory phase, and luteal phase) of normal female menstrual cycle and the parameters related to functional knee stability (Isokinetic hamstring quadriceps ratio (HQR) at angular velocity of 60°/sec , HQR at angular velocity of 180°/sec) of each phase was compared with the parameters of other two phases within the same subject. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Isokinetic hamstring quadriceps ratio (HQR) at angular velocity 60°/sec
The Biodex Isokinetic System 3 had been used to assess the isokinetic HQR. HQR was measured at two angular velocities: 60°/sec. The selected mode used to examine HQR was Hamstring (eccentric) to Quadriceps (concentric) with extension/flexion pattern of movement. The test was repeated at different menstrual cycles : early follicular phase (first 5 days of the menstrual cycle), ovulation days (13th, 14th, and 15th days), and mid-luteal phase (days from 20th to 25th) of a 28-days normal menstrual cycle.
Measured: 3 consecutive menstrual cycles
Isokinetic hamstring quadriceps ratio (HQR) at angular velocity 180°/sec
The Biodex Isokinetic System 3 had been used to assess the isokinetic HQR. HQR was measured at two angular velocities:180°/sec. The selected mode used to examine HQR was Hamstring (eccentric) to Quadriceps (concentric) with extension/flexion pattern of movement. The test was repeated at different menstrual cycles: early follicular phase (first 5 days of the menstrual cycle), ovulation days (13th, 14th, and 15th days), and mid-luteal phase (days from 20th to 25th) of a 28-days normal menstrual cycle.
Measured: 3 consecutive menstrual cycles
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted30 Oct 2026
- Study start1 Jan 2026
- Primary completion15 Jul 2026
- Study completion30 Jul 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Menstrual CycleStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Retrospective
- Enrolment
- 30 participants (actual)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Mohamed Abdelmoneim Saeed, Cairo University
- Investigators
- Marwa A Mohamed, Professor, Study director, Cairo UniversityKhadega S AbdulAziz, Professor, Study chair, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07907471
- Sponsor's protocol ID
- P.T.REC/012/006712
- Status last verified
- Oct 2026
- First submitted
- 25 Oct 2026
- Last updated
- 30 Oct 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 30 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Dynamic Knee Stability in Middle Aged Women Through Different Phases of Menstrual Cycle
- ClinicalTrials.gov ID
- NCT07907471
- Acronym / sponsor ID
- P.T.REC/012/006712
- Conditions
- Menstrual Cycle
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 30 participants (actual)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 1 Jan 2026 (actual)
- Primary completion
- 15 Jul 2026 (actual)
- Study completion
- 30 Jul 2026 (actual)
- First posted
- 30 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of the study was to provide a data base about knee functional stability in normal adult female and to clarify the effect of monthly hormonal fluctuations during phases of normal female menstrual cycle on functional knee performance.
Detailed description
The significance of the study was based on the concept of "prevention is better than cure" especially in sports field. Trying to reduce the rate of ACL injuries in susceptible groups is surely one of the most worthwhile enterprises taken on by the health care community.
Because the menstrual cycle with its monthly hormonal fluctuations is one of the most basic differences between men and women, the association between the incidence of anterior cruciate ligament tears and menstrual cycle phases was investigated. Estrogen has been implicated as a potential risk factor for injury. The discovery of estrogen and progesterone receptors in the human ACL has further fueled interest in the role of hormonal risk factors.
Study design
- Observational model
- Other
- Time perspective
- Retrospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Adult athletic female group | – | –This study was conducted on thirty single adult female subjects within age between 18 and 30 years. Each individual was evaluated at three phases (phase I: follicular phase, phase II: ovulatory phase, and luteal phase) of normal female menstrual cycle and the parameters related to functional knee stability (Isokinetic hamstring quadriceps ratio (HQR) at angular velocity of 60°/sec , HQR at angular velocity of 180°/sec) of each phase was compared with the parameters of other two phases within the same subject. |
Who may qualify
- Ages
- 18 to 30 years
- Sex
- Female only
- Healthy volunteers
- Accepted
- Age groups
- Adult
- Study population
- This study was conducted on thirty single adult female subjects within age between 18 and 30 years. Each individual was evaluated at three phases (phase I: follicular phase, phase II: ovulatory phase, and luteal phase) of normal female menstrual cycle and the parameters related to functional knee stability (Isokinetic hamstring quadriceps ratio (HQR) at angular velocity of 60°/sec , HQR at angular velocity of 180°/sec) of each phase was compared with the parameters of other two phases within the same subject.
Key inclusion criteria (5 listed)
- Adult females who met the following inclusion criteria were participated in the study:
- Normal (not suffering from any orthopedic, neurological, cardiopulmonary or gynecological disorders).
- Single.
- Aging between 18 and 30 years.
- 28-days menstrual cycle.
Key exclusion criteria (6 listed)
- Subjects were excluded for any of the following reasons:
- Serious knee injury at the time of the testing.
- History of previous surgeries or traumas in lower limbs.
- Concurrent injuries in the lower limbs and trunk.
- Subjects with history of disturbed menstrual cycle or endocrinal deficits.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Other | Adult athletic female group |
Primary outcome
Isokinetic hamstring quadriceps ratio (HQR) at angular velocity 60°/sec
Time frame: 3 consecutive menstrual cycles
The Biodex Isokinetic System 3 had been used to assess the isokinetic HQR. HQR was measured at two angular velocities: 60°/sec. The selected mode used to examine HQR was Hamstring (eccentric) to Quadriceps (concentric) with extension/flexion pattern of movement. The test was repeated at different menstrual cycles : early follicular phase (first 5 days of the menstrual cycle), ovulation days (13th, 14th, and 15th days), and mid-luteal phase (days from 20th to 25th) of a 28-days normal menstrual cycle.
Isokinetic hamstring quadriceps ratio (HQR) at angular velocity 180°/sec
Time frame: 3 consecutive menstrual cycles
The Biodex Isokinetic System 3 had been used to assess the isokinetic HQR. HQR was measured at two angular velocities:180°/sec. The selected mode used to examine HQR was Hamstring (eccentric) to Quadriceps (concentric) with extension/flexion pattern of movement. The test was repeated at different menstrual cycles: early follicular phase (first 5 days of the menstrual cycle), ovulation days (13th, 14th, and 15th days), and mid-luteal phase (days from 20th to 25th) of a 28-days normal menstrual cycle.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Oct 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Marwa A Mohamed, Professor study director
Cairo University
Khadega S AbdulAziz, Professor study chair
Cairo University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Menstrual Cycle, run by Cairo University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 30 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Isokinetic hamstring quadriceps ratio (HQR) at angular velocity 60°/sec (time frame: 3 consecutive menstrual cycles). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Oct 2026; AzTrials last refreshed its copy on 1 Nov 2026.