AzTrials
AzTrials

ObesityPhase 3ENLIGHTEN-10NCT07900633

A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight, Type 2 Diabetes, and Increased Cardiovascular Risk

A Phase 3 study testing Eloralintide in people with Obesity and Overweight, run by Eli Lilly and Company at 309 sites in 21 countries.

Not yet recruiting

Opening soon. The study is approved but enrolment has not started yet. Sites may already take enquiries.

Sites and contacts
Official record
Search all trials

Trial summary

The main purpose of this study is to evaluate the efficacy and safety of eloralintide compared with a placebo in participants with obesity or overweight, type 2 diabetes, and increased cardiovascular risk. Read more about this study

Who is it for?
Ages 45 years and older
Conditions the study is for
Obesity, Overweight, Cardiovascular Diseases
What is being tested?
Eloralintide
Type of treatment
Injection or infusion
Could I receive a placebo?
Yes, some participants may receive a placebo
How many people
3,000 participants
Where
309 sitesin 21 countries
Study dates
Dec 2026to Dec 2029
Phase
Phase 3
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 45 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Have type 2 diabetes
  • Have a HbA1c value between ≥ 6.5% and ≤ 9.5% at screening
  • Are on stable treatment with an unchanged dose of at least 1 and no more than 4 antihyperglycemic therapies for at least 90 days before screening
  • Have an increased risk of cardiovascular events
  • Have a BMI ≥ 25.0 kg/m2 at screening
  • Have a stable body weight (<5% body weight change) for 90 days prior to screening
  • Have a history of at least one self-reported unsuccessful dietary effort to reduce body weight

Who cannot join

  • Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed >1 year before screening)
  • Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening)
  • Have type 1 diabetes
  • Have a history or diagnosis of New York Heart Association Functional Classification IV congestive heart failure
  • Have had within 60 days prior to screening:
  • acute myocardial infarction
Show all 10Show fewer
  • stroke
  • hospitalization for congestive heart failure, or
  • coronary, peripheral, or carotid artery revascularization procedure
  • Have received treatment combining sulfonylurea and insulin within 90 days prior to screening

Trial locations and contacts

309 sites in 21 countries. Contact the study team or a site near you to ask about taking part.

Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or contact

317-615-4559

LillyTrials@Lilly.com

Physicians interested in becoming principal investigators please contact contact

clinical_inquiry_hub@lilly.com

309 sites in 21 countries

United States70 sites

  • Omega Research Orlando

    Altamonte Springs, Florida, 32714

    386-668-4202

    Kwabena Ayesu

  • Amarillo Medical Specialists

    Amarillo, Texas, 79124

    806-358-8331

    William Biggs

  • Smiths Medical Center

    Apache Junction, Arizona, 85120

    404-585-8358

    Paul Olorunfemi

  • Virginia Nephrology Group

    Arlington, Virginia, 22205

    Renuka Sothinathan

  • Care Access - Arlington 2

    Arlington, Virginia, 22206

    877-791-0656

    Chih Chao Yang

  • Care Access - Arlington Heights

    Arlington Heights, Illinois, 60005

    877-791-0656

    Peta-Gay Jackson Booth

  • Southeastern Clinical Research Institute

    Augusta, Georgia, 30904

    7069223005

    Matthew Diamond

  • Care Access - Baltimore

    Baltimore, Maryland, 21213

    877-791-0656

    Peta-Gay Jackson Booth

  • Ascension Saint Agnes Heart Care

    Baltimore, Maryland, 21229

    443-798-2670

    Jeffrey Cole

  • Central Research Associates

    Birmingham, Alabama, 35205

    2053271077

    David Pendley

  • University of Alabama - Department of Nutrition Sciences

    Birmingham, Alabama, 35294

    205-996-4733

    William Garvey

  • Care Access - Brandon

    Brandon, Florida, 33510

    813-582-7224

    Parenkumar Patel

  • Kidney and Hypertension Center

    Cincinnati, Ohio, 45212

    513-861-0800

    James Davis

  • The Corvallis Clinic, P.C.

    Corvallis, Oregon, 97330

    Daniel Barrett

  • Valley Clinical Trials, Inc.

    Covina, California, 91723

    310-309-9491

    Linda Glaser

  • American Research Institute

    Cutler Bay, Florida, 33157

    Manuel Garcia Estrada

  • Renal Disease Research Institute

    Dallas, Texas, 75246

    2143666125

    Bernard Fischbach

  • Nephrology Associates - East Providence

    East Providence, Rhode Island, 02914

    401-438-5950

    Michael Thursby

  • Headlands Research-El Paso

    El Paso, Texas, 79902

    (915) 910 7088

    Ryan Casey

  • Neighborhood Healthcare Institute of Health

    Escondido, California, 92025

    7607376984

    Cheryl Thompson

  • Clinical Renal Associates, Ltd.

    Exton, Pennsylvania, 19341

    6108728501

    Chike Okechukwu

  • Fleming Island Center for Clinical Research

    Fleming Island, Florida, 32003

    9046210390

    Jennifer Sidey

  • Valley Institute of Research - Fort Worth

    Fort Worth, Texas, 76164

    8176257733

    Alex Guevara

  • American Health Network of Indiana, LLC - Franklin

    Franklin, Indiana, 46131

    317-718-5479

    George Cornett

  • Prime Medical Group, LLC dba Gilbert Center for Family Medicine, LLC

    Gilbert, Arizona, 85296

    480-691-2213

    Sunildat Maheshwari

  • American Health Network of Indiana, LLC - Greenfield

    Greenfield, Indiana, 46140

    (317)462-1825

    Andrew Daluga

  • East-West Medical Research Institute

    Honolulu, Hawaii, 96814

    8085316886

    Cindy Pau

  • Biopharma Informatic, LLC

    Houston, Texas, 77043

    (281) 944-3610

    Syed Humayun Naqvi, MD

  • Research Physicians Network, LLC

    Houston, Texas, 77089

    2819443610

    Amir Hassan

  • Quality First Family Health/SKYCRNG

    Humble, Texas, 77396

    2818354449

    Eli Newsome

  • Nephrology Consultants

    Huntsville, Alabama, 35805

    2565334626

    Michael Quadrini

  • Northeast Research Institute - Downtown Office

    Jacksonville, Florida, 32204

    904-541-8225

    David Sutton

  • First Valley Medical Group

    Lancaster, California, 93534

    661-948-6011

    Kanagaratnam Sivalingam

  • DaVita Clinical Research - Las Vegas

    Las Vegas, Nevada, 89107

    7028771887

    MARK VISHNEPOLSKY

  • Excel Clinical Research, LLC

    Las Vegas, Nevada, 89109

    7026801500

    Robby Quintos

  • Lakeview Institute of Clinical Research

    Leesburg, Florida, 34748

    352-782-0606

    Khai Chang

  • Ark Clinical Research

    Long Beach, California, 90815

    5629971000

    Apinya Vutikullird

  • DCOL Center for Clinical Research

    Longview, Texas, 75605

    903-238-8854

    Kathleen Harris

  • Biopharma Informatic, LLC

    McAllen, Texas, 78503

    2819443610

    Gloria Ortiz, MD

  • Revival Research Institute, LLC

    McKinney, Texas, 75071

    Syed Saghir

  • Clinical Renal Associates Ltd.

    Media, Pennsylvania, 19063

    610-872-8501

    Heather Mascio

  • Millennium Medical Research - Miami

    Miami, Florida, 33126

    7869538858

    Aurelio Ortiz

  • Onhealth Research Center

    Miami, Florida, 33186

    Jimena Blandon

  • West Clinical Research

    Morehead City, North Carolina, 28557

    2525150050

    Patrick Morgante

  • Southern Nh Diabetes and Endocrinology

    Nashua, New Hampshire, 03063

    603-577-7574

    John Poremba

  • Lucida Clinical Trials

    New Bedford, Massachusetts, 02740

    508-720-2015

    David Shih

  • York Clinical Research

    Norfolk, Virginia, 23504

    757-373-8478

    Charles Lovell

  • Valley Clinical Trials, LLC dba Flourish Research

    Northridge, California, 91325

    818-280-4220

    Christopher Chow

  • Advanced Research Institute

    Ogden, Utah, 84405

    801-409-2040

    Michael Woolman

  • FOMAT Medical Research

    Oxnard, California, 93030

    805-483-1185

    Augusto Focil

  • Renal Specialists of Houston

    Pasadena, Texas, 77504

    713-947-9507

    Vijay Koka

  • Center for Diabetes, Obesity, and Metabolism

    Pembroke Pines, Florida, 33024

    754-888-9122

    Rodolfo Galindo

  • Elite Clinical Studies, LLC

    Phoenix, Arizona, 85018

    602-788-3437

    Joseph Lillo, DO

  • Peace River Cardiovascular Center

    Port Charlotte, Florida, 33952

    941-629-5356

    David Hotchkiss

  • Eastside Research Associates

    Redmond, Washington, 98052

    (425) 869-6828

    Christopher Price

  • Dominion Medical Associates, Inc.

    Richmond, Virginia, 23219

    8042492111

    Richard Jackson

  • SKY Integrative Medical Center/SKYCRNG

    Ridgeland, Mississippi, 39157

    601-567-1321

    Bob Hutchins

  • Rochester Clinical Research, LLC

    Rochester, New York, 14609

    585-288-0890

    Patrick Connors

  • Lake Michigan Nephrology

    Saint Joseph, Michigan, 49085

    269-428-0819

    Oliver Songlingco

  • Clinical Advancement Center

    San Antonio, Texas, 78212

    210-223-4444

    Pablo Pergola

  • Acclaim Clinical Research

    San Diego, California, 92120

    (858) 299-0009

    Mitch Biermann

  • Care Access - Santa Clarita

    Santa Clarita, California, 91321

    661-371-7272

    Sina Tebi

  • Revive Research Institute, Inc.

    Southfield, Michigan, 48075

    248-829-3103

    Syed Raza

  • Clinvest Headlands Llc

    Springfield, Missouri, 65807

    4178837889

    Cory Bethmann

  • Southwest Kidney Institute - Surprise

    Surprise, Arizona, 85374

    (480) 610-6100

    Minesh Rajpal

  • Healthcare Research Network - Chicago

    Tinley Park, Illinois, 60477

    7083382245

    Ronald Stumbris

  • Chase Medical Research, LLC

    Waterbury, Connecticut, 06708

    2034194420

    Joseph Soufer

  • Millennium Clinical Trials

    Westlake Village, California, 91361

    805-496-3322

    Razmig Krumian

  • Trial Management Associates - Wilmington - Floral Parkway

    Wilmington, North Carolina, 28403

    William Jones

  • Medrasa Clinical Research

    Wylie, Texas, 75098

    469-449-3645

    Tanvir Ahmad

Other trials in United States

Argentina23 sites

  • CIPREC

    Buenos Aires, 1061

    5491144074402

    Cesar Zaidman

  • CARDIAMET Investigaciones Médicas

    Buenos Aires, C1014ACP

    5491165496764

    Angela Romero Zarante

  • Investigaciones Medicas Imoba Srl

    Buenos Aires, C1056ABH

    541160884234

    Silvia Orio

  • Centro de Investigaciones Metabólicas (CINME)

    Buenos Aires, C1056ABI

    08003450697

    Federico Perez Manghi

  • Centro Médico Viamonte

    Buenos Aires, C1120AAC

    54 1149635650

    Diego Aizenberg

  • Mautalen Salud e Investigación

    Buenos Aires, C1128AAF

    541145143400

    Jose Fretes

  • Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada

    Buenos Aires, C1425AGC

    1159054134

    Mariana Scandizzo

  • Fundación Respirar

    Buenos Aires, C1426ABP

    Maria Nemesio

  • CEDIC

    CABA, C1060ABN

    541148236838

    Cecilia Igarzabal

  • Centro Diabetológico Dr. Waitman

    Córdoba, 5000

    54 9 351 4245162

    Silvana Ernestina Solis

  • Instituto de Investigaciones Clínicas Córdoba

    Córdoba, X5000AAW

    543514253456

    Ines Bartolacci

  • Centro de Investigaciones Clínicas Baigorria

    Granadero Baigorria, 2152

    5493412106243

    Juan Dominguez

  • CIMeL

    Lanus, B1824KAJ

    541142493412

    Mariano Chahin

  • Centro de Investigaciones Médicas Mar del Plata

    Mar del Plata, 7600

    542234917628

    Andres Alvarisqueta

  • Instituto de Investigaciones Clínicas Mar del Plata

    Mar del Plata, B7600FZO

    54 223 496 3224

    Virginia Sernia

  • DIM Clínica Privada

    Ramos Mejía, B1704ETD

    54011 46562828

    Oscar Montaña

  • INECO Neurociencias Oroño

    Rosario, 2000

    (0341) 425 8695

    María Cappiello

  • Instituto Médico Catamarca IMEC

    Rosario, 2000

    3416176661

    Natacha Maldonado

  • Instituto Médico Fundación Grupo Colaborativo Rosario Investigación y Prevención Medica

    Rosario, 2000

    543416928531

    Horacio Sessa

  • Instituto de Investigaciones Clinicas Rosario

    Rosario, S2000CVD

    5493415109204

    Carolina Chacón

  • Centro Médico Respire

    San Fernando, 1646

    54 9 11 47448707

    Pablo Sorensen

  • Go Centro Medico San Nicolás

    San Nicolás, 2900

    5493364571637

    Paulina Lanchiotti

  • Centro de Investigaciones Clinicas del Litoral

    Santa Fe, S3000FWO

    5403424562779

    Miguel Hominal

Other trials in Argentina

China21 sites

  • Xuanwu Hospital Capital Medical University

    Beijing, 100053

    Yu Sun

  • Peking University Third Hospital

    Beijing, 100091

    13810103532

    Dan Zhu

  • Sichuan Provincial People's Hospital

    Chengdu, 610072

    Limin Tian

  • West China Hospital, Sichuan University

    Chengdu, 610041

    Fang Liu

  • Zhujiang Hospital

    Guangzhou, 510280

    Haibo Long

  • The Second Affiliated Hospital of Zhejiang University School of Medicine - Jiefanglu Campus

    Hangzhou, 310009

    Xiaojie Xie

  • The First Hospital of Harbin Medical University

    Harbin, 150001

    Yue Li

  • Jinan Central Hospital

    Jinan, 250013

    Nianrong Mi

  • Panjin Liaoyou Baoshihua Hospital

    Liaoyou, 124009

    Ju Gao

  • The First Affiliated Hospital of Henan University of Science &Technology

    Luoyang Shi, 471003

    13653880139

    Hongwei Jiang

  • Nanjing First Hospital

    Nanjing, 210006

    Qian Li

  • Zhongda Hospital Southeast University

    Nanjing, 210009

    Ling Li

  • Shanghai Putuo District Center Hospital

    Shanghai, 200062

    Zongjun Liu

  • Jiading District Central Hospital

    Shanghai, 201800

    Lixia Suo

  • The Third Hospital of Hebei Medical University

    Shijiazhuang, 050051

    Yanqing Chi

  • Hebei General Hospital

    Shijiazhuang, 500051

    Luping Ren

  • Tianjin Medical University General Hospital

    Tianjin, 300052

    18322017516

    Ming Liu

  • The 2nd Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University

    Wenzhou, 315100

    13806542929

    Chaoming Wu

  • The Affiliated Hospital of Xuzhou Medical College

    Xuzhou, 221006

    Hong Zhu

  • The Second People's Hospital of Yibin

    Yibin, 644000

    Chenli Zhang

  • Zigong First People's Hospital

    Zigong, 643000

    Jian Li

Other trials in China

Italy17 sites

  • Azienda USL 8 di Arezzo

    Arezzo, 52100

    Alessia Scatena

  • Ospedale di Baggiovara

    Baggiovara, 41126

    0593962453

    Vincenzo Rochira

  • IRCCS - AOU di Bologna

    Bologna, 40138

    39 0512144190

    Uberto Pagotto

  • Osepdale Civile Fr 5

    Ceccano, 03023

    +39 06225419151

    Nicola Napoli

  • Università degli Studi Gabriele D' Annunzio

    Chieti, 66100

    0871541322

    Francesca Santilli

  • Azienda Ospedaliera Universitaria Careggi

    Florence, 50134

    055 7946514

    Edoardo Mannucci

  • Ospedale San Raffaele

    Milan, 20132

    0226432819

    Emanuela Setola

  • University of Naples Federico II

    Naples, 80131

    Antonio Cittadini

  • Azienda Ospedale - Università Padova

    Padova, 35128

    GianPaolo Fadini

  • A.O.U. Policlinico Paolo Giaccone

    Palermo, 90127

    39 091 6552251

    Silvio Buscemi

  • Azienda Ospedaliero Universitaria di Parma

    Parma, 43126

    Alessandra Dei Cas

  • Azienda Ospedaliera Universitaria Pisana

    Pisa, 56124

    39050995001

    Ferruccio Santini

  • IRCCS San Raffaele Roma

    Roma, 00166

    Massimiliano Caprio

  • Azienda Ospedaliera Sant'Andrea

    Roma, 00189

    Giorgio Sesti

  • IRCCS Istituto Clinico Humanitas

    Rozzano, 20089

    +390282247222

    Marco Mirani

  • Ospedale Le Scotte

    Siena, 53100

    00390577585406

    Maria Grazia Castagna

  • ASL Città di Torino

    Torino, 10122

    Salvatore Oleandri

Other trials in Italy

Brazil15 sites

  • Centro de Pesquisa Clinica do Coracao

    Aracaju, 49055-530

    557999987-0794

    FÁBIO SILVEIRA

  • Centro de Pesquisa Clinica do Brasil

    Brasília, 71625-175

    556133643364

    Joao Lindolfo Borges

  • Centro de Pesquisa Sao Lucas

    Campinas, 13060-803

    55 19 3343-8688

    Danilo Villagelin Neto

  • Quanta Diagnóstico e Terapia

    Curitiba, 80045170

    5541999736442

    Rosangela Rea

  • Instituto de Ensino e Pesquisa Clinica do Ceara

    Fortaleza, 60125058

    00558532579646

    Maria Cerqueira

  • Private Practice - Dr.Miguel N. Hissa

    Fortaleza, 60430-350

    55 85 3214.6530

    Miguel Hissa

  • Núcleo de Pesquisa Clínica do Rio Grande do Sul

    Porto Alegre, 90430-001

    555137796400

    Luis Henrique Canani

  • Hospital Moinhos de Vento

    Porto Alegre, 90560032

    55 (51) 3537-8258

    Tiago Schuch

  • Rede AME SAÚDE

    Recife, 50720-110

    Audes Feitosa

  • IBPClin - Instituto Brasil de Pesquisa Clínica

    Rio de Janeiro, 20241-180

    552125277979

    Renata Alexandra Pinheiro

  • Instituto de Pesquisa Clinica

    São Paulo, 01223-001

    Christiani Poço

  • CPHosp Medicina, Ensino e Pesquisa (CPQuali)

    São Paulo, 01228-000

    55 11 2776-6801

    Gustavo Augusto

  • CPCLIN

    São Paulo, 01228-200

    551126303777

    Denise Franco

  • CEPIC - Centro Paulista de Investigação Clínica

    São Paulo, 04266-010

    551122713450

    Breno Balabem Alves

  • CEDOES

    Vitória, 29055450

    552721250202

    Rachel Armani

Other trials in Brazil

Mexico15 sites

  • Centro de Atencion al Diabetico Actopan

    Actopan, 42500

    Patricia Nuriulu Escobar

  • Investigación Clínica Cuernavaca, S.C.

    Cuernavaca, 62448

    +527772024934

    Ivan Lopez Paz

  • Centro Para El Desarrollo de La Medicina Y de Asistencia Medica Especializada S.C.

    Culiacán, 80230

    Ricardo Borrego Montoya

  • Lahoja. Asociacion Para La Investigacion Y La Farmacovigilancia

    Durango, 34000

    +52 6188114091

    Juan Núñez Fragoso

  • Diseno y Planeacion en Investigacion Medica - Guadalajara - Calle Amado Nervo

    Guadalajara, 44600

    5233305493

    Cesar Calvo Vargas

  • Instituto Cardiovascular de León S.C.

    León, 37530

    52 477 2582008

    Luis Venegas Carrillo

  • Instituto Nacional de Cardiologia Ignacio Chavez

    México, 14080

    52 55 35661465

    Jose Lopez Gil

  • Centro de Investigación Clinica Chapultepec

    Mexico City, 04100

    5560660026

    Jose Gotes Palazuelos

  • Gastrobariátrica Santa Fe

    Mexico City, 05348

    Juan Mauricio Vera Zertuche

  • Centro Especializado En Diabetes, Obesidad Y Prevencion De Enfermedades Cardiovasculares

    Mexico City, 11650

    52 5585340943

    Melchor Alpizar Salazar

  • Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran

    Mexico City, 14080

    +525579597066

    Ricardo Correa-Rotter

  • Servicios de Oncologia Medica Integral, S.A. de C.V. Sucursal Renal

    Monterrey, 64060

    Jesus Villarreal

  • UBAM Unidad Biomedica Avanzada Monterrey

    Monterrey, 64460

    8113578896

    Raymundo García Reza

  • Centro de investigación y control metabólico

    Monterrey, 66465

    81 83488973

    Víctor Castelán Vargas

  • Centro de Estudios Clínicos de Querétaro (CECLIQ)

    Querétaro, 76000

    4422153067

    Marco Alcocer Gamba

Other trials in Mexico

South Korea15 sites

  • The Catholic University of Korea, Bucheon St. Mary's Hospital

    Bucheon-si, 14647

    Jang Won Son

  • Kosin University Gospel Hospital

    Busan, 49267

    Bukyung Kim

  • Hanyang University Guri Hospital

    Guri-si, 11923

    Chang Beom Lee

  • Chosun University Hospital

    Gwangju, 61453

    Sang Yong Kim

  • Yeungnam Univeristy Medical Center

    Gyeongsan-si, 42415

    82-10-9370-3846

    KYUCHANG WON

  • Inha University Hospital

    Incheon, 22332

    So Hun Kim

  • Konyang University Hospital

    Seogu, 35365

    Geun Yong Park

  • Seoul National University Bundang Hospital

    Seongnam, 13620

    Soo Lim

  • Nowon Eulji Medical Center, Eulji University

    Seoul, 01830

    1093908214

    kyungwan Min

  • Korea University Anam Hospital

    Seoul, 02841

    Sin Gon Kim

  • Severance Hospital, Yonsei University Health System

    Seoul, 03722

    Byung Wan Lee

  • Asan Medical Center

    Seoul, 05505

    Se Hee Min

  • The Catholic Univ. of Korea Seoul St. Mary's Hospital

    Seoul, 06591

    Eun Young Lee

  • Ulsan University Hospital

    Ulsan, 44033

    01032352748

    ILSEONG NAMGOONG

  • Yonsei University-Wonju Severance Christian Hospital

    Wŏnju, 26426

    033-741-1248

    Choon Hee Chung

Other trials in South Korea

Spain14 sites

  • CHUAC-Complejo Hospitalario Universitario A Coruña

    A Coruña, 15006

    655624017

    Alfonso Soto Gonzalez

  • Hospital Universitario de La Ribera

    Alzira, 46600

    34657845358

    carmen fajardo

  • Complejo Hospitalario Universitario de Ferrol (CHUF)- Hospital Naval

    Ferrol, 15405

    34981454513

    DIEGO BELLIDO GUERRERO

  • Hospital Vithas La Salud

    Granada, 18008

    658011529

    Cristobal Morales Portillo

  • Hospital Ribera Polusa

    Lugo, 27004

    982 22 28 54

    Secundino Cigarran

  • Hospital Universitario La Paz

    Madrid, 28046

    + 34 699924659

    ALMUDENA CASTRO

  • Hospital Universitario Puerta de Hierro Majadahonda

    Majadahonda, 28222

    911916000

    Maria Marques Vidas

  • Hospital Universitari Son Espases

    Palma, 07120

    34 871 205256

    Santiago Tofe Povedano

  • Hospital Universitario Quironsalud Madrid

    Pozuelo de Alarcón, 28223

    34914522000

    Esteban Jodar Gimeno

  • Hospital Universitario Marqués de Valdecilla

    Santander, 39008

    34639659866

    Luis Vazquez Salvi

  • Clínica nuevas Tecnologías en Diabetes y Endocrinología (NTDE)

    Seville, 41003

    + 34 954709183

    Alberto Aliaga Verdugo

  • Hospital Universitario Virgen Del Rocio

    Seville, 41013

    955012000

    Virginia Bellido

  • Vithas Hospital Sevilla

    Seville, 41950

    658011529

    Cristobal Morales Portillo

  • Hospital Clinico de Valencia

    Valencia, 46010

    Jose Gorriz

Other trials in Spain

France12 sites

  • Centre Hospitalier Sud Francilien

    Corbeil-Essonnes, 91106

    Coralie AMADOU

  • Chu Grenoble Alpes

    La Tronche, 38700

    0476765517

    Pierre-Louis Carron

  • Centre Hospitalier Louis Pasteur

    Le Coudray, 28630

    0237334299

    Mariana Barbat

  • Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu

    Nantes, 44093 Cedex 1

    Simon VILLE

  • Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes

    Nantes, 44093

    33 2 53 48 27 01

    david jacobi

  • Hôpital Européen Georges Pompidou

    Paris, 75015

    3356095517

    Sebastien CZERNICHOW

  • Hôpital Bichat - Claude-Bernard

    Paris, 75018

    +33140258880

    louis potier

  • Centre Hospitalier Lyon Sud

    Pierre-Bénite, 69494 Cédex

    33 4 78 86 14 87

    Emmanuel DISSE

  • Centre Hospitalier Universitaire de Poitiers

    Poitiers, 86021

    Claire BOULETI

  • CHU Charles Nicolle

    Rouen, 76031

    Eric Durand

  • CHU Rangueil

    Toulouse, 31059

    33 5 61 32 30 18

    Pierre Gourdy

  • Groupe Hospitalier Mutualiste Les Portes du Sud

    Vénissieux, 69200

    33607527530

    Chantal Bully

Other trials in France

Germany12 sites

  • FutureMeds Berlin

    Berlin, 10629

    +49 30 439741 239

    Peter Hahn

  • Private Practice - Dr. Andrea Rinke

    Bochum, 44789

    004923460144350

    Andrea Rinke

  • ZKS Suedbrandenburg

    Elsterwerda, 04910

    49-3533-489721

    Andreas Hagenow

  • ClinPhenomics CVC GmbH

    Frankfurt, 60596

    06957702866

    Martin Duersch

  • UKSH Campus Lübeck, Med. 1 - AG Meyhöfer

    Lübeck, 23562

    49451 50075673

    Svenja Meyhöfer

  • CRS Clinical Research Services Mannheim

    Mannheim, 68167

    004962115045279

    Thomas Forst

  • FutureMeds Offenbach

    Offenbach, 63065

    0049 69 247433849

    Christel Contzen

  • RED-Institut GmbH

    Oldenburg, 23758

    0049436150630128

    Thomas Schaum

  • Ceda-Research

    Pohlheim, 35415

    01722074613

    Joachim van Gellecom

  • Marienhospital Stuttgart

    Stuttgart, 70199

    0049711-6489-2102

    Monika Kellerer

  • Nephrologisches Zentrum Villingen-Schwenningen

    Villingen-Schwenningen, 78052

    0049772199850

    Martina Guthoff

  • Medislim GmbH

    Weinheim, 69469

    0049620112080

    Beate Moeckesch

Other trials in Germany

Turkey (Türkiye)12 sites

  • Çukurova Üniversitesi Tıp Fakültesi Adana Hastanesi

    Adana, 01330

    05327656585

    Bekir Tamer Tetiker

  • Ankara Etlik City Hospital

    Ankara, 06170

    905320521426

    Hakan Gullu

  • Ankara Bilkent Şehir Hastanesi

    Ankara, 06800

    Ihsan ATES

  • Hacettepe Universite Hastaneleri

    Ankara

    0905333272917

    MUSTAFA ARICI

  • Akdeniz Universitesi Hastanesi

    Antalya, 07070

    90 5337670913

    Ramazan Sari

  • Dicle Üniversitesi

    Diyarbakır, 21100

    05523163206

    ALPASLAN TUZCU

  • Eskisehir Osmangazi University

    Eskişehir, 26480

    Yuksel Cavusoglu

  • Istanbul University Cerrahpasa Medical School Internal Diseases Institute

    Istanbul, 34098

    Nurhan Seyahi

  • Erciyes Universitesi Tıp Fakultesi Hastaneleri

    Kayseri, 380380

    90 530 346 22 10

    Ismail Kocyigit

  • Kocaeli Üniversitesi

    Kocaeli, 41380

    905554512188

    Tayfun Sahin

  • Kocaeli Üniversitesi

    Kocaeli, 41380

    05076771924

    Necmi Eren

  • Baskent University Dr. Turgut Noyan Research and Training Center

    Yüreğir, 01250

    0905333208241

    Okan Bakiner

Other trials in Turkey (Türkiye)

Australia11 sites

  • Nightingale Research

    Adelaide, 5000

    Andrew Hamilton

  • Box Hill Hospital

    Box Hill, 3128

    0390926753

    Rosemary Wong

  • Royal Brisbane and Women's Hospital

    Brisbane, 4029

    +61736468111

    Donald McLeod

  • Nightingale Research - Frankston

    Frankston, 3199

    Olivier van den Brink

  • Canberra Hospital

    Garran, 2605

    0251242821

    Richard Singer

  • Ipswich Hospital

    Ipswich, 4305

    0402112100

    Thomas Dover

  • Life Clinical Research

    Ipswich, 4305

    Andrew McCann

  • Momentum Sunshine

    Melbourne, 3021

    0395096166

    King Cheung

  • Paratus Clinical Research - Melbourne

    Melbourne, 3070

    Kianoosh Noori Samie

  • Royal North Shore Hospital

    St Leonards, 2065

    Sarah Glastras

  • Innovate Clinical Research

    Waitara, 2077

    Rachel Graham

Other trials in Australia

Canada11 sites

  • Centricity Research Brampton Endocrinology

    Brampton, L6S 0C6

    905 595 0560

    Harpreet Bajaj

  • Well Health Diagnostic Center- Brampton Center

    Brampton, L6W 2X7

    2894046123

    Ursula Jurt

  • C-health Research

    Calgary, T2V 4J2

    Shaheed Sorathia

  • NSHA-QEII Health Sciences Centre-Dickson Bldg

    Halifax, B3H 1V7

    9024733106

    Thomas Ransom

  • Kelowna Health and Memory Centre

    Kelowna, V1Y 5A8

    Colleen Maytham

  • Endocrinologie Oasis

    Montreal, H4J 1E3

    1 (514) 442-0791

    Zeina Yared

  • Centricity Research Pointe-Claire Multispecialty

    Pointe-Claire, H9R 4S3

    514-694-9940

    Waheed Rehman

  • IUCPQ

    Québec, G1V 4G5

    Olivier Bertrand

  • NL Health Services

    St. John's, A1B 3V6

    7097775976

    Sahar Iqbal

  • Centre de Medecine Metabolique de Lanaudiere (CMML)

    Terrebonne, J6X 4P7

    5149075101

    Yves Robitaille

  • Clinical Research Solutions - Kitchener

    Waterloo, N2T 0C1

    519 743 2573

    Shivinder Jolly

Other trials in Canada

Japan10 sites

  • NewHeart Watanabe Institute

    Hamadayama, Suginami-ku, 168-0065

    81120023812

    Tatsuya Sugimoto

  • Hyogo Prefectural Harima-Himeji General Medical Center

    Himeji, 670-8560

    81120023812

    NAOKO HASHIMOTO

  • Kimitsu Chuo Hospital

    Kisarazu, 292-8535

    81120023812

    Ryoichi Ishibashi

  • Seino Internal Medicine Clinic

    Kōriyama, 963-8851

    81120023812

    Hiroaki Seino

  • Jinnouchi Hospital

    Kumamoto, 862-0976

    81120023812

    Hideaki Jinnouchi

  • St. Mary's Hospital

    Kurume, 830-8543

    81120023812

    Yuji Uchizono

  • Medical Research Institute KITANO HOSPITAL, PIIF Tazuke-Kofukai

    Osaka, 530-8480

    81120023812

    Akihiro Hamasaki

  • Yasuda Diabetes Clinic

    Osaka, 536-0002

    81120023812

    Koichiro Yasuda

  • Yotsuya Internal Medicine Clinic

    Shinjyuku, 160-0017

    81120023812

    takahiro yokoyama

  • Uji-Tokushukai Medical Center

    Uji, 611-0041

    81120023812

    Atsushi Sueyoshi

Other trials in Japan

Romania10 sites

  • CMI Dr.Pletea Noemi SRL

    Bacau, 600154

    40744775762

    NOEMI PLETEA

  • Private Practice - Dr. Mercea Corina Delia

    Baia Mare, 430123

    0723090107

    DELIA MERCEA

  • Futuremeds - Brașov

    Brasov, 500299

    +40 722 566 616

    Ioana-Emilia Ferariu

  • Geea Medical Easy Diet

    Bucharest, 010627

    40314288633

    Georgeta Vacaru

  • Futuremeds - București

    Bucharest, 031441

    +40 723 680 497

    Oana-Andreea Parliteanu

  • Futuremeds - Craiova

    Craiova, 200515

    40763670811

    Ionela Mihaela Vladu

  • Futuremeds - Galați

    Galați, 800183

    0040724405355

    Cristina-Victoria Mistodie

  • Gama Diamed

    Mangalia, 905500

    0040241740581

    Amalia Thury-Burileanu

  • Clinica Korall

    Satu Mare, 440055

    40746013882

    Adriana Filimon

  • Rinart Diab SRL

    Targoviste, 130168

    0040724372432

    Anca Nicoara

Other trials in Romania

Ukraine10 sites

  • Regional Communal Non-commercial enterprise "Chernivtsi regional clinical hospital"

    Chernivtsi, 58000

    380506604554

    Nataliia Pashkovska

  • Clinical Diagnostic Center

    Ivano-Frankivsk, 76018

    +380986445126

    Vadym Berenfus

  • Institute of Endocrinology and Metabolism named after Komissarenko

    Kiev, 04114

    +380976444044

    Olesia Zinych

  • Edelweiss Medics

    Kyiv, 02002

    +380445949200

    Oleksandra Tymofeieva

  • Medbud Clinic

    Kyiv, 03037

    380445947078

    Svitlana Postol

  • ARTEM

    Kyiv, 04050

    380632355558

    Borys Mankovsky

  • Lviv City Clinical Hospital #4

    Lviv, 79011

    Bohdan Chulovskyi

  • Zakarpattia Endoclinic

    Uzhhorod, 88000

    +380505191209

    Olga Oleksyk

  • Vinnytsia Regional Clinical Endocrinology Dispensary

    Vinnytsia, 21010

    +380432531735

    Maryna Vlasenko

  • "University Clinic" of Vinnytsia National Memorial Medical University n.a. M.I.Pyrohov (Treatment-educatio -T

    Vinnytsia, 21029

    Sergii Shevchuk

Other trials in Ukraine

Hungary8 sites

  • DRC Gyógyszervizsgáló Központ

    Balatonfüred, 8230

    3687481616

    Jozsef Pauer

  • Semmelweis University

    Budapest, 1122

    3614586840

    Béla Merkely

  • Strazsahegy Medicina Bt.

    Budapest, H1171

    36309214740

    Miklos Kajetan

  • Debreceni Egyetem Klinikai Központ

    Debrecen, 4031

    36306630741

    Gizella Petro

  • Debreceni Egyetem Klinikai Kozpont

    Debrecen, 4032

    0036309657913

    Denes Pall

  • Nagykanizsai Kanizsai Dorottya Korhaz

    Nagykanizsa, 8800

    Tunde Balint

  • Medifarma 98 Kft

    Nyíregyháza, 4400

    0036209530430

    Zsolt Zilahi

  • Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ

    Szeged, 6725

    36204986434

    Robert Takacs

Other trials in Hungary

India8 sites

  • KLES Dr. Prabhakar Kore Hospital & M.R.C

    Belagavi, 590010

    0831-240700

    Sanjay Kumar Porwal

  • Endolife Speciality Hospitals

    Guntur, 522001

    Anjith VUPPUTURI

  • Gauhati Medical College and Hospital

    Guwahati, 781032

    Farhin Iqbal

  • King Edward Memorial Hospital & Seth Gordhandas Sunderdas Medical College

    Mumbai, 400012

    91 97691 33740

    Charan Lanjewar

  • Kingsway Hospitals (Best Multispeciality Hospital in Nagpur)

    Nagpur, 440001

    Rishi Lohiya

  • Arogyaseva Medical Academy of India - Ace Hospital

    Pune, 411004

    9619284398

    Hemant Kokane

  • All India Institute of Medical Sciences - Rishikesh

    Rishikesh, 249203

    Barun Kumar

  • Nirmal Hospital Pvt Ltd.

    Surat, 395002

    Pritesh Parekh

Other trials in India

Czechia6 sites

  • Interni a diabetologicka ordinace, s.r.o.

    Náchod, 547 01

    420 491 424 191

    Petra Sejvlova

  • Nemocnice AGEL Novy Jicin a.s.

    Nový Jičín, 74101

    +420723098731

    Vaclava Honova

  • EUC Klinika Praha

    Prague, 150 00

    420257288617

    Katarina Halciakova

  • Praglandia s.r.o

    Prague, 150 00

    420731586736

    Vaclav Pavlinak

  • Nemocnice Roudnice nad Labem

    Roudnice nad Labem, 413 01

    00420775355153

    Andrej Bajo

  • Dia doktor

    Ústí nad Labem, 400 07

    Petra Siroka

Other trials in Czechia

Poland6 sites

  • Uniwersytecki Szpital Kliniczny w Białymstoku

    Bialystok, 15-276

    +48 85 831 8130

    Anna Poplawska-Kita

  • Nova Reuma Domyslawska i Rusilowicz Spolka Partnerska Lekarza Reumatologa i Fizjoterapeuty

    Bialystok, 15-707

    +48 513172646

    Irena Glowinska

  • Linden sp. z o. o. sp. k.

    Krakow, 30-105

    +48693643789

    Katarzyna Palka

  • Medyczne Centrum Diabetologiczno Endokrynologiczno Metaboliczne DIAB-ENDO-MET

    Krakow, 31-261

    48126237122

    Joanna Mirocka

  • Drelich Grzegorz Centrum Kardiologiczne Kardio-Med

    Lublin, 20-518

    48 601 651 647

    Grzegorz Drelich

  • IRMED

    Piotrkow Trybunalski, 97-300

    48447890484

    TOMASZ CIURUS

Other trials in Poland

Puerto Rico3 sites

  • Puerto Rico Health and Wellness Institute

    Dorado, 00646

    7877961049

    Elham Ghorbani

  • Puerto Rico Medical Research

    Ponce, 00717

    787-284-5366

    Jose Santiago

  • Mgcendo Llc

    San Juan, 00921

    7874842757

    Martha Gomez-Cuellar

Other trials in Puerto Rico

About this study

Official title: A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Once-Weekly Eloralintide in Adult Participants With Obesity or Overweight, Type 2 Diabetes, and Increased CV Risk

The main purpose of this study is to evaluate the efficacy and safety of eloralintide compared with a placebo in participants with obesity or overweight, type 2 diabetes, and increased cardiovascular risk.

Being tested
Eloralintide, Placebo
Medical subject headings
Obesity, Overweight, Cardiovascular Diseases, Diabetes Mellitus, Type 2

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • EloralintideDrug

    Also called LY3841136

    Administered SC

  • PlaceboDrug

    Administered SC

Study groups in NCT07900633
Study groupRoleWhat they receive
EloralintideExperimentalParticipants will receive eloralintide subcutaneously (SC)
Receives: Drug: Eloralintide
PlaceboPlacebo comparatorParticipants will receive placebo SC
Receives: Drug: Placebo

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Percent Change from Baseline in Body Weight

    Measured: Baseline, Week 64

  2. Change from Baseline in Hemoglobin A1c (HbA1c)

    Measured: Baseline, Week 36

Secondary outcomes (9)

  1. Change from Baseline in Waist-to-Height Ratio

    Measured: Baseline, Week 64

  2. Change from Baseline in Systolic Blood Pressure

    Measured: Baseline, Week 36

  3. Percent Change from Baseline in High-Sensitivity C-reactive Protein (hsCRP)

    Measured: Baseline, Week 36

  4. Percent Change from Baseline in Triglycerides

    Measured: Baseline, Week 36

  5. Change from Baseline in Body Mass Index (BMI)

    Measured: Baseline, Week 64

  6. Change from Baseline in Short Form-36 (SF-36 v2) Score

    Measured: Baseline, Week 64

  7. Change from Baseline in Estimated Glomerular Filtration Rate (eGFR)

    Measured: Baseline, Week 64

  8. Pharmacokinetics (PK): Maximum Concentration at Steady State (Cmax,ss)

    Measured: Baseline through Week 64

  9. PK: Area Under the Concentration Versus Time Curve for One Dosing Interval at Steady State (AUC(0-ᴛ)ss)

    Measured: Baseline through Week 64

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted28 Oct 2026
  2. Study startDec 2026 (estimated)
  3. Primary completionNov 2029 (estimated)
  4. Study completionDec 2029 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 3
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
Double blind
Who is masked
Participant, Investigator
Enrolment
3,000 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07900633
Sponsor's protocol ID
27870
Other IDs
J3R-MC-YDAS, 2026-525919-14-00
Acronym
ENLIGHTEN-10
Status last verified
Oct 2026
First submitted
22 Oct 2026
Last updated
3 Nov 2026
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
Yes
FDA-regulated device
No
Individual data sharing
Yes: Anonymized individual patient level data will be provided in a secure access environment upon approval of a research proposal and a signed data sharing agreement.

Questions about this trial

What is this clinical trial studying?

A Phase 3 study testing Eloralintide in people with Obesity and Overweight, run by Eli Lilly and Company at 309 sites in 21 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 7 inclusion and 10 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: opening soon, as of the sponsor's last update on 3 Nov 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 309 sites in United States, Argentina, China, Italy, Brazil and 16 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or (317-615-4559, LillyTrials@Lilly.com), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Percent Change from Baseline in Body Weight (time frame: Baseline, Week 64). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07900633.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Nov 2026.

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