Dental ImplantPhase 1/2NCT07899983
Effect of Povidone Iodine on the Dental Implant Internal Surface Microbiome
A Phase 1/2 study testing Povidone-Iodine in people with Dental Implant, run by Madigan Army Medical Center at 1 site in United States.
Trial summary
We hope to learn if applying antiseptic to the inside of a dental implant will decrease or alter the types of bacteria inside it which may then decrease the incidence of implant failure associated with bone loss, infection, and other complications. Read more about this study
- Who is it for?
- Ages 18 to 55 years
- Conditions the study is for
- Dental Implant
- What is being tested?
- Povidone-Iodine
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteUnited States
- Study dates
- 1 Dec 2026to 1 Sep 2027
- Phase
- Phase 1/2
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 55 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Active Duty Military
- 18-55 years old
- Over 6 months remaining at local duty station (Joint Base Lewis McChord)
- Will be undergoing surgery to receive at least two dental implants
Who cannot join
- Tobacco user
- Taking medications affecting soft tissue or bone healing (e.g., IV bisphosphonates)
- Metabolic disorder affecting soft tissue or bone healing (e.g., diabetes where AIC is above 7.0)
- Active periodontal disease
- Pregnant at time of enrollment (these surgeries are not typically performed on pregnant women)
- Known or suspected allergy to OR previous adverse reaction to povidone iodine
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site
Madigan Army Medical Center
Tacoma, Washington, 98431
Zachary Colburn, PhD, 253-968-3455, zachary.t.colburn.civ@health.mil
About this study
We hope to learn if applying antiseptic to the inside of a dental implant will decrease or alter the types of bacteria inside it which may then decrease the incidence of implant failure associated with bone loss, infection, and other complications. During your implant placement appointment, an antiseptic (povidone iodine) will be applied to the inside one of your two new dental implants, no antiseptic will be applied to your other dental implant (this is what would occur if you choose not to participate in this study), before covering both of them with a cover screw or healing abutment. You will return to the Madigan Oral \& Maxillofacial Surgery Clinic 3-6 months later when your implant hardware is removed a swab of the implants internal cavities will be collected. Your participation in this research will last up to 6 months and require one additional minute during both your implant placement and hardware removal appointments.
- Conditions
- Dental Implant
- Being tested
- Povidone-Iodine
- Keywords
- Dental Implant, Povidone Iodine, Microbiome
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Povidone-IodineDrug
All participants will receive this intervention in one implant and no intervention in a second implant.
| Study group | Role | What they receive |
|---|---|---|
| Case-Control Group | Other | The internal cavity of one dental implant will have a small volume of povidone iodine added to it before closure. The other dental implant will remain untreated. Receives: Drug: Povidone-Iodine |
What is being measured
The primary outcome is the main question the study is designed to answer.
Microbiome Diversity
Inverse Simpson index calculated following 16S microbiome sequencing
Measured: From enrollment to hardware removal 3-6 months later
Secondary outcomes (1)
Implant Success Rate
Measured: From enrollment to hardware removal 3-6 months later
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted28 Oct 2026
- Study start1 Dec 2026 (estimated)
- Primary completion1 Jul 2027 (estimated)
- Study completion1 Sep 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Dental ImplantStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 1/2
- Primary purpose
- Prevention
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Madigan Army Medical Center
- Sponsor type
- US federal agency
- Responsible party
- Sponsor
- Investigators
- Kevin Smith, DMD, FACS, Principal investigator, Madigan Army Medical Center
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07899983
- Sponsor's protocol ID
- 226117
- Status last verified
- Oct 2026
- First submitted
- 20 Oct 2026
- Last updated
- 28 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- Yes
- FDA-regulated device
- No
- Individual data sharing
- Yes: Data may be shared if the appropriate regulatory approvals and agreements are in place.
Study at a glance
From the registry record, last updated by the sponsor on 28 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Povidone Iodine on the Dental Implant Internal Surface Microbiome
- ClinicalTrials.gov ID
- NCT07899983
- Acronym / sponsor ID
- 226117
- Conditions
- Dental Implant
- Keywords
- Dental Implant, Povidone Iodine, Microbiome
- Phase
- Phase 1/2
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- Madigan Army Medical CenterUS federal agency
- Study start
- 1 Dec 2026 (estimated)
- Primary completion
- 1 Jul 2027 (estimated)
- Study completion
- 1 Sep 2027 (estimated)
- First posted
- 28 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
We hope to learn if applying antiseptic to the inside of a dental implant will decrease or alter the types of bacteria inside it which may then decrease the incidence of implant failure associated with bone loss, infection, and other complications. During your implant placement appointment, an antiseptic (povidone iodine) will be applied to the inside one of your two new dental implants, no antiseptic will be applied to your other dental implant (this is what would occur if you choose not to participate in this study), before covering both of them with a cover screw or healing abutment. You will return to the Madigan Oral \& Maxillofacial Surgery Clinic 3-6 months later when your implant hardware is removed a swab of the implants internal cavities will be collected. Your participation in this research will last up to 6 months and require one additional minute during both your implant placement and hardware removal appointments.
Study design
- Primary purpose
- Prevention
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Case-Control Group | Other | Drug: Povidone-IodineThe internal cavity of one dental implant will have a small volume of povidone iodine added to it before closure. The other dental implant will remain untreated. |
Who may qualify
- Ages
- 18 to 55 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Active Duty Military
- 18-55 years old
- Over 6 months remaining at local duty station (Joint Base Lewis McChord)
- Will be undergoing surgery to receive at least two dental implants
Key exclusion criteria (6 listed)
- Tobacco user
- Taking medications affecting soft tissue or bone healing (e.g., IV bisphosphonates)
- Metabolic disorder affecting soft tissue or bone healing (e.g., diabetes where AIC is above 7.0)
- Active periodontal disease
- Pregnant at time of enrollment (these surgeries are not typically performed on pregnant women)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Povidone-IodineAll participants will receive this intervention in one implant and no intervention in a second implant. | Drug | Case-Control Group |
Primary outcome
Microbiome Diversity
Time frame: From enrollment to hardware removal 3-6 months later
Inverse Simpson index calculated following 16S microbiome sequencing
1 secondary outcome
Implant Success Rate
Time frame: From enrollment to hardware removal 3-6 months later
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 28 Oct 2026.
- Individual participant dataSharing planned: Yes. Data may be shared if the appropriate regulatory approvals and agreements are in place.
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Safety Assessment of Placing a Single Dental Implant Without Antibiotic Prophylaxis in Simple Cases: A Pilot Study
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Clinical and Radiographic Evaluation of Dentsply Sirona PrimeTaper Implants
Dental Implants
Active, not recruiting
The Aim of the Study Will be Clinically and Radio Graphically Comparison of Two Implant Designs Used to Treat Atrophied Mandible . Implant Design Comparison Will Done for Implant Stability,Peri-implant Soft Tissue Health Changes and Bone Changes .Patients Will be Divided Randomly Into Two Group
Dental Implant Bone Loss, Peri-Implant Health
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Kevin Smith, DMD, FACS principal investigator
Madigan Army Medical Center
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A Phase 1/2 study testing Povidone-Iodine in people with Dental Implant, run by Madigan Army Medical Center at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 28 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
What does this combined phase mean?
Phase 1 studies test a treatment in a small group of people for the first time or in a new way, mainly to check safety and find the right dose.
Phase 2 studies give the treatment to a larger group to see whether it has the intended effect and to keep checking safety.
Not every study follows the same path, and some studies (observational studies, device studies) have no phase.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Zachary Colburn, PhD (253-968-3455, zachary.t.colburn.civ@health.mil), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Microbiome Diversity (time frame: From enrollment to hardware removal 3-6 months later). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 Oct 2026.