Ischemic StrokeNCT07899710
Neurological Rehabilitation and Neuroplasticity After Ischemic Stroke
An observational study of Ischemic Stroke and Stroke Rehabilitaion, run by Medical University of Lodz.
Trial summary
This observational study evaluates the effects of neurological rehabilitation on biological markers associated with neuroplasticity and neurotransmitter profiles in patients after ischemic stroke. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Ischemic Stroke, Stroke Rehabilitaion
- How many people
- 60 participants
- Where
- No sites listed yet
- Study dates
- Oct 2026to Oct 2028
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Adult patients with ischemic stroke (ICD-10: I63) hospitalized in the Neurological Rehabilitation Department. The study population will include patients in different phases after stroke, including the early subacute phase and the late subacute phase (approximately 3-6 months after stroke). Participants will undergo a standard neurological rehabilitation program and will be assessed for changes in neuroplasticity-related markers and neurotransmitter profiles.
Who may be able to join
- Age >18 years.
- Diagnosis of ischemic stroke according to ICD-10 code I63.
- Subacute phase of ischemic stroke (7 days to 6 months after stroke onset).
- Written informed consent provided by the patient for participation in the study.
- Ability to establish basic logical verbal communication.
Who cannot join
- Lack of patient consent to participate in the study.
- Hemorrhagic stroke.
- Severe general condition.
- Presence of brain tumors or other diseases of the central nervous system.
- Inflammatory diseases accompanied by fever.
- Systemic diseases.
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- Severe cardiovascular diseases, including myocardial infarction within the previous 30 days, unstable angina, or heart failure.
- Severe arrhythmia.
- Uncontrolled metabolic and endocrine diseases.
- Respiratory failure.
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Effects of Neurological Rehabilitation on the Expression of Neuroplasticity Markers and Neurotransmitter Profiles in Patients at Different Stages Following Ischemic Stroke
This observational study evaluates the effects of neurological rehabilitation on biological markers associated with neuroplasticity and neurotransmitter profiles in patients after ischemic stroke. The study will include patients at different stages after stroke who undergo neurological rehabilitation as part of their standard care. The aim of the study is to assess whether rehabilitation is associated with changes in neuroplasticity-related markers and neurotransmitter levels, which may contribute to a better understanding of recovery processes after ischemic stroke.
Read the detailed description
Stroke is one of the leading causes of long-term disability worldwide. Neurological rehabilitation plays a key role in promoting functional recovery after ischemic stroke, but the biological mechanisms underlying rehabilitation-induced neuroplasticity are not fully understood.
This prospective observational study aims to investigate the association between neurological rehabilitation and changes in the expression of neuroplasticity-related biomarkers and neurotransmitter profiles in patients at different stages following ischemic stroke. Participants will receive standard neurological rehabilitation according to routine clinical practice. Biological samples and clinical assessments will be collected at predefined time points to evaluate changes associated with the rehabilitation process.
The findings of this study may improve the understanding of the molecular mechanisms involved in post-stroke recovery and contribute to the identification of biomarkers associated with rehabilitation outcomes. This knowledge may support the development of more personalized rehabilitation strategies for patients after ischemic stroke.
- Conditions
- Ischemic Stroke, Stroke Rehabilitaion
- Medical subject headings
- Ischemic Stroke
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Early Subacute Ischemic Stroke Cohort | Patients with ischemic stroke in the early subacute phase undergoing standard neurological rehabilitation. | |
| Late Subacute Ischemic Stroke Cohort | Patients with ischemic stroke in the late subacute phase (approximately 3-6 months after stroke) undergoing neurological rehabilitation. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Expression of Neuroplasticity Markers and Neurotransmitter Profiles
Assessment of changes in the expression of neuroplasticity-related markers and neurotransmitter profiles in blood samples collected from patients with ischemic stroke undergoing neurological rehabilitation. The analysis will compare biomarker levels between patients in different stages after stroke and evaluate changes associated with the rehabilitation process.
Measured: At baseline and after 4 weeks of neurological rehabilitation
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Oct 2026
- Study startOct 2026 (estimated)
- Primary completionOct 2028 (estimated)
- Study completionOct 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Ischemic StrokeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Medical University of Lodz
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07899710
- Sponsor's protocol ID
- RNN/163/26/KE
- Status last verified
- Jul 2026
- First submitted
- 20 Oct 2026
- Last updated
- 27 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be shared with other researchers.
Study at a glance
From the registry record, last updated by the sponsor on 27 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Neurological Rehabilitation on the Expression of Neuroplasticity Markers and Neurotransmitter Profiles in Patients at Different Stages Following Ischemic Stroke
- ClinicalTrials.gov ID
- NCT07899710
- Acronym / sponsor ID
- RNN/163/26/KE
- Conditions
- Ischemic Stroke, Stroke Rehabilitaion
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- Medical University of LodzUniversity, hospital or other
- Study start
- Oct 2026 (estimated)
- Primary completion
- Oct 2028 (estimated)
- Study completion
- Oct 2028 (estimated)
- First posted
- 27 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This observational study evaluates the effects of neurological rehabilitation on biological markers associated with neuroplasticity and neurotransmitter profiles in patients after ischemic stroke. The study will include patients at different stages after stroke who undergo neurological rehabilitation as part of their standard care. The aim of the study is to assess whether rehabilitation is associated with changes in neuroplasticity-related markers and neurotransmitter levels, which may contribute to a better understanding of recovery processes after ischemic stroke.
Detailed description
Stroke is one of the leading causes of long-term disability worldwide. Neurological rehabilitation plays a key role in promoting functional recovery after ischemic stroke, but the biological mechanisms underlying rehabilitation-induced neuroplasticity are not fully understood.
This prospective observational study aims to investigate the association between neurological rehabilitation and changes in the expression of neuroplasticity-related biomarkers and neurotransmitter profiles in patients at different stages following ischemic stroke. Participants will receive standard neurological rehabilitation according to routine clinical practice. Biological samples and clinical assessments will be collected at predefined time points to evaluate changes associated with the rehabilitation process.
The findings of this study may improve the understanding of the molecular mechanisms involved in post-stroke recovery and contribute to the identification of biomarkers associated with rehabilitation outcomes. This knowledge may support the development of more personalized rehabilitation strategies for patients after ischemic stroke.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Early Subacute Ischemic Stroke Cohort | – | –Patients with ischemic stroke in the early subacute phase undergoing standard neurological rehabilitation. |
| Late Subacute Ischemic Stroke Cohort | – | –Patients with ischemic stroke in the late subacute phase (approximately 3-6 months after stroke) undergoing neurological rehabilitation. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Adult patients with ischemic stroke (ICD-10: I63) hospitalized in the Neurological Rehabilitation Department. The study population will include patients in different phases after stroke, including the early subacute phase and the late subacute phase (approximately 3-6 months after stroke). Participants will undergo a standard neurological rehabilitation program and will be assessed for changes in neuroplasticity-related markers and neurotransmitter profiles.
Key inclusion criteria (5 listed)
- Age >18 years.
- Diagnosis of ischemic stroke according to ICD-10 code I63.
- Subacute phase of ischemic stroke (7 days to 6 months after stroke onset).
- Written informed consent provided by the patient for participation in the study.
- Ability to establish basic logical verbal communication.
Key exclusion criteria (10 listed)
- Lack of patient consent to participate in the study.
- Hemorrhagic stroke.
- Severe general condition.
- Presence of brain tumors or other diseases of the central nervous system.
- Inflammatory diseases accompanied by fever.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Expression of Neuroplasticity Markers and Neurotransmitter Profiles
Time frame: At baseline and after 4 weeks of neurological rehabilitation
Assessment of changes in the expression of neuroplasticity-related markers and neurotransmitter profiles in blood samples collected from patients with ischemic stroke undergoing neurological rehabilitation. The analysis will compare biomarker levels between patients in different stages after stroke and evaluate changes associated with the rehabilitation process.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Oct 2026.
- Individual participant dataSharing planned: No. Individual participant data will not be shared with other researchers.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
An observational study of Ischemic Stroke and Stroke Rehabilitaion, run by Medical University of Lodz.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 10 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 27 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Elzbieta Miller, Professor (48426721988, elzbieta.dorota.miller@umed.lodz.pl), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Expression of Neuroplasticity Markers and Neurotransmitter Profiles (time frame: At baseline and after 4 weeks of neurological rehabilitation). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Oct 2026.