Critical IllnessNCT07892222
Stress Hyperglycemia Ratio and Glucose Variability in Critically Ill Patients
An observational study of Critical Illness and Hyperglycemia, run by Assiut University.
Trial summary
This prospective cohort study aims to evaluate the stress hyperglycemia ratio and glucose variability among critically ill patients admitted to the intensive care unit. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Critical Illness, Hyperglycemia
- How many people
- 75 participants
- Where
- No sites listed yet
- Study dates
- 20 Oct 2026to 10 Mar 2028
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Adult patients aged 18 years or older admitted to the intensive care unit at Assiut University Hospital with an expected stay of at least 24 hours.
Who may be able to join
- Adult patients aged 18 years or older
- Admitted to the ICU with expected stay of at least 24 hours
- HbA1c and admission blood glucose obtainable within the first 24 hours
- Written informed consent from the patient or legal guardian
Who cannot join
- - Age less than 18 years
- Death or ICU discharge within 24 hours of admission
- Pregnancy
- Diabetic ketoacidosis or hyperosmolar hyperglycemic state at presentation
- Conditions that falsely alter HbA1c
- Fewer than 3 glucose measurements in the first 24 hours
- Terminal illness with palliative or do-not-resuscitate decision
- Refusal of consent
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Role of Stress Hyperglycemia Ratio and Glucose Variability in Predicting All-Cause Mortality in Critically Ill Patients
This prospective cohort study aims to evaluate the stress hyperglycemia ratio and glucose variability among critically ill patients admitted to the intensive care unit.
Read the detailed description
Critical illness is often accompanied by stress-induced hyperglycemia and glucose fluctuations. The stress hyperglycemia ratio relates admission glucose to estimated average glucose derived from HbA1c, while glucose variability reflects fluctuations over time.
This observational study will calculate the stress hyperglycemia ratio and glucose variability indices from routine laboratory data in adult patients admitted to the intensive care unit and will record 28-day mortality.
- Conditions
- Critical Illness, Hyperglycemia
- Keywords
- Critically ill, Stress hyperglycemia ratio, Glucose variability, ICU mortality, Assiut
- Medical subject headings
- Critical Illness, Hyperglycemia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Critically Ill Patients | Adult patients admitted to the intensive care unit who will undergo calculation of stress hyperglycemia ratio and glucose variability indices. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Number of deaths
Number of patients who die from any cause within 28 days from intensive care unit admission.
Measured: At 28 days
Secondary outcomes (4)
Stress hyperglycemia ratio
Mean stress hyperglycemia ratio calculated as admission glucose divided by estimated average glucose derived from HbA1c.
Measured: Baseline
Glucose coefficient of variation
Mean coefficient of variation of glucose values calculated as standard deviation divided by mean glucose multiplied by 100.
Measured: At 24 hours
ICU length of stay
Mean length of stay in the intensive care unit in days.
Measured: At 28 days
Number of patients requiring mechanical ventilation
Number of patients who require invasive mechanical ventilation during the intensive care unit stay.
Measured: At 28 days
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted23 Oct 2026
- Study start20 Oct 2026 (estimated)
- Primary completion20 Oct 2027 (estimated)
- Study completion10 Mar 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Critical IllnessStudies of the same condition, open and under way.
- More trials run by Assiut UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 75 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Assiut University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Andraws Hroun Abdou, Assiut University
- Investigators
- Ahmed M Obaidullah, prof, Study chair, Internal Medicine Department, Assiut University Hospitals
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07892222
- Sponsor's protocol ID
- SHR-GV-ICU-Assiut-2026
- Status last verified
- Oct 2026
- First submitted
- 17 Oct 2026
- Last updated
- 23 Oct 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 23 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Role of Stress Hyperglycemia Ratio and Glucose Variability in Predicting All-Cause Mortality in Critically Ill Patients
- ClinicalTrials.gov ID
- NCT07892222
- Acronym / sponsor ID
- SHR-GV-ICU-Assiut-2026
- Conditions
- Critical Illness, Hyperglycemia
- Keywords
- Critically ill, Stress hyperglycemia ratio, Glucose variability, ICU mortality, Assiut
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 75 participants (estimated)
- Lead sponsor
- Assiut UniversityUniversity, hospital or other
- Study start
- 20 Oct 2026 (estimated)
- Primary completion
- 20 Oct 2027 (estimated)
- Study completion
- 10 Mar 2028 (estimated)
- First posted
- 23 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This prospective cohort study aims to evaluate the stress hyperglycemia ratio and glucose variability among critically ill patients admitted to the intensive care unit.
Detailed description
Critical illness is often accompanied by stress-induced hyperglycemia and glucose fluctuations. The stress hyperglycemia ratio relates admission glucose to estimated average glucose derived from HbA1c, while glucose variability reflects fluctuations over time.
This observational study will calculate the stress hyperglycemia ratio and glucose variability indices from routine laboratory data in adult patients admitted to the intensive care unit and will record 28-day mortality.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Critically Ill Patients | – | –Adult patients admitted to the intensive care unit who will undergo calculation of stress hyperglycemia ratio and glucose variability indices. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Adult patients aged 18 years or older admitted to the intensive care unit at Assiut University Hospital with an expected stay of at least 24 hours.
Key inclusion criteria (4 listed)
- Adult patients aged 18 years or older
- Admitted to the ICU with expected stay of at least 24 hours
- HbA1c and admission blood glucose obtainable within the first 24 hours
- Written informed consent from the patient or legal guardian
Key exclusion criteria (8 listed)
- - Age less than 18 years
- Death or ICU discharge within 24 hours of admission
- Pregnancy
- Diabetic ketoacidosis or hyperosmolar hyperglycemic state at presentation
- Conditions that falsely alter HbA1c
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Number of deaths
Time frame: At 28 days
Number of patients who die from any cause within 28 days from intensive care unit admission.
4 secondary outcomes
Stress hyperglycemia ratio
Time frame: Baseline
Glucose coefficient of variation
Time frame: At 24 hours
ICU length of stay
Time frame: At 28 days
Number of patients requiring mechanical ventilation
Time frame: At 28 days
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 23 Oct 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Ahmed M Obaidullah, prof study chair
Internal Medicine Department, Assiut University Hospitals
Questions about this trial
What is this clinical trial studying?
An observational study of Critical Illness and Hyperglycemia, run by Assiut University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 23 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Andraws H Abdo, Resident (01554575509, andraws.18313318@med.aun.edu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Number of deaths (time frame: At 28 days). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 23 Oct 2026.