Multiple Sclerosis (MS) - Relapsing-remittingNCT07890974
Tai Chi Training for Persons With Multiple Sclerosis.
A study testing Tai Chi training in people with Multiple Sclerosis (MS) - Relapsing-remitting, run by Karolinska Institutet at 1 site in Sweden.
Trial summary
Tai Chi combines strength and neuromuscular training with diaphragmatic breathing, attention, imagery and relaxation. After an initial learning period, participants can practise independently, potentially supporting self-efficacy and sustained self-management. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Multiple Sclerosis (MS) - Relapsing-remitting
- What is being tested?
- Tai Chi training
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 35 participants
- Where
- 1 siteSweden
- Study dates
- 1 Mar 2025to Mar 2028
- Phase
- Interventional
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Inclusion criteria are age over 18 years, definite MS diagnosis, ability to walk more than 100 m, no relapse or pharmacological treatment adjustment in the preceding eight weeks, no Tai Chi practice in the preceding six months, and ability to understand and communicate in Swedish or English. -
Who cannot join
- Exclusion criteria are dementia, alcoholism and serious medical comorbidity preventing participation.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Assessing Tai Chi Based Rehabilitation to Improve Physical and Mental Health of Persons With Multiple Sclerosis.
Tai Chi combines strength and neuromuscular training with diaphragmatic breathing, attention, imagery and relaxation. After an initial learning period, participants can practise independently, potentially supporting self-efficacy and sustained self-management. Studies in chronic disease report benefits for physical function and psychological wellbeing.
We will evaluate a 12-week Tai Chi rehabilitation programme in a clincial trial. The Multiple Sclerosis Impact Scale (MSIS-29) is the primary clinical outcome, reflecting the physical and psychological consequences of multiple sclerosis (MS). Assessments take place before training and at 12 weeks (the primary endpoint).
The study will address whether Tai Chi improves physical and mental health; reduces fatigue, anxiety, depression and pain; improves lower-limb strength, gait and balance; and improves quality of life and self-efficacy.
Read the detailed description
The randomized controlled trial compares 12 weeks of Tai Chi. The intervention comprises two 75-minute sessions each week. Clinical outcomes are measured before and after training to examine the maintenance of benefits and self-management behaviours.
Inclusion criteria are age over 18 years, definite MS diagnosis, ability to walk more than 100 m, no relapse or pharmacological treatment adjustment in the preceding eight weeks, no Tai Chi practice in the preceding six months, and ability to understand and communicate in Swedish or English. Exclusion criteria are dementia, alcoholism and serious medical comorbidity preventing participation.
Participants are recruited through MS and rehabilitation clinics in Region Stockholm, Neuro Sweden and social media advertisements. Screening confirms eligibility and provides a baseline assessment. Oral and written information is given and informed consent obtained before enrollment. Baseline data include age, sex, civil and employment status, and disease characteristics, including MS severity. Participants may withdraw without consequences for their care.
Tai Chi programme Training comprises three components: warm-up exercises to improve mobility and flexibility, reduce tension and introduce relaxed breathing; simple Tai Chi movements and a short sequence to develop coordinated, gentle weight shifts; and Standing like a Tree Qigong to develop upright posture, relaxation and breathing awareness. The programme teaches foundational skills and supports regular practice that can be integrated into daily living.
Participants are encouraged to maintain their usual activities but avoid starting additional exercise programmes during the intervention. Home Tai Chi practice is encouraged and recorded. Four make-up classes per month are available, and participants receive an instructional video to support continued practice after the supervised programme.
Clinical outcome measures MSIS-29 assesses the physical and psychological impact of MS [15]. Secondary outcomes are fatigue (FSMC), anxiety and depression (HADS), pain (BPI-SF), and lower-limb strength (30-second chair-stand). Gait is assessed with the 10-metre walk test and 6MWT, and balance with the Mini-BESTest. Quality of life is assessed with the Brunnsviken Brief Quality of Life Scale (BBQ), and self-efficacy with the Self-Efficacy for Managing Chronic Disease scale (SEMCD) [16-24]. Self-efficacy is of particular interest because confidence in managing symptoms may support continued use of rehabilitation skills.
- Being tested
- Tai Chi training
- Keywords
- multiple sclerosis, rehabilitation, physical health, mental health
- Medical subject headings
- Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Psychological Well-Being
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Tai Chi trainingOther
Training comprises three components: warm-up exercises to improve mobility and flexibility, reduce tension and introduce relaxed breathing; simple Tai Chi movements and a short sequence to develop coordinated, gentle weight shifts; and Standing like a Tree Qigong to develop upright posture, relaxation and breathing awareness. The programme teaches foundational skills and supports regular practice that can be integrated into daily living.
| Study group | Role | What they receive |
|---|---|---|
| Tai Chi training | Other | Not described Receives: Other: Tai Chi training |
What is being measured
The primary outcome is the main question the study is designed to answer.
MSIS-29
MSIS-29 assesses the physical and psychological impact of MS
Measured: From enrollment to the end of treatment at 12 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted23 Oct 2026
- Study start1 Mar 2025
- Primary completionDec 2027 (estimated)
- Study completionMar 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Multiple Sclerosis (MS) - Relapsing-remittingStudies of the same condition, open and under way.
- More trials run by Karolinska InstitutetThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 35 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Karolinska Institutet
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Manuel Zeitelhofer, Karolinska Institutet
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07890974
- Sponsor's protocol ID
- 2023-03661-01
- Other IDs
- 2023
- Status last verified
- Oct 2026
- First submitted
- 18 Oct 2026
- Last updated
- 23 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No