AzTrials
AzTrials

DementiaHLC-CogMarkNCT07890207

Human-LLM Conversations as a Digital Signature of Cognitive Performance in Adults

An observational study of Dementia, run by Technion, Israel Institute of Technology.

Not yet recruiting

Opening soon. The study is approved but enrolment has not started yet. Sites may already take enquiries.

Official record
Search all trials

Trial summary

Subtle changes in language are among the early signs of cognitive decline in Alzheimer's disease and related conditions. Researchers are therefore studying whether language can help identify cognitive changes earlier and at larger scale. Read more about this study

Who is it for?
Ages 60 years and olderHealthy volunteers can take part
Conditions the study is for
Dementia
How many people
100 participants
Where
No sites listed yet
Study dates
1 Dec 2026to 30 Jun 2027
Phase
Observational
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 60 years and older
  • All sexes
  • Healthy volunteers accepted
  • Adult, Older adult

Study population: Adults over the age of 60, proficient in English, regular (daily) use of AI-based chatbots. All levels of cognitive performance.

Who may be able to join

  • Adults over the age of 60, proficient in English, regular (daily) use of AI-based chatbots.

Who cannot join

  • All else.

About this study

Subtle changes in language are among the early signs of cognitive decline in Alzheimer's disease and related conditions. Researchers are therefore studying whether language can help identify cognitive changes earlier and at larger scale. Conversational AI tools (large language models, or LLMs) such as ChatGPT, Gemini, and Claude are now widely used, including by middle-aged and older adults. A conversation with an AI chatbot is more than a sample of written language: it shows how a person works toward a goal over several exchanges. This includes how they phrase requests, add constraints, keep track of context, notice errors, and revise their instructions. These behaviors may reflect language, attention, working memory, planning, and other aspects of cognitive function.

This exploratory, observational study will examine whether features of people's conversations with AI chatbots are associated with performance on a standard cognitive screening test. The study does not involve any treatment or intervention and is not intended to diagnose Alzheimer's disease, mild cognitive impairment, dementia, or any other condition.

Read more

Participants: 100 adults aged 60 and above who use AI chatbots and are proficient in English. Participants are recruited online through research crowdsourcing platforms (Prolific and DataForce). They do not need to have, or report, any diagnosis. No participants are recruited through clinics or hospitals.

Procedure: Participants complete a single online session of about 20 to 30 minutes. After giving informed consent, they:

Complete a background questionnaire covering demographics, language background, and AI chatbot use. Optional questions cover relevant medical and family history.

Upload three to five of their own previous conversations with an AI chatbot. They are asked to remove names and other identifying details first and to avoid highly sensitive conversations. They then answer a few short questions about each conversation.

Complete two short everyday tasks with a chatbot in the study interface: planning an activity and drafting a short message. The timing of typing and messages within the study interface is recorded.

Complete a remote MoCA test (XpressO), a validated self-administered digital cognitive screening tool, and the PHQ-8, a brief questionnaire on depressive symptoms.

A subset of participants may be invited to an optional additional assessment: the standard Montreal Cognitive Assessment (MoCA), administered by a trained examiner over video call. This is used to check how well the online test agrees with standard administration, and requires separate consent.

Outcomes: The primary outcome is the association between linguistic and interactional features of participants' AI conversations and their cognitive screening score, analyzed mainly as a continuous measure. Features include how specific and well structured requests are, how context is maintained, repetition, clarification, error recognition, revision strategies, progress through multi-step tasks, and typing and timing patterns. Secondary aims are to describe how adults aged 60 and over use AI chatbots, and to assess whether these features could support future computational methods for studying early cognitive change. Demographic, language, health, mood, and technology-use variables are considered as possible confounders.

Risks and safeguards: The study is minimal risk. The main risk is to privacy, because past chatbot conversations may contain personal information. Participants choose which conversations to share and are asked to remove identifying details. The research team removes any remaining direct identifiers, and data are stored on secure, access-restricted university servers. Data are analyzed by the academic research team and its research partner for research purposes only. Participants may feel mild fatigue or frustration; they can skip questions, take breaks, or stop at any time, and receive proportional compensation if they stop early. Individual scores are not reported. Participants whose screening score falls in the range that may indicate impairment receive a non-diagnostic note that explains the limits of screening tests and suggests discussing any memory concerns with a physician.

Conditions
Dementia
Being tested
No Intervention: Observational Cohort
Keywords
Dementia, AI, LLM, NLP, GPT, Large language models
Medical subject headings
Dementia

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • No Intervention: Observational CohortOther

    No intervention. Collecting cohort and analyzing data.

Study groups in NCT07890207
Study groupRoleWhat they receive
All participantsAdults over the age of 60, proficient in English, who regularly use LLMs like GPT.
Receives: Other: No Intervention: Observational Cohort

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Association between features of human-AI chatbot conversations and cognitive screening score

    The study measures linguistic and interactional features from participants' uploaded AI chatbot conversations and from two standardized chatbot tasks. Examples include request specificity and structure, context maintenance, repetition, clarification, error recognition, revision strategies, task progression, and typing and timing patterns. The association between these features and the MoCA XpressO total score is analyzed, with the score treated as a continuous measure.

    Measured: Day 1 (single online session at enrollment, about 20-30 minutes)

Secondary outcomes (2)
  1. Patterns of AI chatbot use

    Descriptive summary of self-reported AI chatbot use: platforms used, duration and frequency of use, main purposes, language of use, and whether others help with use. Collected by questionnaire.

    Measured: Day 1 (single online session at enrollment)

  2. Performance of conversation features in estimating cognitive screening score

    How well computational models based on conversation features estimate the MoCA XpressO score, assessed with cross-validation. Reported as correlation with the observed score and as the area under the ROC curve for classifying scores above versus below the validated cutoff.

    Measured: Day 1 (single online session at enrollment)

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted22 Oct 2026
  2. Study start1 Dec 2026 (estimated)
  3. Primary completion30 Mar 2027 (estimated)
  4. Study completion30 Jun 2027 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Observational
Observational model
Case only
Time perspective
Cross-sectional
Enrolment
100 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07890207
Sponsor's protocol ID
Technion- Israel Institute for
Acronym
HLC-CogMark
Status last verified
Oct 2026
First submitted
18 Oct 2026
Last updated
22 Oct 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No

Questions about this trial

What is this clinical trial studying?

An observational study of Dementia, run by Technion, Israel Institute of Technology.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: opening soon, as of the sponsor's last update on 22 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Association between features of human-AI chatbot conversations and cognitive screening score (time frame: Day 1 (single online session at enrollment, about 20-30 minutes)). It is what the study was designed to measure, not a finding.

Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 Oct 2026.

Free account

Log in to keep searching

You’ve used your 3 free searches. AzTrials is free: log in or create a free account to keep searching clinical trials and save the ones you want to follow.

Create a free accountLog in