Knee OsteoarthritisNCT07888920
Effects of Visual and Vestibular Rehabilitation in Individuals With Knee Osteoarthritis
A study testing Conventional Physiotherapy, Visual Rehabilitation and Vestibular Rehabilitation in people with Knee Osteoarthritis and Visual Rehabilitation, run by Istanbul Aydın University at 2 sites in Turkey (Türkiye).
Trial summary
This study aims to investigate the effects of visual rehabilitation and vestibular rehabilitation added to conventional physiotherapy on postural stability, pain, and functional status in individuals with knee osteoarthritis. Read more about this study
- Who is it for?
- Ages 40 to 65 years
- Conditions the study is for
- Knee Osteoarthritis, Visual Rehabilitation, Vestibular Rehabilitation
- What is being tested?
- Conventional Physiotherapy, Visual Rehabilitation and Vestibular Rehabilitation
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 42 participants
- Where
- 2 sitesTurkey (Türkiye)
- Study dates
- 28 Oct 2026to 1 Apr 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Clinical and radiological diagnosis of knee osteoarthritis.
- Kellgren-Lawrence Grade 2-3 knee osteoarthritis.
- Age 40-65 years.
- Ability to ambulate independently.
- Voluntary participation and provision of written informed consent. -
Who cannot join
- Kellgren-Lawrence Grade 4 knee osteoarthritis.
- History of lower extremity surgery.
- Other orthopedic pathologies accompanying knee osteoarthritis.
- History of neurological, vestibular, or central nervous system disease.
- Ophthalmological disease that may affect visual perception, visual field, or peripheral vision even with corrected vision (e.g., glaucoma, retinal pathologies, advanced cataract).
- Participation in a balance or vestibular rehabilitation program within the previous 6 months.
- Systemic disease that would prevent exercise participation (e.g., cardiovascular disease or uncontrolled hypertension).
- -
Trial locations and contacts
2 sites in 1 country. Contact the study team or a site near you to ask about taking part.
Turkey (Türkiye)2 sites
Istanbul Aydin University Medical Park Florya Hospital
Istanbul, Istanbul, 34295
Kamer Ünal Eren, PhD, +90 (544) 207 89 42, kamerunaleren@aydin.edu.tr
Istanbul Aydin University
Istanbul, Istanbul, 34295
Kamer Ünal Eren, PhD, +90 (544) 207 89 42, kamerunaleren@aydin.edu.tr
About this study
Official title: Effects of Visual and Vestibular Rehabilitation on Postural Stability, Pain, Functional Status, and Lower Extremity Biomechanics in Individuals With Knee Osteoarthritis: A Randomized Controlled Trial
This study aims to investigate the effects of visual rehabilitation and vestibular rehabilitation added to conventional physiotherapy on postural stability, pain, and functional status in individuals with knee osteoarthritis. Participants will be randomly assigned to three groups: conventional physiotherapy, conventional physiotherapy combined with visual rehabilitation, or conventional physiotherapy combined with vestibular rehabilitation. The study will evaluate changes in balance, pain, and functional performance before and after the intervention.
- Conditions
- Knee Osteoarthritis, Visual Rehabilitation, Vestibular Rehabilitation, Postural Stability, Balance, Pain
- Being tested
- Conventional Physiotherapy, Visual Rehabilitation, Vestibular Rehabilitation
- Medical subject headings
- Osteoarthritis, Knee, Pain
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Conventional PhysiotherapyBehavioural
Participants will receive conventional physiotherapy consisting of transcutaneous electrical nerve stimulation (TENS), cold pack application, grade I-II patellar mobilization, quadriceps isometric exercises, progressive resistance exercises, straight leg raises, and static hamstring and gastrocnemius stretching. The intervention will be provided three times per week for six weeks, with a total of 18 sessions.
Visual RehabilitationBehavioural
Participants will receive conventional physiotherapy combined with peripheral vision-focused visual rehabilitation. Visual rehabilitation will involve peripheral visual stimuli presented using the Smart Optometry Pro application while participants maintain central fixation and respond to the stimuli with motor actions. The intervention will be provided for 20 minutes per session, three times per week for six weeks, for a total of 18 sessions.
Vestibular RehabilitationBehavioural
Participants will receive conventional physiotherapy combined with vestibular rehabilitation involving standardized rhythmic head movements. Head movements will be performed in right-left and anterior-posterior directions at a standardized rhythm using a metronome application. The intervention will be provided for 20 minutes per session, three times per week for six weeks, for a total of 18 sessions.
| Study group | Role | What they receive |
|---|---|---|
| Conventional Physiotherapy | Active comparator | Participants in this arm will receive conventional physiotherapy, including transcutaneous electrical nerve stimulation (TENS), cold pack application, patellar mobilization, quadriceps isometric exercises, progressive resistance exercises, straight leg raises, and hamstring and gastrocnemius stretching. Receives: Behavioral: Conventional Physiotherapy |
| Conventional Physiotherapy + Visual Rehabilitation | Experimental | Participants in this arm will receive conventional physiotherapy combined with peripheral vision-focused visual rehabilitation. Receives: Behavioral: Conventional Physiotherapy; Behavioral: Visual Rehabilitation |
| Conventional Physiotherapy + Vestibular Rehabilitation | Experimental | Participants in this arm will receive conventional physiotherapy combined with vestibular rehabilitation involving standardized rhythmic head movements. Receives: Behavioral: Conventional Physiotherapy; Behavioral: Vestibular Rehabilitation |
What is being measured
The primary outcome is the main question the study is designed to answer.
Postural Stability
Postural stability will be assessed using the Ottometriks Balance Platform. Center of pressure (COP) displacement and postural sway in the anteroposterior and mediolateral directions will be evaluated.
Measured: At baseline and immediately after the 6-week intervention
Secondary outcomes (6)
Pain Intensity
Pain intensity will be assessed using the Short-Form McGill Pain Questionnaire (SF-MPQ).
Measured: At baseline and immediately after the 6-week intervention
WOMAC
Functional status will be assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC).
Measured: At baseline and immediately after the 6-week intervention
Timed Up and Go Test (TUG)
Functional mobility will be assessed using the Timed Up and Go Test (TUG).
Measured: At baseline and immediately after the 6-week intervention
Y Balance Test
Dynamic balance will be assessed using the Y Balance Test.
Measured: At baseline and immediately after the 6-week intervention
Berg Balance Scale (BBS)
Balance performance will be assessed using the Berg Balance Scale (BBS).
Measured: At baseline and immediately after the 6-week intervention
Peripheral Vision
Peripheral vision will be assessed using the standardized photo-based assessment method specified in the study protocol.
Measured: At baseline and immediately after the 6-week intervention
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Oct 2026
- Study start28 Oct 2026 (estimated)
- Primary completion30 Oct 2026 (estimated)
- Study completion1 Apr 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Knee OsteoarthritisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 42 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Istanbul Aydın University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Kamer Ünal Eren, Principal investigator, Istanbul Aydın University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07888920
- Sponsor's protocol ID
- IAU-FTR-2026-01Busra BEDIR
- Status last verified
- Oct 2026
- First submitted
- 16 Oct 2026
- Last updated
- 22 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 22 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Visual and Vestibular Rehabilitation on Postural Stability, Pain, Functional Status, and Lower Extremity Biomechanics in Individuals With Knee Osteoarthritis: A Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07888920
- Acronym / sponsor ID
- IAU-FTR-2026-01Busra BEDIR
- Conditions
- Knee Osteoarthritis, Visual Rehabilitation, Vestibular Rehabilitation, Postural Stability, Balance, Pain
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 42 participants (estimated)
- Lead sponsor
- Istanbul Aydın UniversityUniversity, hospital or other
- Study start
- 28 Oct 2026 (estimated)
- Primary completion
- 30 Oct 2026 (estimated)
- Study completion
- 1 Apr 2027 (estimated)
- First posted
- 22 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to investigate the effects of visual rehabilitation and vestibular rehabilitation added to conventional physiotherapy on postural stability, pain, and functional status in individuals with knee osteoarthritis. Participants will be randomly assigned to three groups: conventional physiotherapy, conventional physiotherapy combined with visual rehabilitation, or conventional physiotherapy combined with vestibular rehabilitation. The study will evaluate changes in balance, pain, and functional performance before and after the intervention.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Conventional Physiotherapy | Active comparator | Behavioral: Conventional PhysiotherapyParticipants in this arm will receive conventional physiotherapy, including transcutaneous electrical nerve stimulation (TENS), cold pack application, patellar mobilization, quadriceps isometric exercises, progressive resistance exercises, straight leg raises, and hamstring and gastrocnemius stretching. |
| Conventional Physiotherapy + Visual Rehabilitation | Experimental | Behavioral: Conventional Physiotherapy, Behavioral: Visual RehabilitationParticipants in this arm will receive conventional physiotherapy combined with peripheral vision-focused visual rehabilitation. |
| Conventional Physiotherapy + Vestibular Rehabilitation | Experimental | Behavioral: Conventional Physiotherapy, Behavioral: Vestibular RehabilitationParticipants in this arm will receive conventional physiotherapy combined with vestibular rehabilitation involving standardized rhythmic head movements. |
Who may qualify
- Ages
- 40 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Clinical and radiological diagnosis of knee osteoarthritis.
- Kellgren-Lawrence Grade 2-3 knee osteoarthritis.
- Age 40-65 years.
- Ability to ambulate independently.
- Voluntary participation and provision of written informed consent. -
Key exclusion criteria (8 listed)
- Kellgren-Lawrence Grade 4 knee osteoarthritis.
- History of lower extremity surgery.
- Other orthopedic pathologies accompanying knee osteoarthritis.
- History of neurological, vestibular, or central nervous system disease.
- Ophthalmological disease that may affect visual perception, visual field, or peripheral vision even with corrected vision (e.g., glaucoma, retinal pathologies, advanced cataract).
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Conventional PhysiotherapyParticipants will receive conventional physiotherapy consisting of transcutaneous electrical nerve stimulation (TENS), cold pack application, grade I-II patellar mobilization, quadriceps isometric exercises, progressive resistance exercises, straight leg raises, and static hamstring and gastrocnemius stretching. The intervention will be provided three times per week for six weeks, with a total of 18 sessions. | Behavioural | Conventional Physiotherapy, Conventional Physiotherapy + Vestibular Rehabilitation, Conventional Physiotherapy + Visual Rehabilitation |
| Visual RehabilitationParticipants will receive conventional physiotherapy combined with peripheral vision-focused visual rehabilitation. Visual rehabilitation will involve peripheral visual stimuli presented using the Smart Optometry Pro application while participants maintain central fixation and respond to the stimuli with motor actions. The intervention will be provided for 20 minutes per session, three times per week for six weeks, for a total of 18 sessions. | Behavioural | Conventional Physiotherapy + Visual Rehabilitation |
| Vestibular RehabilitationParticipants will receive conventional physiotherapy combined with vestibular rehabilitation involving standardized rhythmic head movements. Head movements will be performed in right-left and anterior-posterior directions at a standardized rhythm using a metronome application. The intervention will be provided for 20 minutes per session, three times per week for six weeks, for a total of 18 sessions. | Behavioural | Conventional Physiotherapy + Vestibular Rehabilitation |
Primary outcome
Postural Stability
Time frame: At baseline and immediately after the 6-week intervention
Postural stability will be assessed using the Ottometriks Balance Platform. Center of pressure (COP) displacement and postural sway in the anteroposterior and mediolateral directions will be evaluated.
6 secondary outcomes
Pain Intensity
Time frame: At baseline and immediately after the 6-week intervention
WOMAC
Time frame: At baseline and immediately after the 6-week intervention
Timed Up and Go Test (TUG)
Time frame: At baseline and immediately after the 6-week intervention
Y Balance Test
Time frame: At baseline and immediately after the 6-week intervention
Berg Balance Scale (BBS)
Time frame: At baseline and immediately after the 6-week intervention
Peripheral Vision
Time frame: At baseline and immediately after the 6-week intervention
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 22 Oct 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Kamer Ünal Eren principal investigator
Istanbul Aydın University
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Conventional Physiotherapy, Visual Rehabilitation and Vestibular Rehabilitation in people with Knee Osteoarthritis and Visual Rehabilitation, run by Istanbul Aydın University at 2 sites in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 22 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Kamer Ünal Eren, PhD (0544 207 89 42, kamerunaleren@aydin.edu.tr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Postural Stability (time frame: At baseline and immediately after the 6-week intervention). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 Oct 2026; AzTrials last refreshed its copy on 26 Oct 2026.