Cerebral ThrombosisNCT07888062
TOF-MRV Versus Post-Contrast 3D T1 MRI in Dural Venous Sinus Thrombosis
An observational study of Cerebral Thrombosis and Venous Thrombosis, run by Assiut University.
Trial summary
This cross-sectional study aims to compare the diagnostic performance of time-of-flight MR venography and post-contrast 3D T1-weighted MRI in the detection of dural venous sinus thrombosis. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Cerebral Thrombosis, Venous Thrombosis
- How many people
- 80 participants
- Where
- No sites listed yet
- Study dates
- 20 Oct 2026to 10 Jan 2028
- Phase
- Observational
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Adult patients aged 18 years or older with suspected dural venous sinus thrombosis undergoing MRI including both time-of-flight MR venography and post-contrast 3D T1-weighted imaging at Assiut University Hospitals.
Who may be able to join
- - Age 18 years or older
- Patients with suspected dural venous sinus thrombosis
- Written informed consent
Who cannot join
- - Incomplete MRI examination
- Absence of either TOF-MRV or post-contrast 3D T1WI
- Severe motion or susceptibility artifacts
- Previous surgery involving the dural venous sinuses
- Direct tumor invasion of a dural venous sinus
- Poor-quality or technically inadequate MRV
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Comparative Diagnostic Performance of Time-of-Flight MR Venography and Post-Contrast 3D T1-Weighted MRI in the Detection of Dural Venous Sinus Thrombosis
This cross-sectional study aims to compare the diagnostic performance of time-of-flight MR venography and post-contrast 3D T1-weighted MRI in the detection of dural venous sinus thrombosis.
Read the detailed description
Dural venous sinus thrombosis is an uncommon but potentially serious cerebrovascular disorder with variable clinical presentation. Imaging plays a central role in diagnosis.
This observational study will prospectively evaluate patients with suspected dural venous sinus thrombosis using both time-of-flight MR venography and post-contrast 3D T1-weighted imaging to compare their diagnostic findings for thrombosis in the major dural venous sinuses.
- Conditions
- Cerebral Thrombosis, Venous Thrombosis
- Keywords
- Time-of-flight MR venography, Post-contrast 3D T1, Dural venous sinus thrombosis, MRI, Assiut
- Medical subject headings
- Intracranial Thrombosis, Venous Thrombosis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Patients with Suspected Dural Venous Sinus Thrombosis | Adult patients with clinical suspicion of dural venous sinus thrombosis undergoing both time-of-flight MR venography and post-contrast 3D T1-weighted MRI. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Number of patients with positive findings on TOF-MRV
Number of patients showing findings suggestive of dural venous sinus thrombosis on time-of-flight MR venography.
Measured: Baseline
Secondary outcomes (4)
Number of patients with positive findings on post-contrast 3D T1WI
Number of patients showing findings suggestive of dural venous sinus thrombosis on post-contrast 3D T1-weighted imaging.
Measured: Baseline
Number of patients with complete thrombosis on TOF-MRV
Number of patients classified as complete thrombosis or occlusion on time-of-flight MR venography.
Measured: Baseline
Number of patients with complete thrombosis on post-contrast 3D T1WI
Number of patients classified as complete thrombosis or occlusion on post-contrast 3D T1-weighted imaging.
Measured: Baseline
Number of discordant findings
Number of patients with discordant results between time-of-flight MR venography and post-contrast 3D T1-weighted imaging.
Measured: Baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Oct 2026
- Study start20 Oct 2026 (estimated)
- Primary completion20 Oct 2027 (estimated)
- Study completion10 Jan 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Cerebral ThrombosisStudies of the same condition, open and under way.
- More trials run by Assiut UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case only
- Time perspective
- Cross-sectional
- Enrolment
- 80 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Assiut University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Manar Eid Mohammed, Assiut University
- Investigators
- Samy A Abdel Aziz, prof, Study chair, Diagnostic and interventional radiology Department, Assiut University Hospitals
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07888062
- Sponsor's protocol ID
- TOF-MRV-DVST-Assiut-2026
- Status last verified
- Oct 2026
- First submitted
- 15 Oct 2026
- Last updated
- 22 Oct 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No