Transverse Skeletal DiscrepancyNCT07887308
Customized CBCT-Based Assessment of Transverse Discrepancies
An observational study of Transverse Skeletal Discrepancy, run by October University for Modern Sciences and Arts at 1 site in Egypt.
Trial summary
This retrospective cross-sectional observational study aims to develop a customized, patient-specific CBCT-based method for assessing skeletal transverse discrepancies independent of dental compensation. Read more about this study
- Who is it for?
- Ages 15 to 30 years
- Conditions the study is for
- Transverse Skeletal Discrepancy
- How many people
- 120 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Sep 2026to Aug 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 15 to 30 years
- All sexes
- No healthy volunteers
- Child, Adult
Study population: Patients aged 15-30 years with skeletal Class I, Class II, or Class III patterns. A total of 120 previously acquired CBCT scans meeting the eligibility criteria will be retrospectively selected and equally divided into three groups: 40 Class I, 40 Class II, and 40 Class III.
Who may be able to join
- Patients aged 15-30 years.
- Skeletal Class I, II, or III malocclusion.
- High-quality CBCT scans showing both the maxilla and mandible.
- Both male and female patients.
Who cannot join
- History of previous orthodontic or orthopedic treatment.
- Craniofacial anomalies or syndromes.
- Systemic conditions affecting craniofacial growth.
- Severe maxillofacial pathology affecting skeletal structures.
- Poor-quality or incomplete CBCT scans.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Customized CBCT-Based Assessment of Transverse Discrepancies in Various Malocclusions: A Cross-Sectional Study
This retrospective cross-sectional observational study aims to develop a customized, patient-specific CBCT-based method for assessing skeletal transverse discrepancies independent of dental compensation. A total of 120 previously acquired CBCT scans of patients aged 15-30 years will be evaluated and equally divided into skeletal Class I, Class II, and Class III groups (40 scans per group). The study will assess transverse skeletal and dental relationships using standardized CBCT measurements and will evaluate the intra- and inter-examiner reproducibility of the proposed methodology. The distribution and pattern of transverse discrepancies among the three skeletal classes will also be assessed.
- Conditions
- Transverse Skeletal Discrepancy
- Keywords
- Cone-Beam Computed Tomography (CBCT) Transverse Discrepancy Dental Compensation Skeletal Malocclusion Molar Inclination, Cone-Beam Computed Tomography (CBCT), Transverse Discrepancy, Dental Compensation, Skeletal Malocclusion, Molar Inclination, Maxillomandibular Transverse Relationship
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Skeletal Class I | CBCT scans of 40 patients with a skeletal Class I sagittal relationship. | |
| Skeletal Class II | CBCT scans of 40 patients with a skeletal Class II sagittal relationship. | |
| Skeletal Class III | BCT scans of 40 patients with a skeletal Class III sagittal relationship. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Customized Patient-Specific CBCT-Based Assessment of Skeletal Transverse Discrepancy
Measurement of skeletal transverse discrepancy using a customized, patient-specific CBCT-based approach, independent of dental compensation.
Measured: Baseline (at the time of CBCT acquisition)
Secondary outcomes (1)
Intra- and Inter-Examiner Reproducibility of the Customized CBCT Methodology
Reliability of the methodology assessed by intra- and inter-examiner reproducibility in applying the workflow and performing measurements.
Measured: 2 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 Oct 2026
- Study start1 Sep 2026
- Primary completionMar 2027 (estimated)
- Study completionAug 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for Transverse Skeletal DiscrepancyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Retrospective
- Enrolment
- 120 participants (estimated)
Sponsor and investigators
- Lead sponsor
- October University for Modern Sciences and Arts
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07887308
- Sponsor's protocol ID
- ORTH 1.2.1
- Status last verified
- Sep 2026
- First submitted
- 7 Oct 2026
- Last updated
- 21 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be publicly shared due to confidentiality and data protection considerations.
Publications
Diez-Rodrigalvarez D, Bonilla-Morente E, Lopez-Jimenez AJ. A Novel Method for the Diagnosis of Transverse Maxillary Deficiencies Based on CBCT. Diagnostics (Basel). 2026 Mar 30;16(7):1034. doi: 10.3390/diagnostics16071034.
PubMed 41975748Miner RM, Al Qabandi S, Rigali PH, Will LA. Cone-beam computed tomography transverse analyses. Part 2: Measures of performance. Am J Orthod Dentofacial Orthop. 2015 Aug;148(2):253-63. doi: 10.1016/j.ajodo.2015.03.027.
PubMed 26232834Miner RM, Al Qabandi S, Rigali PH, Will LA. Cone-beam computed tomography transverse analysis. Part I: Normative data. Am J Orthod Dentofacial Orthop. 2012 Sep;142(3):300-7. doi: 10.1016/j.ajodo.2012.04.014.
PubMed 22920695
Study at a glance
From the registry record, last updated by the sponsor on 21 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Customized CBCT-Based Assessment of Transverse Discrepancies in Various Malocclusions: A Cross-Sectional Study
- ClinicalTrials.gov ID
- NCT07887308
- Acronym / sponsor ID
- ORTH 1.2.1
- Conditions
- Transverse Skeletal Discrepancy
- Keywords
- Cone-Beam Computed Tomography (CBCT) Transverse Discrepancy Dental Compensation Skeletal Malocclusion Molar Inclination, Cone-Beam Computed Tomography (CBCT), Transverse Discrepancy, Dental Compensation, Skeletal Malocclusion, Molar Inclination, Maxillomandibular Transverse Relationship
- Study type
- Observational
- Recruitment status
- Active, not recruiting
- Enrolment
- 120 participants (estimated)
- Lead sponsor
- October University for Modern Sciences and ArtsUniversity, hospital or other
- Study start
- 1 Sep 2026 (actual)
- Primary completion
- Mar 2027 (estimated)
- Study completion
- Aug 2027 (estimated)
- First posted
- 21 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This retrospective cross-sectional observational study aims to develop a customized, patient-specific CBCT-based method for assessing skeletal transverse discrepancies independent of dental compensation. A total of 120 previously acquired CBCT scans of patients aged 15-30 years will be evaluated and equally divided into skeletal Class I, Class II, and Class III groups (40 scans per group). The study will assess transverse skeletal and dental relationships using standardized CBCT measurements and will evaluate the intra- and inter-examiner reproducibility of the proposed methodology. The distribution and pattern of transverse discrepancies among the three skeletal classes will also be assessed.
Study design
- Observational model
- Other
- Time perspective
- Retrospective
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Skeletal Class I | – | –CBCT scans of 40 patients with a skeletal Class I sagittal relationship. |
| Skeletal Class II | – | –CBCT scans of 40 patients with a skeletal Class II sagittal relationship. |
| Skeletal Class III | – | –BCT scans of 40 patients with a skeletal Class III sagittal relationship. |
Who may qualify
- Ages
- 15 to 30 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult
- Study population
- Patients aged 15-30 years with skeletal Class I, Class II, or Class III patterns. A total of 120 previously acquired CBCT scans meeting the eligibility criteria will be retrospectively selected and equally divided into three groups: 40 Class I, 40 Class II, and 40 Class III.
Key inclusion criteria (4 listed)
- Patients aged 15-30 years.
- Skeletal Class I, II, or III malocclusion.
- High-quality CBCT scans showing both the maxilla and mandible.
- Both male and female patients.
Key exclusion criteria (5 listed)
- History of previous orthodontic or orthopedic treatment.
- Craniofacial anomalies or syndromes.
- Systemic conditions affecting craniofacial growth.
- Severe maxillofacial pathology affecting skeletal structures.
- Poor-quality or incomplete CBCT scans.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Customized Patient-Specific CBCT-Based Assessment of Skeletal Transverse Discrepancy
Time frame: Baseline (at the time of CBCT acquisition)
Measurement of skeletal transverse discrepancy using a customized, patient-specific CBCT-based approach, independent of dental compensation.
1 secondary outcome
Intra- and Inter-Examiner Reproducibility of the Customized CBCT Methodology
Time frame: 2 weeks
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 21 Oct 2026.
- Background: PubMed 41975748Diez-Rodrigalvarez D, Bonilla-Morente E, Lopez-Jimenez AJ. A Novel Method for the Diagnosis of Transverse Maxillary Deficiencies Based on CBCT. Diagnostics (Basel). 2026 Mar 30;16(7):1034. doi: 10.3390/diagnostics16071034.
- Background: PubMed 26232834Miner RM, Al Qabandi S, Rigali PH, Will LA. Cone-beam computed tomography transverse analyses. Part 2: Measures of performance. Am J Orthod Dentofacial Orthop. 2015 Aug;148(2):253-63. doi: 10.1016/j.ajodo.2015.03.027.
- Background: PubMed 22920695Miner RM, Al Qabandi S, Rigali PH, Will LA. Cone-beam computed tomography transverse analysis. Part I: Normative data. Am J Orthod Dentofacial Orthop. 2012 Sep;142(3):300-7. doi: 10.1016/j.ajodo.2012.04.014.
- Individual participant dataSharing planned: No. Individual participant data will not be publicly shared due to confidentiality and data protection considerations.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Transverse Skeletal Discrepancy, run by October University for Modern Sciences and Arts at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 21 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Customized Patient-Specific CBCT-Based Assessment of Skeletal Transverse Discrepancy (time frame: Baseline (at the time of CBCT acquisition)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07887308, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 21 Oct 2026.