Colorectal Cancer SurvivorsNCT07874035
Low Load Blood Flow Restriction Resistance Training in Colorectal Cancer Related Sarcopenia
A study testing Low load blood flow restriction resistance training and Low load resistance training without Blood Flow Restriction in people with Colorectal Cancer Survivors, run by Ahmed Adel Ahmed Elsayed Ali Radwan at 1 site in Egypt.
Trial summary
PURPOSE: To investigate the effects of low-load resistance training combined with blood flow restriction on muscle strength, functional performance, and cancer-related fatigue in colorectal cancer survivors with probable sarcopenia. Read more about this study
- Who is it for?
- Ages 40 to 59 years
- Conditions the study is for
- Colorectal Cancer Survivors
- What is being tested?
- Low load blood flow restriction resistance training and Low load resistance training without Blood Flow Restriction
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 54 participants
- Where
- 1 siteEgypt
- Study dates
- 17 May 2026to 20 Dec 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 to 59 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Colorectal cancer with probable sarcopenia.
- Age 40-59 years.
- Low muscle strength defined by EWGSOP2 criteria using the five-times sit-to-stand test (>15 seconds without upper limb support).
- Current chemotherapy/radiotherapy or postoperative status with confirmed medical stability.
- Medical clearance for supervised exercise.
- Ability to follow instructions and complete assessments.
Who cannot join
- Any contraindication to resistance or blood flow restriction training.
- Uncontrolled cardiovascular disease or hypertension.
- Recent thromboembolic events.
- Severe peripheral vascular disease.
- Uncontrolled treatment-related complications, such as severe anemia or infection.
- Metastatic bone disease in the lower limbs.
- Neurological or musculoskeletal disorders limiting safe participation.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Egypt1 site, 1 recruiting
- Recruiting
Private Clinics
Cairo
Ahmed Adel Radwan, MSc, 00201000623731, ahmedelmasry@cu.edu.eg
About this study
PURPOSE:
To investigate the effects of low-load resistance training combined with blood flow restriction on muscle strength, functional performance, and cancer-related fatigue in colorectal cancer survivors with probable sarcopenia.
Read more
BACKGROUND:
Muscle weakness and cancer-related fatigue are prevalent in colorectal cancer survivors with probable sarcopenia and are associated with adverse outcomes. High-load resistance training is often poorly tolerated in this population. Although low-load resistance training with blood flow restriction shows promise, colorectal cancer-specific randomized evidence remains limited.
HYPOTHESES:
It is hypothesized that low-load blood flow restriction resistance training will lead to significant improvements in muscle strength and functional performance and a significant reduction in cancer-related fatigue in colorectal cancer survivors with probable sarcopenia.
RESEARCH QUESTION:
Does low-load blood flow restriction resistance training lead to significant improvements in muscle strength and functional performance and a significant reduction in cancer-related fatigue in colorectal cancer survivors with probable sarcopenia?
- Conditions
- Colorectal Cancer Survivors
- Being tested
- Low load blood flow restriction resistance training, Low load resistance training without Blood Flow Restriction
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Low load blood flow restriction resistance trainingBehavioural
Low-load resistance training combined with blood flow restriction using pneumatic cuffs applied to the proximal lower limb at 60% arterial occlusion pressure. Resistance exercise is performed at 30% of one-repetition maximum (1RM), using 30-15-15-15 repetitions with 30-60 seconds of rest between sets. The intervention is supervised twice weekly for 12 weeks.
Low load resistance training without Blood Flow RestrictionBehavioural
Low-load resistance training without blood flow restriction. Resistance exercise is performed at 30% of one-repetition maximum (1RM), using 30-15-15-15 repetitions with 30-60 seconds of rest between sets. The intervention is supervised twice weekly for 12 weeks.
| Study group | Role | What they receive |
|---|---|---|
| Low-load resistance training + Blood Flow Restriction | Experimental | Not described Receives: Behavioral: Low load blood flow restriction resistance training |
| Low-load resistance training without Blood Flow Restriction | Active comparator | Not described Receives: Behavioral: Low load resistance training without Blood Flow Restriction |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Lower Limb Muscle Strength
Lower limb muscle strength will be measured using a calibrated digital force gauge. Muscle strength will be assessed at baseline before the intervention and after completion of the 12 weeks intervention.
Measured: Baseline (Week 0) and immediately after completion of the 12-week intervention (Week 12).
Change in Functional Lower Limb Performance
Functional lower limb performance will be assessed using the 30-Second Sit-to-Stand Test at baseline and after completion of the 12-week intervention.
Measured: Baseline (Week 0) and immediately after completion of the 12-week intervention (Week 12).
Change in Cancer Related Fatigue
Cancer-related fatigue will be assessed using the 13-item Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) scale at baseline and immediately after completion of the 12-week intervention. The FACIT-F fatigue subscale ranges from 0 to 52, with higher scores indicating less fatigue and better quality of life.
Measured: Baseline (Week 0) and immediately after completion of the 12-week intervention (Week 12).
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Oct 2026
- Study start17 May 2026
- Primary completion15 Aug 2027 (estimated)
- Study completion20 Dec 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Colorectal Cancer SurvivorsStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 54 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Ahmed Adel Ahmed Elsayed Ali Radwan
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Ahmed Adel Ahmed Elsayed Ali Radwan, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07874035
- Sponsor's protocol ID
- P.T.REC/012/006516
- Status last verified
- Oct 2026
- First submitted
- 8 Oct 2026
- Last updated
- 21 Oct 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 21 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Low Load Blood Flow Restriction Resistance Training in Colorectal Cancer Related Sarcopenia
- ClinicalTrials.gov ID
- NCT07874035
- Acronym / sponsor ID
- P.T.REC/012/006516
- Conditions
- Colorectal Cancer Survivors
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 54 participants (estimated)
- Lead sponsor
- Ahmed Adel Ahmed Elsayed Ali RadwanUniversity, hospital or other
- Study start
- 17 May 2026 (actual)
- Primary completion
- 15 Aug 2027 (estimated)
- Study completion
- 20 Dec 2027 (estimated)
- First posted
- 14 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
PURPOSE:
To investigate the effects of low-load resistance training combined with blood flow restriction on muscle strength, functional performance, and cancer-related fatigue in colorectal cancer survivors with probable sarcopenia.
BACKGROUND:
Muscle weakness and cancer-related fatigue are prevalent in colorectal cancer survivors with probable sarcopenia and are associated with adverse outcomes. High-load resistance training is often poorly tolerated in this population. Although low-load resistance training with blood flow restriction shows promise, colorectal cancer-specific randomized evidence remains limited.
HYPOTHESES:
It is hypothesized that low-load blood flow restriction resistance training will lead to significant improvements in muscle strength and functional performance and a significant reduction in cancer-related fatigue in colorectal cancer survivors with probable sarcopenia.
RESEARCH QUESTION:
Does low-load blood flow restriction resistance training lead to significant improvements in muscle strength and functional performance and a significant reduction in cancer-related fatigue in colorectal cancer survivors with probable sarcopenia?
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Low-load resistance training + Blood Flow Restriction | Experimental | Behavioral: Low load blood flow restriction resistance training |
| Low-load resistance training without Blood Flow Restriction | Active comparator | Behavioral: Low load resistance training without Blood Flow Restriction |
Who may qualify
- Ages
- 40 to 59 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- Colorectal cancer with probable sarcopenia.
- Age 40-59 years.
- Low muscle strength defined by EWGSOP2 criteria using the five-times sit-to-stand test (>15 seconds without upper limb support).
- Current chemotherapy/radiotherapy or postoperative status with confirmed medical stability.
- Medical clearance for supervised exercise.
Key exclusion criteria (7 listed)
- Any contraindication to resistance or blood flow restriction training.
- Uncontrolled cardiovascular disease or hypertension.
- Recent thromboembolic events.
- Severe peripheral vascular disease.
- Uncontrolled treatment-related complications, such as severe anemia or infection.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Low load blood flow restriction resistance trainingLow-load resistance training combined with blood flow restriction using pneumatic cuffs applied to the proximal lower limb at 60% arterial occlusion pressure. Resistance exercise is performed at 30% of one-repetition maximum (1RM), using 30-15-15-15 repetitions with 30-60 seconds of rest between sets. The intervention is supervised twice weekly for 12 weeks. | Behavioural | Low-load resistance training + Blood Flow Restriction |
| Low load resistance training without Blood Flow RestrictionLow-load resistance training without blood flow restriction. Resistance exercise is performed at 30% of one-repetition maximum (1RM), using 30-15-15-15 repetitions with 30-60 seconds of rest between sets. The intervention is supervised twice weekly for 12 weeks. | Behavioural | Low-load resistance training without Blood Flow Restriction |
Primary outcome
Change in Lower Limb Muscle Strength
Time frame: Baseline (Week 0) and immediately after completion of the 12-week intervention (Week 12).
Lower limb muscle strength will be measured using a calibrated digital force gauge. Muscle strength will be assessed at baseline before the intervention and after completion of the 12 weeks intervention.
Change in Functional Lower Limb Performance
Time frame: Baseline (Week 0) and immediately after completion of the 12-week intervention (Week 12).
Functional lower limb performance will be assessed using the 30-Second Sit-to-Stand Test at baseline and after completion of the 12-week intervention.
Change in Cancer Related Fatigue
Time frame: Baseline (Week 0) and immediately after completion of the 12-week intervention (Week 12).
Cancer-related fatigue will be assessed using the 13-item Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) scale at baseline and immediately after completion of the 12-week intervention. The FACIT-F fatigue subscale ranges from 0 to 52, with higher scores indicating less fatigue and better quality of life.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 21 Oct 2026.
Related trials for Colorectal Cancer Survivors
Active, not recruiting
Energy Balance Interventions in Increasing Physical Activity in Breast Cancer Gene Positive Patients, Lynch Syndrome-Positive Patients, CLL Survivors or High-Risk Family Members
Body Mass Index 25 or Greater, BRCA1 Gene Mutation
Recruiting
Testing the Feasibility of a Virtual Application to Support Breast and Colorectal Cancer Survivors
Breast Cancer Survivor, Colorectal Cancer Survivors
RecruitingObservational study
Understanding and Tailored Treatment of Low Anterior Resection Syndrome
Low Anterior Resection Syndrome, Faecal Incontinence With Faecal Urgency
Not yet recruiting
A Study on the Efficacy of the Metaverse Lifestyle Health Education Model Based on the Transtheoretical Model for Improving Quality of Life and Modifying Lifestyle in Colorectal Cancer Survivors
Colorectal Neoplasms, Cancer Survivors
RecruitingObservational study
The Development of MASLD Among Survivors of Breast or Colorectal Cancer
Breast Cancer Survivors, Colorectal (Colon or Rectal) Cancer Survivors
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Low load blood flow restriction resistance training and Low load resistance training without Blood Flow Restriction in people with Colorectal Cancer Survivors, run by Ahmed Adel Ahmed Elsayed Ali Radwan at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 21 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Each site lists its own contact: choose the nearest one under Trial locations. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Lower Limb Muscle Strength (time frame: Baseline (Week 0) and immediately after completion of the 12-week intervention (Week 12).). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 21 Oct 2026; AzTrials last refreshed its copy on 26 Oct 2026.