Developmental DyslexiaAUTO-DYSNCT07868367
Immediate Effects of Active Prisms on Reading Automaticity and Motor Control in Young Adults With Developmental Dyslexia
A study testing Individually Selected Active Prisms. in people with Developmental Dyslexia, run by Lille University at 1 site in France.
Trial summary
Developmental dyslexia is associated with persistent difficulties in reading automaticity. AUTO-DYS investigates whether a single, brief intervention using active prisms changes the complexity of nonlinear movement dynamics and reading automaticity in young adults with dyslexia. Read more about this study
- Who is it for?
- Ages 18 to 30 yearsHealthy volunteers can take part
- Conditions the study is for
- Developmental Dyslexia
- What is being tested?
- Individually Selected Active Prisms.
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 66 participants
- Where
- 1 siteFrance
- Study dates
- 1 Oct 2026to 31 May 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 30 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Adults aged 18-30 years with normal or corrected vision.
- Dyslexia group: documented medical diagnosis of developmental dyslexia and an Alouette-R C index greater than two standard deviations, as specified in the protocol, on the study day.
- Control group: typical readers with an Alouette-R C index less than two standard deviations, as specified in the protocol, on the study day. Eligibility will be verified by the study physician.
Who cannot join
- Optical correction exceeding ±0.75 diopters
- known balance or psychiatric disorder
- another diagnosed neurodevelopmental disorder in the dyslexia group
- any diagnosed neurodevelopmental disorder or proprioceptive dysfunction in the control group
- pregnancy
- legal guardianship
- pathological near-vision Parinaud test (P2)
- refusal of consent.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
France1 site
Université de Lille, Federation for Research in Visual Sciences and Cultures (FR-SCV), Plaine Images, Bâtiment L'Imaginarium
Tourcoing, 59200
About this study
Official title: Effet d'Une Modification de l'état Initial du système Dynamique Sur Les capacités d'Automatisation de Jeunes Adultes Dyslexiques
Developmental dyslexia is associated with persistent difficulties in reading automaticity. AUTO-DYS investigates whether a single, brief intervention using active prisms changes the complexity of nonlinear movement dynamics and reading automaticity in young adults with dyslexia. This single-center, prospective, non-randomized controlled study will enroll 66 adults aged 18-30 years: 33 with developmental dyslexia and 33 typical readers. All participants will undergo reading, postural-control, and working-memory assessments before and after an experimental period during one visit. Only participants with dyslexia will receive individually selected active prisms; typical readers will repeat the assessments without active prisms. The main hypothesis is that modifying tonic muscle distribution with active prisms is associated with increased dynamic complexity and improved reading automaticity in participants with dyslexia.
Read the detailed description
AUTO-DYS is a prospective, single-center, controlled interventional study with repeated measurements during one approximately two-hour visit. The study examines whether an acute change in tonic muscle distribution, induced by individually selected active prisms, is associated with a change in the complexity and adaptability of nonlinear dynamics and with improvements in reading, motor control and attention in young adults with developmental dyslexia.
After written informed consent and medical verification of eligibility, participants will complete proprioceptive assessments and baseline tasks: rapid word naming, silent reading with eye tracking, and single-leg standing tasks with and without working-memory demands while postural movement and gaze-related measures are recorded. Proprioceptive testing will include the podal convergence maneuver and spatial and perceptual assessments; a foveascope assessment is also performed.
In the dyslexia group, active prisms of 0.25-3 prism diopters will be selected to modify tonic muscle distribution. Participants will repeat the baseline tasks while wearing trial frames with active prisms. Typical readers will repeat the same tasks wearing their usual unmodified glasses or trial frames with plain lenses, without active prisms. The control group will provide an estimate of repeated-testing effects. The order of experimental postural tasks and assignment of reading texts will be randomized.
Analyses will examine within-participant changes and differences between groups. Repeated-measures parametric analyses are planned for normally distributed data, with non-parametric alternatives if distributional assumptions are not met. The intervention is brief and is not the complete long-term proprioceptive management program.
- Conditions
- Developmental Dyslexia
- Being tested
- Individually Selected Active Prisms.
- Keywords
- Developmental dyslexia, Reading automaticity, Proprioception, Prismatic lenses, Postural control, Eye tracking, Working memory, Nonlinear dynamics, Multisensory integration
- Medical subject headings
- Dyslexia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Individually Selected Active Prisms.Device
Individually selected active prisms (0.25-3 prism diopters) will be worn during post-intervention assessments by participants with dyslexia to modify tonic muscle distribution. The intervention will take place during one study visit.
| Study group | Role | What they receive |
|---|---|---|
| Active Prisms (Developmental Dyslexia) | Experimental | Participants with documented developmental dyslexia will undergo assessments before and after receiving individually selected active prisms (0.25-3 prism diopters). Receives: Device: Individually Selected Active Prisms. |
| No Active Prisms (Typical Readers) | No intervention | Typical readers will undergo baseline and repeat assessments while wearing their usual unmodified glasses or plain trial lenses, without active prisms. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Detrended Fluctuation Analysis Alpha Coefficient
Change in detrended fluctuation analysis alpha coefficient (α-DFA), reflecting fractal self-similarity and the complexity and adaptability of nonlinear dynamics.
Measured: Baseline and immediately after the intervention/control period, within the same approximately two-hour visit.
Change in High-Frequency Word Reading Effect
Change in the high-frequency word effect during silent reading, used to assess reading automaticity.
Measured: Baseline and immediate post-test during one approximately two-hour visit.
Secondary outcomes (8)
Change in Postural Sway Path Length Measured Using the Polhemus Tracking System
Change in postural displacement path length during single-leg standing, measured using the Polhemus tracking system.
Measured: Baseline and immediately after the intervention/control period, within the same approximately two-hour visit.
Change in Pupil Diameter
Change in pupil diameter during standing balance tasks, measured with eye tracking.
Measured: Baseline and immediate post-test during one approximately two-hour visit.
Change in First Fixation Duration During Silent Reading
Change in first fixation duration during silent reading, measured with eye tracking..
Measured: Baseline and immediate post-test during one approximately two-hour visit.
Change in Gaze Duration During Silent Reading
Change in gaze duration during silent reading, measured with eye tracking.
Measured: Baseline and immediate post-test during one approximately two-hour visit.
Change in Total Fixation Duration During Silent Reading
Change in total fixation duration during silent reading, measured with eye tracking.
Measured: Baseline and immediate post-test during one approximately two-hour visit.
Change in Fractal Self-Similarity of Eye Movements During Silent Reading
Change in fractal self-similarity measures of eye movements during silent reading, measured with eye tracking.
Measured: Baseline and immediate post-test during one approximately two-hour visit.
Change in Rapid Word Naming Performance
Change in performance on the rapid word naming task.
Measured: Baseline and immediate post-test during one approximately two-hour visit.
Change in Pseudoword Reading Performance
Change in performance on the pseudoword reading task.
Measured: Baseline and immediate post-test during one approximately two-hour visit.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Oct 2026
- Study start1 Oct 2026 (estimated)
- Primary completion31 May 2028 (estimated)
- Study completion31 May 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for Developmental DyslexiaStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Model description
- Two pre-existing groups (developmental dyslexia and typical readers) complete matched pre- and post-assessments at a single visit. Only the dyslexia group will receive individually selected active prisms between assessments.
- Masking
- None (open label)
- Enrolment
- 66 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Lille University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07868367
- Sponsor's protocol ID
- D2025-1
- Acronym
- AUTO-DYS
- Status last verified
- Sep 2026
- First submitted
- 29 Sep 2026
- Last updated
- 9 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
Stergiou N, Decker LM. Human movement variability, nonlinear dynamics, and pathology: is there a connection? Hum Mov Sci. 2011 Oct;30(5):869-88. doi: 10.1016/j.humov.2011.06.002. Epub 2011 Jul 29.
PubMed 21802756Quercia P, Seigneuric A, Chariot S, Bron A, Creuzot-Garcher C, Robichon F. [Proprioception changes induced by prismatic glasses wear in children suffering from developmental dyslexia]. J Fr Ophtalmol. 2007 Apr;30(4):380-9. doi: 10.1016/s0181-5512(07)89608-2. French.
PubMed 17486030Virlet L, Sparrow L, Barela J, Berquin P, Bonnet C. Proprioceptive intervention improves reading performance in developmental dyslexia: An eye-tracking study. Res Dev Disabil. 2024 Oct;153:104813. doi: 10.1016/j.ridd.2024.104813. Epub 2024 Aug 19.
PubMed 39163725
Study at a glance
From the registry record, last updated by the sponsor on 9 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effet d'Une Modification de l'état Initial du système Dynamique Sur Les capacités d'Automatisation de Jeunes Adultes Dyslexiques
- ClinicalTrials.gov ID
- NCT07868367
- Acronym / sponsor ID
- AUTO-DYS / D2025-1
- Conditions
- Developmental Dyslexia
- Keywords
- Developmental dyslexia, Reading automaticity, Proprioception, Prismatic lenses, Postural control, Eye tracking, Working memory, Nonlinear dynamics
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 66 participants (estimated)
- Lead sponsor
- Lille UniversityUniversity, hospital or other
- Study start
- 1 Oct 2026 (estimated)
- Primary completion
- 31 May 2028 (estimated)
- Study completion
- 31 May 2028 (estimated)
- First posted
- 9 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Developmental dyslexia is associated with persistent difficulties in reading automaticity. AUTO-DYS investigates whether a single, brief intervention using active prisms changes the complexity of nonlinear movement dynamics and reading automaticity in young adults with dyslexia. This single-center, prospective, non-randomized controlled study will enroll 66 adults aged 18-30 years: 33 with developmental dyslexia and 33 typical readers. All participants will undergo reading, postural-control, and working-memory assessments before and after an experimental period during one visit. Only participants with dyslexia will receive individually selected active prisms; typical readers will repeat the assessments without active prisms. The main hypothesis is that modifying tonic muscle distribution with active prisms is associated with increased dynamic complexity and improved reading automaticity in participants with dyslexia.
Detailed description
AUTO-DYS is a prospective, single-center, controlled interventional study with repeated measurements during one approximately two-hour visit. The study examines whether an acute change in tonic muscle distribution, induced by individually selected active prisms, is associated with a change in the complexity and adaptability of nonlinear dynamics and with improvements in reading, motor control and attention in young adults with developmental dyslexia.
After written informed consent and medical verification of eligibility, participants will complete proprioceptive assessments and baseline tasks: rapid word naming, silent reading with eye tracking, and single-leg standing tasks with and without working-memory demands while postural movement and gaze-related measures are recorded. Proprioceptive testing will include the podal convergence maneuver and spatial and perceptual assessments; a foveascope assessment is also performed.
In the dyslexia group, active prisms of 0.25-3 prism diopters will be selected to modify tonic muscle distribution. Participants will repeat the baseline tasks while wearing trial frames with active prisms. Typical readers will repeat the same tasks wearing their usual unmodified glasses or trial frames with plain lenses, without active prisms. The control group will provide an estimate of repeated-testing effects. The order of experimental postural tasks and assignment of reading texts will be randomized.
Analyses will examine within-participant changes and differences between groups. Repeated-measures parametric analyses are planned for normally distributed data, with non-parametric alternatives if distributional assumptions are not met. The intervention is brief and is not the complete long-term proprioceptive management program.
Study design
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- Two pre-existing groups (developmental dyslexia and typical readers) complete matched pre- and post-assessments at a single visit. Only the dyslexia group will receive individually selected active prisms between assessments.
| Arm | Type | Receives |
|---|---|---|
| Active Prisms (Developmental Dyslexia) | Experimental | Device: Individually Selected Active Prisms.Participants with documented developmental dyslexia will undergo assessments before and after receiving individually selected active prisms (0.25-3 prism diopters). |
| No Active Prisms (Typical Readers) | No intervention | –Typical readers will undergo baseline and repeat assessments while wearing their usual unmodified glasses or plain trial lenses, without active prisms. |
Who may qualify
- Ages
- 18 to 30 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- Adults aged 18-30 years with normal or corrected vision.
- Dyslexia group: documented medical diagnosis of developmental dyslexia and an Alouette-R C index greater than two standard deviations, as specified in the protocol, on the study day.
- Control group: typical readers with an Alouette-R C index less than two standard deviations, as specified in the protocol, on the study day. Eligibility will be verified by the study physician.
Key exclusion criteria (8 listed)
- Optical correction exceeding ±0.75 diopters
- known balance or psychiatric disorder
- another diagnosed neurodevelopmental disorder in the dyslexia group
- any diagnosed neurodevelopmental disorder or proprioceptive dysfunction in the control group
- pregnancy
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Individually Selected Active Prisms.Individually selected active prisms (0.25-3 prism diopters) will be worn during post-intervention assessments by participants with dyslexia to modify tonic muscle distribution. The intervention will take place during one study visit. | Device | Active Prisms (Developmental Dyslexia) |
Primary outcome
Change in Detrended Fluctuation Analysis Alpha Coefficient
Time frame: Baseline and immediately after the intervention/control period, within the same approximately two-hour visit.
Change in detrended fluctuation analysis alpha coefficient (α-DFA), reflecting fractal self-similarity and the complexity and adaptability of nonlinear dynamics.
Change in High-Frequency Word Reading Effect
Time frame: Baseline and immediate post-test during one approximately two-hour visit.
Change in the high-frequency word effect during silent reading, used to assess reading automaticity.
8 secondary outcomes
Change in Postural Sway Path Length Measured Using the Polhemus Tracking System
Time frame: Baseline and immediately after the intervention/control period, within the same approximately two-hour visit.
Change in Pupil Diameter
Time frame: Baseline and immediate post-test during one approximately two-hour visit.
Change in First Fixation Duration During Silent Reading
Time frame: Baseline and immediate post-test during one approximately two-hour visit.
Change in Gaze Duration During Silent Reading
Time frame: Baseline and immediate post-test during one approximately two-hour visit.
Change in Total Fixation Duration During Silent Reading
Time frame: Baseline and immediate post-test during one approximately two-hour visit.
Change in Fractal Self-Similarity of Eye Movements During Silent Reading
Time frame: Baseline and immediate post-test during one approximately two-hour visit.
Change in Rapid Word Naming Performance
Time frame: Baseline and immediate post-test during one approximately two-hour visit.
Change in Pseudoword Reading Performance
Time frame: Baseline and immediate post-test during one approximately two-hour visit.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 9 Oct 2026.
- Background: PubMed 21802756Stergiou N, Decker LM. Human movement variability, nonlinear dynamics, and pathology: is there a connection? Hum Mov Sci. 2011 Oct;30(5):869-88. doi: 10.1016/j.humov.2011.06.002. Epub 2011 Jul 29.
- Background: PubMed 17486030Quercia P, Seigneuric A, Chariot S, Bron A, Creuzot-Garcher C, Robichon F. [Proprioception changes induced by prismatic glasses wear in children suffering from developmental dyslexia]. J Fr Ophtalmol. 2007 Apr;30(4):380-9. doi: 10.1016/s0181-5512(07)89608-2. French.
- Background: PubMed 39163725Virlet L, Sparrow L, Barela J, Berquin P, Bonnet C. Proprioceptive intervention improves reading performance in developmental dyslexia: An eye-tracking study. Res Dev Disabil. 2024 Oct;153:104813. doi: 10.1016/j.ridd.2024.104813. Epub 2024 Aug 19.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Individually Selected Active Prisms. in people with Developmental Dyslexia, run by Lille University at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 9 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Cédrick Bonnet, PhD (+33 (0)6 16 89 41 75, cedrick.bonnet@univ-lille.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Detrended Fluctuation Analysis Alpha Coefficient (time frame: Baseline and immediately after the intervention/control period, within the same approximately two-hour visit.). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07868367, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Oct 2026.