Trapeziometacarpal OsteoarthritisNCT07866703
Thumb Muscle Activation During Different Activities of Daily Living in Thumb Base Osteoarthritis and Healthy Controls
An observational study of Trapeziometacarpal Osteoarthritis, run by University of Malaga at 1 site in Spain.
Trial summary
The aim of this study is to investigate whether there are differences in muscle activation of the first dorsal interosseous (FDI) and the abductor pollicis longus (APL) between individuals with and without thumb trapeziopometacarpal joint osteoarthritis (OA TMC) during the performance of activities of daily living… Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Trapeziometacarpal Osteoarthritis
- How many people
- 60 participants
- Where
- 1 siteSpain
- Study dates
- 26 Sep 2026to 30 Dec 2026
- How long will I take part?
- 1 Day
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: The study population will include adults aged 18 years and older, both men and women, divided into two groups. The first group will consist of individuals with a clinical diagnosis of thumb trapeziometacarpal osteoarthritis, and the second group will consist of healthy controls without musculoskeletal or neurological disorders affecting the hand.
Who may be able to join
- Clinical diagnosis of thumb TMC osteoarthritis.
- Healthy group:Participants with no history of musculoskeletal or neurological disorders affecting the dominant hand were included.
Who cannot join
- Presence of numbness, tingling, or other sensory disturbances
- Upper limb entrapment neuropathy or cervical radiculopathy
- History of neuromuscular disease, polyneuropathy, or plexopathy
- Systemic diseases such as diabetes, hypothyroidism, or chronic liver or kidney disease
- History of cancer, rheumatoid arthritis, active anticoagulation therapy, chemotherapy, or exposure to neurotoxins
- Recent upper limb soft tissue or bone injury (trauma, fracture, or surgery of the arm or neck).
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Thumb Muscle Activation During Six Activities of Daily Living in Thumb Base Osteoarthritis and Healthy Controls
The aim of this study is to investigate whether there are differences in muscle activation of the first dorsal interosseous (FDI) and the abductor pollicis longus (APL) between individuals with and without thumb trapeziopometacarpal joint osteoarthritis (OA TMC) during the performance of activities of daily living (ADL).
The FDI muscle has been identified as a key stabilizer of the thumb TMC joint. However, scientific literature lacks information regarding the activation of the FDI and the APL during ADL, particularly in comparison with healthy individuals. OA TMC can lead to pain, reduced thumb strength, impaired hand function, and difficulty performing ADL. Determining whether differences in muscle activation patterns exist between individuals with and without OA TMC is crucial for understanding how this condition affects hand function and for guiding more specific and effective rehabilitation strategies.
Read more
Participants will perform six standardized functional tasks simulating everyday activities: turning a key to open, turning a key to close, picking up a coin, writing, squeezing a tube of toothpaste, and holding a glass of water. Muscle activity will be recorded using surface electromyography (sEMG) during all tasks.
Adults aged 30 years and older, both men and women, with thumb CMC osteoarthritis and healthy controls without osteoarthritis will be invited to participate.
Researchers will measure the activation patterns of the FDI and APL muscles during the ADL, with the aim of identifying differences between both groups and providing evidence to guide the rehabilitation of patients with thumb base osteoarthritis.
Read the detailed description
Trapeziometacarpal osteoarthritis (OA TMC) of the thumb is a chronic and progressive degenerative disease characterized by loss of articular cartilage, subchondral sclerosis, capsuloligamentous laxity, and osteophyte formation in the first metacarpal. Patients typically present with pain and muscle weakness, which impair hand function and limit activities of daily living (ADLs), resulting in a considerable personal and social burden, including reduced quality of life and work disability. Previous studies have highlighted the clinical importance of thumb TMC joint stabilizers. Research has demonstrated that the first dorsal interosseous (FDI) functions as the main stabilizer of the TMC joint, whereas the abductor pollicis longus (APL) acts as a primary destabilizer. However, despite the clinical importance of these muscles, the literature reports limited information on how the FDI and APL behave during activities of daily living, particularly in comparison with healthy individuals.
The aim of this study is to investigate whether there are differences in muscle activation of the FDI and APL between individuals with and without thumb OA TMC during the performance of activities of daily living. Understanding whether muscle activation patterns differ between groups during functional tasks is essential to comprehend how this condition affects hand function and to guide more specific and effective rehabilitation strategies.
This is a cross-sectional observational comparative study with a between-group analysis. The study includes two groups: adults aged 40 years and older, both men and women, with a clinical diagnosis of OA TMC and healthy controls without musculoskeletal or neurological disorders affecting the hand. Exclusion criteria include sensory disturbances such as numbness or tingling, cardiac pacemaker implantation, upper limb entrapment neuropathies or cervical radiculopathy, neuromuscular diseases, systemic conditions including diabetes or hypothyroidism, history of cancer, rheumatoid arthritis, anticoagulation therapy, chemotherapy, exposure to neurotoxins, or recent upper limb trauma or surgery.
Surface electromyography (sEMG) is used to record muscle activity of the FDI and APL. Skin is prepared by shaving if necessary and cleaning with alcohol to reduce impedance and ensure optimal adherence of surface electrodes. Bipolar surface electrodes with a diameter of 20 millimeters and an inter-electrode distance of 20 millimeters are placed according to SENIAM guidelines. For the FDI, electrodes are positioned over the dorsal belly of the muscle aligned with fiber direction, with one electrode in the distal ulnar region between the first and second metacarpals. For the APL, electrodes are placed approximately five centimeters distal to the wrist, medial to the radius, longitudinally aligned and transversely away from adjacent muscles. Electrode placement is verified by palpation and selective activation tasks.
Participants perform six standardized functional tasks simulating ADLs commonly affected in OA TMC of the thumb: turning a key toward the ulnar side, turning a key toward the radial side, picking up a coin, writing a word with a pen, squeezing a full tube of toothpaste, and holding a glass of water while performing a drinking gesture. Each task is performed in three consecutive three-second isometric repetitions with a thirty-second rest between repetitions to minimize fatigue.
It is hypothesized that individuals with thumb TMC osteoarthritis will demonstrate altered activation patterns of the FDI and APL compared with healthy controls during the performance of activities of daily living, providing evidence to guide the rehabilitation of patients with thumb base osteoarthritis.
- Conditions
- Trapeziometacarpal Osteoarthritis
- Keywords
- trapeziometacarpal osteoarthritis, muscle activation, surface electromyography, first dorsal interosseous, Abductor pollicis longus
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| OA GROUP | Adults aged 18 years and older with a clinical diagnosis of thumb trapeziometacarpal (TMC) osteoarthritis. Participants will perform six standardized functional tasks simulating activities of daily living while surface electromyography (sEMG) of the first dorsal interosseous (FDI) and abductor pollicis longus (APL) muscles is recorded. No pharmacological or physical intervention is administered; this is an observational measurement of muscle activation during functional tasks. | |
| HEALTHY GROUP | Adults aged 18 years and older without musculoskeletal or neurological disorders affecting the hand, and without thumb TMC osteoarthritis. Participants will perform the same six standardized functional tasks simulating activities of daily living while surface electromyography (sEMG) of the FDI and APL muscles is recorded, to serve as a comparison group. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Surface electromyographic amplitude of the First Dorsal Interosseous muscle.
Mean surface electromyographic amplitude of the First Dorsal Interosseous muscle recorded during each of the 6 activities of daily living
Measured: Day 1
Surface electromyographic amplitude of the Abductor Pollicis Longus muscle
Mean surface electromyographic amplitude of the Abductor Pollicis Longus muscle recorded during each of the 6 activities of daily living.
Measured: Day 1
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 Oct 2026
- Study start26 Sep 2026 (estimated)
- Primary completion2 Oct 2026 (estimated)
- Study completion30 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (13)Papers the sponsor has linked to this study.
- Other trials for Trapeziometacarpal OsteoarthritisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Cross-sectional
- Enrolment
- 60 participants (estimated)
- Target duration
- 1 Day
Sponsor and investigators
- Lead sponsor
- University of Malaga
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, carmen menaya fernandez, University of Malaga
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07866703
- Sponsor's protocol ID
- UMA-AOTMC-2026-003
- Status last verified
- Oct 2026
- First submitted
- 27 Sep 2026
- Last updated
- 8 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
Kerkhof FD, Deleu G, D'Agostino P, Vereecke EE. Subject-specific thumb muscle activity during functional tasks of daily life. J Electromyogr Kinesiol. 2016 Oct;30:131-6. doi: 10.1016/j.jelekin.2016.06.009. Epub 2016 Jul 1.
PubMed 27403854Brorsson S, Nilsdotter A, Thorstensson C, Bremander A. Differences in muscle activity during hand-dexterity tasks between women with arthritis and a healthy reference group. BMC Musculoskelet Disord. 2014 May 15;15:154. doi: 10.1186/1471-2474-15-154.
PubMed 24886491Haugen IK, Englund M, Aliabadi P, Niu J, Clancy M, Kvien TK, Felson DT. Prevalence, incidence and progression of hand osteoarthritis in the general population: the Framingham Osteoarthritis Study. Ann Rheum Dis. 2011 Sep;70(9):1581-6. doi: 10.1136/ard.2011.150078. Epub 2011 May 27.
PubMed 21622766Sodha S, Ring D, Zurakowski D, Jupiter JB. Prevalence of osteoarthrosis of the trapeziometacarpal joint. J Bone Joint Surg Am. 2005 Dec;87(12):2614-2618. doi: 10.2106/JBJS.E.00104.
PubMed 16322609Villafane JH, Valdes K. Combined thumb abduction and index finger extension strength: a comparison of older adults with and without thumb carpometacarpal osteoarthritis. J Manipulative Physiol Ther. 2013 May;36(4):238-44. doi: 10.1016/j.jmpt.2013.05.004. Epub 2013 May 27.
PubMed 23719517Cantero-Tellez R, Algar LA, Valdes KA, Naughton N. Clinical effects of proprioceptive thumb exercise for individuals with carpometacarpal joint osteoarthritis: A randomized controlled trial. J Hand Ther. 2022 Jul-Sep;35(3):358-366. doi: 10.1016/j.jht.2022.06.009. Epub 2022 Aug 23.
PubMed 36008246Osteras N, Hagen KB, Grotle M, Sand-Svartrud AL, Mowinckel P, Kjeken I. Limited effects of exercises in people with hand osteoarthritis: results from a randomized controlled trial. Osteoarthritis Cartilage. 2014 Sep;22(9):1224-33. doi: 10.1016/j.joca.2014.06.036. Epub 2014 Jul 5.
PubMed 25008206McVeigh KH, Kannas SN, Ivy CC, Garner HW, Barnes CS, Heckman MG, Brushaber DE, Murray PM. Dynamic stabilization home exercise program for treatment of thumb carpometacarpal osteoarthritis: A prospective randomized control trial. J Hand Ther. 2022 Jul-Sep;35(3):435-446. doi: 10.1016/j.jht.2021.06.002. Epub 2021 Jul 24.
PubMed 34312043Deveza LA, Hunter DJ, Wajon A, Bennell KL, Vicenzino B, Hodges P, Eyles JP, Jongs R, Riordan EA, Duong V, Min Oo W, O'Connell R, Meneses SR. Efficacy of combined conservative therapies on clinical outcomes in patients with thumb base osteoarthritis: protocol for a randomised, controlled trial (COMBO). BMJ Open. 2017 Jan 12;7(1):e014498. doi: 10.1136/bmjopen-2016-014498.
PubMed 28082368Tossini NB, Melo CS, Braz de Oliveira MP, Moreira RFC, Serrao PRMDS. Effect of physical therapy interventions in individuals with primary thumb carpometacarpal osteoarthritis: a systematic review and meta-analysis. Disabil Rehabil. 2024 Dec;46(26):6251-6265. doi: 10.1080/09638288.2024.2325652. Epub 2024 Mar 7.
PubMed 38450686Ahern M, Skyllas J, Wajon A, Hush J. The effectiveness of physical therapies for patients with base of thumb osteoarthritis: Systematic review and meta-analysis. Musculoskelet Sci Pract. 2018 Jun;35:46-54. doi: 10.1016/j.msksp.2018.02.005. Epub 2018 Feb 21.
PubMed 29510316Whitford M, Kukulka CG. Task-related variations in the surface EMG of the human first dorsal interosseous muscle. Exp Brain Res. 2011 Nov;215(2):101-13. doi: 10.1007/s00221-011-2875-9. Epub 2011 Oct 1.
PubMed 21964867McGee C, O'Brien V, Van Nortwick S, Adams J, Van Heest A. First dorsal interosseous muscle contraction results in radiographic reduction of healthy thumb carpometacarpal joint. J Hand Ther. 2015 Oct-Dec;28(4):375-80; quiz 381. doi: 10.1016/j.jht.2015.06.002. Epub 2015 Jun 27.
PubMed 26209165
Study at a glance
From the registry record, last updated by the sponsor on 8 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Thumb Muscle Activation During Six Activities of Daily Living in Thumb Base Osteoarthritis and Healthy Controls
- ClinicalTrials.gov ID
- NCT07866703
- Acronym / sponsor ID
- UMA-AOTMC-2026-003
- Conditions
- Trapeziometacarpal Osteoarthritis
- Keywords
- trapeziometacarpal osteoarthritis, muscle activation, surface electromyography, first dorsal interosseous, Abductor pollicis longus
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- University of MalagaUniversity, hospital or other
- Study start
- 26 Sep 2026 (estimated)
- Primary completion
- 2 Oct 2026 (estimated)
- Study completion
- 30 Dec 2026 (estimated)
- First posted
- 8 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this study is to investigate whether there are differences in muscle activation of the first dorsal interosseous (FDI) and the abductor pollicis longus (APL) between individuals with and without thumb trapeziopometacarpal joint osteoarthritis (OA TMC) during the performance of activities of daily living (ADL).
The FDI muscle has been identified as a key stabilizer of the thumb TMC joint. However, scientific literature lacks information regarding the activation of the FDI and the APL during ADL, particularly in comparison with healthy individuals. OA TMC can lead to pain, reduced thumb strength, impaired hand function, and difficulty performing ADL. Determining whether differences in muscle activation patterns exist between individuals with and without OA TMC is crucial for understanding how this condition affects hand function and for guiding more specific and effective rehabilitation strategies.
Participants will perform six standardized functional tasks simulating everyday activities: turning a key to open, turning a key to close, picking up a coin, writing, squeezing a tube of toothpaste, and holding a glass of water. Muscle activity will be recorded using surface electromyography (sEMG) during all tasks.
Adults aged 30 years and older, both men and women, with thumb CMC osteoarthritis and healthy controls without osteoarthritis will be invited to participate.
Researchers will measure the activation patterns of the FDI and APL muscles during the ADL, with the aim of identifying differences between both groups and providing evidence to guide the rehabilitation of patients with thumb base osteoarthritis.
Detailed description
Trapeziometacarpal osteoarthritis (OA TMC) of the thumb is a chronic and progressive degenerative disease characterized by loss of articular cartilage, subchondral sclerosis, capsuloligamentous laxity, and osteophyte formation in the first metacarpal. Patients typically present with pain and muscle weakness, which impair hand function and limit activities of daily living (ADLs), resulting in a considerable personal and social burden, including reduced quality of life and work disability. Previous studies have highlighted the clinical importance of thumb TMC joint stabilizers. Research has demonstrated that the first dorsal interosseous (FDI) functions as the main stabilizer of the TMC joint, whereas the abductor pollicis longus (APL) acts as a primary destabilizer. However, despite the clinical importance of these muscles, the literature reports limited information on how the FDI and APL behave during activities of daily living, particularly in comparison with healthy individuals.
The aim of this study is to investigate whether there are differences in muscle activation of the FDI and APL between individuals with and without thumb OA TMC during the performance of activities of daily living. Understanding whether muscle activation patterns differ between groups during functional tasks is essential to comprehend how this condition affects hand function and to guide more specific and effective rehabilitation strategies.
This is a cross-sectional observational comparative study with a between-group analysis. The study includes two groups: adults aged 40 years and older, both men and women, with a clinical diagnosis of OA TMC and healthy controls without musculoskeletal or neurological disorders affecting the hand. Exclusion criteria include sensory disturbances such as numbness or tingling, cardiac pacemaker implantation, upper limb entrapment neuropathies or cervical radiculopathy, neuromuscular diseases, systemic conditions including diabetes or hypothyroidism, history of cancer, rheumatoid arthritis, anticoagulation therapy, chemotherapy, exposure to neurotoxins, or recent upper limb trauma or surgery.
Surface electromyography (sEMG) is used to record muscle activity of the FDI and APL. Skin is prepared by shaving if necessary and cleaning with alcohol to reduce impedance and ensure optimal adherence of surface electrodes. Bipolar surface electrodes with a diameter of 20 millimeters and an inter-electrode distance of 20 millimeters are placed according to SENIAM guidelines. For the FDI, electrodes are positioned over the dorsal belly of the muscle aligned with fiber direction, with one electrode in the distal ulnar region between the first and second metacarpals. For the APL, electrodes are placed approximately five centimeters distal to the wrist, medial to the radius, longitudinally aligned and transversely away from adjacent muscles. Electrode placement is verified by palpation and selective activation tasks.
Participants perform six standardized functional tasks simulating ADLs commonly affected in OA TMC of the thumb: turning a key toward the ulnar side, turning a key toward the radial side, picking up a coin, writing a word with a pen, squeezing a full tube of toothpaste, and holding a glass of water while performing a drinking gesture. Each task is performed in three consecutive three-second isometric repetitions with a thirty-second rest between repetitions to minimize fatigue.
It is hypothesized that individuals with thumb TMC osteoarthritis will demonstrate altered activation patterns of the FDI and APL compared with healthy controls during the performance of activities of daily living, providing evidence to guide the rehabilitation of patients with thumb base osteoarthritis.
Study design
- Observational model
- Case-control
- Time perspective
- Cross-sectional
- Target follow-up
- 1 Day
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| OA GROUP | – | –Adults aged 18 years and older with a clinical diagnosis of thumb trapeziometacarpal (TMC) osteoarthritis. Participants will perform six standardized functional tasks simulating activities of daily living while surface electromyography (sEMG) of the first dorsal interosseous (FDI) and abductor pollicis longus (APL) muscles is recorded. No pharmacological or physical intervention is administered; this is an observational measurement of muscle activation during functional tasks. |
| HEALTHY GROUP | – | –Adults aged 18 years and older without musculoskeletal or neurological disorders affecting the hand, and without thumb TMC osteoarthritis. Participants will perform the same six standardized functional tasks simulating activities of daily living while surface electromyography (sEMG) of the FDI and APL muscles is recorded, to serve as a comparison group. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- The study population will include adults aged 18 years and older, both men and women, divided into two groups. The first group will consist of individuals with a clinical diagnosis of thumb trapeziometacarpal osteoarthritis, and the second group will consist of healthy controls without musculoskeletal or neurological disorders affecting the hand.
Key inclusion criteria (2 listed)
- Clinical diagnosis of thumb TMC osteoarthritis.
- Healthy group:Participants with no history of musculoskeletal or neurological disorders affecting the dominant hand were included.
Key exclusion criteria (6 listed)
- Presence of numbness, tingling, or other sensory disturbances
- Upper limb entrapment neuropathy or cervical radiculopathy
- History of neuromuscular disease, polyneuropathy, or plexopathy
- Systemic diseases such as diabetes, hypothyroidism, or chronic liver or kidney disease
- History of cancer, rheumatoid arthritis, active anticoagulation therapy, chemotherapy, or exposure to neurotoxins
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Surface electromyographic amplitude of the First Dorsal Interosseous muscle.
Time frame: Day 1
Mean surface electromyographic amplitude of the First Dorsal Interosseous muscle recorded during each of the 6 activities of daily living
Surface electromyographic amplitude of the Abductor Pollicis Longus muscle
Time frame: Day 1
Mean surface electromyographic amplitude of the Abductor Pollicis Longus muscle recorded during each of the 6 activities of daily living.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 Oct 2026.
- Background: PubMed 27403854Kerkhof FD, Deleu G, D'Agostino P, Vereecke EE. Subject-specific thumb muscle activity during functional tasks of daily life. J Electromyogr Kinesiol. 2016 Oct;30:131-6. doi: 10.1016/j.jelekin.2016.06.009. Epub 2016 Jul 1.
- Background: PubMed 24886491Brorsson S, Nilsdotter A, Thorstensson C, Bremander A. Differences in muscle activity during hand-dexterity tasks between women with arthritis and a healthy reference group. BMC Musculoskelet Disord. 2014 May 15;15:154. doi: 10.1186/1471-2474-15-154.
- Background: PubMed 21622766Haugen IK, Englund M, Aliabadi P, Niu J, Clancy M, Kvien TK, Felson DT. Prevalence, incidence and progression of hand osteoarthritis in the general population: the Framingham Osteoarthritis Study. Ann Rheum Dis. 2011 Sep;70(9):1581-6. doi: 10.1136/ard.2011.150078. Epub 2011 May 27.
- Background: PubMed 16322609Sodha S, Ring D, Zurakowski D, Jupiter JB. Prevalence of osteoarthrosis of the trapeziometacarpal joint. J Bone Joint Surg Am. 2005 Dec;87(12):2614-2618. doi: 10.2106/JBJS.E.00104.
- Background: PubMed 23719517Villafane JH, Valdes K. Combined thumb abduction and index finger extension strength: a comparison of older adults with and without thumb carpometacarpal osteoarthritis. J Manipulative Physiol Ther. 2013 May;36(4):238-44. doi: 10.1016/j.jmpt.2013.05.004. Epub 2013 May 27.
- Background: PubMed 36008246Cantero-Tellez R, Algar LA, Valdes KA, Naughton N. Clinical effects of proprioceptive thumb exercise for individuals with carpometacarpal joint osteoarthritis: A randomized controlled trial. J Hand Ther. 2022 Jul-Sep;35(3):358-366. doi: 10.1016/j.jht.2022.06.009. Epub 2022 Aug 23.
- Background: PubMed 25008206Osteras N, Hagen KB, Grotle M, Sand-Svartrud AL, Mowinckel P, Kjeken I. Limited effects of exercises in people with hand osteoarthritis: results from a randomized controlled trial. Osteoarthritis Cartilage. 2014 Sep;22(9):1224-33. doi: 10.1016/j.joca.2014.06.036. Epub 2014 Jul 5.
- Background: PubMed 34312043McVeigh KH, Kannas SN, Ivy CC, Garner HW, Barnes CS, Heckman MG, Brushaber DE, Murray PM. Dynamic stabilization home exercise program for treatment of thumb carpometacarpal osteoarthritis: A prospective randomized control trial. J Hand Ther. 2022 Jul-Sep;35(3):435-446. doi: 10.1016/j.jht.2021.06.002. Epub 2021 Jul 24.
- Background: PubMed 28082368Deveza LA, Hunter DJ, Wajon A, Bennell KL, Vicenzino B, Hodges P, Eyles JP, Jongs R, Riordan EA, Duong V, Min Oo W, O'Connell R, Meneses SR. Efficacy of combined conservative therapies on clinical outcomes in patients with thumb base osteoarthritis: protocol for a randomised, controlled trial (COMBO). BMJ Open. 2017 Jan 12;7(1):e014498. doi: 10.1136/bmjopen-2016-014498.
- Background: PubMed 38450686Tossini NB, Melo CS, Braz de Oliveira MP, Moreira RFC, Serrao PRMDS. Effect of physical therapy interventions in individuals with primary thumb carpometacarpal osteoarthritis: a systematic review and meta-analysis. Disabil Rehabil. 2024 Dec;46(26):6251-6265. doi: 10.1080/09638288.2024.2325652. Epub 2024 Mar 7.
- Background: PubMed 29510316Ahern M, Skyllas J, Wajon A, Hush J. The effectiveness of physical therapies for patients with base of thumb osteoarthritis: Systematic review and meta-analysis. Musculoskelet Sci Pract. 2018 Jun;35:46-54. doi: 10.1016/j.msksp.2018.02.005. Epub 2018 Feb 21.
- Background: PubMed 21964867Whitford M, Kukulka CG. Task-related variations in the surface EMG of the human first dorsal interosseous muscle. Exp Brain Res. 2011 Nov;215(2):101-13. doi: 10.1007/s00221-011-2875-9. Epub 2011 Oct 1.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Trapeziometacarpal Osteoarthritis, run by University of Malaga at 1 site in Spain.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 8 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Spain. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Carmen Menaya Fernandez, Doctoral Student (658424375 ext. +34, cmenayaf@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Surface electromyographic amplitude of the First Dorsal Interosseous muscle. (time frame: Day 1). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07866703, which also lists 13 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Oct 2026.