Wound HealingNCT07856524
Sutureless Versus Conventional Suturing in Oral Surgery
A study testing Sutureless Wound Closure Using n-Butyl-2-Cyanoacrylate and Conventional Suturing in people with Wound Healing and Wound Healing Complication, run by Jouf University at 1 site in Saudi Arabia.
Trial summary
This randomized clinical study compares sutureless wound closure using n-butyl-2-cyanoacrylate tissue adhesive with conventional silk suturing following minor oral surgical procedures. Read more about this study
- Who is it for?
- Ages 18 to 45 years
- Conditions the study is for
- Wound Healing, Wound Healing Complication, Postoperative Pain
- What is being tested?
- Sutureless Wound Closure Using n-Butyl-2-Cyanoacrylate and Conventional Suturing
- Type of treatment
- Pill or oral medicine, Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 80 participants
- Where
- 1 siteSaudi Arabia
- Study dates
- 1 Feb 2026to 31 May 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 45 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Patients aged 18 to 45 years.
- Classified as ASA physical status I or II.
- Indicated for minor oral surgical procedures, such as impacted mandibular third molar removal, alveoloplasty, or periapical surgery.
- Presence of healthy surrounding soft tissues at the surgical site.
- Willingness to participate and provide written informed consent.
- Ability to comply with postoperative follow-up visits.
Who cannot join
- Systemic diseases known to impair wound healing, including uncontrolled diabetes mellitus, immunocompromised states, autoimmune disorders, and chronic renal or hepatic disease.
- Bleeding disorders or use of anticoagulant/antiplatelet therapy.
- Chronic corticosteroid or immunosuppressive therapy.
- Active local infection at the surgical site.
- History of smoking or smokeless tobacco use within the past 6 months.
- Pregnant or lactating women.
Show all 9Show fewer
- Known hypersensitivity to cyanoacrylate or suture materials.
- Poor oral hygiene, defined clinically by visible plaque accumulation and gingival inflammation.
- Patients requiring bone grafting, membrane placement, or complex flap designs.
Trial locations and contacts
1 site in 1 country.
Saudi Arabia1 site
King Abdulaziz Specialist Hospital
Sakakah, Al Jawf Region, 72345
About this study
Official title: Sutureless Versus Conventional Suturing in Oral Surgery: A Randomized Clinical Study on Healing and Postoperative Outcomes
This randomized clinical study compares sutureless wound closure using n-butyl-2-cyanoacrylate tissue adhesive with conventional silk suturing following minor oral surgical procedures. The study evaluates wound healing as the primary outcome, along with postoperative pain, time to hemostasis, closure time, intraoperative blood loss, and postoperative complications. Eighty patients were randomly allocated in a 1:1 ratio to either sutureless closure or conventional suturing and were followed for 14 days after surgery.
- Conditions
- Wound Healing, Wound Healing Complication, Postoperative Pain, Oral and Maxillofacial Surgery Complications
- Being tested
- Sutureless Wound Closure Using n-Butyl-2-Cyanoacrylate, Conventional Suturing
- Keywords
- Oral Surgery, Postoperative pain, Silk sutures, Wound healing
- Medical subject headings
- Pain, Postoperative
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Sutureless Wound Closure Using n-Butyl-2-CyanoacrylateProcedure or surgery
Also called n-Butyl-2-Cyanoacrylate, Histoacryl®, Cyanoacrylate Tissue Adhesive
The study protocol describes the intervention as n-butyl-2-cyanoacrylate tissue adhesive (Histoacryl) used for sutureless wound closure.
Conventional SuturingProcedure or surgery
Also called 3-0 Black Braided Silk Sutures
The study uses interrupted 3-0 black braided silk sutures, which are removed on postoperative day 7.
| Study group | Role | What they receive |
|---|---|---|
| Sutureless Closure | Experimental | Participants underwent sutureless wound closure using n-butyl-2-cyanoacrylate tissue adhesive (Histoacryl®) following minor oral surgical procedures. The wound margins were manually approximated, and a thin layer of tissue adhesive was applied along the approximated margins. Receives: Procedure: Sutureless Wound Closure Using n-Butyl-2-Cyanoacrylate |
| Conventional Suturing | Active comparator | Participants underwent conventional wound closure using 3-0 black braided silk sutures placed in an interrupted pattern following minor oral surgical procedures. Sutures were removed on postoperative Day 7. Receives: Procedure: Conventional Suturing |
What is being measured
The primary outcome is the main question the study is designed to answer.
Wound Healing Score
Wound healing assessed using the Landry, Turnbull, and Howley Healing Index, with scores ranging from 1 (very poor healing) to 5 (excellent healing).
Measured: Postoperative Days 1, 3, 7, and 14
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted2 Oct 2026
- Study start1 Feb 2026
- Primary completion28 May 2026
- Study completion31 May 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Wound HealingStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 80 participants (actual)
Sponsor and investigators
- Lead sponsor
- Jouf University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Rakhi Issrani, Jouf University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07856524
- Sponsor's protocol ID
- H-13-S-161/118
- Status last verified
- Oct 2026
- First submitted
- 28 Sep 2026
- Last updated
- 6 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 6 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Sutureless Versus Conventional Suturing in Oral Surgery: A Randomized Clinical Study on Healing and Postoperative Outcomes
- ClinicalTrials.gov ID
- NCT07856524
- Acronym / sponsor ID
- H-13-S-161/118
- Conditions
- Wound Healing, Wound Healing Complication, Postoperative Pain, Oral and Maxillofacial Surgery Complications
- Keywords
- Oral Surgery, Postoperative pain, Silk sutures, Wound healing
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 80 participants (actual)
- Lead sponsor
- Jouf UniversityUniversity, hospital or other
- Study start
- 1 Feb 2026 (actual)
- Primary completion
- 28 May 2026 (actual)
- Study completion
- 31 May 2026 (actual)
- First posted
- 2 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized clinical study compares sutureless wound closure using n-butyl-2-cyanoacrylate tissue adhesive with conventional silk suturing following minor oral surgical procedures. The study evaluates wound healing as the primary outcome, along with postoperative pain, time to hemostasis, closure time, intraoperative blood loss, and postoperative complications. Eighty patients were randomly allocated in a 1:1 ratio to either sutureless closure or conventional suturing and were followed for 14 days after surgery.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Sutureless Closure | Experimental | Procedure: Sutureless Wound Closure Using n-Butyl-2-CyanoacrylateParticipants underwent sutureless wound closure using n-butyl-2-cyanoacrylate tissue adhesive (Histoacryl®) following minor oral surgical procedures. The wound margins were manually approximated, and a thin layer of tissue adhesive was applied along the approximated margins. |
| Conventional Suturing | Active comparator | Procedure: Conventional SuturingParticipants underwent conventional wound closure using 3-0 black braided silk sutures placed in an interrupted pattern following minor oral surgical procedures. Sutures were removed on postoperative Day 7. |
Who may qualify
- Ages
- 18 to 45 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- Patients aged 18 to 45 years.
- Classified as ASA physical status I or II.
- Indicated for minor oral surgical procedures, such as impacted mandibular third molar removal, alveoloplasty, or periapical surgery.
- Presence of healthy surrounding soft tissues at the surgical site.
- Willingness to participate and provide written informed consent.
Key exclusion criteria (9 listed)
- Systemic diseases known to impair wound healing, including uncontrolled diabetes mellitus, immunocompromised states, autoimmune disorders, and chronic renal or hepatic disease.
- Bleeding disorders or use of anticoagulant/antiplatelet therapy.
- Chronic corticosteroid or immunosuppressive therapy.
- Active local infection at the surgical site.
- History of smoking or smokeless tobacco use within the past 6 months.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Sutureless Wound Closure Using n-Butyl-2-CyanoacrylateAlso: n-Butyl-2-Cyanoacrylate, Histoacryl®, Cyanoacrylate Tissue AdhesiveThe study protocol describes the intervention as n-butyl-2-cyanoacrylate tissue adhesive (Histoacryl) used for sutureless wound closure. | Procedure or surgery | Sutureless Closure |
| Conventional SuturingAlso: 3-0 Black Braided Silk SuturesThe study uses interrupted 3-0 black braided silk sutures, which are removed on postoperative day 7. | Procedure or surgery | Conventional Suturing |
Primary outcome
Wound Healing Score
Time frame: Postoperative Days 1, 3, 7, and 14
Wound healing assessed using the Landry, Turnbull, and Howley Healing Index, with scores ranging from 1 (very poor healing) to 5 (excellent healing).
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Oct 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Sutureless Wound Closure Using n-Butyl-2-Cyanoacrylate and Conventional Suturing in people with Wound Healing and Wound Healing Complication, run by Jouf University at 1 site in Saudi Arabia.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 6 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Saudi Arabia. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Wound Healing Score (time frame: Postoperative Days 1, 3, 7, and 14). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Oct 2026.