Not Applicable - Healthy ParticipantsMEMRINCT07849075
MEMRI: Memory Emergence Using MRI
An observational study of Not Applicable - Healthy Participants and Focus is the Memory System, run by Paediatric Neuroimaging Research Group.
Trial summary
Episodic memory is our ability to remember personal experiences, such as a birthday party or a visit to the park. This study aims to understand how this type of memory develops during the first two years of a baby's life. Read more about this study
- Who is it for?
- Ages 0 weeks to 1 weekHealthy volunteers can take part
- Conditions the study is for
- Not Applicable - Healthy Participants, Focus is the Memory System, Paediatric
- How many people
- 20 participants
- Where
- No sites listed yet
- Study dates
- 1 Mar 2027to 1 Jul 2031
- How long will I take part?
- 26 Months
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 0 weeks to 1 week
- All sexes
- Healthy volunteers accepted
- Child
Study population: Participants in this study will be infants born at the John Radcliffe Hospital, Oxford at or after 35+0 weeks gestation with a postnatal age of <7 days.
Who may be able to join
- Infants born at the John Radcliffe Hospital, Oxford
- Infants born at or after 35+0 weeks gestation
- Infants with a postnatal age of <7 days
- Infants for whom parents/legal guardians have given written informed consent for participation.
Who cannot join
- Hypoxic Ischaemic Encephalopathy (HIE)
- Intraventricular haemorrhage (IVH) > grade II
- Received any analgesics or sedatives in the last 24 hours
- Congenital malformation or genetic condition known to affect neurological development
- Born to mothers who have a history of substance abuse
- Any MRI contradictions
About this study
Official title: Emergence of Distinct Cortical Anatomy Associated With the Human Medial Temporal Lobe in the First Two Years of Life Revealed Using Precision High-resolution Neuroimaging at 7-Tesla
Episodic memory is our ability to remember personal experiences, such as a birthday party or a visit to the park. This study aims to understand how this type of memory develops during the first two years of a baby's life. Researchers will use a safe, non-invasive brain scanning technique called magnetic resonance imaging (MRI) to study healthy babies from birth until they are two years old. By following the same children over time, researchers will see how the brain's memory system develops and how it becomes connected with other parts of the brain. The findings will help us understand how babies develop the ability to remember personal experiences. They will also provide new knowledge about how the human brain develops during the earliest stages of life.
- Keywords
- Memory, Neonatal, Paediatric, MRI
What is being measured
The primary outcome is the main question the study is designed to answer.
FMRI connectivity
Differences in functional connectivity of spontaneous fMRI brain activity
Measured: Two years
Secondary outcomes (1)
Changes in fMRI connectivity
Longitudinal changes in fMRI connectivity over the entire duration of the study
Measured: Two years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted30 Sep 2026
- Study start1 Mar 2027 (estimated)
- Primary completion1 Mar 2030 (estimated)
- Study completion1 Jul 2031 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Not Applicable - Healthy ParticipantsStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 20 participants (estimated)
- Target duration
- 26 Months
Sponsor and investigators
- Lead sponsor
- Paediatric Neuroimaging Research Group
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07849075
- Sponsor's protocol ID
- 374049
- Acronym
- MEMRI
- Status last verified
- Sep 2026
- First submitted
- 24 Sep 2026
- Last updated
- 30 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 30 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Emergence of Distinct Cortical Anatomy Associated With the Human Medial Temporal Lobe in the First Two Years of Life Revealed Using Precision High-resolution Neuroimaging at 7-Tesla
- ClinicalTrials.gov ID
- NCT07849075
- Acronym / sponsor ID
- MEMRI / 374049
- Keywords
- Memory, Neonatal, Paediatric, MRI
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 20 participants (estimated)
- Lead sponsor
- Paediatric Neuroimaging Research GroupUniversity, hospital or other
- Study start
- 1 Mar 2027 (estimated)
- Primary completion
- 1 Mar 2030 (estimated)
- Study completion
- 1 Jul 2031 (estimated)
- First posted
- 30 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Episodic memory is our ability to remember personal experiences, such as a birthday party or a visit to the park. This study aims to understand how this type of memory develops during the first two years of a baby's life. Researchers will use a safe, non-invasive brain scanning technique called magnetic resonance imaging (MRI) to study healthy babies from birth until they are two years old. By following the same children over time, researchers will see how the brain's memory system develops and how it becomes connected with other parts of the brain. The findings will help us understand how babies develop the ability to remember personal experiences. They will also provide new knowledge about how the human brain develops during the earliest stages of life.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Target follow-up
- 26 Months
Who may qualify
- Ages
- 0 weeks to 1 week
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child
- Study population
- Participants in this study will be infants born at the John Radcliffe Hospital, Oxford at or after 35+0 weeks gestation with a postnatal age of <7 days.
Key inclusion criteria (4 listed)
- Infants born at the John Radcliffe Hospital, Oxford
- Infants born at or after 35+0 weeks gestation
- Infants with a postnatal age of <7 days
- Infants for whom parents/legal guardians have given written informed consent for participation.
Key exclusion criteria (6 listed)
- Hypoxic Ischaemic Encephalopathy (HIE)
- Intraventricular haemorrhage (IVH) > grade II
- Received any analgesics or sedatives in the last 24 hours
- Congenital malformation or genetic condition known to affect neurological development
- Born to mothers who have a history of substance abuse
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
FMRI connectivity
Time frame: Two years
Differences in functional connectivity of spontaneous fMRI brain activity
1 secondary outcome
Changes in fMRI connectivity
Time frame: Two years
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Sep 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
Questions about this trial
What is this clinical trial studying?
An observational study of Not Applicable - Healthy Participants and Focus is the Memory System, run by Paediatric Neuroimaging Research Group.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 30 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
FMRI connectivity (time frame: Two years). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Sep 2026.