AlcoholNCT07848906
Alcohol and Cancer Message Testing Experiment
A study testing Alcohol health harm message exposure in people with Alcohol and Message Perception, run by University of Connecticut.
Trial summary
Alcohol increases the risk for at least seven cancers, yet recent estimates suggest only between one-third and one-half of US adults are aware of this risk. The current study aims to develop and test alcohol-cancer messages designed for a mass media public health campaign. Read more about this study
- Who is it for?
- Ages 21 years and olderHealthy volunteers can take part
- Conditions the study is for
- Alcohol, Message Perception, PME
- What is being tested?
- Alcohol health harm message exposure
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 1,400 participants
- Where
- No sites listed yet
- Study dates
- Sep 2026to Oct 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 21 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- currently reside in the US;
- be aged 21 years or older; and
- speak English.
Who cannot join
- none beyond failure to meet the inclusion criteria.
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Public Health Messaging Survey
Alcohol increases the risk for at least seven cancers, yet recent estimates suggest only between one-third and one-half of US adults are aware of this risk. The current study aims to develop and test alcohol-cancer messages designed for a mass media public health campaign. The messages will be informed by theory-based constructs proximal to health behavior change (e.g., perceived likelihood/severity of harm, response efficacy). We will evaluate messages via an online, cross-sectional message testing randomized experiment. Participants will be US adults aged 21+ recruited from Qualtrics Panels.
Read the detailed description
Rational:
Alcohol increases the risk for at least seven cancers, yet recent estimates suggest only between one-third and one-half of US adults are aware of this risk. Raising public awareness of the alcohol-cancer link can encourage better informed choices about alcohol and promote reduced consumption, yet the most effective strategies for raising such awareness remain to be determined.
One potential strategy is the use of alcohol-cancer risk messages, which could be disseminated through various communication channels (e.g., public service announcements, communication campaigns). However, such messages can differ in numerous ways, including their substantive content and the specific language used to communicate risk, and the optimal design of these messages and their effects on audiences remains to be determined.
Ours and others' prior work has tested different alcohol-cancer warning label messages in experimental studies. These experiments have tested the effects of using causal vs. hedging language, the utility of adding pictograms in warning labels, different ways to frame the alcohol-cancer risk relationship, and the type of cancer to communicate in warning labels. The overarching goal of these studies was to develop effective warning labels that could be added to alcohol beverages.
The current study aims to extend this work by developing and preliminarily evaluating alcohol-cancer messages designed for a mass media public health campaign. These messages will be informed by theory-based constructs proximal to health behavior change (e.g., perceived likelihood/severity of harm, response efficacy). We will evaluate messages via an online, cross-sectional message testing randomized experiment. Participants will be US adults aged 21+ recruited from Qualtrics Panels.
Objective:
The primary objective of this study is to identify how different alcohol-cancer message frames affect message-related perceptions and related health outcomes (e.g., perceived message effectiveness, risk beliefs, drinking intentions). Findings will help inform future alcohol harm reduction health communication efforts.
Guiding research question:
- Do different alcohol-cancer message frames affect people's a) message receptivity, b) alcohol-related attitudes and risk perceptions, and c) drinking intentions?
- Do any factors moderate the effects of exposure to different alcohol-cancer message frames (e.g., drinking status as a moderator)?
- Conditions
- Alcohol, Message Perception, PME
- Being tested
- Alcohol health harm message exposure
- Keywords
- Message testing experiment, Alcohol risk messages, Alcohol and cancer
- Medical subject headings
- Neoplasms
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Alcohol health harm message exposureBehavioural
Randomized exposure to one of five alcohol-cancer health campaign message frames, or a non-cancer alcohol harms frame.
| Study group | Role | What they receive |
|---|---|---|
| Perceived likelihood frame | Experimental | Exposure to two alcohol-cancer messages that convey the probability of experiencing a health harm (i.e., cancer) from a particular hazard (i.e., drinking alcohol).
The intervention will be administered in an online survey experiment as static images displayed to participants. Receives: Behavioral: Alcohol health harm message exposure |
| Harm reduction frame | Experimental | Exposure to two alcohol-cancer messages that encourage reducing how much alcohol people drink. The intervention will be administered in an online survey experiment as static images displayed to participants. Receives: Behavioral: Alcohol health harm message exposure |
| Perceived severity frame | Experimental | Exposure to two alcohol-cancer messages that convey how serious getting alcohol-associated cancer will be. The intervention will be administered in an online survey experiment as static images displayed to participants. Receives: Behavioral: Alcohol health harm message exposure |
| Response efficacy frame | Experimental | Exposure to two alcohol-cancer messages that emphasize the effectiveness of protective behaviors for reducing alcohol-associated cancer risk. The intervention will be administered in an online survey experiment as static images displayed to participants. Receives: Behavioral: Alcohol health harm message exposure |
| Harm prevention frame | Experimental | Exposure to two alcohol-cancer messages that emphasize completely abstaining from drinking alcohol. The intervention will be administered in an online survey experiment as static images displayed to participants. Receives: Behavioral: Alcohol health harm message exposure |
| Surgeon General's frame | Active comparator | Exposure to two alcohol-cancer messages that do not discuss alcohol-associated cancer risk. Instead, the messages use language from the existing U.S. Surgeon General's warning on alcoholic beverages. The intervention will be administered in an online survey experiment as static images displayed to participants. Receives: Behavioral: Alcohol health harm message exposure |
| Control | No intervention | Participants randomized to control will not be exposed to any message stimuli. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Perceived message effectiveness - effects perceptions
A 3-item scale adapted from prior effects perception PME and substance use literature. After each message exposure, participants will be asked to respond to the following items: 1) This message discourages me from wanting to drink alcohol; 2) This message makes me concerned about the health effects of drinking alcohol; and 3) This message makes drinking alcohol seem unpleasant to me. Items will be assessed on a 5-point scale ranging from strongly disagree (1) to strongly agree (5). We will assess internal consistency using Cronbach's alpha. Assuming adequate measure reliability, we will average the items into a single composite PME measure.
Measured: Day 1; post intervention exposure
Secondary outcomes (11)
Drinking intentions
Intentions will be assessed with a 3-item scale adapted from prior substance use and health communication research. Participants will answer each of the following questions: How likely is it that you will drink alcohol in the... 1) next week, 2) next month, and 3) next year. Responses will be on 5-point scales ranging from "not at all" (1) to "extremely" (5). We will assess internal consistency using Cronbach's alpha. Assuming adequate measure reliability, we will average the items into a single composite measure.
Measured: Day 1; post intervention exposure
Message reactance
Message reactance will be assessed with a brief 3-item scale used in prior research. Participants will respond to the following statements: 1) This message is trying to manipulate me, 2) The health effect in this message is overblown, and 3) This message annoys me. Responses will be assessed on 5-point scales ranging from "strongly disagree" (1) to "strongly agree" (5). We will assess internal consistency using Cronbach's alpha. Assuming adequate measure reliability, we will average the items into a single composite measure.
Measured: Day 1; post intervention exposure
Non-alcoholic beer message perceptions
A single item that has participants respond to the following statement: "This message makes me think drinking non-alcoholic beer is healthier than alcoholic beer." This item will be assessed on a 5-point scale ranging from strongly disagree (1) to strongly agree (5).
Measured: Day 1; post intervention exposure
Perceived message effectiveness - message perceptions
A 5-item scale assessing perceptions of each message, adapted from prior work. After each message exposure, participants will respond to the following items: 1) "This message grabs my attention"; 2) "This message is believable"; 3) "This message is credible"; 4) "This message is trustworthy"; and 5) "I learned something new from this message." Items will be assessed on a 5-point scale ranging from strongly disagree (1) to strongly agree (5). We will assess internal consistency using Cronbach's alpha. Assuming adequate measure reliability, we will average the items into a single composite measure.
Measured: Day 1; post intervention exposure
Attitudes toward alcohol
A 3-item measure assessing attitudes toward drinking alcohol. Participants will rate drinking alcohol on three 5-point bipolar scales: 1) harmful/safe; 2) bad/good; and 3) unhealthy/healthy. We will assess internal consistency using Cronbach's alpha. Assuming adequate reliability, we will average the items into a single composite attitude measure.
Measured: Day 1; post intervention exposure
Intentions to reduce alcohol use
Assessed only among participants who currently drink alcohol. Participants will be asked, "How likely are you to reduce how much alcohol you drink?" Responses will be assessed on a 5-point scale ranging from not at all (1) to very much (5).
Measured: Day 1; post intervention exposure
Alcohol-cancer causal beliefs
Causal beliefs will be assessed with a single item: "How likely do you think it is that alcohol causes cancer?" Responses will be assessed on a 5-point scale ranging from not at all (1) to very much (5).
Measured: Day 1; post intervention exposure
Intentions to quit drinking alcohol
Participants who currently drink alcohol will be asked, "How likely are you to quit drinking alcohol?" Responses will be assessed on a 5-point scale ranging from not at all (1) to very much (5).
Measured: Day 1; post intervention exposure
Alcohol-cancer risk beliefs
We will assess risk beliefs using a 3-item scale assessing affective, experiential, and deliberative perceptions of cancer risk among participants who currently drink alcohol. The measure stem will state, "If you continue to drink alcohol at your current level…" Participants will then answer the following items: 1) "How worried are you about eventually getting cancer?"; 2) "To what extent could you see yourself eventually getting cancer?"; and 3) "How likely do you think it is that you will eventually get cancer?" Items will be assessed on a 5-point scale ranging from not at all (1) to very much (5). We will assess these items separately, as they tap into different tri-risk constructs; however, for exploratory purposes we will also assess internal consistency of the three items using Cronbach's alpha. Assuming adequate reliability, we will average the items into a single composite measure.
Measured: Day 1; post intervention exposure
Support for message on alcohol containers
Assessed with a single item: "I believe a message like this should be added to alcohol beverage containers." Responses will be assessed on a 5-point scale ranging from strongly disagree (1) to strongly agree (5).
Measured: Day 1; post intervention exposure
Perceived effectiveness of message on alcohol containers
Assessed with a single item: "Seeing a message like this on an alcoholic beverage would make me think twice about drinking alcohol." Responses will be assessed on a 5-point scale ranging from strongly disagree (1) to strongly agree (5).
Measured: Day 1; post intervention exposure
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted30 Sep 2026
- Study startSep 2026 (estimated)
- Primary completionOct 2026 (estimated)
- Study completionOct 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for AlcoholStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 1,400 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Connecticut
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Jacob Rohde, University of Connecticut
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07848906
- Sponsor's protocol ID
- B2026-0294
- Other IDs
- Faculty Startup Funds
- Status last verified
- Sep 2026
- First submitted
- 17 Sep 2026
- Last updated
- 30 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: We will share anonymized IPD with researchers upon reasonable request to the project Principal Investigator.
Study at a glance
From the registry record, last updated by the sponsor on 30 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Public Health Messaging Survey
- ClinicalTrials.gov ID
- NCT07848906
- Acronym / sponsor ID
- B2026-0294
- Conditions
- Alcohol, Message Perception, PME
- Keywords
- Message testing experiment, Alcohol risk messages, Alcohol and cancer
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 1,400 participants (estimated)
- Lead sponsor
- University of ConnecticutUniversity, hospital or other
- Study start
- Sep 2026 (estimated)
- Primary completion
- Oct 2026 (estimated)
- Study completion
- Oct 2026 (estimated)
- First posted
- 30 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Alcohol increases the risk for at least seven cancers, yet recent estimates suggest only between one-third and one-half of US adults are aware of this risk. The current study aims to develop and test alcohol-cancer messages designed for a mass media public health campaign. The messages will be informed by theory-based constructs proximal to health behavior change (e.g., perceived likelihood/severity of harm, response efficacy). We will evaluate messages via an online, cross-sectional message testing randomized experiment. Participants will be US adults aged 21+ recruited from Qualtrics Panels.
Detailed description
Rational:
Alcohol increases the risk for at least seven cancers, yet recent estimates suggest only between one-third and one-half of US adults are aware of this risk. Raising public awareness of the alcohol-cancer link can encourage better informed choices about alcohol and promote reduced consumption, yet the most effective strategies for raising such awareness remain to be determined.
One potential strategy is the use of alcohol-cancer risk messages, which could be disseminated through various communication channels (e.g., public service announcements, communication campaigns). However, such messages can differ in numerous ways, including their substantive content and the specific language used to communicate risk, and the optimal design of these messages and their effects on audiences remains to be determined.
Ours and others' prior work has tested different alcohol-cancer warning label messages in experimental studies. These experiments have tested the effects of using causal vs. hedging language, the utility of adding pictograms in warning labels, different ways to frame the alcohol-cancer risk relationship, and the type of cancer to communicate in warning labels. The overarching goal of these studies was to develop effective warning labels that could be added to alcohol beverages.
The current study aims to extend this work by developing and preliminarily evaluating alcohol-cancer messages designed for a mass media public health campaign. These messages will be informed by theory-based constructs proximal to health behavior change (e.g., perceived likelihood/severity of harm, response efficacy). We will evaluate messages via an online, cross-sectional message testing randomized experiment. Participants will be US adults aged 21+ recruited from Qualtrics Panels.
Objective:
The primary objective of this study is to identify how different alcohol-cancer message frames affect message-related perceptions and related health outcomes (e.g., perceived message effectiveness, risk beliefs, drinking intentions). Findings will help inform future alcohol harm reduction health communication efforts.
Guiding research question:
- Do different alcohol-cancer message frames affect people's a) message receptivity, b) alcohol-related attitudes and risk perceptions, and c) drinking intentions?
- Do any factors moderate the effects of exposure to different alcohol-cancer message frames (e.g., drinking status as a moderator)?
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, investigator)
- Number of arms
- 7
| Arm | Type | Receives |
|---|---|---|
| Perceived likelihood frame | Experimental | Behavioral: Alcohol health harm message exposureExposure to two alcohol-cancer messages that convey the probability of experiencing a health harm (i.e., cancer) from a particular hazard (i.e., drinking alcohol). The intervention will be administered in an online survey experiment as static images displayed to participants. |
| Harm reduction frame | Experimental | Behavioral: Alcohol health harm message exposureExposure to two alcohol-cancer messages that encourage reducing how much alcohol people drink. The intervention will be administered in an online survey experiment as static images displayed to participants. |
| Perceived severity frame | Experimental | Behavioral: Alcohol health harm message exposureExposure to two alcohol-cancer messages that convey how serious getting alcohol-associated cancer will be. The intervention will be administered in an online survey experiment as static images displayed to participants. |
| Response efficacy frame | Experimental | Behavioral: Alcohol health harm message exposureExposure to two alcohol-cancer messages that emphasize the effectiveness of protective behaviors for reducing alcohol-associated cancer risk. The intervention will be administered in an online survey experiment as static images displayed to participants. |
| Harm prevention frame | Experimental | Behavioral: Alcohol health harm message exposureExposure to two alcohol-cancer messages that emphasize completely abstaining from drinking alcohol. The intervention will be administered in an online survey experiment as static images displayed to participants. |
| Surgeon General's frame | Active comparator | Behavioral: Alcohol health harm message exposureExposure to two alcohol-cancer messages that do not discuss alcohol-associated cancer risk. Instead, the messages use language from the existing U.S. Surgeon General's warning on alcoholic beverages. The intervention will be administered in an online survey experiment as static images displayed to participants. |
| Control | No intervention | –Participants randomized to control will not be exposed to any message stimuli. |
Who may qualify
- Ages
- 21 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- currently reside in the US;
- be aged 21 years or older; and
- speak English.
Key exclusion criteria (1 listed)
- none beyond failure to meet the inclusion criteria.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Alcohol health harm message exposureRandomized exposure to one of five alcohol-cancer health campaign message frames, or a non-cancer alcohol harms frame. | Behavioural | Harm prevention frame, Harm reduction frame, Perceived likelihood frame, Perceived severity frame, Response efficacy frame, Surgeon General's frame |
Primary outcome
Perceived message effectiveness - effects perceptions
Time frame: Day 1; post intervention exposure
A 3-item scale adapted from prior effects perception PME and substance use literature. After each message exposure, participants will be asked to respond to the following items: 1) This message discourages me from wanting to drink alcohol; 2) This message makes me concerned about the health effects of drinking alcohol; and 3) This message makes drinking alcohol seem unpleasant to me. Items will be assessed on a 5-point scale ranging from strongly disagree (1) to strongly agree (5). We will assess internal consistency using Cronbach's alpha. Assuming adequate measure reliability, we will average the items into a single composite PME measure.
11 secondary outcomes
Drinking intentions
Time frame: Day 1; post intervention exposure
Message reactance
Time frame: Day 1; post intervention exposure
Non-alcoholic beer message perceptions
Time frame: Day 1; post intervention exposure
Perceived message effectiveness - message perceptions
Time frame: Day 1; post intervention exposure
Attitudes toward alcohol
Time frame: Day 1; post intervention exposure
Intentions to reduce alcohol use
Time frame: Day 1; post intervention exposure
Alcohol-cancer causal beliefs
Time frame: Day 1; post intervention exposure
Intentions to quit drinking alcohol
Time frame: Day 1; post intervention exposure
Alcohol-cancer risk beliefs
Time frame: Day 1; post intervention exposure
Support for message on alcohol containers
Time frame: Day 1; post intervention exposure
Perceived effectiveness of message on alcohol containers
Time frame: Day 1; post intervention exposure
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Sep 2026.
- Individual participant dataSharing planned: Yes. We will share anonymized IPD with researchers upon reasonable request to the project Principal Investigator.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
A study testing Alcohol health harm message exposure in people with Alcohol and Message Perception, run by University of Connecticut.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 30 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Jacob A Rohde, PhD, MPH ((860) 486-2834, jacob.rohde@uconn.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Perceived message effectiveness - effects perceptions (time frame: Day 1; post intervention exposure). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Sep 2026.