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AlcoholNCT07848906

Alcohol and Cancer Message Testing Experiment

A study testing Alcohol health harm message exposure in people with Alcohol and Message Perception, run by University of Connecticut.

Not yet recruiting

Opening soon. The study is approved but enrolment has not started yet. Sites may already take enquiries.

Sites and contacts
Official record
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Trial summary

Alcohol increases the risk for at least seven cancers, yet recent estimates suggest only between one-third and one-half of US adults are aware of this risk. The current study aims to develop and test alcohol-cancer messages designed for a mass media public health campaign. Read more about this study

Who is it for?
Ages 21 years and olderHealthy volunteers can take part
Conditions the study is for
Alcohol, Message Perception, PME
What is being tested?
Alcohol health harm message exposure
Could I receive a placebo?
No, everyone receives an active treatment
How many people
1,400 participants
Where
No sites listed yet
Study dates
Sep 2026to Oct 2026
Phase
Interventional
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 21 years and older
  • All sexes
  • Healthy volunteers accepted
  • Adult, Older adult

Who may be able to join

  • currently reside in the US;
  • be aged 21 years or older; and
  • speak English.

Who cannot join

  • none beyond failure to meet the inclusion criteria.

Trial locations and contacts

No sites are listed yet. Contact the study team or a site near you to ask about taking part.

Jacob A Rohde, PhD, MPH contact

(860) 486-2834

jacob.rohde@uconn.edu

About this study

Official title: Public Health Messaging Survey

Alcohol increases the risk for at least seven cancers, yet recent estimates suggest only between one-third and one-half of US adults are aware of this risk. The current study aims to develop and test alcohol-cancer messages designed for a mass media public health campaign. The messages will be informed by theory-based constructs proximal to health behavior change (e.g., perceived likelihood/severity of harm, response efficacy). We will evaluate messages via an online, cross-sectional message testing randomized experiment. Participants will be US adults aged 21+ recruited from Qualtrics Panels.

Read the detailed description

Rational:

Alcohol increases the risk for at least seven cancers, yet recent estimates suggest only between one-third and one-half of US adults are aware of this risk. Raising public awareness of the alcohol-cancer link can encourage better informed choices about alcohol and promote reduced consumption, yet the most effective strategies for raising such awareness remain to be determined.

One potential strategy is the use of alcohol-cancer risk messages, which could be disseminated through various communication channels (e.g., public service announcements, communication campaigns). However, such messages can differ in numerous ways, including their substantive content and the specific language used to communicate risk, and the optimal design of these messages and their effects on audiences remains to be determined.

Ours and others' prior work has tested different alcohol-cancer warning label messages in experimental studies. These experiments have tested the effects of using causal vs. hedging language, the utility of adding pictograms in warning labels, different ways to frame the alcohol-cancer risk relationship, and the type of cancer to communicate in warning labels. The overarching goal of these studies was to develop effective warning labels that could be added to alcohol beverages.

The current study aims to extend this work by developing and preliminarily evaluating alcohol-cancer messages designed for a mass media public health campaign. These messages will be informed by theory-based constructs proximal to health behavior change (e.g., perceived likelihood/severity of harm, response efficacy). We will evaluate messages via an online, cross-sectional message testing randomized experiment. Participants will be US adults aged 21+ recruited from Qualtrics Panels.

Objective:

The primary objective of this study is to identify how different alcohol-cancer message frames affect message-related perceptions and related health outcomes (e.g., perceived message effectiveness, risk beliefs, drinking intentions). Findings will help inform future alcohol harm reduction health communication efforts.

Guiding research question:

  1. Do different alcohol-cancer message frames affect people's a) message receptivity, b) alcohol-related attitudes and risk perceptions, and c) drinking intentions?
  2. Do any factors moderate the effects of exposure to different alcohol-cancer message frames (e.g., drinking status as a moderator)?
Being tested
Alcohol health harm message exposure
Keywords
Message testing experiment, Alcohol risk messages, Alcohol and cancer
Medical subject headings
Neoplasms

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Alcohol health harm message exposureBehavioural

    Randomized exposure to one of five alcohol-cancer health campaign message frames, or a non-cancer alcohol harms frame.

Study groups in NCT07848906
Study groupRoleWhat they receive
Perceived likelihood frameExperimentalExposure to two alcohol-cancer messages that convey the probability of experiencing a health harm (i.e., cancer) from a particular hazard (i.e., drinking alcohol). The intervention will be administered in an online survey experiment as static images displayed to participants.
Receives: Behavioral: Alcohol health harm message exposure
Harm reduction frameExperimentalExposure to two alcohol-cancer messages that encourage reducing how much alcohol people drink. The intervention will be administered in an online survey experiment as static images displayed to participants.
Receives: Behavioral: Alcohol health harm message exposure
Perceived severity frameExperimentalExposure to two alcohol-cancer messages that convey how serious getting alcohol-associated cancer will be. The intervention will be administered in an online survey experiment as static images displayed to participants.
Receives: Behavioral: Alcohol health harm message exposure
Response efficacy frameExperimentalExposure to two alcohol-cancer messages that emphasize the effectiveness of protective behaviors for reducing alcohol-associated cancer risk. The intervention will be administered in an online survey experiment as static images displayed to participants.
Receives: Behavioral: Alcohol health harm message exposure
Harm prevention frameExperimentalExposure to two alcohol-cancer messages that emphasize completely abstaining from drinking alcohol. The intervention will be administered in an online survey experiment as static images displayed to participants.
Receives: Behavioral: Alcohol health harm message exposure
Surgeon General's frameActive comparatorExposure to two alcohol-cancer messages that do not discuss alcohol-associated cancer risk. Instead, the messages use language from the existing U.S. Surgeon General's warning on alcoholic beverages. The intervention will be administered in an online survey experiment as static images displayed to participants.
Receives: Behavioral: Alcohol health harm message exposure
ControlNo interventionParticipants randomized to control will not be exposed to any message stimuli.

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Perceived message effectiveness - effects perceptions

    A 3-item scale adapted from prior effects perception PME and substance use literature. After each message exposure, participants will be asked to respond to the following items: 1) This message discourages me from wanting to drink alcohol; 2) This message makes me concerned about the health effects of drinking alcohol; and 3) This message makes drinking alcohol seem unpleasant to me. Items will be assessed on a 5-point scale ranging from strongly disagree (1) to strongly agree (5). We will assess internal consistency using Cronbach's alpha. Assuming adequate measure reliability, we will average the items into a single composite PME measure.

    Measured: Day 1; post intervention exposure

Secondary outcomes (11)
  1. Drinking intentions

    Intentions will be assessed with a 3-item scale adapted from prior substance use and health communication research. Participants will answer each of the following questions: How likely is it that you will drink alcohol in the... 1) next week, 2) next month, and 3) next year. Responses will be on 5-point scales ranging from "not at all" (1) to "extremely" (5). We will assess internal consistency using Cronbach's alpha. Assuming adequate measure reliability, we will average the items into a single composite measure.

    Measured: Day 1; post intervention exposure

  2. Message reactance

    Message reactance will be assessed with a brief 3-item scale used in prior research. Participants will respond to the following statements: 1) This message is trying to manipulate me, 2) The health effect in this message is overblown, and 3) This message annoys me. Responses will be assessed on 5-point scales ranging from "strongly disagree" (1) to "strongly agree" (5). We will assess internal consistency using Cronbach's alpha. Assuming adequate measure reliability, we will average the items into a single composite measure.

    Measured: Day 1; post intervention exposure

  3. Non-alcoholic beer message perceptions

    A single item that has participants respond to the following statement: "This message makes me think drinking non-alcoholic beer is healthier than alcoholic beer." This item will be assessed on a 5-point scale ranging from strongly disagree (1) to strongly agree (5).

    Measured: Day 1; post intervention exposure

  4. Perceived message effectiveness - message perceptions

    A 5-item scale assessing perceptions of each message, adapted from prior work. After each message exposure, participants will respond to the following items: 1) "This message grabs my attention"; 2) "This message is believable"; 3) "This message is credible"; 4) "This message is trustworthy"; and 5) "I learned something new from this message." Items will be assessed on a 5-point scale ranging from strongly disagree (1) to strongly agree (5). We will assess internal consistency using Cronbach's alpha. Assuming adequate measure reliability, we will average the items into a single composite measure.

    Measured: Day 1; post intervention exposure

  5. Attitudes toward alcohol

    A 3-item measure assessing attitudes toward drinking alcohol. Participants will rate drinking alcohol on three 5-point bipolar scales: 1) harmful/safe; 2) bad/good; and 3) unhealthy/healthy. We will assess internal consistency using Cronbach's alpha. Assuming adequate reliability, we will average the items into a single composite attitude measure.

    Measured: Day 1; post intervention exposure

  6. Intentions to reduce alcohol use

    Assessed only among participants who currently drink alcohol. Participants will be asked, "How likely are you to reduce how much alcohol you drink?" Responses will be assessed on a 5-point scale ranging from not at all (1) to very much (5).

    Measured: Day 1; post intervention exposure

  7. Alcohol-cancer causal beliefs

    Causal beliefs will be assessed with a single item: "How likely do you think it is that alcohol causes cancer?" Responses will be assessed on a 5-point scale ranging from not at all (1) to very much (5).

    Measured: Day 1; post intervention exposure

  8. Intentions to quit drinking alcohol

    Participants who currently drink alcohol will be asked, "How likely are you to quit drinking alcohol?" Responses will be assessed on a 5-point scale ranging from not at all (1) to very much (5).

    Measured: Day 1; post intervention exposure

  9. Alcohol-cancer risk beliefs

    We will assess risk beliefs using a 3-item scale assessing affective, experiential, and deliberative perceptions of cancer risk among participants who currently drink alcohol. The measure stem will state, "If you continue to drink alcohol at your current level…" Participants will then answer the following items: 1) "How worried are you about eventually getting cancer?"; 2) "To what extent could you see yourself eventually getting cancer?"; and 3) "How likely do you think it is that you will eventually get cancer?" Items will be assessed on a 5-point scale ranging from not at all (1) to very much (5). We will assess these items separately, as they tap into different tri-risk constructs; however, for exploratory purposes we will also assess internal consistency of the three items using Cronbach's alpha. Assuming adequate reliability, we will average the items into a single composite measure.

    Measured: Day 1; post intervention exposure

  10. Support for message on alcohol containers

    Assessed with a single item: "I believe a message like this should be added to alcohol beverage containers." Responses will be assessed on a 5-point scale ranging from strongly disagree (1) to strongly agree (5).

    Measured: Day 1; post intervention exposure

  11. Perceived effectiveness of message on alcohol containers

    Assessed with a single item: "Seeing a message like this on an alcoholic beverage would make me think twice about drinking alcohol." Responses will be assessed on a 5-point scale ranging from strongly disagree (1) to strongly agree (5).

    Measured: Day 1; post intervention exposure

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted30 Sep 2026
  2. Study startSep 2026 (estimated)
  3. Primary completionOct 2026 (estimated)
  4. Study completionOct 2026 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Prevention
Allocation
Randomised
Intervention model
Parallel groups
Masking
Double blind
Who is masked
Participant, Investigator
Enrolment
1,400 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07848906
Sponsor's protocol ID
B2026-0294
Other IDs
Faculty Startup Funds
Status last verified
Sep 2026
First submitted
17 Sep 2026
Last updated
30 Sep 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
Yes: We will share anonymized IPD with researchers upon reasonable request to the project Principal Investigator.

Questions about this trial

What is this clinical trial studying?

A study testing Alcohol health harm message exposure in people with Alcohol and Message Perception, run by University of Connecticut.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 3 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: opening soon, as of the sponsor's last update on 30 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact Jacob A Rohde, PhD, MPH ((860) 486-2834, jacob.rohde@uconn.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Perceived message effectiveness - effects perceptions (time frame: Day 1; post intervention exposure). It is what the study was designed to measure, not a finding.

Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Sep 2026.

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