Muskuloskeletal DiseasesNCT07845708
Proton MRI of MSK Disorders
An observational study of Muskuloskeletal Diseases and Healthy, run by Laura Walkup at 1 site in United States.
Trial summary
In this research study, the investigators want to learn about new ways to use MRI (Magnetic Resonance Imaging) to take clearer pictures of the lungs. The investigators will be using types of MRI called UTE (Ultra Short Echo Time) and bSSFP (balanced Steady-State Free Precession) as well as traditional MRI. Read more about this study
- Who is it for?
- Ages 5 years and olderHealthy volunteers can take part
- Conditions the study is for
- Muskuloskeletal Diseases, Healthy, Respiratory
- What is being tested?
- MRI
- How many people
- 100 participants
- Where
- 1 siteUnited States
- Study dates
- 17 Jun 2025to Jun 2030
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 5 years and older
- All sexes
- Healthy volunteers accepted
- Child, Adult, Older adult
Study population: We plan to enroll about 50 subjects with diagnosed respiratory and/or musculoskeletal disease and about 50 subjects with no diagnosed respiratory or musculoskeletal disease to serve as healthy controls. Participants will be recruited from the general population without restriction to a specific location or clinic.
Who may be able to join
- Age ≥ 5 years
Who cannot join
- History of any comorbidity reviewed at the Screening phone call that, in the opinion of the investigator, might confound the results of the study or pose an additional risk to the subject.
- Standard MRI exclusion criteria as set forth by the CCHMC Radiology Department and IRC.
- Pregnancy
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229
Ashley Borden, MPH, 5136360143, ashley.borden@cchmc.org
About this study
Official title: Ultra-Short Echo Time 1H MRI in Individuals With Thoracic Musculoskeletal Disorders
In this research study, the investigators want to learn about new ways to use MRI (Magnetic Resonance Imaging) to take clearer pictures of the lungs. The investigators will be using types of MRI called UTE (Ultra Short Echo Time) and bSSFP (balanced Steady-State Free Precession) as well as traditional MRI. The investigators also want to collect images and health information about lungs that are healthy or those in people with different kinds of lung, muscular, and bone diseases. This collection will help us in the future to better understand lung variations in health and disease.
- Conditions
- Muskuloskeletal Diseases, Healthy, Respiratory
- Being tested
- MRI
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
MRIDiagnostic test
This intervention uses specialized MRI sequences, UTE and bSSFP, alongside traditional MRI to capture high-resolution images of lung structure and function. These sequences are optimized for imaging pulmonary tissues and airspaces, which is not typical in standard clinical MRI protocols. The study focuses on both healthy participants and those with lung, muscular, and bone diseases to evaluate variations in lung imaging.
What is being measured
The primary outcome is the main question the study is designed to answer.
Develop, optimize, and validate of 1H MRI sequences for assessment of lung structure and function
Structural 1H MRI parameters such as relative 1H signal intensity and radiologists interpretation will be compared to retrospective clinical images to determine viability of 1H MRI to assess lung disease.
Measured: Through study completion, an average of 5 years
Generate preliminary bSSFP UTE 1H MRI data in healthy individuals and individuals with thoracic musculoskeletal disorders.
Free-breathing bSSFP UTE 1H MRI images will be compared to other conventional structural 1H MRI techniques and aspects like relative 1H signal between images will be compared.
Measured: Through study completion, an average of 5 years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted29 Sep 2026
- Study start17 Jun 2025
- Primary completionJun 2030 (estimated)
- Study completionJun 2030 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Muskuloskeletal DiseasesStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Cross-sectional
- Enrolment
- 100 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Laura Walkup
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Laura Walkup, Children's Hospital Medical Center, Cincinnati
- Investigators
- Laura Walkup, PhD, Principal investigator, Children's Hospital Medical Center, Cincinnati
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07845708
- Sponsor's protocol ID
- 2024-0256
- Status last verified
- Sep 2026
- First submitted
- 22 Sep 2026
- Last updated
- 16 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 16 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Ultra-Short Echo Time 1H MRI in Individuals With Thoracic Musculoskeletal Disorders
- ClinicalTrials.gov ID
- NCT07845708
- Acronym / sponsor ID
- 2024-0256
- Conditions
- Muskuloskeletal Diseases, Healthy, Respiratory
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 100 participants (estimated)
- Lead sponsor
- Laura WalkupUniversity, hospital or other
- Study start
- 17 Jun 2025 (actual)
- Primary completion
- Jun 2030 (estimated)
- Study completion
- Jun 2030 (estimated)
- First posted
- 29 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
In this research study, the investigators want to learn about new ways to use MRI (Magnetic Resonance Imaging) to take clearer pictures of the lungs. The investigators will be using types of MRI called UTE (Ultra Short Echo Time) and bSSFP (balanced Steady-State Free Precession) as well as traditional MRI. The investigators also want to collect images and health information about lungs that are healthy or those in people with different kinds of lung, muscular, and bone diseases. This collection will help us in the future to better understand lung variations in health and disease.
Study design
- Observational model
- Cohort
- Time perspective
- Cross-sectional
Who may qualify
- Ages
- 5 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult, Older adult
- Study population
- We plan to enroll about 50 subjects with diagnosed respiratory and/or musculoskeletal disease and about 50 subjects with no diagnosed respiratory or musculoskeletal disease to serve as healthy controls. Participants will be recruited from the general population without restriction to a specific location or clinic.
Key inclusion criteria (1 listed)
- Age ≥ 5 years
Key exclusion criteria (3 listed)
- History of any comorbidity reviewed at the Screening phone call that, in the opinion of the investigator, might confound the results of the study or pose an additional risk to the subject.
- Standard MRI exclusion criteria as set forth by the CCHMC Radiology Department and IRC.
- Pregnancy
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| MRIThis intervention uses specialized MRI sequences, UTE and bSSFP, alongside traditional MRI to capture high-resolution images of lung structure and function. These sequences are optimized for imaging pulmonary tissues and airspaces, which is not typical in standard clinical MRI protocols. The study focuses on both healthy participants and those with lung, muscular, and bone diseases to evaluate variations in lung imaging. | Diagnostic test | – |
Primary outcome
Develop, optimize, and validate of 1H MRI sequences for assessment of lung structure and function
Time frame: Through study completion, an average of 5 years
Structural 1H MRI parameters such as relative 1H signal intensity and radiologists interpretation will be compared to retrospective clinical images to determine viability of 1H MRI to assess lung disease.
Generate preliminary bSSFP UTE 1H MRI data in healthy individuals and individuals with thoracic musculoskeletal disorders.
Time frame: Through study completion, an average of 5 years
Free-breathing bSSFP UTE 1H MRI images will be compared to other conventional structural 1H MRI techniques and aspects like relative 1H signal between images will be compared.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Oct 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Laura Walkup, PhD principal investigator
Children's Hospital Medical Center, Cincinnati
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Muskuloskeletal Diseases and Healthy, run by Laura Walkup at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 16 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Ashley Borden, MPH (5136360143, ashley.borden@cchmc.org), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Develop, optimize, and validate of 1H MRI sequences for assessment of lung structure and function (time frame: Through study completion, an average of 5 years). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Oct 2026.