Thyroid SurgeriesNCT07843589
Comparative Study of Ultrasound Guided Superficial vs Intermediate Cervical Plexus Block for Perioperative Analgesia in Thyroid Surgeries.
A study testing Ultrasound guided superficial cervical plexus block and ultrasound guided intermediate cervical plexus block in people with Thyroid Surgeries, run by Menoufia University at 1 site in Egypt.
Trial summary
The investigator compare the analgesic efficacy of ultrasound-guided subcutaneous cervical plexus block vs ultrasound-guided intermediate cervical plexus block pre-intra and postoperative thyroid surgery Read more about this study
- Who is it for?
- Ages 20 to 60 years
- Conditions the study is for
- Thyroid Surgeries
- What is being tested?
- Ultrasound guided superficial cervical plexus block and ultrasound guided intermediate cervical plexus block
- Type of treatment
- Injection or infusion, Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 90 participants
- Where
- 1 siteEgypt
- Study dates
- Oct 2026to May 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 60 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Patients with ASA physical status 1 or 2 and 3
- Patients undergoing elective total thyroidectomy (with normal thyroid function tests)
- Patients aged 20 to 60 years of both sexes
Who cannot join
- Patients with known bleeding diathesis
- History of allergy to local anaesthetics or known diaphragmatic motion abnormalities
- Patient who refuse to participate
- BMI (Body Mass Index) more than 35 kg/m2
- Previous neck surgeries/Burns injury to neck/ contractures in neck
- Patients with known seizure disorder
- Patients with history of radiation exposure on neck.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Egypt1 site, 1 recruiting
- Recruiting
Faculty of medicine Menoufia University
Alexandria, Shebin Elkom
Nevine Soliman, 201128861471, mostafanevine@gmail.com
About this study
Official title: Comparative Study of Ultrasound Guided Superficial vs Intermediate Cervical Plexus Block for Perioperative Analgesia in Patients Undergoing Thyroid Surgeries.
The investigator compare the analgesic efficacy of ultrasound-guided subcutaneous cervical plexus block vs ultrasound-guided intermediate cervical plexus block pre-intra and postoperative thyroid surgery
- Conditions
- Thyroid Surgeries
- Being tested
- Ultrasound guided superficial cervical plexus block, ultrasound guided intermediate cervical plexus block
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Ultrasound guided superficial cervical plexus blockProcedure or surgery
Ultrasoundguided subcutaneous superficial cervical plexus block. The linear probe will be placed transversely over the lateral side of the neck at the midpoint of the posterior border of the sternocleidomastoid muscle (SCM) such that the tapering end (posterior border on the ultrasound image) of the SCM comes to the center of the screen. After infiltrating the skin with 1 mL of 2% lignocaine, the needle will be introduced from the posterior aspect through the skin and platysma where 10 mL of 0.25% bupivacaine with 5 µg/mL of epinephrine (50 µg) and 100 µg dexmedetomidine (with concentration of 200µg/2ml) diluted in 2 ml saline) will be deposited just behind this landmark to give a single point subcutaneous superficial cervical plexus block. Block will be repeated on the other side as well
ultrasound guided intermediate cervical plexus blockProcedure or surgery
The transducer probe will be placed transversely over the midpoint of the sternocleidomastoid muscle such that the tapering posterior edge was positioned in the middle of the screen (at the level of the cricoid cartilage, where the external jugular vein crosses sternocleidomastoid). With the in-plane technique, after infiltrating the skin with 1 mL of 2% lignocaine, the block needle will be advanced adjacent to the superficial cervical plexus in the plane deep to sternocleidomastoid, underneath the investing fascia (sternocleidomastoid-trapezius fascia) and immediately above the interscalene groove [Figure 3]. After negative aspiration, 10 mL of 0.25% bupivacaine with 5 µg/mL of epinephrine (50 µg) and 100 µg dexmedetomidine (with concentration of 200µg/2ml) diluted in 2 ml saline) will be deposited under the fascia after feeling the click or 'pop' on piercing this fascia. The same formulation will be given on the other side as well.
| Study group | Role | What they receive |
|---|---|---|
| Ultrasound guided subcutaneous superficial cervical plexus block | Active comparator | Not described Receives: Procedure: Ultrasound guided superficial cervical plexus block |
| Ultrasound guided intermediate cervical plexus block | Active comparator | Not described Receives: Procedure: ultrasound guided intermediate cervical plexus block |
What is being measured
The primary outcome is the main question the study is designed to answer.
Postoperative VAS scores
The postoperative VAS scores at 0 (just after extubation), 2, 4, 6, 12, 18 and 24 hours.
Measured: VAS scores at 0 (just after extubation), 2, 4, 6, 12, 18 and 24 hours.
Secondary outcomes (2)
Total dose of rescue analgesic required
Measured: first 24 hours
Diaphragmatic excursion measured by ultrasound M-mode
Measured: 30 minutes after the block and after endotracheal extubation
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted28 Sep 2026
- Study startOct 2026 (estimated)
- Primary completionMar 2027 (estimated)
- Study completionMay 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Thyroid SurgeriesStudies of the same condition, open and under way.
- More trials run by Menoufia UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind
- Who is masked
- Participant, Care provider, Outcomes assessor
- Enrolment
- 90 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Menoufia University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Nevine Mostafa Soliman, Menoufia University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07843589
- Sponsor's protocol ID
- 9/2026ANET7
- Status last verified
- Sep 2026
- First submitted
- 21 Sep 2026
- Last updated
- 29 Sep 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 29 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparative Study of Ultrasound Guided Superficial vs Intermediate Cervical Plexus Block for Perioperative Analgesia in Patients Undergoing Thyroid Surgeries.
- ClinicalTrials.gov ID
- NCT07843589
- Acronym / sponsor ID
- 9/2026ANET7
- Conditions
- Thyroid Surgeries
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 90 participants (estimated)
- Lead sponsor
- Menoufia UniversityUniversity, hospital or other
- Study start
- Oct 2026 (estimated)
- Primary completion
- Mar 2027 (estimated)
- Study completion
- May 2027 (estimated)
- First posted
- 28 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The investigator compare the analgesic efficacy of ultrasound-guided subcutaneous cervical plexus block vs ultrasound-guided intermediate cervical plexus block pre-intra and postoperative thyroid surgery
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, care provider, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Ultrasound guided subcutaneous superficial cervical plexus block | Active comparator | Procedure: Ultrasound guided superficial cervical plexus block |
| Ultrasound guided intermediate cervical plexus block | Active comparator | Procedure: ultrasound guided intermediate cervical plexus block |
Who may qualify
- Ages
- 20 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- Patients with ASA physical status 1 or 2 and 3
- Patients undergoing elective total thyroidectomy (with normal thyroid function tests)
- Patients aged 20 to 60 years of both sexes
Key exclusion criteria (7 listed)
- Patients with known bleeding diathesis
- History of allergy to local anaesthetics or known diaphragmatic motion abnormalities
- Patient who refuse to participate
- BMI (Body Mass Index) more than 35 kg/m2
- Previous neck surgeries/Burns injury to neck/ contractures in neck
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Ultrasound guided superficial cervical plexus blockUltrasoundguided subcutaneous superficial cervical plexus block. The linear probe will be placed transversely over the lateral side of the neck at the midpoint of the posterior border of the sternocleidomastoid muscle (SCM) such that the tapering end (posterior border on the ultrasound image) of the SCM comes to the center of the screen. After infiltrating the skin with 1 mL of 2% lignocaine, the needle will be introduced from the posterior aspect through the skin and platysma where 10 mL of 0.25% bupivacaine with 5 µg/mL of epinephrine (50 µg) and 100 µg dexmedetomidine (with concentration of 200µg/2ml) diluted in 2 ml saline) will be deposited just behind this landmark to give a single point subcutaneous superficial cervical plexus block. Block will be repeated on the other side as well | Procedure or surgery | Ultrasound guided subcutaneous superficial cervical plexus block |
| ultrasound guided intermediate cervical plexus blockThe transducer probe will be placed transversely over the midpoint of the sternocleidomastoid muscle such that the tapering posterior edge was positioned in the middle of the screen (at the level of the cricoid cartilage, where the external jugular vein crosses sternocleidomastoid). With the in-plane technique, after infiltrating the skin with 1 mL of 2% lignocaine, the block needle will be advanced adjacent to the superficial cervical plexus in the plane deep to sternocleidomastoid, underneath the investing fascia (sternocleidomastoid-trapezius fascia) and immediately above the interscalene groove [Figure 3]. After negative aspiration, 10 mL of 0.25% bupivacaine with 5 µg/mL of epinephrine (50 µg) and 100 µg dexmedetomidine (with concentration of 200µg/2ml) diluted in 2 ml saline) will be deposited under the fascia after feeling the click or 'pop' on piercing this fascia. The same formulation will be given on the other side as well. | Procedure or surgery | Ultrasound guided intermediate cervical plexus block |
Primary outcome
Postoperative VAS scores
Time frame: VAS scores at 0 (just after extubation), 2, 4, 6, 12, 18 and 24 hours.
The postoperative VAS scores at 0 (just after extubation), 2, 4, 6, 12, 18 and 24 hours.
2 secondary outcomes
Total dose of rescue analgesic required
Time frame: first 24 hours
Diaphragmatic excursion measured by ultrasound M-mode
Time frame: 30 minutes after the block and after endotracheal extubation
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 29 Sep 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Ultrasound guided superficial cervical plexus block and ultrasound guided intermediate cervical plexus block in people with Thyroid Surgeries, run by Menoufia University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 29 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Nevine Soliman, MD (201128861471, mostafanevine@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Postoperative VAS scores (time frame: VAS scores at 0 (just after extubation), 2, 4, 6, 12, 18 and 24 hours.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 Sep 2026.