Transcranial Direct Current StimulationNCT07831512
Effect of Transcranial Direct Current Stimulation on Flywheel Resistance Training
A study testing tDCS-a and tDCS-c in people with Transcranial Direct Current Stimulation, run by Federal University of Vicosa.
Trial summary
Transcranial direct current stimulation (tDCS) has been investigated as an ergogenic strategy; however, its acute effects on muscle power-especially when combined with flywheel resistance training (FRT)-have not yet been explored. Read more about this study
- Who is it for?
- Ages 18 to 40 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Transcranial Direct Current Stimulation
- What is being tested?
- tDCS-a and tDCS-c
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 30 participants
- Where
- No sites listed yet
- Study dates
- 25 Aug 2026to Oct 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Male sex,
- Age 18-40 years,
- Performance of barbell squats with a load > 1.5 times body mass (BM),
- No current use or use within the last 6 months of ergogenic aids,
- No history of muscle and/or ligament injuries in the last six months,
- Absence of skin conditions that could be affected by tDCS,
- Absence of unstable medical conditions,
- No metallic objects near the electrodes.
Who cannot join
- Failure to complete any stage of the study,
- Injury during the intervention,
- Reports of unbearable discomfort.
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Acute Effect of Transcranial Direct Current Stimulation on Power During Flywheel Squatting: a Randomized, Placebo-controlled, Crossover Clinical Trial
Transcranial direct current stimulation (tDCS) has been investigated as an ergogenic strategy; however, its acute effects on muscle power-especially when combined with flywheel resistance training (FRT)-have not yet been explored. The aim of this study is to investigate the acute effects of anodal, cathodal, and sham tDCS on muscle power and neuromuscular variables during flywheel squat exercise. This is a randomized, double-blind, placebo-controlled, crossover clinical trial; 22 physically active men aged 18 to 35 years with strength training experience will be recruited. Volunteers will complete a minimum of three familiarization sessions and three experimental sessions, during which they will undergo anodal, cathodal, or sham tDCS conditions (2 mA, 20 min) in random order, with a minimum 48-hour interval between sessions. Following each stimulation, they will perform four sets of 1+8 repetitions of the flywheel squat. Concentric and eccentric power, the eccentric/concentric ratio, electromyographic activation (RMS, median and peak frequency), and subjective ratings of perceived exertion and discomfort will be analyzed. A repeated-measures ANOVA (3 conditions × 4 sets × 3 periods) will be performed, with Bonferroni post-hoc testing and a significance level of p < 0.05 for all analyses.
- Conditions
- Transcranial Direct Current Stimulation
- Being tested
- tDCS-a, tDCS-c, Sham - tDCS
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
tDCS-aOther
For anodic stimulation (tDCS-a), the anode (positive electrode) will be positioned over the left M1 (point C3 of the international 10-20 system) (Figure 2), while the cathode will be placed over the contralateral deltoid.
tDCS-cOther
In cathodal stimulation (tDCS-c), the polarity is reversed: the cathode is positioned at C3 and the anode on the contralateral deltoid.
Sham - tDCSOther
For the placebo condition (sham-tDCS), the electrodes will be placed in the same position as in the anodal condition, but the stimulator will be turned off after 30 seconds. This procedure, considered ineffective for inducing cortical changes, allows subjects to feel only the initial tingling sensation, ensuring participant blinding regarding the type of intervention received.
| Study group | Role | What they receive |
|---|---|---|
| anodal transcranial direct current stimulation | Experimental | Not described Receives: Other: tDCS-a |
| catodal transcranial direct current stimulation | Experimental | Not described Receives: Other: tDCS-c |
| sham transcranial direct current stimulation | Placebo comparator | Not described Receives: Other: Sham - tDCS |
What is being measured
The primary outcome is the main question the study is designed to answer.
Muscular power
Measured by a rotary encoder
Measured: 2 weeks, with 3 visits to the laboratory
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 Sep 2026
- Study start25 Aug 2026 (estimated)
- Primary completionSep 2026 (estimated)
- Study completionOct 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Transcranial Direct Current StimulationStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 30 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Federal University of Vicosa
- Sponsor type
- University, hospital or other
- Collaborators
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Responsible party
- Principal investigator, Leonardo Silveira Goulart Silva, Federal University of Vicosa
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07831512
- Sponsor's protocol ID
- 97621426.7.0000.5153
- Status last verified
- Sep 2026
- First submitted
- 10 Aug 2026
- Last updated
- 21 Sep 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 21 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Acute Effect of Transcranial Direct Current Stimulation on Power During Flywheel Squatting: a Randomized, Placebo-controlled, Crossover Clinical Trial
- ClinicalTrials.gov ID
- NCT07831512
- Acronym / sponsor ID
- 97621426.7.0000.5153
- Conditions
- Transcranial Direct Current Stimulation
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- Federal University of VicosaUniversity, hospital or other
- Collaborators
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Study start
- 25 Aug 2026 (estimated)
- Primary completion
- Sep 2026 (estimated)
- Study completion
- Oct 2026 (estimated)
- First posted
- 21 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Transcranial direct current stimulation (tDCS) has been investigated as an ergogenic strategy; however, its acute effects on muscle power-especially when combined with flywheel resistance training (FRT)-have not yet been explored. The aim of this study is to investigate the acute effects of anodal, cathodal, and sham tDCS on muscle power and neuromuscular variables during flywheel squat exercise. This is a randomized, double-blind, placebo-controlled, crossover clinical trial; 22 physically active men aged 18 to 35 years with strength training experience will be recruited. Volunteers will complete a minimum of three familiarization sessions and three experimental sessions, during which they will undergo anodal, cathodal, or sham tDCS conditions (2 mA, 20 min) in random order, with a minimum 48-hour interval between sessions. Following each stimulation, they will perform four sets of 1+8 repetitions of the flywheel squat. Concentric and eccentric power, the eccentric/concentric ratio, electromyographic activation (RMS, median and peak frequency), and subjective ratings of perceived exertion and discomfort will be analyzed. A repeated-measures ANOVA (3 conditions × 4 sets × 3 periods) will be performed, with Bonferroni post-hoc testing and a significance level of p < 0.05 for all analyses.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| anodal transcranial direct current stimulation | Experimental | Other: tDCS-a |
| catodal transcranial direct current stimulation | Experimental | Other: tDCS-c |
| sham transcranial direct current stimulation | Placebo comparator | Other: Sham - tDCS |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (8 listed)
- Male sex,
- Age 18-40 years,
- Performance of barbell squats with a load > 1.5 times body mass (BM),
- No current use or use within the last 6 months of ergogenic aids,
- No history of muscle and/or ligament injuries in the last six months,
Key exclusion criteria (3 listed)
- Failure to complete any stage of the study,
- Injury during the intervention,
- Reports of unbearable discomfort.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| tDCS-aFor anodic stimulation (tDCS-a), the anode (positive electrode) will be positioned over the left M1 (point C3 of the international 10-20 system) (Figure 2), while the cathode will be placed over the contralateral deltoid. | Other | anodal transcranial direct current stimulation |
| tDCS-cIn cathodal stimulation (tDCS-c), the polarity is reversed: the cathode is positioned at C3 and the anode on the contralateral deltoid. | Other | catodal transcranial direct current stimulation |
| Sham - tDCSFor the placebo condition (sham-tDCS), the electrodes will be placed in the same position as in the anodal condition, but the stimulator will be turned off after 30 seconds. This procedure, considered ineffective for inducing cortical changes, allows subjects to feel only the initial tingling sensation, ensuring participant blinding regarding the type of intervention received. | Other | sham transcranial direct current stimulation |
Primary outcome
Muscular power
Time frame: 2 weeks, with 3 visits to the laboratory
Measured by a rotary encoder
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 21 Sep 2026.
- Individual participant dataSharing planned: No
Related trials for Transcranial Direct Current Stimulation
Recruiting
Additional Effects on tDCS With AOT on Lower Limb Functions on Children With Diplegic CP
Diplegic Cerebral Palsy
Active, not recruiting
Improving Visual Field Deficits With Noninvasive Brain Stimulation
Visual Field Defect, Peripheral, Stroke
Enrolling by invitation
Brain Stimulation Paired With Structured Reading Instruction in Children With Dyslexia
Dyslexia, Reading Disability
Recruiting
Cumulative and Booster Effects of Multisession Prefrontal tDCS in ASD Adolescents
Transcranial Direct Current Stimulation, Autistic Spectrum Disorder
Enrolling by invitation
Brain Stimulation Paired With Structured Language Learning in Adults
Language Development, Learning
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
A study testing tDCS-a and tDCS-c in people with Transcranial Direct Current Stimulation, run by Federal University of Vicosa.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 21 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Leonardo S G Silva (+55 37991355713, leonardo.goulart@ufv.br), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Muscular power (time frame: 2 weeks, with 3 visits to the laboratory). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 21 Sep 2026.