Eyebrow GrowthNCT07819721
Effects of CosmeRNA Brow Revitalizing Serum on Eyebrow Density and Length
A study testing Eyebrow serum containing SDS-DNA-2/RNA-6 in people with Eyebrow Growth, run by BIONEER Corporation at 1 site in South Korea.
Trial summary
This study evaluated the effects of CosmeRNA Brow Revitalizing Serum on eyebrow density and length in healthy Korean adults. Each participant applied the investigational serum to one eyebrow and a control serum to the other eyebrow once daily for 8 weeks. Read more about this study
- Who is it for?
- Ages 20 years and olderHealthy volunteers can take part
- Conditions the study is for
- Eyebrow Growth
- What is being tested?
- Eyebrow serum containing SDS-DNA-2/RNA-6
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 26 participants
- Where
- 1 siteSouth Korea
- Study dates
- 13 Apr 2026to 12 Jun 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Healthy Korean adults aged 20 years or older
- Individuals who received sufficient information about the purpose and procedures of the study and voluntarily signed the informed consent form
- Individuals without acute or chronic physical illnesses, including skin diseases
- Individuals able to participate in follow-up assessments throughout the study period
Who cannot join
- Individuals who were pregnant, breastfeeding, or planning to become pregnant
- Individuals with a psychiatric disorder or an infectious skin disease
- Individuals who had used a topical corticosteroid for the treatment of a skin disease for 1 month or longer
- Individuals who had participated in the same study within the previous 6 months
- Individuals with sensitive or hypersensitive skin
- Individuals with abnormal skin findings at the assessment area, including moles, acne, erythema, or telangiectasia
Show all 10Show fewer
- Individuals who had used cosmetics, medications, or other products with the same or similar claimed effects on the assessment area within the previous 3 months
- Individuals who had received dermatologic or cosmetic procedures on the assessment area within the previous 6 months, including liposuction, laser treatment, ultrasound-assisted fat reduction, or other skin care procedures
- Employees of the study institution
- Individuals considered unsuitable for study participation by the principal investigator
Trial locations and contacts
1 site in 1 country.
About this study
Official title: A Human Application Study to Evaluate the Effects of CosmeRNA Brow Revitalizing Serum on Eyebrow Density and Length
This study evaluated the effects of CosmeRNA Brow Revitalizing Serum on eyebrow density and length in healthy Korean adults. Each participant applied the investigational serum to one eyebrow and a control serum to the other eyebrow once daily for 8 weeks. Eyebrow density and length were assessed before product use and after 4 and 8 weeks of use. Product compliance, participant-reported outcomes, and skin adverse reactions were also evaluated.
Read the detailed description
This was an 8-week, within-participant, controlled human application study conducted in healthy Korean adults aged 20 years or older.
For each participant, the face was divided vertically, with one eyebrow assigned to the investigational product and the contralateral eyebrow assigned to the control product. The investigational product was CosmeRNA Brow Revitalizing Serum, and the control product was a vehicle control serum. Participants applied an appropriate amount of each assigned product to the corresponding eyebrow once daily, either in the morning or evening, for 8 weeks.
Eyebrow density was evaluated using Folliscope 5.0. Images of the eyebrow areas were obtained at baseline and after 4 and 8 weeks of product use. For repeated measurements, eyebrow hairs in the assessment areas were trimmed, and phototrichogram analysis was performed to determine the number of eyebrow hairs per square centimeter.
Eyebrow length was evaluated from images obtained using Folliscope 5.0 at baseline and after 4 and 8 weeks. Eyebrow hair length was analyzed using Image-Pro 10 image analysis software.
Compliance was assessed using participant-completed product-use diaries. Participants also completed a questionnaire regarding their experience with the investigational product. Throughout the study, investigators monitored skin adverse reactions and the use of concomitant medications that could affect study evaluation.
- Conditions
- Eyebrow Growth
- Being tested
- Eyebrow serum containing SDS-DNA-2/RNA-6, Control eyebrow serum without SDS-DNA-2/RNA-6
- Keywords
- Eyebrow Density, Eyebrow Length, Eyebrow Hair Growth, Eyebrow Serum, Cosmetic Product, Human Application Study
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Eyebrow serum containing SDS-DNA-2/RNA-6Other
A transparent, viscous cosmetic serum containing SDS-DNA-2/RNA-6. Participants applied an appropriate amount to the assigned eyebrow once daily, in the morning or evening, for 8 weeks. After application, the eyebrow area was gently massaged using the silicone applicator tip and lightly patted to aid absorption.
Control eyebrow serum without SDS-DNA-2/RNA-6Other
A transparent, viscous control cosmetic serum formulated without SDS-DNA-2/RNA-6. Participants applied an appropriate amount to the assigned eyebrow once daily, in the morning or evening, for 8 weeks, using the same application procedure as for the investigational serum.
| Study group | Role | What they receive |
|---|---|---|
| Investigational Product-Treated Eyebrow | Experimental | CosmeRNA Brow Revitalizing Serum containing SDS-DNA-2/RNA-6 was applied to the assigned eyebrow once daily for 8 weeks. Receives: Other: Eyebrow serum containing SDS-DNA-2/RNA-6 |
| Control Product-Treated Eyebrow | Placebo comparator | The control serum formulated without SDS-DNA-2/RNA-6 was applied to the assigned eyebrow once daily for 8 weeks. Receives: Other: Control eyebrow serum without SDS-DNA-2/RNA-6 |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change From Baseline in Eyebrow Density
Eyebrow density was measured as the total number of eyebrow hairs per square centimeter using phototrichogram images obtained with Folliscope 5.0. Changes from baseline were evaluated for the eyebrow treated with the investigational serum and the contralateral eyebrow treated with the control serum.
Measured: Baseline to Week 4 and Baseline to Week 8
Change From Baseline in Eyebrow Hair Length
Eyebrow hair length was measured in pixels using Image-Pro 10 software applied to images obtained with Folliscope 5.0. Changes from baseline were evaluated for the eyebrow treated with the investigational serum and the contralateral eyebrow treated with the control serum.
Measured: Baseline to Week 4 and Baseline to Week 8
Secondary outcomes (2)
Participant-Reported Evaluation of the Investigational Serum
Participants evaluated their experience with the investigational serum using a 6-point questionnaire, where 1 indicated "strongly disagree" and 6 indicated "strongly agree." Responses of 4 to 6 were classified as positive responses. Results were summarized as the percentage of participants providing a positive response to each questionnaire item.
Measured: Week 8
Incidence of Skin Adverse Reactions
Skin adverse reactions were assessed throughout the study based on participant reports and physical examination by a dermatologist. The outcome was summarized as the number of participants with any skin adverse reaction during product use.
Measured: From baseline through Week 8
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted15 Sep 2026
- Study start13 Apr 2026
- Primary completion12 Jun 2026
- Study completion12 Jun 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Eyebrow GrowthStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- All participants received both interventions concurrently in a within-participant, split-face design. The investigational product was applied to one eyebrow and the control product to the contralateral eyebrow for 8 weeks.
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 26 participants (actual)
Sponsor and investigators
- Lead sponsor
- BIONEER Corporation
- Sponsor type
- Industry (pharma, biotech, devices)
- Responsible party
- Sponsor
- Investigators
- Won-Kyu Hong, MD, Principal investigator, Human Skin Clinical Trial Center
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07819721
- Sponsor's protocol ID
- B-B-2412-729_C1
- Status last verified
- Sep 2026
- First submitted
- 9 Sep 2026
- Last updated
- 15 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 15 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Human Application Study to Evaluate the Effects of CosmeRNA Brow Revitalizing Serum on Eyebrow Density and Length
- ClinicalTrials.gov ID
- NCT07819721
- Acronym / sponsor ID
- B-B-2412-729_C1
- Conditions
- Eyebrow Growth
- Keywords
- Eyebrow Density, Eyebrow Length, Eyebrow Hair Growth, Eyebrow Serum, Cosmetic Product, Human Application Study
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 26 participants (actual)
- Lead sponsor
- BIONEER CorporationIndustry (pharma, biotech, devices)
- Study start
- 13 Apr 2026 (actual)
- Primary completion
- 12 Jun 2026 (actual)
- Study completion
- 12 Jun 2026 (actual)
- First posted
- 15 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study evaluated the effects of CosmeRNA Brow Revitalizing Serum on eyebrow density and length in healthy Korean adults. Each participant applied the investigational serum to one eyebrow and a control serum to the other eyebrow once daily for 8 weeks. Eyebrow density and length were assessed before product use and after 4 and 8 weeks of use. Product compliance, participant-reported outcomes, and skin adverse reactions were also evaluated.
Detailed description
This was an 8-week, within-participant, controlled human application study conducted in healthy Korean adults aged 20 years or older.
For each participant, the face was divided vertically, with one eyebrow assigned to the investigational product and the contralateral eyebrow assigned to the control product. The investigational product was CosmeRNA Brow Revitalizing Serum, and the control product was a vehicle control serum. Participants applied an appropriate amount of each assigned product to the corresponding eyebrow once daily, either in the morning or evening, for 8 weeks.
Eyebrow density was evaluated using Folliscope 5.0. Images of the eyebrow areas were obtained at baseline and after 4 and 8 weeks of product use. For repeated measurements, eyebrow hairs in the assessment areas were trimmed, and phototrichogram analysis was performed to determine the number of eyebrow hairs per square centimeter.
Eyebrow length was evaluated from images obtained using Folliscope 5.0 at baseline and after 4 and 8 weeks. Eyebrow hair length was analyzed using Image-Pro 10 image analysis software.
Compliance was assessed using participant-completed product-use diaries. Participants also completed a questionnaire regarding their experience with the investigational product. Throughout the study, investigators monitored skin adverse reactions and the use of concomitant medications that could affect study evaluation.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
- Model description
- All participants received both interventions concurrently in a within-participant, split-face design. The investigational product was applied to one eyebrow and the control product to the contralateral eyebrow for 8 weeks.
| Arm | Type | Receives |
|---|---|---|
| Investigational Product-Treated Eyebrow | Experimental | Other: Eyebrow serum containing SDS-DNA-2/RNA-6CosmeRNA Brow Revitalizing Serum containing SDS-DNA-2/RNA-6 was applied to the assigned eyebrow once daily for 8 weeks. |
| Control Product-Treated Eyebrow | Placebo comparator | Other: Control eyebrow serum without SDS-DNA-2/RNA-6The control serum formulated without SDS-DNA-2/RNA-6 was applied to the assigned eyebrow once daily for 8 weeks. |
Who may qualify
- Ages
- 20 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Healthy Korean adults aged 20 years or older
- Individuals who received sufficient information about the purpose and procedures of the study and voluntarily signed the informed consent form
- Individuals without acute or chronic physical illnesses, including skin diseases
- Individuals able to participate in follow-up assessments throughout the study period
Key exclusion criteria (10 listed)
- Individuals who were pregnant, breastfeeding, or planning to become pregnant
- Individuals with a psychiatric disorder or an infectious skin disease
- Individuals who had used a topical corticosteroid for the treatment of a skin disease for 1 month or longer
- Individuals who had participated in the same study within the previous 6 months
- Individuals with sensitive or hypersensitive skin
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Eyebrow serum containing SDS-DNA-2/RNA-6A transparent, viscous cosmetic serum containing SDS-DNA-2/RNA-6. Participants applied an appropriate amount to the assigned eyebrow once daily, in the morning or evening, for 8 weeks. After application, the eyebrow area was gently massaged using the silicone applicator tip and lightly patted to aid absorption. | Other | Investigational Product-Treated Eyebrow |
| Control eyebrow serum without SDS-DNA-2/RNA-6A transparent, viscous control cosmetic serum formulated without SDS-DNA-2/RNA-6. Participants applied an appropriate amount to the assigned eyebrow once daily, in the morning or evening, for 8 weeks, using the same application procedure as for the investigational serum. | Other | Control Product-Treated Eyebrow |
Primary outcome
Change From Baseline in Eyebrow Density
Time frame: Baseline to Week 4 and Baseline to Week 8
Eyebrow density was measured as the total number of eyebrow hairs per square centimeter using phototrichogram images obtained with Folliscope 5.0. Changes from baseline were evaluated for the eyebrow treated with the investigational serum and the contralateral eyebrow treated with the control serum.
Change From Baseline in Eyebrow Hair Length
Time frame: Baseline to Week 4 and Baseline to Week 8
Eyebrow hair length was measured in pixels using Image-Pro 10 software applied to images obtained with Folliscope 5.0. Changes from baseline were evaluated for the eyebrow treated with the investigational serum and the contralateral eyebrow treated with the control serum.
2 secondary outcomes
Participant-Reported Evaluation of the Investigational Serum
Time frame: Week 8
Incidence of Skin Adverse Reactions
Time frame: From baseline through Week 8
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 15 Sep 2026.
- Individual participant dataSharing planned: No
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Won-Kyu Hong, MD principal investigator
Human Skin Clinical Trial Center
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Eyebrow serum containing SDS-DNA-2/RNA-6 in people with Eyebrow Growth, run by BIONEER Corporation at 1 site in South Korea.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 10 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 15 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in South Korea. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change From Baseline in Eyebrow Density (time frame: Baseline to Week 4 and Baseline to Week 8). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Sep 2026.