Quality of Recovery at Days 5-7 After Ankle Surgery: a Multicenter Study in Seine-Maritime

Anesthetic management for ankle surgery relies on three main options: general anesthesia (GA), neuraxial regional anesthesia (spinal anesthesia), and truncal regional anesthesia via peripheral nerve blocks of the lower limb.

General anesthesia remains the most widely used technique in many centers. However, it carries a risk of common adverse effects (postoperative nausea and vomiting, drowsiness, unexpected pain upon awakening) and does not provide prolonged residual analgesia.

Spinal anesthesia offers rapid, reliable sensory and motor blockade of the lower limb and is quick to perform. Nevertheless, it can be associated with specific side effects: arterial hypotension, urinary retention, post-puncture lower back pain, and-more rarely-post-dural puncture headache. These effects can delay functional recovery and compromise patient comfort.

Peripheral nerve blocks of the lower limb (such as the popliteal sciatic nerve block, saphenous or femoral nerve block, or combinations like the HabiBloc) have gained popularity in recent years thanks to ultrasound guidance. They provide targeted, prolonged analgesia with a superior hemodynamic profile (less hypotension, no urinary retention) and the potential to significantly reduce opioid consumption. While postoperative pain remains a fundamental assessment criterion, modern approaches to perioperative medicine increasingly emphasize patient-reported outcomes (PROs)-results reported directly by patients. Factors such as pain, fatigue, sleep quality, functional independence, and satisfaction constitute an essential component of perioperative care, yet one that is not yet sufficiently integrated.

The QoR-15 (Quality of Recovery-15) questionnaire is a validated, concise tool (15 items, score range 0-150) that measures five dimensions of postoperative recovery: physical comfort, physical independence, pain, psychological well-being, and support. A French version has been validated with good psychometric properties, and its validity has been confirmed even in the context of emergency surgery. The minimal clinically important difference for the QoR-15 is estimated at 8 points, making it a sensitive tool for detecting differences in recovery between anesthetic techniques.

A trial by Yoo et al. (2024), comparing combined peripheral nerve block versus spinal anesthesia in 101 patients undergoing below-knee lower-limb surgery, demonstrated that-despite similar pain scores between the groups-peripheral nerve block offered superior physical independence, significantly higher satisfaction, and a markedly higher rate of patients willing to "choose the same anesthesia again." However, the global QoR-15 score at 24 hours did not differ significantly between the two groups; similarly, in the AnAnkle trial, QoR-15 scores at 24 hours were comparable between nerve block and spinal anesthesia. These results suggest that measuring quality of recovery at a later stage (days 5-7)-once the nerve block has worn off and the patient faces the realities of functional recovery at home-might be more discriminatory. Conversely, Droog et al. demonstrated in upper-limb surgery that regional anesthesia was not consistently associated with higher satisfaction; discomfort associated with the nerve block, waiting times, and fear could detract from the overall experience. These findings highlight that satisfaction and quality of recovery are not determined solely by analgesia but depend on the entire care pathway.

The meta-analysis by Lee et al.-the most comprehensive review on the subject-identified only two studies reporting satisfaction as an outcome measure, and none using a standardized quality-of-recovery score as the primary outcome. Similarly, large epidemiological cohort studies on ankle surgery have focused on in-hospital complications and readmissions, without incorporating patient-reported outcomes. Furthermore, existing studies have predominantly compared peripheral nerve blocks with spinal anesthesia without consistently including a general anesthesia-only group, even though the latter remains widely used in routine practice. Finally, almost all available data come from single-center trials conducted in diverse geographic settings; to our knowledge, no French multicenter study has evaluated the quality of recovery following ankle surgery by comparing these three anesthetic techniques.

The aim of this research project is to compare the quality of postoperative recovery at days 5-7, measured by the global QoR-15F score (15-18), between patients undergoing ankle surgery under:

• regional nerve block (peripheral nerve block), and
• spinal anesthesia.