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Hematopoietic and Lymphatic System NeoplasmCEVICNCT07805083

Community Enhanced Virtual Informed Consent

A study testing Educational Cancer Intervention, ICF Text Version 1 and ICF Text Version 2 in people with Hematopoietic and Lymphatic System Neoplasm and Malignant Solid Neoplasm, run by Mayo Clinic at 1 site in United States.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
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Trial summary

The goal of this clinical trial is to examine perceptions of virtual human communicators and cancer research recruitment messages. This study will also examine how different informed consent approaches influence decisions to participate in research. Read more about this study

Who is it for?
Ages 18 years and olderHealthy volunteers can take part
What is being tested?
Educational Cancer Intervention, ICF Text Version 1 and ICF Text Version 2
Could I receive a placebo?
No, everyone receives an active treatment
How many people
600 participants
Where
1 siteUnited States
Study dates
21 Jul 2026to 20 Jul 2029
Phase
Interventional
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • Healthy volunteers accepted
  • Adult, Older adult

Who may be able to join

  • Able to speak, read, or understand English sufficiently to provide informed consent
  • 18 years of age or older
  • White or Black
  • Living in the United States

Who cannot join

  • Unable to speak, read, or understand English sufficiently to provide informed consent
  • Inability on the part of the patient to understand the informed consent or be compliant with the protocol

Trial locations and contacts

1 site in 1 country. Contact the study team or a site near you to ask about taking part.

ETCH Lab contact

904-953-5375

ETCH@mayo.edu

United States1 site, 1 recruiting

  • Mayo Clinic in Florida

    Jacksonville, Florida, 32224-9980

    L. ETCH Lab, 904-953-5375, ETCH@mayo.edu

    Janice L. Krieger, PhD

    Recruiting

Other trials in United States

About this study

Official title: Exploring Health Communication Message Factors That Influence Cancer Research Recruitment

The goal of this clinical trial is to examine perceptions of virtual human communicators and cancer research recruitment messages. This study will also examine how different informed consent approaches influence decisions to participate in research.

Being tested
Educational Cancer Intervention, ICF Text Version 1, ICF Text Version 2, ICF Video Version 1, ICF Video Version 2

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Educational Cancer InterventionBehavioural

    Also called Behavioural

    Participants will view informed consent messaging presented in different formats

  • ICF Text Version 1Other

    Also called Formal Consent, Informed Consent, INFORMED CONSENT OBTAINED

    Receive a text-based informed consent form

  • ICF Text Version 2Other

    Also called Formal Consent, Informed Consent, INFORMED CONSENT OBTAINED

    Receive an adapted text-based informed consent form

  • ICF Video Version 1Other

    Also called Formal Consent, Informed Consent, INFORMED CONSENT OBTAINED

    Receive a video-based informed consent form delivered by virtual human #1

  • ICF Video Version 2Other

    Also called Formal Consent, Informed Consent, INFORMED CONSENT OBTAINED

    Receive a video-based informed consent form delivered by virtual human #2

  • ICF Video Version 3Other

    Also called Formal Consent, Informed Consent, INFORMED CONSENT OBTAINED

    Receive a video-based informed consent form delivered by virtual human #3

  • ICF Video Version 4Other

    Also called Formal Consent, Informed Consent, INFORMED CONSENT OBTAINED

    Receive a video-based informed consent form delivered by virtual human #4

  • Survey AdministrationOther

    Ancillary studies

Study groups in NCT07805083
Study groupRoleWhat they receive
Arm I - ICF Text Version 1ExperimentalPatients receive a standard of care-based informed consent form. Patients then complete an educational cancer messaging intervention where patients view images of virtual humans, view cancer recruitment study message frames and view images of hospital/institutional single-endorsement and multi-endorsement cancer study recruitment advertisements and rate them for credibility.
Receives: Behavioral: Educational Cancer Intervention; Other: ICF Text Version 1; Other: Survey Administration
Arm II - ICF Text Version 2ExperimentalPatients receive a modified community-enhanced language text-based informed consent form. Patients then complete an educational cancer messaging intervention where patients view images of virtual humans, view cancer recruitment study message frames and view images of hospital/institutional single-endorsement and multi-endorsement cancer study recruitment advertisements and rate them for credibility.
Receives: Behavioral: Educational Cancer Intervention; Other: ICF Text Version 2; Other: Survey Administration
Arm III - ICF Video Version 1ExperimentalPatients receive a video-based community-enhanced informed consent form delivered by a virtual human educator (Physician A). The virtual human explains the informed consent form content using the language from Arm II. Patients then complete an educational cancer messaging intervention where patients view images of virtual humans, view cancer recruitment study message frames and view images of hospital/institutional single-endorsement and multi-endorsement cancer study recruitment advertisements and rate them for credibility.
Receives: Behavioral: Educational Cancer Intervention; Other: ICF Video Version 1; Other: Survey Administration
Arm IV - ICF Video Version 2ExperimentalPatients receive a video-based community-enhanced informed consent form delivered by a virtual human educator (Physician B). The virtual human explains the informed consent form content using the language from Arm II. Patients then complete an educational cancer messaging intervention where patients view images of virtual humans, view cancer recruitment study message frames and view images of hospital/institutional single-endorsement and multi-endorsement cancer study recruitment advertisements and rate them for credibility.
Receives: Behavioral: Educational Cancer Intervention; Other: ICF Video Version 2; Other: Survey Administration
Arm V - ICF Video Version 3ExperimentalPatients receive a video-based community-enhanced informed consent form delivered by a virtual human educator (Community Member A). The virtual human explains the informed consent form content using the language from Arm II. Patients then complete an educational cancer messaging intervention where patients view images of virtual humans, view cancer recruitment study message frames and view images of hospital/institutional single-endorsement and multi-endorsement cancer study recruitment advertisements and rate them for credibility.
Receives: Behavioral: Educational Cancer Intervention; Other: ICF Video Version 3; Other: Survey Administration
Arm VI - ICF Video Version 4ExperimentalPatients receive a video-based community-enhanced informed consent form delivered by a virtual human educator (Community Member B). The virtual human explains the informed consent form content using the language from Arm II. Patients then complete an educational cancer messaging intervention where patients view images of virtual humans, view cancer recruitment study message frames and view images of hospital/institutional single-endorsement and multi-endorsement cancer study recruitment advertisements and rate them for credibility.
Receives: Behavioral: Educational Cancer Intervention; Other: ICF Video Version 4; Other: Survey Administration

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Self-efficacy (Aim 1)

    Assessed by 3 questions in the study-specific survey. The questions are answered on a scale of 1 (strongly disagree) to 5=strongly agree. Higher scores indicate greater feelings of self-efficacy.

    Measured: Baseline (immediately following intervention)

  2. Trustworthiness (Aim 2)

    Assessed by a study-specific survey asking participants to rate the intervention on a scale of 1 (untrustworthy) to 7 (trustworthy). Higher scores indicate greater perception of trustworthiness.

    Measured: Baseline (immediately following intervention)

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted4 Sep 2026
  2. Study start21 Jul 2026
  3. Primary completion20 Jul 2027 (estimated)
  4. Study completion20 Jul 2029 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Health services research
Allocation
Randomised
Intervention model
Parallel groups
Masking
None (open label)
Enrolment
600 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07805083
Sponsor's protocol ID
26-000655
Other IDs
NCI-2026-05713
Acronym
CEVIC
Status last verified
Sep 2026
First submitted
1 Sep 2026
Last updated
8 Sep 2026
Results posted
No
FDA-regulated drug
No
FDA-regulated device
No

Questions about this trial

What is this clinical trial studying?

A study testing Educational Cancer Intervention, ICF Text Version 1 and ICF Text Version 2 in people with Hematopoietic and Lymphatic System Neoplasm and Malignant Solid Neoplasm, run by Mayo Clinic at 1 site in United States.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 4 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 8 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact ETCH Lab (904-953-5375, ETCH@mayo.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Self-efficacy (Aim 1) (time frame: Baseline (immediately following intervention)). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07805083.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Sep 2026.

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