Population Health ManagementASCEND-MANCT07804095
AI-Supported Care Engagement for Next-step Delivery - Medicare Advantage
A study testing AI-Supported Rising-Risk Care Navigation in people with Population Health Management and Patient Navigation, run by Intermountain Health Care, Inc. at 1 site in United States.
Trial summary
ASCEND-MA is an embedded, health-services study of at-risk Medicare Advantage members attributed to Intermountain Health in Utah. Participants are quasi-randomized based on their medical-record-number parity to either AI-supported, nurse-reviewed proactive care navigation or usual care. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Population Health Management, Patient Navigation
- What is being tested?
- AI-Supported Rising-Risk Care Navigation
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 9,906 participants
- Where
- 1 siteUnited States
- Study dates
- 17 Aug 2026to 17 Nov 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- •.Enrolled in an eligible Medicare Advantage plan and attributed to Intermountain Health in Utah.
- Continuous Medicare Advantage enrollment for at least 6 months before the index date.
- PRM Rising-Risk score (an internally derived prediction model) of at least 0.70 and Current-Risk score below 0.95 at index
- Predicted year-over-year cost increase of at least 30%.
- At least one targeted chronic condition: diabetes mellitus, heart failure, chronic obstructive pulmonary disease, chronic kidney disease, hypertension, or hyperlipidemia.
Who cannot join
- Hospice enrollment at index.
- End-stage renal disease requiring chronic dialysis at index.
- Active oncology treatment at index.
- Long-term institutional residence, including skilled-nursing-facility residence, at index.
- Primary language cannot be supported through patient-directed outreach and no feasible alternative care-team communication pathway is available.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site
Intermountain Health - ASCEND-MA Statewide Cohort
Murray, Utah, 84107
About this study
Official title: AI-Supported Care Engagement for Next-step Delivery - Medicare Advantage (ASCEND-MA)
ASCEND-MA is an embedded, health-services study of at-risk Medicare Advantage members attributed to Intermountain Health in Utah. Participants are quasi-randomized based on their medical-record-number parity to either AI-supported, nurse-reviewed proactive care navigation or usual care. The study will evaluate whether the program changes cumulative payor-paid healthcare spending over 12 months.
Read the detailed description
An additional ancillary, separately consented consumer-experience sub-study will sample roughly 45 intervention-arm participants for surveys and interviews about the acceptability, burden, and perceived usefulness of the care-navigation workflow.
- Conditions
- Population Health Management, Patient Navigation
- Being tested
- AI-Supported Rising-Risk Care Navigation
- Keywords
- Population Health, Care Navigation, Medicare Advantage, Artificial Intelligence, Clinical Decision Support, Care Management, Health Services Research, Chronic Disease Management, Risk Stratification, Preventative Care, Health Care Utilization, Health Care Costs
- Medical subject headings
- Patient Acceptance of Health Care
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
AI-Supported Rising-Risk Care NavigationOther
AI-supported proactive care navigation involves the generation of guideline-informed candidate care-navigation actions from protocol-authorized structured data, human-in-the-loop review by a nurse, and then delivery of the approved suggestion through existing care-management or clinical workflows. The nurse may accept, modify, reroute, or reject each candidate before participant outreach or care-team routing. Reassessment is planned approximately every 90 days and may change intervention delivery, but not assigned-group membership.
| Study group | Role | What they receive |
|---|---|---|
| AI Supported Rising Risk Care Navigation | Experimental | Participants receive routine clinical care plus the AI Supported Rising Risk Care Navigation strategy. The strategy periodically assesses for care opportunities; every candidate nudge undergoes human clinical review before routing or outreach, and no outreach occurs when no clinically appropriate action is identified Receives: Other: AI-Supported Rising-Risk Care Navigation |
| Usual Care | No intervention | Participants receive routine clinical care and existing care-management services under standard eligibility and operating rules. The study introduces no AI-supported care-navigation nudges for this arm and withholds no otherwise available care because of assignment |
What is being measured
The primary outcome is the main question the study is designed to answer.
Cumulative payer-paid health care spending per participant
Mean cumulative payer-paid health care spending (in U.S. dollars) recorded in claims per participant.
Measured: 1 year
Secondary outcomes (1)
Rate of All-Cause Acute-Care Episodes
Inpatient admissions, emergency department visits, and observation stays will be combined into acute-care episodes, with related encounters counted once.
Measured: 1 year
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted4 Sep 2026
- Study start17 Aug 2026
- Primary completion17 Nov 2027 (estimated)
- Study completion17 Nov 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Population Health ManagementStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Health services research
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Model description
- Eligible participants are quasi-randomized 1:1 at the individual level using medical-record-number parity.
- Masking
- None (open label)
- Enrolment
- 9,906 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Intermountain Health Care, Inc.
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07804095
- Sponsor's protocol ID
- 1053851
- Acronym
- ASCEND-MA
- Status last verified
- Aug 2026
- First submitted
- 27 Aug 2026
- Last updated
- 4 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 4 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- AI-Supported Care Engagement for Next-step Delivery - Medicare Advantage (ASCEND-MA)
- ClinicalTrials.gov ID
- NCT07804095
- Acronym / sponsor ID
- ASCEND-MA / 1053851
- Conditions
- Population Health Management, Patient Navigation
- Keywords
- Population Health, Care Navigation, Medicare Advantage, Artificial Intelligence, Clinical Decision Support, Care Management, Health Services Research, Chronic Disease Management
- Study type
- Interventional
- Recruitment status
- Enrolling by invitation
- Enrolment
- 9,906 participants (estimated)
- Lead sponsor
- Intermountain Health Care, Inc.University, hospital or other
- Study start
- 17 Aug 2026 (actual)
- Primary completion
- 17 Nov 2027 (estimated)
- Study completion
- 17 Nov 2027 (estimated)
- First posted
- 4 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
ASCEND-MA is an embedded, health-services study of at-risk Medicare Advantage members attributed to Intermountain Health in Utah. Participants are quasi-randomized based on their medical-record-number parity to either AI-supported, nurse-reviewed proactive care navigation or usual care. The study will evaluate whether the program changes cumulative payor-paid healthcare spending over 12 months.
Detailed description
An additional ancillary, separately consented consumer-experience sub-study will sample roughly 45 intervention-arm participants for surveys and interviews about the acceptability, burden, and perceived usefulness of the care-navigation workflow.
Study design
- Primary purpose
- Health services research
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- Eligible participants are quasi-randomized 1:1 at the individual level using medical-record-number parity.
| Arm | Type | Receives |
|---|---|---|
| AI Supported Rising Risk Care Navigation | Experimental | Other: AI-Supported Rising-Risk Care NavigationParticipants receive routine clinical care plus the AI Supported Rising Risk Care Navigation strategy. The strategy periodically assesses for care opportunities; every candidate nudge undergoes human clinical review before routing or outreach, and no outreach occurs when no clinically appropriate action is identified |
| Usual Care | No intervention | –Participants receive routine clinical care and existing care-management services under standard eligibility and operating rules. The study introduces no AI-supported care-navigation nudges for this arm and withholds no otherwise available care because of assignment |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- •.Enrolled in an eligible Medicare Advantage plan and attributed to Intermountain Health in Utah.
- Continuous Medicare Advantage enrollment for at least 6 months before the index date.
- PRM Rising-Risk score (an internally derived prediction model) of at least 0.70 and Current-Risk score below 0.95 at index
- Predicted year-over-year cost increase of at least 30%.
- At least one targeted chronic condition: diabetes mellitus, heart failure, chronic obstructive pulmonary disease, chronic kidney disease, hypertension, or hyperlipidemia.
Key exclusion criteria (5 listed)
- Hospice enrollment at index.
- End-stage renal disease requiring chronic dialysis at index.
- Active oncology treatment at index.
- Long-term institutional residence, including skilled-nursing-facility residence, at index.
- Primary language cannot be supported through patient-directed outreach and no feasible alternative care-team communication pathway is available.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| AI-Supported Rising-Risk Care NavigationAI-supported proactive care navigation involves the generation of guideline-informed candidate care-navigation actions from protocol-authorized structured data, human-in-the-loop review by a nurse, and then delivery of the approved suggestion through existing care-management or clinical workflows. The nurse may accept, modify, reroute, or reject each candidate before participant outreach or care-team routing. Reassessment is planned approximately every 90 days and may change intervention delivery, but not assigned-group membership. | Other | AI Supported Rising Risk Care Navigation |
Primary outcome
Cumulative payer-paid health care spending per participant
Time frame: 1 year
Mean cumulative payer-paid health care spending (in U.S. dollars) recorded in claims per participant.
1 secondary outcome
Rate of All-Cause Acute-Care Episodes
Time frame: 1 year
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Sep 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing AI-Supported Rising-Risk Care Navigation in people with Population Health Management and Patient Navigation, run by Intermountain Health Care, Inc. at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: enrolling by invitation, as of the sponsor's last update on 4 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Cumulative payer-paid health care spending per participant (time frame: 1 year). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Sep 2026.