OpioidsWWNCT07799766
WorkWell - Preventing Prescription Opioid Misuse Among Employees Working in High Risk Industries
A study testing WorkWell in people with Opioids, run by Prevention Strategies, LLC at 2 sites in United States.
Trial summary
WorkWell is a mobile-delivered behavioral intervention designed to prevent prescription opioid misuse and overuse among construction workers and healthcare workers. Two sequential randomized factorial optimization trials evaluated intervention lessons targeting opioid-related beliefs, norms, pain-management… Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Opioids
- What is being tested?
- WorkWell
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 759 participants
- Where
- 2 sitesUnited States
- Study dates
- 7 Aug 2024to 5 Jan 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Age 18 years or older Construction worker, nurse, or nursing assistant
Who cannot join
- Under 18 years of age Not employed as a construction worker, nurse, or nursing assistant
Trial locations and contacts
2 sites in 1 country.
United States2 sites
Cone Health
Greensboro, North Carolina, 27401
Samet Corporation
Greensboro, North Carolina, 27409
About this study
Official title: Preventing Prescription Opioid Misuse Among Employees Working in High Risk Industries
WorkWell is a mobile-delivered behavioral intervention designed to prevent prescription opioid misuse and overuse among construction workers and healthcare workers. Two sequential randomized factorial optimization trials evaluated intervention lessons targeting opioid-related beliefs, norms, pain-management alternatives, and patient-provider communication. Participants completed assessments at baseline, immediately after the intervention, and approximately 30 days later.
- Conditions
- Opioids
- Being tested
- WorkWell
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
WorkWellBehavioural
Mobile-delivered behavioral intervention designed to prevent prescription opioid misuse and overuse among construction workers and nurses. WorkWell includes lessons addressing opioid-related knowledge, expectancies, norms, pain management alternatives, and patient-provider communication.
| Study group | Role | What they receive |
|---|---|---|
| Knowledge Lesson Only | Experimental | Participants received the WorkWell Knowledge lesson but did not receive the four experimentally varied lessons: Norms, Expectancies, Pain Management Alternatives, or Patient-Provider Communication. Receives: Behavioral: WorkWell |
| Knowledge + Norms | Experimental | Participants received the Knowledge lesson and the Norms lesson. Receives: Behavioral: WorkWell |
| Knowledge + Expectancies | Experimental | Participants received the Knowledge lesson and the Expectancies lesson. Receives: Behavioral: WorkWell |
| Knowledge + Pain Management Alternatives | Experimental | Participants received the Knowledge lesson and the Pain Management Alternatives lesson. Receives: Behavioral: WorkWell |
| Knowledge + Patient-Provider Communication | Experimental | Participants received the Knowledge lesson and the Patient-Provider Communication lesson. Receives: Behavioral: WorkWell |
| Knowledge + Norms + Expectancies | Experimental | Participants received the Knowledge, Norms, and Expectancies lessons. Receives: Behavioral: WorkWell |
| Knowledge + Norms + Pain Management | Experimental | Participants received the Knowledge, Norms, and Pain Management Alternatives lessons. Receives: Behavioral: WorkWell |
| Knowledge + Norms + Patient-Provider Communication | Experimental | Participants received the Knowledge, Norms, and Patient-Provider Communication lessons. Receives: Behavioral: WorkWell |
| Knowledge + Expectancies + Pain Management Alternatives | Experimental | Participants received the Knowledge, Expectancies, and Pain Management Alternatives lessons. Receives: Behavioral: WorkWell |
| Knowledge + Expectancies + Patient-Provider Communication | Experimental | Participants received the Knowledge, Expectancies, and Patient-Provider Communication lessons. Receives: Behavioral: WorkWell |
| Knowledge + Pain Management + Patient-Provider Communication | Experimental | Participants received the Knowledge, Pain Management Alternatives, and Patient-Provider Communication lessons. Receives: Behavioral: WorkWell |
| Knowledge + Norms + Expectancies + Pain Management | Experimental | Participants received the Knowledge, Norms, Expectancies, and Pain Management Alternatives lessons. Receives: Behavioral: WorkWell |
| Knowledge + Norms + Expectancies + Patient-Provider Communication | Experimental | Participants received the Knowledge, Norms, Expectancies, and Patient-Provider Communication lessons. Receives: Behavioral: WorkWell |
| Knowledge + Norms + Pain Management Alternatives + Patient-Provider Communication | Experimental | Participants received the Knowledge, Norms, Pain Management Alternatives, and Patient-Provider Communication lessons. Receives: Behavioral: WorkWell |
| Knowledge + Expectancies + Pain Management Alternatives + Patient-Provider Communication | Experimental | Participants received the Knowledge, Expectancies, Pain Management Alternatives, and Patient-Provider Communication lessons. Receives: Behavioral: WorkWell |
| All WorkWell Lessons | Experimental | Participants received the Knowledge, Norms, Expectancies, Pain Management Alternatives, and Patient-Provider Communication lessons. Receives: Behavioral: WorkWell |
What is being measured
The primary outcome is the main question the study is designed to answer.
Expectancies
Prescription opioid misuse and/or overuse expectancies held by construction workers and nurses.
Measured: Measured at pre-survey, immediate post survey, and then 30 days following post survey
Normative Perceptions
Prescription opioid misuse and/or overuse normative perceptions held by construction workers and nurses.
Measured: Measured at pre-survey, immediate post survey, and then 30 days following post survey
Behavioral Contral
Perceived behavioral control of prescription opioid misuse and/or overuse intentions held by construction workers and nurses.
Measured: Measured at pre-survey, immediate post survey, and then 30 days following post survey
Intentions
Intentions to misuse and/or overuse prescription opioids among construction workers and nurses.
Measured: Measured at pre-survey, immediate post survey, and then 30 days following post survey
Secondary outcomes (3)
Initiation
Initiation of prescription opioid misuse and/or overuse among construction workers and nurses.
Measured: Measured at pre-survey and then 30 days following post survey
Opioid Misuse
Prescription opioid misuse reported by construction workers and nurses.
Measured: Measured at pre-survey and then 30 days following post survey
Opioid Overuse
Prescription opioid overuse reported by construction workers.
Measured: Measured at pre-survey and then 30 days following post survey
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted2 Sep 2026
- Study start7 Aug 2024
- Primary completion5 Jan 2026
- Study completion5 Jan 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for OpioidsStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Factorial
- Masking
- None (open label)
- Enrolment
- 759 participants (actual)
Sponsor and investigators
- Lead sponsor
- Prevention Strategies, LLC
- Sponsor type
- Industry (pharma, biotech, devices)
- Collaborators
- National Institute on Drug Abuse (NIDA)
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07799766
- Sponsor's protocol ID
- R44DA050404
- Other IDs
- 5R44DA050404-03
- Acronym
- WW
- Status last verified
- Aug 2026
- First submitted
- 28 Aug 2026
- Last updated
- 2 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 2 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Preventing Prescription Opioid Misuse Among Employees Working in High Risk Industries
- ClinicalTrials.gov ID
- NCT07799766
- Acronym / sponsor ID
- WW / R44DA050404
- Conditions
- Opioids
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 759 participants (actual)
- Lead sponsor
- Prevention Strategies, LLCIndustry (pharma, biotech, devices)
- Collaborators
- National Institute on Drug Abuse (NIDA)
- Study start
- 7 Aug 2024 (actual)
- Primary completion
- 5 Jan 2026 (actual)
- Study completion
- 5 Jan 2026 (actual)
- First posted
- 2 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
WorkWell is a mobile-delivered behavioral intervention designed to prevent prescription opioid misuse and overuse among construction workers and healthcare workers. Two sequential randomized factorial optimization trials evaluated intervention lessons targeting opioid-related beliefs, norms, pain-management alternatives, and patient-provider communication. Participants completed assessments at baseline, immediately after the intervention, and approximately 30 days later.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Factorial
- Masking
- None (open label)
- Number of arms
- 16
| Arm | Type | Receives |
|---|---|---|
| Knowledge Lesson Only | Experimental | Behavioral: WorkWellParticipants received the WorkWell Knowledge lesson but did not receive the four experimentally varied lessons: Norms, Expectancies, Pain Management Alternatives, or Patient-Provider Communication. |
| Knowledge + Norms | Experimental | Behavioral: WorkWellParticipants received the Knowledge lesson and the Norms lesson. |
| Knowledge + Expectancies | Experimental | Behavioral: WorkWellParticipants received the Knowledge lesson and the Expectancies lesson. |
| Knowledge + Pain Management Alternatives | Experimental | Behavioral: WorkWellParticipants received the Knowledge lesson and the Pain Management Alternatives lesson. |
| Knowledge + Patient-Provider Communication | Experimental | Behavioral: WorkWellParticipants received the Knowledge lesson and the Patient-Provider Communication lesson. |
| Knowledge + Norms + Expectancies | Experimental | Behavioral: WorkWellParticipants received the Knowledge, Norms, and Expectancies lessons. |
| Knowledge + Norms + Pain Management | Experimental | Behavioral: WorkWellParticipants received the Knowledge, Norms, and Pain Management Alternatives lessons. |
| Knowledge + Norms + Patient-Provider Communication | Experimental | Behavioral: WorkWellParticipants received the Knowledge, Norms, and Patient-Provider Communication lessons. |
| Knowledge + Expectancies + Pain Management Alternatives | Experimental | Behavioral: WorkWellParticipants received the Knowledge, Expectancies, and Pain Management Alternatives lessons. |
| Knowledge + Expectancies + Patient-Provider Communication | Experimental | Behavioral: WorkWellParticipants received the Knowledge, Expectancies, and Patient-Provider Communication lessons. |
| Knowledge + Pain Management + Patient-Provider Communication | Experimental | Behavioral: WorkWellParticipants received the Knowledge, Pain Management Alternatives, and Patient-Provider Communication lessons. |
| Knowledge + Norms + Expectancies + Pain Management | Experimental | Behavioral: WorkWellParticipants received the Knowledge, Norms, Expectancies, and Pain Management Alternatives lessons. |
| Knowledge + Norms + Expectancies + Patient-Provider Communication | Experimental | Behavioral: WorkWellParticipants received the Knowledge, Norms, Expectancies, and Patient-Provider Communication lessons. |
| Knowledge + Norms + Pain Management Alternatives + Patient-Provider Communication | Experimental | Behavioral: WorkWellParticipants received the Knowledge, Norms, Pain Management Alternatives, and Patient-Provider Communication lessons. |
| Knowledge + Expectancies + Pain Management Alternatives + Patient-Provider Communication | Experimental | Behavioral: WorkWellParticipants received the Knowledge, Expectancies, Pain Management Alternatives, and Patient-Provider Communication lessons. |
| All WorkWell Lessons | Experimental | Behavioral: WorkWellParticipants received the Knowledge, Norms, Expectancies, Pain Management Alternatives, and Patient-Provider Communication lessons. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- Age 18 years or older Construction worker, nurse, or nursing assistant
Key exclusion criteria (1 listed)
- Under 18 years of age Not employed as a construction worker, nurse, or nursing assistant
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| WorkWellMobile-delivered behavioral intervention designed to prevent prescription opioid misuse and overuse among construction workers and nurses. WorkWell includes lessons addressing opioid-related knowledge, expectancies, norms, pain management alternatives, and patient-provider communication. | Behavioural | All WorkWell Lessons, Knowledge + Expectancies, Knowledge + Expectancies + Pain Management Alternatives, Knowledge + Expectancies + Pain Management Alternatives + Patient-Provider Communication, Knowledge + Expectancies + Patient-Provider Communication, Knowledge + Norms, Knowledge + Norms + Expectancies, Knowledge + Norms + Expectancies + Pain Management, Knowledge + Norms + Expectancies + Patient-Provider Communication, Knowledge + Norms + Pain Management, Knowledge + Norms + Pain Management Alternatives + Patient-Provider Communication, Knowledge + Norms + Patient-Provider Communication, Knowledge + Pain Management + Patient-Provider Communication, Knowledge + Pain Management Alternatives, Knowledge + Patient-Provider Communication, Knowledge Lesson Only |
Primary outcome
Expectancies
Time frame: Measured at pre-survey, immediate post survey, and then 30 days following post survey
Prescription opioid misuse and/or overuse expectancies held by construction workers and nurses.
Normative Perceptions
Time frame: Measured at pre-survey, immediate post survey, and then 30 days following post survey
Prescription opioid misuse and/or overuse normative perceptions held by construction workers and nurses.
Behavioral Contral
Time frame: Measured at pre-survey, immediate post survey, and then 30 days following post survey
Perceived behavioral control of prescription opioid misuse and/or overuse intentions held by construction workers and nurses.
Intentions
Time frame: Measured at pre-survey, immediate post survey, and then 30 days following post survey
Intentions to misuse and/or overuse prescription opioids among construction workers and nurses.
3 secondary outcomes
Initiation
Time frame: Measured at pre-survey and then 30 days following post survey
Opioid Misuse
Time frame: Measured at pre-survey and then 30 days following post survey
Opioid Overuse
Time frame: Measured at pre-survey and then 30 days following post survey
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 2 Sep 2026.
- Individual participant dataSharing planned: No
Related trials for Opioids
Not yet recruiting
Prescribe to Prevent HIV: A Hybrid Trial Helping Addiction Clinics Prevent HIV & Infections Through Safer Drug Use Support
People Who Use Opioids/People With Opioid Use Disorder (OUD)
Enrolling by invitationObservational study
Development of an Interview-Informed Timeline Follow-Back (TLFB) for Opioid Use in the Era of Fentanyl
Substance Use Disorders (SUDs)
Recruiting
Tele-HOPE: A Telehealth Pharmacist Opioid Patient Education Pilot Study
Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
Not yet recruiting
Comprehensive Opioid Management and Breathing During Sleep
Sleep-Disordered Breathing, Chronic Opioid Use
Active, not recruitingPhase 2
Wellcome Leap Psilocybin for OUD
Opioid Use Disorder
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing WorkWell in people with Opioids, run by Prevention Strategies, LLC at 2 sites in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 2 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Expectancies (time frame: Measured at pre-survey, immediate post survey, and then 30 days following post survey). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Sep 2026.